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8-K - FORM 8-K - PDL BIOPHARMA, INC.d8k.htm
Cowen
30
Annual
Health
Care
Conference
March 2010
Exhibit 99.1
th


Forward Looking Statements
This
presentation
contains
forward-looking
statements,
including
PDL’s
expectations
with
respect
to
its
future
royalty
revenues, expenses, net income, and cash provided by operating activities.
Each of these forward-looking statements involves risks and uncertainties. Actual results may differ materially from those,
express or implied, in these forward-looking statements. Factors that may cause differences between current expectations
and actual results include, but are not limited to, the following:
The
expected
rate
of
growth
in
royalty-bearing
product
sales
by
PDL’s
existing
licensees;
The relative mix of royalty-bearing Genentech products manufactured and sold outside the U.S. versus manufactured or
sold in the U.S.;
The ability of our licensees to receive regulatory approvals to market and launch new royalty-bearing products and
whether such products, if launched, will be commercially successful;
Changes
in
any
of
the
other
assumptions
on
which
PDL’s
projected
royalty
revenues
are
based;
The outcome of pending litigation, interferences or disputes; and
The failure of licensees to comply with existing license agreements, including any failure to pay royalties due.
Other
factors
that
may
cause
PDL’s
actual
results
to
differ
materially
from
those
expressed
or
implied
in
the
forward-
looking
statements
in
this
presentation
are
discussed
in
PDL’s
filings
with
the
SEC,
including
the
"Risk
Factors"
sections
of
its
annual
and
quarterly
reports
filed
with
the
SEC.
Copies
of
PDL’s
filings
with
the
SEC
may
be
obtained
at
the
"Investors"
updates
or
revisions
to
any
forward-looking
statements
contained
herein
to
reflect
any
change
in
PDL’s
expectations
with
regard thereto or any change in events, conditions or circumstances on which any such statements are based for any
reason, except as required by law, even as new information becomes available or other events occur in the future. All
forward-looking statements in this presentation are qualified in their entirety by this cautionary statement.
2
section
of
PDL’s
website
at
www.pdl.com.
PDL
expressly
disclaims
any
obligation
or
undertaking
to
release
publicly
any


Agenda
Overview of PDL BioPharma
Royalty revenue & licensed products
Optimizing stockholder return
3


Overview of PDL BioPharma
4


Company Background
PDL pioneered the
humanization of monoclonal antibodies
which enabled the discovery of a new generation of
targeted treatments for cancer and immunologic diseases
PDL’s primary assets are its antibody humanization patents
and royalty assets which consist of its Queen et al. patents
and license agreements
Licensees consist of large biotechnology and
pharmaceutical companies including Roche/Genentech,
Elan/BiogenIDEC, Wyeth and Chugai
5


Mission
Manage patent portfolio
Manage license agreements
Optimize return for shareholders
6


2009 Performance
7
We
do
not
invest
in
R&D
or
in
operating
companies
PDL is a highly profitable company with revenue in 2009 in
of $318 million and fewer than 10 employees
PDL is domiciled in Nevada where there is no state
corporate income tax
PDL’s
mission is to improve shareholder return
We paid three dividends of $0.50/share in April, $0.50/share in
October and $1.67/share in December totaling $2.67 in 2009
Our goal is to pay dividends annually & have declared two dividends
of $0.50 each/share in 2010
We signed one new license under the Queen et al. patents in 2009
and are seeking new licenses in 2010


Legal Matters
Genentech
Settlement agreement resolved all disputes regarding infringement of the Genentech
products and the validity and enforceability of our patents
Multiple product licenses with tiered royalty structure
Alexion
Settlement in December 2008 stipulated infringement, validity and enforceability of
PDL patents and no future contest of PDL patents
License for Soliris
in exchange for $25 million and option for four additional licenses at
4% royalty
MedImmune
In 2008, MEDI initiated litigation seeking
declaratory judgment of patent
invalidity and non-infringement and a lower royalty rate based on its “most favored
licensee”
(MFL) rights
-
PDL
believes
that
it
has
no
obligation
to
offer
a
lower
royalty
rate
to
MEDI
under
the
MFL
clause
PDL is suing MEDI for patent infringement because PDL has cancelled the MEDI
license agreement due to MEDI’s
failure to pay all royalties due and blockage of PDL’s
exercise of its contractual rights
UCB/Celltech
US Patent Office has declared two interference proceedings between certain claims of
Queen et al. patents and pending claims of Adair et al.
UCB/Celltech
is the assignee of the Adair et al. patent
8


