Exhibit 99.1

Contact:		Michael Mitchell
		The Medicines Company
		973-290-6000
		investor.relations@themedco.com

FOR IMMEDIATE RELEASE:

THE MEDICINES COMPANY REPORTS THIRD QUARTER 2010 FINANCIAL RESULTS

PARSIPPANY, NJ, October 27, 2010 – The Medicines Company (NASDAQ: MDCO) today announced its financial results for the third quarter of 2010.

Financial highlights for the third quarter of 2010:

•

Net revenue increased to $105.7 million for the third quarter from $98.8 million for the third quarter 2009.

	•		Angiomax U.S. sales increased 9% to $100.2 million compared to $92.2 million for the third quarter 2009.
	•		Angiox European sales increased 38% to $4.0 million compared to $2.9 million for the third quarter 2009.
	•		Rest of world Angiomax/Angiox sales decreased 42% to $1.5 million compared to $2.6 million for the third quarter 2009 on account of ordering patterns by partners

•		Net income was $21.2 million, or $0.40 per share, compared to net loss of ($3.2) million, or ($0.06) per share for the third quarter 2009.
•		Non-GAAP net income was $22.8 million, or $0.43 per share, compared to non-GAAP net income of $5.1 million, or $0.10 per share for the same period 2009. Non-GAAP net income excludes the transaction charges related to the 2009 Targanta acquisition, stock-based compensation expense and non-cash income taxes.

Clive Meanwell, MD, PhD, Chairman and Chief Executive Officer, stated, “In the third quarter we continued revenue and volume growth compared to 2009 in the U.S. and Europe. All of our development portfolio projects made advances. We continued to pursue tight cost control, resulting in strong earnings for the quarter. We expect to continue to run our business efficiently with an eye to top and bottom line results.”

Financial highlights for the first nine months of 2010:

•

Net revenue increased to $318 million for the first nine months of 2010 from $302.2 million for same period 2009.

•

Angiomax U.S. sales increased to $300.3 million compared to $286.6 million for same period 2009.

•

Angiomax/Angiox international net revenue increased to $16.9 million compared to $13.1 million for same period 2009.

•		Net income was $46.1 million, or $0.87 per share, compared to net loss of ($2.7) million, or ($0.05) per share for same period 2009.
•		Non-GAAP net income was $53.6 million, or $1.02 per share, compared to non-GAAP net income of $20.9 million, or $0.40 per share for the same period 2009. Non-GAAP net income excludes the transaction charges related to the 2009 Targanta acquisition, stock-based compensation expense and non-cash income taxes.

The following table provides reconciliations between GAAP and non-GAAP net income (loss) for third quarter (Q3) and first nine months (9M) of 2010. Non-GAAP net income excludes the transaction charges related to the first quarter 2009 Targanta acquisition, stock-based compensation expense and non-cash income taxes:

										FAS 123R
										Stock-Based				Non-cash Provision
		Reported GAAP				Targanta				Compensation				(Benefit) for				Non-GAAP Net
(in millions)		Net Income (Loss)				Acquisition Costs				Expense				Income Taxes				Income(1)
Q3 2010		$	21.2			$	—			$	1.8			$	(0.2	)		$	22.8
Q3 2009		$	(3.2	)		$	—			$	4.4			$	3.8			$	5.1
9M 2010		$	46.1			$	—			$	6.8			$	0.7			$	53.6
9M 2009		$	(2.7	)		$	4.3			$	15.3			$	4.0			$	20.9

Note: Amounts may not sum due to rounding.

(1)		Excluding the Targanta acquisition costs, stock-based compensation expense and the non-cash provision (benefit) for income taxes.

Reconciliations between GAAP and non-GAAP fully diluted earnings per share (EPS) for the third quarter (Q3) and first nine months (9M) of 2010 and 2009 are provided in the following table:

										FAS 123R
										Stock-Based				Non-cash Provision
		Reported GAAP				Targanta				Compensation				(Benefit) for				Non-GAAP
(per share)		EPS				Acquisition Costs				Expense				Income Taxes				EPS(1)
Q3 2010		$	0.40			$	—			$	0.03			$	—			$	0.43
Q3 2009		$	(0.06	)		$	—			$	0.09			$	0.07			$	0.10
9M 2010		$	0.87			$	—			$	0.13			$	0.01			$	1.02
9M 2009		$	(0.05	)		$	0.08			$	0.29			$	0.08			$	0.40

Note: Amounts may not sum due to rounding.

