Exhibit 10.4

SECOND AMENDMENT TO LICENSE AND SUPPLY AGREEMENT

This SECOND AMENDMENT TO LICENSE AND SUPPLY AGREEMENT (this “Amendment”) is entered into as of May 4, 2015, by and between Nephros, Inc., a Delaware corporation (“Nephros”), and Medica S.p.A. (“Medica”), and sometimes referred to individually as a “Party” and collectively as the “Parties”.

RECITALS

A.           Nephros and Medica are parties to that certain License and Supply Agreement entered into as of April 23, 2012, as amended as of April 10, 2013 (collectively, the “Agreement”), whereby the Parties agreed to an exclusive supply arrangement for the Medica Products and Nephros Products.

B.           The Parties have agreed to make certain amendments to the Agreement relating to the scope of the Territory, certain minimum purchase requirements and royalties on certain Medica Products.

NOW, THEREFORE, in consideration of the foregoing and of the mutual representations, warranties and covenants contained herein, the Parties agree as follows:

1.           Territory. Notwithstanding Section 2.5 of the Agreement, the Parties agree that Italy shall be excluded from the Territory for the duration of the Term.

2.           2015 Minimum Purchase Requirement. Section 3.2 of the Agreement is hereby amended to provide that the total minimum amount of purchases by Nephros from Medica for calendar year 2015 shall be €1,000,000.

3.           Individual Water Purifier Royalties. Section 4.2 of the Agreement shall be amended and restated in its entirety, as follows:

“4.2           Royalties. As further consideration for the license and other rights granted to Nephros under this Agreement, for the period beginning on April 23, 2014 through and including December 31, 2022 (the “Royalty Term”), in addition to any payments set forth in this Section 4, Nephros shall pay to Medica a royalty at the rate of 3% of Net Sales, subject to reduction as set forth in Section 5.6. Notwithstanding the foregoing, in the event Nephros sub-licenses to a Third Party its right to market and sell its Individual Water Purifier (also known as HydraGuard) products, then no such royalty shall be owed to Medica solely with respect to Net Sales of such Individual Water Purifier products, and in lieu thereof, Medica shall charge a fee of €2.00 for each unit of Individual Water Purifier product that is Supplied by Medica pursuant to Section 5 of this Agreement.”

4.           Pricing Summary. Notwithstanding anything to the contrary contained in the Agreement, the parties agree that for purposes of Section 5.8 of the Agreement the terms of pricing for supply of Individual Water Purifier (HydraGuard) products shall be as set forth on Schedule B attached hereto.

5.           No Further Amendment. Except as expressly modified hereby, the Agreement remains in full force and effect. In the event that any provision of this Amendment, or any provision of the Agreement as amended hereby, is or becomes legally ineffective, this shall not affect the validity of the remaining provisions hereof or thereof, and in lieu of the invalid provisions, the Parties shall agree upon a valid provision that approaches best the commercial purposes of the intended provision.

6.           Counterparts; Facsimile Signatures. This Amendment may be executed in multiple counterparts, all of which, when executed, shall be deemed to be an original and all of which together shall constitute one and the same document. Signatures provided by facsimile transmission shall be deemed to be original signatures.

7.           Capitalized Terms. Capitalized terms used but not otherwise defined in this Amendment shall have the meanings ascribed to such terms in the Agreement.

IN WITNESS WHEREOF, each Party has executed this Amendment as of the date first set forth above.

Schedule B

Medica HydraGuard Pricing Agreement Summary

Medica per filter (ex-works Medolla):

- price includes cost for Medica (DDP-Medolla) for the accessories (straw, flush ports, bite-valve, etc.), assuming current cost of 6 euro

- price includes Medica’s tooling investment paid back with 5 euro overcharge on the first 100k filters

Notes: