Attached files

file filename
S-1 - REGISTRATION STATEMENT ON FORM S1 - Signal Advance IncRS_S1_SAI.txt
EX-10 - PROMISSORY NOTE - Signal Advance IncEX-10.2_Promissory_Note.txt
EX-10 - LEASE AGREEMENT - Signal Advance IncEX-10.1_Lease_Agrmt.txt
EX-10 - INTELLECTUAL PROPERTY ASSIGNMENT - Signal Advance IncEX-10.4_IP_Assignment.txt
EX-10 - CONSULTING AGREEMENT - Signal Advance IncEX-10.3_Consulting_Agreement.txt
EX-23 - CONSENT - AUDITOR, BOBBY J HUTTON - Signal Advance IncEX-23.1_Consent_Auditor.txt
EX-14 - CODE OF ETHICS - Signal Advance IncEX-14.1_Code_of_Ethics.txt
EX-23 - CONSENT - ATTORNEY, RICHARD C SELTZER - Signal Advance IncEX-23.2_Consent_Atty.txt
EX-23 - CONSENT - CONSULTANT, DR RUSSELL - Signal Advance IncEX-23.3_Consent_Consultant.txt
EX-23 - CONSENT - PATENT ATTORNEY, DAVID HENRY - Signal Advance IncEX-23.4_Consent_Patent_Atty.txt
EX-3 - ARTICLES OF INCORPORATION - JUL02 - Signal Advance IncEX-3.1_Art_of_Inc_JUL_92.txt
EX-3 - ARTICLES OF AMENDMENT - SEP04 - Signal Advance IncEX-3.2_Art_of_Amend_SEP_04.txt
EX-3 - ARTICLES OF AMENDMENT - JUL05 - Signal Advance IncEX-3.3_Art_of_Amend_JUL_05.txt
EX-3 - ARTICLES OF AMENDMENT - JUN07 - Signal Advance IncEX-3.4_Art_of_Amend_JUN_07.txt
EX-3 - CORPORATE BYLAWS - Signal Advance IncEX-3.6_Bylaws_of_Registrant.txt
EX-99 - EXPERT OPINION, DR RUSSELL - Signal Advance IncEX-99.2_Opinion_H_Russell.txt
EX-99 - LETTER OF COLLABORATION - DR MICHELETTI - Signal Advance IncEX-99.3_Collab_UTMB_Health.txt
EX-99 - LETTER OF COLLABORATION - DR SINENCIO- SANCHEZ - Signal Advance IncEX-99.4_Collab_TAMU_ECE.txt
EX-99 - LETTER OF COLLABORATION - DR SHIH - Signal Advance IncEX-99.5_Collab_Dr_Shih.txt
EX-3 - ARTICLES OF AMENDMENT - JUL11 - Signal Advance IncEX-3.5_Art_of_Amend_JUL_11.txt
EX-99 - 5TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.10_5th_Draft_Reg_Stmt.txt
EX-99 - 1ST DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.6_1st_Draft_Reg_Stmt.txt
EX-99 - 2ND DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.7_2nd_Draft_Reg_Stmt.txt
EX-99 - 3RD DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.8_3rd_Draft_Reg_Stmt.txt
EX-99 - 4TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.9_4th_Draft_Reg_Stmt.txt
EX-99 - 6TH DRAFT - CONFIDENTIAL DRAFT REGISTRATION STATEMENT ON FORM S1 FOR SIGNAL ADVANCE, INC. WITH EXHIBITS - Signal Advance IncEX-99.11_6th_Draft_Reg_Stmt.txt
EX-5 - LEGAL OPINION - VALIDITY OF STOCK - RICHARD C SELTZER - Signal Advance IncEX-5.1_Legal_Opinion_Stock.txt

EXHIBIT 99.1 - Expert Opinion, David G. Henry, Registered Patent Attorney


On the Letterhead of David G. Henry


                             DAVID G. HENRY
                       Registered Patent Attorney


14 May 2007

To Whom It May Concern:

I have been practicing patent law for over twenty years, and have been
teaching the patent law courses at Baylor Law School for fourteen years.
Despite dealing with hundreds of patent matters (as someone in my position
inevitably does), one rarely comes across truly "pioneering" or "landmark"
inventions. Chris Hymel's systems and methods pertaining to, and made
possible by the unprecedented, early detection of precursors to physio-
logical, electrochemical phenomena in humans appear to be just such an
invention (or family of inventions).

Based on currently available information and understanding, it is my opinion
that Mr. Hymel's inventions will first constitute the foundation of a wholly
new branch of diagnostics and medical treatment. Also, preliminary efforts
are underway to identify and to start to reduce to practice applications of
Mr. Hymel's methodologies in a variety of other fields. In that regard, and
with appropriate capitalization, I expect to see Mr. Hymel's methods and
related systems come to underlie ground-breaking advances in fields which
range from psychiatry to law enforcement to combat training and weaponry to
biomechanical prosthetics.

I and my firm, as well as other outside patent and technical consultants,
are currently working on patent protection, both for protecting Mr. Hymel's
basic methodologies (which are common to all presently anticipated
applications), as well as for a variety of specific applications which are
under active consideration or development, as previously mentioned.

"Excited" is not too strong a description of my reaction to this technology
and its future potential not a term I often use in this context.

Cordially,

/s/ David G. Henry
David G. Henr