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Exhibit 21.1

Osmotica Pharmaceuticals plc

Subsidiary
  State or Other Jurisdiction of Organization

Osmotica Holdings S.C.Sp. 

  Luxembourg

Osmotica Holdings US LLC

  Delaware

Osmotica Holdings Corp LTD

  Cyprus

Osmotica Kereskedelmi es Szolgaltato Kft

  Hungary

Osmotica Pharmaceutical Corp. 

  Delaware

RevitaLid, Inc. 

  Delaware

Osmotica Argentina, S.A. 

  Argentina

Orbit Blocker I LLC

  Delaware

Orbit Blocker II LLC

  Delaware

Valkyrie Group Holdings, Inc. 

  Delaware

Vertical/Trigen Holdings, LLC(1)

  Delaware

Osmotica Pharmaceutical US, LLC

  Delaware

Vertical/Trigen Midco, LLC

  Delaware

Vertical/Trigen Opco, LLC

  Delaware

Trigen Laboratories, LLC

  Delaware

Vertical Pharmaceuticals, LLC

  Delaware

(1)
Vertical/Trigen Holdings, LLC is jointly-owned by Orbit Blocker I, LLC, Orbit Blocker II, LLC, Valkyrie Group Holdings, Inc. and Osmotica Pharmaceutical Corp.



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