Introductory Comment – Use of Terminology

Throughout this Current Report on Form 8-K, the terms “Company,” “we,” “us,” and “our” refers to Tyme Technologies, Inc. and, unless the context indicates otherwise, its direct and indirect subsidiaries, Tyme Inc. and Luminant Biosciences, LLC, on a consolidated basis.

Item 1.01  Entry into a Material Definitive Agreement.

We have entered into a new employment arrangement with Robert Dickey IV, our Vice President - Finance and Chief Financial Officer. The new employment arrangement is set forth in a letter agreement, dated as of January 27, 2016 (the “New Employment Agreement”), which supersedes our prior letter agreement with Mr. Dickey which was dated as of May 15, 2015 (the “Prior Employment Agreement”). We filed a Current Report on Form 8-K (Date of Report: May 15, 2015) with the U.S. Securities and Exchange Commission on May 20, 2015 in connection with our initial retention of Mr. Dickey and the entry into of the Prior Employment Agreement.

Under the New Employment Agreement, Mr. Dickey will be required to devote his full working time, efforts and attention to his duties with our Company. Mr. Dickey was required to devote only one-third of his business time to our Company under the Prior Employment Agreement, although the Prior Employment Agreement contemplated that his working time devoted to us would increase as we expand our research and development activities, regulatory filings and otherwise grow our Company and that we would negotiate with him in good faith an increase in his compensation if his work for our Company causes him to devote more than one-third of his business time to our Company. In addition to his performing the usual and customary duties, responsibilities and authority of a person in positions of a vice president - finance and chief financial officer and such other duties assigned by our Board of Directors (“our Board”) and/or our Chief Executive Officer (“our CEO”), in either case, which are consistent with such positions, Mr. Dickey also is to provide advice and assistance to the CEO and Board with respect to soliciting and developing relationships with prospective investors and broker-dealers and a private placement of securities of our Company. Mr. Dickey’s annual compensation has been increased to $200,000 under the New Employment Agreement from an annual rate of $80,000 under the Prior Employment Agreement. In addition to such cash compensation, we have also granted Mr. Dickey a five year option to purchase up to 200,000 shares of our common stock at a per share purchase price of $11.00, the closing price of our common stock on the date of the New Employment Agreement. One-half of the shares subject to such option vested immediately upon grant and the remaining 100,000 shares subject to the option will vest on July 27, 2016, provided that Mr. Dickey is still employed by us on said vesting date. The option we granted to Mr. Dickey under the Prior Employment Agreement has not been terminated and remains exercisable in accordance with its terms.

- 2 -