Attached files

file filename
S-1 - REGISTRATION STATEMENT ON FORM S1 - Signal Advance IncRS_S1_SAI.txt
EX-10 - PROMISSORY NOTE - Signal Advance IncEX-10.2_Promissory_Note.txt
EX-10 - LEASE AGREEMENT - Signal Advance IncEX-10.1_Lease_Agrmt.txt
EX-10 - INTELLECTUAL PROPERTY ASSIGNMENT - Signal Advance IncEX-10.4_IP_Assignment.txt
EX-10 - CONSULTING AGREEMENT - Signal Advance IncEX-10.3_Consulting_Agreement.txt
EX-23 - CONSENT - AUDITOR, BOBBY J HUTTON - Signal Advance IncEX-23.1_Consent_Auditor.txt
EX-14 - CODE OF ETHICS - Signal Advance IncEX-14.1_Code_of_Ethics.txt
EX-23 - CONSENT - ATTORNEY, RICHARD C SELTZER - Signal Advance IncEX-23.2_Consent_Atty.txt
EX-23 - CONSENT - CONSULTANT, DR RUSSELL - Signal Advance IncEX-23.3_Consent_Consultant.txt
EX-23 - CONSENT - PATENT ATTORNEY, DAVID HENRY - Signal Advance IncEX-23.4_Consent_Patent_Atty.txt
EX-3 - ARTICLES OF INCORPORATION - JUL02 - Signal Advance IncEX-3.1_Art_of_Inc_JUL_92.txt
EX-3 - ARTICLES OF AMENDMENT - SEP04 - Signal Advance IncEX-3.2_Art_of_Amend_SEP_04.txt
EX-3 - ARTICLES OF AMENDMENT - JUL05 - Signal Advance IncEX-3.3_Art_of_Amend_JUL_05.txt
EX-3 - ARTICLES OF AMENDMENT - JUN07 - Signal Advance IncEX-3.4_Art_of_Amend_JUN_07.txt
EX-3 - CORPORATE BYLAWS - Signal Advance IncEX-3.6_Bylaws_of_Registrant.txt
EX-99 - EXPERT OPINION, DAVID HENRY - Signal Advance IncEX-99.1_Opinion_DG_Henry.txt
EX-99 - EXPERT OPINION, DR RUSSELL - Signal Advance IncEX-99.2_Opinion_H_Russell.txt
EX-99 - LETTER OF COLLABORATION - DR SINENCIO- SANCHEZ - Signal Advance IncEX-99.4_Collab_TAMU_ECE.txt
EX-99 - LETTER OF COLLABORATION - DR SHIH - Signal Advance IncEX-99.5_Collab_Dr_Shih.txt
EX-3 - ARTICLES OF AMENDMENT - JUL11 - Signal Advance IncEX-3.5_Art_of_Amend_JUL_11.txt
EX-99 - 5TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.10_5th_Draft_Reg_Stmt.txt
EX-99 - 1ST DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.6_1st_Draft_Reg_Stmt.txt
EX-99 - 2ND DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.7_2nd_Draft_Reg_Stmt.txt
EX-99 - 3RD DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.8_3rd_Draft_Reg_Stmt.txt
EX-99 - 4TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.9_4th_Draft_Reg_Stmt.txt
EX-99 - 6TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.11_6th_Draft_Reg_Stmt.txt
EX-5 - LEGAL OPINION - VALIDITY OF STOCK - RICHARD C SELTZER - Signal Advance IncEX-5.1_Legal_Opinion_Stock.txt

EXHIBIT 99.3 - Letter of Collaboration, Larry S. Micheletti, Ph.D.,


On the Letterhead of:

               Larry S. Micheletti, Ph.D., Dept. of Pediatrics,UTMB Health


Dear Chris Hymel,

As the Principal Investigator of research dealing with school age children, I
am currently seeking approval from the University of Texas Medical Branch and
the Institutional Review Board (IRB) to begin a study in Galveston Texas
working with the Galveston Independent School District.

The purpose of my study is to determine if normally developing children can
make large and long lasting gains in their IQ test scores after receiving brief
and inexpensive repetitive training with EEG-Driven neurofeedback. A previous
three year series of studies funded by the U.S. Department of Education found
that attention deficit disordered (ADHD) children made large and long lasting
gains in their IQ test score after receiving this type of training.

In neurofeedback (NP) training, bioelectric signals (EEG's) produced by the
brain are detected and used to adjust the feedback presented to the subject.
The effectiveness of the neurofeedback training is closely related to the
ability of the technology to match as nearly as possible the frequency of
stimulation of each person to the dominant frequency of that individual's brain
wave (EEG) activity (a process called entrainment). The time delay between EEG
detection and stimulus presentation to the subject (feedback) influences the
effectiveness if the training.

I anticipate that implementing Signal Advance technology could reduce or
eliminate the feedback delay and thus significantly improve the effectiveness
of NF training by increasing the speed and accuracy of the matching or
entrainment. Any increases in effectiveness could result in achieving the same
result with fewer sessions, thereby lowering time and costs of the training.

In my capacity as faculty in the Department of Pediatrics, I look forward to
collaborating with you in determining if Signal Advance technology can
significantly increase and improve the effectiveness of NF training in
increasing children's IQ test scores.

Sincerely,

/s/ Larry S. Micheletti, Ph.D.                    11/1/2012

University of Texas Medical Branch
Department of Pediatrics
Assistant Professor of Pediatrics
Teen Health Center Inc.
Mental Health Director
UTMB Healt