Attached files

file filename
S-1 - REGISTRATION STATEMENT ON FORM S1 - Signal Advance IncRS_S1_SAI.txt
EX-10 - PROMISSORY NOTE - Signal Advance IncEX-10.2_Promissory_Note.txt
EX-10 - LEASE AGREEMENT - Signal Advance IncEX-10.1_Lease_Agrmt.txt
EX-10 - INTELLECTUAL PROPERTY ASSIGNMENT - Signal Advance IncEX-10.4_IP_Assignment.txt
EX-10 - CONSULTING AGREEMENT - Signal Advance IncEX-10.3_Consulting_Agreement.txt
EX-23 - CONSENT - AUDITOR, BOBBY J HUTTON - Signal Advance IncEX-23.1_Consent_Auditor.txt
EX-14 - CODE OF ETHICS - Signal Advance IncEX-14.1_Code_of_Ethics.txt
EX-23 - CONSENT - ATTORNEY, RICHARD C SELTZER - Signal Advance IncEX-23.2_Consent_Atty.txt
EX-23 - CONSENT - CONSULTANT, DR RUSSELL - Signal Advance IncEX-23.3_Consent_Consultant.txt
EX-23 - CONSENT - PATENT ATTORNEY, DAVID HENRY - Signal Advance IncEX-23.4_Consent_Patent_Atty.txt
EX-3 - ARTICLES OF INCORPORATION - JUL02 - Signal Advance IncEX-3.1_Art_of_Inc_JUL_92.txt
EX-3 - ARTICLES OF AMENDMENT - SEP04 - Signal Advance IncEX-3.2_Art_of_Amend_SEP_04.txt
EX-3 - ARTICLES OF AMENDMENT - JUL05 - Signal Advance IncEX-3.3_Art_of_Amend_JUL_05.txt
EX-3 - ARTICLES OF AMENDMENT - JUN07 - Signal Advance IncEX-3.4_Art_of_Amend_JUN_07.txt
EX-3 - CORPORATE BYLAWS - Signal Advance IncEX-3.6_Bylaws_of_Registrant.txt
EX-99 - EXPERT OPINION, DAVID HENRY - Signal Advance IncEX-99.1_Opinion_DG_Henry.txt
EX-99 - LETTER OF COLLABORATION - DR MICHELETTI - Signal Advance IncEX-99.3_Collab_UTMB_Health.txt
EX-99 - LETTER OF COLLABORATION - DR SINENCIO- SANCHEZ - Signal Advance IncEX-99.4_Collab_TAMU_ECE.txt
EX-99 - LETTER OF COLLABORATION - DR SHIH - Signal Advance IncEX-99.5_Collab_Dr_Shih.txt
EX-3 - ARTICLES OF AMENDMENT - JUL11 - Signal Advance IncEX-3.5_Art_of_Amend_JUL_11.txt
EX-99 - 5TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.10_5th_Draft_Reg_Stmt.txt
EX-99 - 1ST DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.6_1st_Draft_Reg_Stmt.txt
EX-99 - 2ND DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.7_2nd_Draft_Reg_Stmt.txt
EX-99 - 3RD DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.8_3rd_Draft_Reg_Stmt.txt
EX-99 - 4TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.9_4th_Draft_Reg_Stmt.txt
EX-99 - 6TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.11_6th_Draft_Reg_Stmt.txt
EX-5 - LEGAL OPINION - VALIDITY OF STOCK - RICHARD C SELTZER - Signal Advance IncEX-5.1_Legal_Opinion_Stock.txt

EXHIBIT 99.2 - Expert Opinion, Harold L. Russell, Ph.D., Neuromedics
	       Technology, Inc.


On the Letterhead of Harold L. Russell, Ph.D., Neuromedics Technology, Inc.


Harold L Russell, PhD
NeuroMedics Technology, Inc.
PO Box 240, Galveston, TX 77553
(409) 763 5568
harold.r@sbcglobal.net


October 14, 2012

Dr. Chris M Hymel, President
Signal Advance, Inc.
2520 County Road 81
Rosharon, Texas 77583

Dear Chris:
I am looking forward with much anticipation to collaborating with you to
demonstrate the degree to which Signal Advance technology will improve the
performance of my own technology - repetitive EEG-Driven Light and Sound
Stimulation (rEDLSS) neuro-therapy systems. I expect the reduced response
delay will markedly increase treatment efficacy, thereby decreasing the amount
of time required to produce significant and long lasting increases in children
memory and cognitive abilities as indicated by IQ test scores. Increased
scores on IQ tests are usually thought to be indicative of an increased
ability to learn and perform well in school.

Increased effectiveness resulting from the incorporation of Signal Advance
technology could significantly improve the precision of the stimulation,
improving treatment efficiency and thus, significantly decrease treatment
time. The direct cost of EDLSS treatment could then become even more
affordable to most schools and parents.

It is my belief that Signal Advance technology will likely be seen as a
disruptive technology that forces rapid change in the field of biomedical
instrumentation with early adopters of this technology gaining a significant
commercial advantage over later adopters in the same field.

I am pleased to be able to be a part of and support the development and
 implementation of Signal Advance technology.


/s/ Harold L. Russell, Ph.D.

Harold L Russell, Ph