(1)		Excluding the Targanta acquisition costs, stock-based compensation expense and the non-cash provision for income taxes.

The Company believes that presenting the non-GAAP information contained in the financial tables and in this press release assists investors and others in gaining a better understanding of the Company’s core operating results and future prospects, expected growth rates or forecasted guidance, particularly as related to transaction charges associated with the Targanta acquisition, stock-based compensation expense and non-cash income taxes. Management uses this non-GAAP information, in addition to the GAAP information, as the basis for measuring the Company’s core operating performance and comparing such performance to that of prior periods and to the performance of its competitors. Such measures are also used by management in its financial and operating decision-making. Non-GAAP information is not meant to be considered superior to or a substitute for the Company’s results of operations prepared in accordance with GAAP. A reconciliation of GAAP results with non-GAAP results may also be found in the attached financial tables.

There will be a conference call with management today at 8:30 a.m. Eastern Time to discuss financial results and operational developments. The conference call will be available via phone and webcast. The webcast can be accessed at The Medicines Company website at www.themedicinescompany.com.

The dial in information is listed below:

Domestic Dial In:		866-700-6067
International Dial In:		617-213-8834
Passcode for both dial in numbers:		19125468

Replay is available from 11:30 a.m. Eastern Time following the conference call through November 11, 2010. To hear a replay of the call dial 888-286-8010 (domestic) and 617-801-6888 (international). Passcode for both dial in numbers is 61529947.

About The Medicines Company

The Medicines Company (NASDAQ: MDCO) provides medical solutions to improve health outcomes for patients in acute and intensive care hospitals worldwide. These solutions comprise medicines and knowledge that directly impact the survival and well being of critically ill patients. The Medicines Company’s website is www.themedicinescompany.com.

Statements contained in this press release about The Medicines Company that are not purely historical, and all other statements that are not purely historical, may be deemed to be forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Without limiting the foregoing, the words “believes,” “anticipates” and “expects” and similar expressions, including the Company’s preliminary revenue results, are intended to identify forward-looking statements. These forward-looking

statements involve known and unknown risks and uncertainties that may cause the Company’s actual results, levels of activity, performance or achievements to be materially different from those expressed or implied by these forward-looking statements. Important factors that may cause or contribute to such differences include the extent of the commercial success of Angiomax, the Company’s ability to develop its global operations and penetrate foreign markets, whether the Company’s products will advance in the clinical trials process on a timely basis or at all, whether the Company will make regulatory submissions for product candidates on a timely basis, whether its regulatory submissions will receive approvals from regulatory agencies on a timely basis or at all, whether physicians, patients and other key decision makers will accept clinical trial results, risks associated with the establishment of international operations, and such other factors as are set forth in the risk factors detailed from time to time in the Company’s periodic reports and registration statements filed with the Securities and Exchange Commission including, without limitation, the risk factors detailed in the Company’s Quarterly Report on Form 10-Q filed on August 9, 2010, which are incorporated herein by reference. The Company specifically disclaims any obligation to update these forward-looking statements.

The Medicines Company
Condensed Consolidated Statements of Operations
(unaudited)

		Three months ended September 30,
(in thousands, except per share data)		2010				2009
Net revenue		$	105,743			$	98,789
Operating expenses:
Cost of revenue			31,568				28,308
Research and development			16,676				22,464
Selling, general and administrative			35,788				47,358
Total operating expenses			84,032				98,130
Income from operations			21,711				659
Other income			483				151
Income before income taxes			22,194				810
Provision for income taxes			(989	)			(4,007	)
Net income (loss)		$	21,205			$	(3,197	)
Basic earnings (loss) per common share		$	0.40			$	(0.06	)
Shares used in computing basic earnings (loss) per common share			52,991				52,298
Diluted earnings (loss) per common share		$	0.40			$	(0.06	)
Shares used in computing diluted earnings (loss) per common share			53,359				52,298

The Medicines Company
Condensed Consolidated Statements of Operations
(unaudited)

