Attached files

file filename
S-1/A - S-1/A - Blueprint Medicines Corpa2224211zs-1a.htm
EX-5.1 - EX-5.1 - Blueprint Medicines Corpa2224211zex-5_1.htm
EX-4.1 - EX-4.1 - Blueprint Medicines Corpa2224211zex-4_1.htm

QuickLinks -- Click here to rapidly navigate through this document


Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

          We consent to the reference of our firm under the caption "Experts" and to the use of our report dated February 19, 2015, except for Note 12B, as to which the date is April 20, 2015, in Amendment No. 2 to the Registration Statement (Form S-1 No. 333-202938) and related Prospectus of Blueprint Medicines Corporation dated April 20, 2015.

/s/ Ernst & Young LLP                                

Boston, Massachusetts
April 20, 2015




QuickLinks