Attached files
| file | filename |
|---|---|
| S-1/A - S-1/A - BIOCANCELL THERAPEUTICS INC. | s-1.htm |
| EX-23.1 - EXHIBIT 23.1 - BIOCANCELL THERAPEUTICS INC. | ex23-1.htm |
EXHIBIT 10.1(iv)
AMENDMENT
This Amendment is made as of this 24th day of January 2011, by and between YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., of Hi Tech Park, Edmond J. Safra Campus, Givat Ram, Jerusalem 91390, Israel (“Yissum”); and
BIOCANCELL THERAPEUTICS ISRAEL LTD. of Beit Beck, Har Hotzvim, Jerusalem, Israel (the “Company"), of the second part;
WHEREAS, the Company and Yissum executed an amended and restated license agreement on November 14, 2005, as supplemented and amended (the “License Agreement”), pursuant to which the Company obtained an exclusive license to certain patents owned by Yissum; and
WHEREAS the Parties wish to amend the License Agreement to add new patents and patent applications to the list of Patents exclusively licensed to the Company as part of the Licensed Technology.
NOW THEREFORE, in consideration of the mutual promises and covenants set forth herein, the parties hereby agree, as follows:
|
1.
|
All capitalized terms not defined herein shall have the meaning ascribed to them in the License Agreement.
|
|
2.
|
Appendix 1 of the License Agreement shall be amended to add the following patents and patent applications:
|
|
|
·
|
NUCLEIC ACID CONSTRUCTS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING SAME FOR TREATING CANCER (H19 + Tnf Alpha), Yissum Ref# 2989
|
|
|
·
|
NUCLEIC ACID AGENTS FOR DOWNREGULATING H19, AND METHODS OF USING SAME, Yissum Ref# 3025
|
|
|
·
|
NUCLEIC ACID CONSTRUCTS AND METHODS FOR SPECIFIC SILENCING OF H19 (siRNA H19 - cancer + stem cells) Yissum Ref# 3309
|
|
|
·
|
H19 SILENCING NUCLEIC ACID AGENTS FOR TREATING RHEUMATOID ARTHRITIS (siRNA - RA), Yissum Ref# 3310
|
|
|
·
|
CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY, Yissum Ref# 3423
|
A new Appendix 1 to the License Agreement, including Yissum Reference Numbers, is annexed to this Amendment.
|
3.
|
All other provisions of the License Agreement, including, without limitation, all terms of the Amendment to License Agreement dated September 11, 2007 which shall apply to the terms hereof, shall continue to have the same force and effect as they had prior to this Addendum.
|
IN WITNESS WHEREOF, the parties have executed this Agreement as a deed and delivered on the date first above written.
|
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
|
BIOCANCELL THERAPEUTICS ISRAEL, LTD.
|
|||
|
By: /s/ Shoshi Keynan
Shoshi Keynan
|
/s/ Yaakov Michlin
Yaakov Michlin
|
By: /s/ Uri Danon
Uri Danon
|
/s/ Ira Weinstein
Ira Weinstein
|
|
|
Title: VP Licensing, Pharmaceuticals
|
President & CEO |
Title: CEO
|
CFO | |
|
Date: 30/1/2011
|
30/1/2011 |
Date: 24/1/11
|
24/1/11 | |
APPENDIX 1 – THE PATENTS
|
Family:
|
2148
|
Title:
|
Sensitive Cancer Assay
|
|||||||||||
|
Inventor
|
Faculty/Department
|
|||||||||||||
|
Ariel Ilana
|
Hadassah
|
|||||||||||||
|
Hochberg Avraham
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Application
|
Publication
|
Patent
|
||||||||||||
|
Patent ID
|
Status
|
Country
|
Date
|
Number
|
Date
|
Number
|
Date
|
Number
|
||||||
|
2148-00
|
Granted
|
Israel
|
7/3/1994
|
108879
|
31/08/2000
|
108879
|
