Exhibit 10.6

Tyme Technologies, Inc.

Amendment to

Nonqualified Stock Option Agreement

This Amendment to Nonqualified Stock Option Agreement (the “Amendment”), dated ________, 2018 (the “Effective Date”) is made by and between Tyme Technologies, Inc., a Delaware corporation (the “Company”), and ____________ (the “Optionee”).

WHEREAS,  on May 24, 2018 (the “Date of Grant”), the Company, pursuant to the Company’s 2015 Equity Incentive Plan (the “Plan”), granted Optionee a nonqualified stock option (the “Option”) to purchase a total of _________ shares (the “Shares”) of the common stock, par value $0.0001 per share (the “Common Stock”), of the Company, at the exercise price of $2.90 per Share (the “Exercise Price”), on the terms and conditions set forth in the Nonqualified Stock Option Plan Agreement, dated as of the Date of Grant (the “Prior Award”)

WHEREAS, the Prior Award provided for a four year vesting schedule for the Option;

WHEREAS, the Company wishes to modify the Prior Award to provide the Optionee with a modified vesting schedule of the Option to reflect a three year Option vesting schedule;

NOW, THEREFORE, in consideration of the foregoing and of the representations, warranties, covenants and agreements contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and the Optionee hereby agree as follows:

(a)Except as otherwise provided herein, the Option shall become exercisable according to the following schedule, provided that the Optionee is employed by the Company on such date:

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IN WITNESS WHEREOF, the parties have executed this Amendment to Nonqualified Stock Option Agreement as of the date first written above.

[Signature Page to Amendment to Nonqualified Stock Option Award]