Exhibit 31.2

RULE 13a-14(a)/15d-14(a) CERTIFICATION

I, Luke M. Beshar, Executive Vice President and Chief Financial Officer, certify that:

1.                                      I have reviewed this Amendment No. 1 to Annual Report on Form 10-K of NPS Pharmaceuticals, Inc.; and

2.                                      Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.