Converts and Securitization Note
$200 million 2.75% convertible subordinated notes due August 2023
Conversion rate is 164.7254  shares per $1,000 face amount ($6.07/share)
Holders
have
a
put
right
in
August
2010,
August
2013,
and
August
2018
-
August
2010
put
can
be
for
cash
or
stock,
at
noteholder’s
discretion
-
Subsequent
puts
are
cash
or
stock
at
PDL’s
discretion
Price as of March 3rd was ~118 vs. stock price of $7.00
$228 million 2.00% convertible senior notes due February 2012
Conversion rate is 119.294  shares per $1,000 face amount ($8.38/share)
Price as of March 3rd was ~96 vs. stock price of $7.00
$300 million 10.25% note with expected maturity of December 2012
Securitized by 60% of 5-year NPV of Genentech royalties
Anticipated final maturity is December 2012; legal maturity is March 2015
After final maturity securitized Genentech royalties return to PDL
Distributed $200 million as special dividend of $1.67/share in December 2009
9


Corporate Governance
Management
John McLaughlin
President & CEO
Christine Larson
VP & CFO
Christopher Stone
VP, General Counsel &
Secretary
Karen Wilson
VP of Finance
Board of Directors
Fred Frank
Lead Director
Joseph Klein
Jody Lindell
John McLaughlin
Paul Sandman
Harold Selick
10


Royalty Revenue & Licensed Products
11


Royalty Revenue & Licensed Products
PDL Royalties by Product
($ in millions)
12
$100
$150
$200
$250
$300
$350
Herceptin
Avastin
Lucentis
Synagis
Tysabri
Other
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
$0
$50


Royalties: When Licensed Product is Made or Sold
PDL’s
revenues consist of royalties generated on sales of licensed products
Sold before the expiration of the Queen et al. patents in 2013/14
or
Made prior to the expiration of the Queen et al. patents and sold anytime thereafter
13
Example of Antibody Formulation, Fill and Finish Schedule
½
month
1 month
½
month
2-3 months
Thaw, Formulation
& Vial Filling
Quality
Release
Packaging
& Quality
Inventory
Example of Antibody Bulk Manufacturing Schedule
Cell
Culture
Quality Release
Testing
Bulk Frozen Storage
1 mo
3 mos
5 mos
10 mos
15 mos
20 mos
27 mos
Purification to Concentrated Bulk/Frozen
3 mos
2-18 months
1mo
1mo


Product Made in US
Net Sales up to $1.5 Billion
3.0%
Net Sales Between $1.5 Billion and $2.5 Billion
2.5%
Net Sales Between $2.5 Billion and $4.0 Billion
2.0%
Net Sales Over $4.0 Billion
1.0%
Product Made and Sold Ex-US
All Sales
3.0%
Genentech/Roche Royalties
In 2009, only 12% of Genentech/Roche sales was ex-US
manufactured and sold product
Average royalty rate on all Genentech/Roche products
under Genentech license was 1.14%
14


Genentech/Roche—Future Manufacturing
Roche has begun to move some manufacturing ex-US
Two new plants in Singapore
More production at Penzburg, Germany plant
Roche says it will complete global restructuring of manufacturing in 2010
15


Select Licensed Products
16
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
HER2+ stomach and gastro-esophageal Cancers
trastuzumab-DM1
Phase 2 and 3
Breast HER2+ Cancer
Lucentis
Approved
Phase 3
AMD
RVO
DME
Xolair
Approved
sBLA
Moderate-Severe Asthma
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes


Select Licensed Products
17
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Ela
Roc
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On November 16, 2009, Roche filed two sBLAs with FDA for treatment of women who
have not received chemotherapy for metastatic HER2-negative breast cancer (first-line
treatment)
One sBLA is for use of Avastin in combination with docetaxel chemotherapy
Second sBLA is for Avastin in combination with a taxanes.
On November 24, 2009, Roche made similar filings in Europe. 
Avastin is currently approved in combination with paclitaxel chemotherapy for first-line
treatment of advanced HER2-negative breast cancer


Select Licensed Products
18
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On December 11, 2009, Roche announced results from a Phase 3 study (RIBBON 2) in
women who had previously been treated with initial (first-line) chemotherapy for advanced
HER2-negative breast cancer and needed additional (second-line) treatment
The study
showed
that
women
who
received
Avastin
in
combination
with
a
commonly
used
chemotherapy had a 28% improvement in the likelihood of living without the disease
getting worse, compared with those who received chemotherapy alone (hazard ratio=0.78;
p=0.0072)


Select Licensed Products
19
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Xolair
Approved
sBLA
Moderate-Severe Asthma
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On February 24, 2010, Roche announce that Phase 3 study showed the combination of
Avastin
and
chemotherapy
followed
by
maintenance
use
of
Avastin
alone
increased
the
time women with previously untreated advanced ovarian cancer lived without the disease
worsening (progression-free survival), compared to chemotherapy


