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8-K - FORM 8-K - Oncotelic Therapeutics, Inc.d263280d8k.htm

Exhibit 16.1

December 14, 2016

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Ladies and Gentlemen:

We have read Item 4.01 of Form 8-K dated December 9, 2016, of Mateon Therapeutics, Inc. and are in agreement with the statements contained in the first, second, third, and fifth paragraphs on page 2 therein. We have no basis to agree or disagree with other statements of the registrant contained therein.

/s/ Ernst & Young LLP