UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): December 20, 2013

QUINTILES TRANSNATIONAL

HOLDINGS INC.

(Exact name of registrant as specified in its charter)

Registrant’s telephone number, including area code: (919) 998-2000

Not Applicable

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Item 1.01 Entry into a Material Definitive Agreement.

On December 20, 2013, Quintiles Transnational Corp. (“Quintiles”), a wholly owned subsidiary of Quintiles Transnational Holdings Inc., entered into Amendment No. 3 (the “Amendment”) to the Credit Agreement, dated as of June 8, 2011, as amended, among Quintiles, the lenders from time to time party thereto, JPMorgan Chase Bank, N.A., as administrative agent, and the other agents party thereto.

The Amendment replaces the $121.8 million outstanding under Quintiles’ existing senior secured term B-1 loan and the $1.939 billion outstanding under Quintiles’ existing senior secured term B-2 loan with a new $2.061 billion senior secured term B-3 loan on substantially the same terms as the term B-1 loan and term B-2 loan, other than a lower interest rate. Borrowings under the term B-3 loan will bear interest at LIBOR plus an applicable margin of 2.50% or a base rate plus an applicable margin of 1.50%, and reflect a reduction of 0.75% to the term B-1 loan interest rate and a reduction of 0.25% to the term B-2 loan interest rate. The Amendment also provides additional flexibility for Quintiles to enter into certain securitization financing transactions.

The foregoing description of the Amendment is qualified in its entirety by reference to the full text of the Amendment, which is filed as Exhibit 10.1 to this Form 8-K and incorporated herein by reference.

Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant.

The information provided in Item 1.01 of this report is incorporated by reference into this Item 2.03.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

See the Exhibit Index attached hereto.

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

EXHIBIT INDEX