Select Licensed Products
20
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
Xolair
Approved
sBLA
Moderate-Severe Asthma
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On February 22, 2010, Roche announced that Phase 3 study (AVAGAST) did not meet its
primary
endpoint
of
showing
Avastin
plus
Xeloda
or
5-FU
and
cisplatin
chemotherapy
extended
the
lives
of
people
with
inoperable
or
advanced
stomach
(gastric)
cancer,
compared to chemotherapy alone


Select Licensed Products
21
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
HER2+ stomach and gastro-esophageal Cancers
trastuzumab-DM1
Phase 2 and 3
Breast HER2+ Cancer
Xolair
Approved
sBLA
Moderate-Severe Asthma
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On
January
28,
2010,
Roche
announced
EU
approval
for
the
use
of
Herceptin
first
line
treatment of HER-2 positive stomach or gastro-esophageal junction cancers


Select Licensed Products
22
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
HER2+ stomach and gastro-esophageal Cancers
trastuzumab-DM1
Phase 2 and 3
Breast HER2+ Cancer
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
Ela
Ro
Wy
Ela
Lilly
Additional data from on-going Phase 3 trial in over 3,000 early stage breast cancer patient
showed one year treatment with Herceptin plus one of several commonly used
chemotherapeutics reduced the risk of recurrence by 36% and risk of death by 37%
compared to chemotherapy alone - at least 80% of the women who received one year
treatment with Herceptin were cancer free at five years
Additional data from on-going open label Phase 3 trial in 3,400 early stage breast cancer
patients showed disease free survival rates at five years of 80% and 84% (depending on
whether Herceptin treatment was sequential or concurrent with chemotherapy,
respectively) compared to 72% for chemotherapy alone


Select Licensed Products
23
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
HER2+ stomach and gastro-esophageal Cancers
trastuzumab-DM1
Phase 2 and 3
Breast HER2+ Cancer
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
Licensee
Product
Status
Indications
Roche announced results from a Phase 2 study of T-DM1 showing that it shrank the tumors in
33% of women with HER2+ breast cancer that had worsened following previous treatment. In this
single-arm study of over 100 patients; 45% of women experienced a clinical benefit. This is
significant because the women had essentially exhausted all other medical options
Roche
has
said
that
it
expects
to
discuss
this
data
with
the
FDA
to
ascertain
whether
it
can
file
a
BLA for third line treatment in 2010
For
second
line
treatment,
patient
enrollment
is
on
track
in
the
Phase
3
trial
For first line treatment, patient enrollment has been completed in a Phase 2 with interim data
expected this year, and a first line Phase 3 trial is targeted to begin mid-2010
Ela
Ro
Wy
Ela
Lill


Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
HER2+ stomach and gastro-esophageal Cancers
trastuzumab-DM1
Phase 2 and 3
Breast HER2+ Cancer
Lucentis
Approved
Phase 3
AMD
RVO
DME
Xolair
Approved
sBLA
Moderate-Severe Asthma
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
Select Licensed Products
24
On December 22, 2009, Genentech announced that it had submitted a sBLA to the FDA for
treatment of patients with macular edema following retinal vein occlusion (RVO) 
Assuming a 10-month standard review, PDUFA date would fall on October 22, 2010 


Select Licensed Products
25
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
DME
Xolair
Approved
sBLA
Moderate-Severe Asthma
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On November 18, the FDA Advisory Committee on Pulmonary-Allergy Drugs Advisory
Committee
did
not
support
approval
of
the
sBLA
to
expand
the
label
from
adults
to
include
children 6 to <12 years old with moderate to severe persistent asthma


Select Licensed Products
26
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
HER2+ stomach and gastro-esophageal Cancers
trastuzumab-DM1
Phase 2 and 3
Breast HER2+ Cancer
Lucentis
Approved
AMD
Xolair
Approved
sBLA
Moderate-Severe Asthma
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
FDA
and
EMEA
changed
the
labeling
to
reflect
risk
of
PML
increased
with duration
of
treatment
Licensee
Product
Status
Indications


Select Licensed Products
27
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
sBLA
Pediatric Asthma
Elan
Tysabri
Approved
Multiple Sclerosis
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On January 8, 2010, Genentech announced US approval for the treatment of adult patients
with
moderately
to
severely
active
rheumatoid
arthritis
(RA)
who
have
had
an
inadequate
response to one or more tumor necrosis factor antagonists
Actemra
was already approved for this indication in the EU


Select Licensed Products
28
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Herceptin
Approved
Breast HER2+ Cancer
HER2+ stomach and gastro-esophageal Cancers
trastuzumab-DM1
Phase 2 and 3
Breast HER2+ Cancer
Ela
Roche/Chugai
Actemra
Approved
Rheumatoid Arthritis
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On February 26, results from a Phase 2 study of 28 patients with Alzheimer’s disease were
reported on Lancet Neurology which showed 9 percent reduction in amyloid-beta deposits
on the brain from a baseline in treated patients compared to a plaque increase of 15
percent in placebo patients
Amyloid-beta deposits were measured using a neuroimaging technique known as PiB PET


