Attached files

file filename
EXCEL - IDEA: XBRL DOCUMENT - Epizyme, Inc.Financial_Report.xls
10-K - FORM 10-K - Epizyme, Inc.d869037d10k.htm
EX-32.1 - EX-32.1 - Epizyme, Inc.d869037dex321.htm
EX-23.2 - EX-23.2 - Epizyme, Inc.d869037dex232.htm
EX-10.9 - EX-10.9 - Epizyme, Inc.d869037dex109.htm
EX-31.1 - EX-31.1 - Epizyme, Inc.d869037dex311.htm
EX-31.2 - EX-31.2 - Epizyme, Inc.d869037dex312.htm
EX-10.37 - EX-10.37 - Epizyme, Inc.d869037dex1037.htm
EX-10.40 - EX-10.40 - Epizyme, Inc.d869037dex1040.htm

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statement (Form S-3 No. 333-196692) and related Prospectus of Epizyme, Inc., the Registration Statement (Form S-8 No. 333-189629) pertaining to the 2008 Stock Incentive Plan, 2013 Stock Incentive Plan, and 2013 Employee Stock Purchase Plan of Epizyme, Inc., and the Registration Statement (Form S-8 No. 333-194205) pertaining to the 2013 Stock Incentive Plan and 2013 Employee Stock Purchase Plan of Epizyme, Inc. of our report dated March 12, 2015, with respect to the consolidated financial statements of Epizyme, Inc. included in this Annual Report (Form 10-K) for the year ended December 31, 2014.

/s/ Ernst & Young LLP

Boston, Massachusetts

March 12, 2015