||||||||
|
2148-01
|
Published
|
PCT
|
6/3/1995
|
PCT/EP95/00823
|
4/9/1995
|
WO95/24503
|
||||||||
|
2148-03
|
Granted
|
US
|
6/9/1996
|
08/704,786
|
21/09/1999
|
5,955,273
|
||||||||
|
2148-04
|
Granted
|
Europe
|
6/3/1995
|
95927570
|
29/05/2002
|
759092
|
||||||||
|
Family:
|
2324
|
Title:
|
Methods and Compositions for Inducing Tumor-Specific Cytotoxicity
|
|||||||||||
|
Inventor
|
Faculty/Department
|
|||||||||||||
|
Ayesh Suhail
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Hochberg Avraham
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Application
|
Publication
|
Patent
|
||||||||||||
|
Patent ID
|
Status
|
Country
|
Date
|
Number
|
Date
|
Number
|
Date
|
Number
|
||||||
|
2324-00
|
Abandoned
|
US
|
3/10/1997
|
08/943,608
|
||||||||||
|
2324-01
|
Exhausted
|
PCT
|
4/10/1998
|
PCT/IL98/00486
|
8/12/1999
|
WO 99/18195
|
||||||||
|
2324-02
|
Exhausted
|
PCT
|
22/10/2002
|
PCT/IL02/00843
|
1/5/2003
|
WO 03/035883
|
||||||||
|
2324-03
|
Granted
|
US
|
1/10/1998
|
09/165,240
|
11/7/2000
|
6,087,164
|
||||||||
|
2324-04
|
Granted
|
China
|
4/10/1998
|
98811834
|
30/11/2005
|
ZL 98811833.5
|
||||||||
|
2324-05
|
Granted
|
Europe
|
4/10/1998
|
98947759
|
1019499
|
10/9/2008
|
1019499
|
|||||||
|
2324-06
|
Filed
|
Hungary
|
4/10/1998
|
P0003745
|
||||||||||
|
2324-07
|
Granted
|
Israel
|
4/10/1998
|
135430
|
19/08/2007
|
Pat & Designs J. 6/2007
|
20/11/2007
|
135430
|
||||||
|
2324-08
|
Granted
|
Korea
|
4/10/1998
|
2000-7003609
|
20/10/2005
|
524262
|
||||||||
|
2324-09
|
Filed
|
Mexico
|
4/10/1998
|
2000-003843
|
||||||||||
|
2324-10
|
Abandoned
|
New Zealand
|
4/10/1998
|
503843
|
||||||||||
|
2324-11
|
Allowed
|
Norway
|
4/10/1998
|
20001684
|
||||||||||
|
2324-12
|
Abandoned
|
Poland
|
4/10/1998
|
P339949
|
||||||||||
|
2324-13
|
Granted
|
Russian Federation
|
4/10/1998
|
2E+09
|
2214280
|
20/10/2003
|
2214280
|
|||||||
|
2324-14
|
Granted
|
US
|
10/5/2000
|
09/568,059
|
23/10/2001
|
6,306,833
|
||||||||
|
2324-15
|
Granted
|
US
|
22/10/2001
|
10/012,131
|
29/04/2004
|
US-2004-0082529
|
9/5/2006
|
7,041,654
|
||||||
|
2324-16
|
Granted
|
Australia
|
4/10/1998
|
94571/98
|
19/12/2002
|
755774
|
||||||||
|
2324-17
|
Examination
|
Japan
|
4/10/1998
|
2000-514993
|
||||||||||
|
2324-18
|
Granted
|
Canada
|
4/10/1998
|
2,308,124
|
8/7/2008
|
2,308,124
|
||||||||
|
2324-19
|
Granted
|
Singapore
|
4/10/1998
|
200001824-2
|
4/6/2002
|
72207
|
||||||||
|
2324-20
|
Granted
|
Czech Republic
|
4/10/1998
|
PV2000-1201
|
16/02/2005
|
294694
|
||||||||
|
2324-21
|
Abandoned
|
Europe
|
22/10/2002
|
2779859.4
|
21/07/2004
|
1438412
|
||||||||
|
2324-22
|
Abandoned
|
China
|
22/10/2002
|
2825940.8
|
||||||||||
|
2324-23
|
Abandoned
|
Japan
|
22/10/2002
|
2003-538383
|
||||||||||
|
2324-24
|
Abandoned
|
Israel
|
22/10/2002
|
161553
|
||||||||||
|
2324-25
|
Abandoned
|
Canada
|
22/10/2002
|
2,464,394
|
||||||||||
|
2324-26
|
Abandoned
|
Australia
|
22/10/2002
|
2.002E+09
|
||||||||||
|
2324-27
|
Abandoned
|
Mexico
|
22/10/2002
|
PAa2004/003732
|
||||||||||
|
2324-28
|
Granted
|
Czech Republic
|
18/06/2004
|
PV 2004-741
|
14/02/2005
|
294941
|
||||||||
|
2324-29
|
Allowed
|
Brazil
|
4/10/1998
|
PI9812717-9
|
||||||||||
|
2324-30
|
Examination
|
Japan
|
24/05/2006
|
2006-144648
|
9/11/2006
|
2006-304801
|
||||||||
|
2324-31
|
Granted