		Year to Date September 30,
(in thousands, except per share data)		2010				2009
Net revenue		$	317,966			$	302,181
Operating expenses:
Cost of revenue			93,905				86,958
Research and development			54,128				68,685
Selling, general and administrative			121,318				146,863
Total operating expenses			269,351				302,506
Income (loss) from operations			48,615				(325	)
Other income			55				2,055
Income before income taxes			48,670				1,730
Provision for income taxes			(2,607	)			(4,465	)
Net income (loss)		$	46,063			$	(2,735	)
Basic earnings (loss) per common share		$	0.87			$	(0.05	)
Shares used in computing basic earnings (loss) per common share			52,773				52,225
Diluted earnings (loss) per common share		$	0.87			$	(0.05	)
Shares used in computing diluted earnings (loss) per common share			53,005				52,225

The Medicines Company
Condensed Consolidated Balance Sheets

		September 30,				December 31
(in thousands)		2010				2009
ASSETS
Cash, cash equivalents and available for sales securities		$	227,453			$	176,191
Accrued interest receivable			922				922
Accounts receivable, net			34,070				29,789
Inventory			29,624				25,836
Prepaid expenses and other current assets			7,367				9,984
Total current assets			299,436				242,722
Fixed assets, net			21,387				25,072
Intangible assets, net			83,363				84,678
Restricted cash			5,764				7,049
Goodwill			14,671				14,934
Other assets			269				321
Total assets		$	424,890			$	374,776
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities		$	77,767			$	86,619
Contingent purchase price			25,932				23,667
Deferred tax liability			19,105				18,395
Other long term liabilities			5,829				5,706
Stockholders’ equity			296,257				240,389
Total liabilities and stockholders’ equity		$	424,890			$	374,776

The Medicines Company
Reconciliation of GAAP to non-GAAP Measures
(All amounts in thousands, except per share amounts)
(Unaudited)

		Three Months Ended September 30,
		2010
		GAAP(1)				Targanta								Non-cash				Non-GAAP(5)
		As Reported				Acquisition(2)				SFAS 123R				Tax Provision				As Adjusted
Net revenue		$	105,743			$	—			$	—			$	—			$	105,743
Operating expenses:
Cost of revenue			31,568				—				(57	) (3)			—				31,511
Research and development			16,676				—				(331	) (3)			—				16,345
Selling, general and administrative			35,788				—				(1,387	) (3)			—				34,401
Total operating expenses			84,032				—				(1,775	)			—				82,257
Income from operations			21,711				—				1,775				—				23,486
Other (loss) income			483				—				—				—				483
Income before income taxes			22,194				—				1,775				—				23,969
(Provision) benefit for income taxes			(989	)			—				—				(148	) (4)			(1,137	)
Net income			21,205				—				1,775				(148	)			22,832
Basic earnings per common share		$	0.40			$	—			$	0.03				—			$	0.43
Shares used in computing basic earnings per common share			52,991				52,991				52,991				52,991				52,991
Diluted earnings per common share		$	0.40			$	—			$	0.03			$	—			$	0.43
Shares used in computing diluted earnings per common share			53,359				53,359				53,359				53,359				53,359

The Medicines Company
Reconciliation of GAAP to non-GAAP Measures
(All amounts in thousands, except per share amounts)
(Unaudited)

		Nine Months Ended September 30,
		2010
						Targanta								Non-cash				Non-GAAP(5)
		GAAP(1)				Acquisition(2)				SFAS 123R				Tax Provision				As Adjusted
Net revenue		$	317,966			$	—			$	—			$	—			$	317,966
Costs and expenses:
Cost of revenue			93,905				—				(218	) (3)			—				93,687
Research and development			54,128				—				(1,569	) (3)			—				52,559
Selling, general and administrative			121,318				—				(5,068	) (3)			—				116,250
Total operating expenses			269,351				—				(6,855	)			—				262,496
Income from operations			48,615				—				6,855				—				55,470
Other (loss) income			55				—				—				—				55
Income before income taxes			48,670				—				6,855				—				55,525
(Provision) benefit for income taxes			(2,607	)			—				—				710	(4)			(1,897	)
Net income			46,063				—				6,855				710				53,628
Basic earnings per common share		$	0.87			$	—			$	0.13			$	0.01			$	1.02
Shares used in computing basic earnings per common share			52,773				52,773				52,773				52,773				52,773
Diluted earnings per common share		$	0.87			$	—			$	0.13			$	0.01			$	1.01
Shares used in computing diluted earnings per common share			53,005				53,005				53,005				53,005				53,005