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S-1/A - FORM S-1/A - TETRAPHASE PHARMACEUTICALS INCd441172ds1a.htm

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated February 21, 2013, in the Registration Statement (Form S-1/A) and related Prospectus of Tetraphase Pharmaceuticals, Inc., for the registration of shares of its common stock.

/s/ Ernst & Young LLP

Boston, Massachusetts

February 21, 2013