|
Mexico
|
4/10/1998
|
PA/a/2000/03251
|
10/4/2007
|
244867
|
||||||||
|
2324-32
|
Examination
|
Japan
|
24/05/2006
|
2007-270777
|
19/06/2008
|
2008-136480
|
||||||||
|
2324-33
|
Filed
|
Norway
|
20093194
|
|||||||||||
|
Family:
|
2989
|
Title:
|
Nucleic Acid Constructs, Pharmaceutical Compositions and Methods of Using Same for Treating Cancer (H19 + Tnf Alpha)
|
|||||||||||
|
Inventor
|
Faculty/Department
|
|||||||||||||
|
Hochberg Avraham
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Application
|
Publication
|
Patent
|
||||||||||||
|
Patent ID
|
Status
|
Country
|
Date
|
Number
|
Date
|
Number
|
Date
|
Number
|
||||||
|
2989-00
|
Expired
|
US
|
22/09/2005
|
60/719,178
|
||||||||||
|
2989-01
|
Exhausted
|
PCT
|
21/09/2006
|
PCT/IL2006/001110
|
29/03/2007
|
WO 2007/034487
|
||||||||
|
2989-02
|
Examination
|
US
|
21/09/2006
|
12/067,410
|
||||||||||
|
2989-03
|
Examination
|
Israel
|
21/09/2006
|
190311
|
||||||||||
|
2989-04
|
Published
|
Japan
|
21/09/2006
|
2008-531883
|
5/3/2009
|
2009-508516
|
||||||||
|
2989-05
|
Granted
|
Europe
|
21/09/2006
|
6780498.9
|
4/6/2008
|
1926814
|
28/04/2010
|
1926814
|
||||||
|
Family:
|
3025
|
Title:
|
NUCLEIC ACID AGENTS FOR DOWNREGULATING H19, AND METHODS OF USING SAME
|
|||||||||||
|
Inventor
|
Faculty/Department
|
|||||||||||||
|
Matouk Imad
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Hochberg Avraham
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Application
|
Publication
|
Patent
|
||||||||||||
|
Patent ID
|
Status
|
Country
|
Date
|
Number
|
Date
|
Number
|
Date
|
Number
|
||||||
|
3025-00
|
Expired
|
US
|
7/7/2005
|
60/696,795
|
||||||||||
|
3025-01
|
Exhausted
|
PCT
|
6/7/2006
|
PCT/IL2006/000785
|
18/01/2007
|
WO 2007/007317
|
||||||||
|
3025-02
|
Examination
|
US
|
16/01/2008
|
12/015,325
|
||||||||||
|
3025-03
|
Published
|
Japan
|
6/7/2006
|
2008-520061
|
11/12/2008
|
2008-545011
|
||||||||
|
3025-04
|
Examination
|
US
|
6/7/2006
|
11/994,810
|
4/6/2009
|
US- 2009/0143321 A1
|
||||||||
|
3025-05
|
Filed
|
Canada
|
6/7/2006
|
2,614,531
|
||||||||||
|
3025-06
|
Exhausted
|
Australia
|
6/7/2006
|
2.006E+09
|
||||||||||
|
3025-07
|
Examination
|
Europe
|
6/7/2006
|
6766118.1
|
30/04/2008
|
1915448
|
||||||||
|
3025-08
|
Filed
|
India
|
6/7/2006
|
2008/DELNP/758
|
||||||||||
|
3025-09
|
Examination
|
China
|
21/05/2006
|
2.007E+11
|
||||||||||
|
3025-10
|
Examination
|
Israel
|
188501
|
|||||||||||
|
Family:
|
3309
|
Title:
|
NUCLEIC ACID CONSTRUCTS AND METHODS FOR SPECIFIC SILENCING OF H19 (siRNA H19 - cancer + stem cells)
|
|||||||||||
|
Inventor
|
Faculty/Department
|
|||||||||||||
|
Hochberg Avraham
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Application
|
Publication
|
Patent
|
||||||||||||
|
Patent ID
|
Status
|
Country
|
Date
|
Number
|
Date
|
Number
|
Date
|
Number
|
||||||
|
3309-00
|
Expired
|
US
|
16/01/2007
|
60/880,425
|
||||||||||
|
3309-01
|
Exhausted
|
PCT
|
16/01/2008
|
PCT/IL2008/000072
|
24/07/2008
|
WO 2008/087642 A2
|
||||||||
|
3309-02
|
Examination
|
Europe
|
16/01/2008
|
8702653
|
28/10/2009
|
2111450
|
||||||||
|
3309-03
|
Filed
|
Israel
|
16/01/2008
|
199867
|
||||||||||
|
3309-04
|
Filed
|
Canada
|
16/01/2008
|
2,675,967
|
||||||||||
|
3309-05
|
Published
|
US
|
16/01/2008
|
12/523,298
|
8/4/2010
|
US-2010/0086526 A1.
