CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
I, J. Michael French, the President and Chief
Executive Officer of Marina Biotech, Inc. (“Marina Biotech”), certify, pursuant to 18 U.S.C. Section 1350, as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that the Quarterly Report of Marina Biotech on Form 10-Q for the fiscal
quarter ended September 30, 2014 fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act
of 1934, as amended, and that the information contained in the Quarterly Report on Form 10-Q fairly presents in all material respects
the financial condition and results of operations of Marina Biotech.
||/s/ J. Michael French |
||J. Michael French|
||President and Chief Executive Officer|
||(Principal Executive Officer and|
||Principal Financial Officer)|
Date: November 14, 2014
A signed original of this written statement
required by Section 906 has been provided to Marina Biotech and will be retained by Marina Biotech and furnished to the Securities
Exchange Commission or its staff upon request.
This certification accompanies each periodic
report pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 and shall not, except to the extent required by the Sarbanes-Oxley
Act of 2002, be deemed filed by Marina Biotech for purposes of Section 18 of the Securities Exchange Act of 1934, as amended.