Select Licensed Products
29
Licensee
Product
Status
Indications
Roche (Genentech)
Avastin
Approved
Phase 3
Colorectal Cancer
NSCLC
Metastatic Breast Cancer
Glioblastoma
Metastatic Renal Cell
Ovarian Cancer
Gastric
Prostate Cancer
Adjuvant settings
Elan
Roc
Wyeth
Mylotarg
Approved
Acute Myeloid Leukemia
Elan/J&J/Pfizer
Bapineuzumab
Phase 3
Alzheimer’s Disease
Lilly
Solanezumab
Phase 3
Alzheimer’s Disease
Teplizumab
Phase 3
Newly Diagnosed Type 1 Diabetes
On December  21, 2009, PDL and Lilly entered into a non-exclusive license with respect to
teplizumab, a humanized anti-CD3 monoclonal antibody, as well as other potential next
generation anti-CD3 molecules
Teplizumab
is
currently
being
studied
by
Lilly
and
its
partner
MacroGenics
for
the
treatment
of individuals with newly-diagnosed type 1 diabetes mellitus
In June 2009, the pivotal Phase 2/3 reached its targeted enrollment
Also in June 2009, a Phase 3 global study was initiated and is designed to capture patient-
reported outcome measures in addition to safety and efficacy data


Genentech/Roche—Future Products
In December 2008, Genentech exercised options for four
additional antigens and extended other options paying fees
totaling $1.8 million
Genentech can seek to convert the exercised options into
license agreements by identifying the target antigen and so
long as certain other conditions are met
Genentech/Roche has a number of humanized antibodies in
Phase 3
Pertuzumab
HER2+
breast
cancer-
Phase
3
started
in
1Q08
GA101
CLL,
NHL
Phase
3
started
in
Q409
Orcrelizumab
RA
Positive
Phase
3
in
4Q09,
methotrexate
naive
and TNF inadequate responders in 2010
but
Roche/BIIB
announced
on Monday suspension of RA trials based on safety concerns raised
by DSMB
30


Genentech / Roche –
US & EU Filings
31
2009
2010
2011
2012
Avastin
+ docetaxel
mBC
1L (US)
Avastin
mBC
2L
Avastin
Recurrent ovarian ca
platinum sensitive
Avastin
BC adj
HER2-
Avastin
+STD chemo mBC
1L
Avastin
CC adj
Avastin
Prostrate ca
Herceptin
SC formulation (EU)
Herceptin
Gastric ca HER+ (EU)
Avastin
Ovarian  ca 1L
Avastin
+ Herceptin
mBC
HER2+ 1L
GA 101
1
CLL
Lucentis
Retinal vein occlusion (US)
Herceptin
Gastric ca HER2+ (US)
Pertuzumab
1
mBC
HER2+
T-DM1
mBC
HER2+ 2L
T-DM1
mBC
HER2+ 3L (US)
Lucentis
Diabetic macular edema (US)
Avastin
Herceptin
Lucentis
T-DM1
Pertuzumab
1
GA-101
1
1.
Not a licensed product


Optimizing Stockholder Return
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Optimizing Stockholder Return
Intend to distribute royalty revenues, net of operating
expenses, debt service and income taxes
Will pay special dividend of $0.50 per share on April 1, 2010 to
holders of record on March 15, 2010
Will pay second special dividend of $0.50 per share on
October 1, 2010 to holders of record on September 15, 2010
Continuously evaluating alternatives
Purchase of commercial stage, royalty generating assets
Convertible note buyback or share repurchase
Company sale
Do not expect to securitize any additional assets in 2010
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High Dividend Yield with Upside Optionality
Inventory on hand at Queen patent et al. expiry 12/2014
Change in manufacturing US / ex-US mix for
Roche/Genentech resulting in higher average royalty rates
New Phase 2/3 indications with existing commercial
products
New Phase 2/3 pipeline products:
Solanezumab
(Alzheimer’s disease)
Bapineuzumab
(Alzheimer’s disease)
Teplizumab
(newly diagnosed Type 1 Diabetes)
Genentech exercised 4 options in December 2008
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Investment Rationale
Strong revenue growth from approved products
Potential for additional indications from existing products
and new product approvals
Significantly reduced expenses with no R&D burn
Liquidity—Volume averages 2 to 3 million share per day
Return to stockholders
Declared three special cash dividends totaling $2.67/share in 2009
Will pay two special cash dividends totaling $1.00/share in 2010
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