|
||||||||
|
3309-06
|
Filed
|
India
|
16/01/2008
|
5257/DELNP/2009
|
||||||||||
|
Family:
|
3310
|
Title:
|
H19 SILENCING NUCLEIC ACID AGENTS FOR TREATING RHEUMATOID ARTHRITIS (siRNA - RA)
|
|||||||||||
|
Inventor
|
Faculty/Department
|
|||||||||||||
|
Hochberg Avraham
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Application
|
Publication
|
Patent
|
||||||||||||
|
Patent ID
|
Status
|
Country
|
Date
|
Number
|
Date
|
Number
|
Date
|
Number
|
||||||
|
3310-00
|
Expired
|
US
|
16/01/2007
|
60/880,430
|
||||||||||
|
3310-01
|
Exhausted
|
PCT
|
16/01/2008
|
PCT/IL2008/000071
|
24/07/2008
|
WO 2008/087641 A2
|
||||||||
|
3310-02
|
Examination
|
Europe
|
16/01/2008
|
8702652
|
28/10/2009
|
2111449
|
||||||||
|
3310-03
|
Filed
|
Canada
|
16/01/2008
|
2,675,964
|
||||||||||
|
3310-04
|
Allowed
|
US
|
16/01/2008
|
12/523,288
|
29/04/2010
|
US- 2010/0105759 A1
|
||||||||
|
3310-05
|
Filed
|
Israel
|
16/01/2008
|
199866
|
||||||||||
|
3310-06
|
Filed
|
India
|
16/01/2008
|
5271/DELNP/2009
|
||||||||||
|
Family:
|
3423
|
Title:
|
CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY
|
|||||||||||
|
Inventor
|
Faculty/Department
|
|||||||||||||
|
Amit Doron
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Hochberg Avraham
|
HUJI Faculty of Science The Alexander Silberman Institute for Life Sciences
|
|||||||||||||
|
Application
|
Publication
|
Patent
|
||||||||||||
|
Patent ID
|
Status
|
Country
|
Date
|
Number
|
Date
|
Number
|
Date
|
Number
|
||||||
|
3423-00
|
Expired
|
US
|
25/10/2007
|
60/982,442
|
||||||||||
|
3423-01
|
Exhausted
|
PCT
|
23/10/2008
|
PCT/IL2008/001405
|
30/04/2009
|
WO 2009/053982
|
||||||||
|
3423-02
|
Filed
|
Russian Federation
|
23/10/2008
|
2.01E+09
|
||||||||||
|
3423-03
|
Published
|
US
|
23/10/2010
|
12/738,620
|
7/10/2010
|
US 2010/0256225 A1
|
||||||||
|
3423-04
|
Filed
|
Canada
|
23/10/2008
|
2,703,774
|
||||||||||
|
3423-05
|
Filed
|
Brazil
|
23/10/2008
|
PI 0818937-4
|
||||||||||
|
3423-06
|
Filed
|
India
|
23/10/2008
|
2846/DELNP/2010
|
||||||||||
|
3423-07
|
Pre-Filing
|
Korea
|
||||||||||||
|
3423-08
|
Filed
|
China
|
23/10/2008
|
2.009E+11
|
||||||||||
|
3423-09
|
Examination
|
Europe
|
23/10/2008
|
8842129.2
|
7/7/2010
|
2203187
|
||||||||
|
3423-10
|
Filed
|
Israel
|
23/10/2008
|
205048
|
||||||||||
|
3423-11
|
Filed
|
Australia
|
23/10/2008
|
2.008E+09
|
||||||||||
|
3423-12
|
Filed
|
Japan
|
23/10/2008
|
2010-530628
|
||||||||||