Exhibit 99. 1

ChemoCentryx Reports Third Quarter 2014 Financial Results and

Provides Corporate Update

— Conference Call Today at 5:00 p.m. Eastern Time —

MOUNTAIN VIEW, Calif., November 5, 2014 (GLOBE NEWSWIRE) — ChemoCentryx, Inc., (Nasdaq:CCXI), a clinical-stage biopharmaceutical company focused on autoimmune diseases, inflammatory disorders and cancer, today reported financial results for the third quarter ended September 30, 2014 and provided an update on the Company’s corporate and clinical development activities.

“Our clinical pipeline of novel inhibitors of chemoattractant receptors continued to advance this quarter,” said Thomas J. Schall, Ph.D., President and Chief Executive Officer, ChemoCentryx. “The focus of our ongoing clinical programs has been on renal and orphan diseases, and we look forward to reporting 52-week data with our CCR2 inhibitor, CCX140, in patients with diabetic nephropathy later this year. Also, the progress we made during the quarter will enable us in the coming months to start two clinical trials with our complement C5a receptor inhibitor, CCX168, one in ANCA-associated vasculitis in North America and another in atypical hemolytic uremic syndrome, representing our initial steps to broaden this important program. In addition, we are expanding our development portfolio into immuno-oncology.”

Recent Developments and Corporate Highlights

C5aR Program - CCX168 targets the chemoattractant receptor known as C5aR (which binds the complement fragment C5a). The Company has successfully completed and reported positive clinical data with CCX168 from the first two steps of a three-step Phase II clinical trial, named the CLEAR trial, in patients with anti-neutrophil cytoplasmic antibody, or ANCA, associated vasculitis, or AAV a disease which can lead to renal and pulmonary failure. C5aR is also believed to play a role in other renal disease settings

such as IgA nephropathy, atypical hemolytic uremic syndrome (aHUS), and lupus nephritis.

CCR9 Program - CCX507 targets the chemokine receptor known as CCR9 and is a second-generation CCR9 inhibitor for the treatment of inflammatory bowel disease, or IBD. Vercirnon is a Phase III-ready drug candidate for the treatment of patients with moderate-to-severe Crohn’s disease.

Corporate

Anticipated Milestones

CCX168, a C5aR inhibitor

CCX140, a CCR2 inhibitor

CCX872, a second-generation CCR2 inhibitor

Immuno-oncology program

Third Quarter 2014 Financial Results

Cash, cash equivalents and investments were $124.7 million at September 30, 2014 compared with $149.9 million at December 31, 2013.

There was no revenue recognized for the three months ended September 30 2014, compared to $1.5 million recognized in the same period in 2013. The decrease in revenue from 2013 to 2014 was due to funding of clinical support in 2013 from former partner, GlaxoSmithKline, for CCX168, a C5aR inhibitor, for the treatment of ANCA-associated vasculitis. The Company’s product development and commercialization agreement with GSK ended in November 2013, and therefore, no revenue has been recorded in 2014.

Research and development expenses were $7.5 million for the three months ended September 30, 2014 compared to $8.2 million for the comparable period in 2013. The decrease in research and development expenses was primarily attributed to lower expenses associated with CCX140, a CCR2 inhibitor, as the Phase II clinical trial in patients with diabetic nephropathy nears completion. These decreases were partially offset by higher expenses associated with CCX168, as this program advanced into the third step of a three-step Phase II clinical trial for the treatment of ANCA-associated vasculitis in the fourth quarter of 2013 and initiated clinical development expansion into North America.

General and administrative expenses were $3.5 million for the three months ended September 30, 2014 compared to $2.9 million in 2013. The increase in general and administrative expenses was primarily due to higher employment related expenses, including stock based compensation expense, intellectual property related expenses and professional service fees relating to business development efforts.

Net loss was $10.9 million for the third quarter of 2014 compared to $9.4 million in same period in 2013.

ChemoCentryx had approximately 43.3 million shares outstanding as of September 30, 2014.

Conference Call and Webcast

The Company will host a conference call and webcast today, November 5, 2014 at 5:00 p.m. Eastern Time / 2:00 p.m. Pacific Time.

To participate by telephone, please dial 877-303-8028 (Domestic) or 760-536-5167 (International). The conference ID number is 76329003.

A live and archived audio webcast can be accessed through the Investors section of the Company’s website at

http://www.globenewswire.com/newsroom/ctr?d=10056923&l=19&a=www.ChemoCentryx.com&u=http%3A%2F%2

Fwww.ChemoCentryx.com. The archived webcast will remain available on the Company’s website for fourteen (14) days following the call.

About ChemoCentryx

ChemoCentryx, Inc. is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing orally-administered therapeutics that target the chemokine and chemoattractant systems in order to treat autoimmune diseases, inflammatory disorders and cancer. The chemokine system is a biological network that regulates inflammation via a collection of secreted chemokine molecules, or ligands, and their specific cell surface receptors. Based on its proprietary drug discovery and drug development platform, ChemoCentryx has generated multiple clinical and preclinical-stage programs, each targeting distinct chemokine and chemoattractant receptors with different small molecule compounds. CCX140, a CCR2 inhibitor, has been shown to be safe and well tolerated while demonstrating clinical activity on glycemic indices in a Phase II clinical trial in type 2 diabetics, and is now in Phase II clinical development for the treatment of diabetic nephropathy. CCX168, a C5aR inhibitor, is in Phase II development for the treatment of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). CCX168 appears to be safe, well tolerated and successful in allowing both reduction and elimination of high-dose corticosteroids, part of standard of care for AAV patients, without compromising efficacy or safety during a 12-week treatment period. Vercirnon (also known as Traficet-EN or CCX282) is a specific CCR9 inhibitor for the treatment of inflammatory bowel disease. Other clinical programs include CCX872, a next generation CCR2 inhibitor currently in Phase I clinical development, CCX507, a next generation CCR9 inhibitor, which has successfully completed Phase I development and CCX354, a CCR1 inhibitor which successfully completed a Phase II clinical trial for the treatment of rheumatoid arthritis. ChemoCentryx also has several programs in advanced preclinical development.

Forward-Looking Statements

ChemoCentryx cautions that statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as “may,” “could,” “will,” “would,” “should,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “intend,” “predict,” “seek,” “contemplate,” “potential” or “continue” or the negative of these terms or other comparable terminology are intended to identify forward-looking statements. These statements include the Company’s statements regarding the achievement of anticipated milestones in 2014 and into 2015. The inclusion of forward-looking statements should not be regarded as a representation by ChemoCentryx that any of its plans will be achieved. Actual results may differ from those set forth in this release due to the risks and uncertainties inherent in the ChemoCentryx business and

other risks described in the Company’s filings with the Securities and Exchange Commission (“SEC”). Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and ChemoCentryx undertakes no obligation to revise or update this news release to reflect events or circumstances after the date hereof. Further information regarding these and other risks is included under the heading “Risk Factors” in ChemoCentryx’s periodic reports filed with the SEC, including ChemoCentryx’s Annual Report on Form 10-K for the year ended December 31, 2013 which is available from the SEC’s website (www.sec.gov) under the heading “Investors.” All forward-looking statements are qualified in their entirety by this cautionary statement. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

Source: ChemoCentryx, Inc.

CCXI-G

ChemoCentryx, Inc.

Consolidated Statement of Operations Data

(in thousands, except per share data)