Exhibit 99.1

Vision-Sciences Announces Record Revenues of $5.0 Million for

Fourth Quarter and $17.1 Million for Full Year Fiscal 2014

Orangeburg, NY – April 28, 2014 – Vision-Sciences, Inc. (NasdaqCM: VSCI), a leading provider of unique flexible endoscopic products utilizing its proprietary sterile disposable EndoSheath^® technology, today announced financial results for the fourth quarter and full year fiscal 2014, ended March 31, 2014.

Fourth Quarter Fiscal Year 2014 Highlights

Full Year Fiscal Year 2014 Highlights

Please refer to the attached Non-GAAP Financial Measures and Reconciliation table for more detail.

“We are pleased with our impressive financial results for both the fourth quarter and fiscal year 2014. This can attributed to the solid execution of our strategy, which is to focus on growth in those areas where we have had historical success, ENT and TNE in the office and ambulatory setting and critical care/pulmonology in the ICU setting,” commented Howard Zauberman, President and Chief Executive Officer of Vision-Sciences, Inc.

“We believe that the market for our patented EndoSheath technology will continue to grow as medical professionals search for a sterile and reliable product to safeguard patients. As we look ahead, we remain focused on our mission: to provide innovative technologies that improve patient care and reduce costs to the healthcare system, with a focus on increasing operating efficiency and further margin improvement,” concluded Mr. Zauberman.

Exhibit 99.1

Results of Operations

Fourth Quarter Fiscal Year 2014 versus Fourth Quarter Fiscal Year 2013

Net sales in the fourth quarter of fiscal 2014 increased by 19% to $5.0 million as compared with $4.2 million in the same period a year ago, attributable to higher sales of our endoscopes and EndoSheath technology in all markets. Sequentially, net sales in the fourth quarter increased by 11% from $4.5 million in the third quarter of fiscal 2014.

Net sales detail (in thousands, except for percentages) for the fourth quarters of fiscal years 2014 and 2013 were as follows:

Gross profit was $0.8 million in the fourth quarter of fiscal 2014, a decrease of $0.4 million, or 31%, compared to the same period last fiscal year. Gross margin decreased by 1,220 basis points to 17.0% in the fourth quarter of fiscal 2014 from 29.2% in the fourth quarter of fiscal 2013. The year-over-year decline in gross margin was primarily attributable to an inventory charge of $0.5 million to write-off slow moving and obsolete materials, an impact of 1,070 basis points. Also contributing to the decrease was unfavorable product sales mix as the Company shipped more endoscopes to Stryker, a lower margin business segment, during the fourth quarter of fiscal 2014.

Selling, general and administrative (“SG&A”) expenses were $2.4 million in the fourth quarter of fiscal 2014, a decrease of $0.4 million, or 13%, compared to the same period last fiscal year. The decrease was primarily attributable to lower expenses related to sales compensation, stock-based compensation, and professional education. As a percentage of net sales, SG&A decreased to 49% in the fourth quarter of fiscal 2014 from 67% reported in the same period last fiscal year.

Research and development (“R&D”) expenses were $0.7 million in the fourth quarter of fiscal 2014, an increase of $0.2 million, or 53%, over the same period last year. The increase was primarily attributable to higher product development costs. As a percentage of net sales, R&D increased to 14% in the fourth quarter of fiscal 2014 from 11% reported during the same period last fiscal year.

The Company’s operating loss increased by 13% to $2.3 million during the fourth quarter of fiscal 2014, primarily due to the lower gross profit realized during the quarter.

Exhibit 99.1

Full Year Fiscal 2014 versus Full Year Fiscal 2013

Net sales for fiscal 2014 increased by 12% to $17.1 million from $15.2 million reported during fiscal 2013. The year-over-year sales growth was primarily attributable to higher sales of our endoscopes and EndoSheath technology in the urology and pulmonology markets.

Net sales detail (in thousands, except for percentages) for fiscal years 2014 and 2013 were as follows:

Gross profit was $4.5 million in fiscal 2014, an increase of $0.2 million, or 4%, over last fiscal year. Gross margin decreased by 210 basis points to 26.3% in fiscal 2014 from 28.4% in fiscal 2013. The year-over-year decline in gross margin was primarily attributable to the inventory charge noted above, which had a 310 basis point impact on the full fiscal year results.

SG&A expenses were $9.8 million in fiscal 2014, a decrease of $1.2 million, or 11%, compared to last fiscal year. The decrease was primarily attributable to lower expenses related to stock-based compensation and corporate and sales compensation. As a percentage of net sales, SG&A decreased to 58% in fiscal 2014 from 72% as reported in fiscal 2013.

R&D expenses were $2.1 million in fiscal 2014, an increase of $0.3 million, or 15%, compared to last fiscal year. The increase was primarily attributable to higher product development costs. As a percentage of net sales, R&D was 12% for fiscal years 2014 and 2013.

The Company’s operating loss improved by 12% to $7.4 million in fiscal 2014 from $8.5 million last fiscal year, primarily attributable to a $0.9 million reduction in operating expenses.

At March 31, 2014, the Company had cash and cash equivalents of $1.2 million and working capital of $6.9 million, as compared to cash and cash equivalents of $0.8 million and working capital of $7.0 million at March 31, 2013. Pursuant to a letter agreement dated June 21, 2013 with Lewis C. Pell, the Company’s Chairman, Mr. Pell has agreed to provide financial assistance to the Company in the amount of up to $5.0 million, if necessary to support the operations, for a period ending on the earlier of (i) July 1, 2014 or (ii) the Company raising debt or equity capital in the amount of $5.0 million or more. As of March 31, 2014, the Company had not utilized the financial assistance agreement.

Exhibit 99.1

Conference Call

Howard Zauberman, President and Chief Executive Officer, and Keith Darragh, VP, Finance, will host a conference call to discuss the fourth quarter and full year fiscal 2014 financial results at 8:30 a.m. EDT, on Tuesday, April 29, 2014.

An audio replay of the conference call will be available from 11:30 a.m. EDT on Tuesday, April 29, 2014, through 11:59 p.m. EDT on Tuesday, May 6, 2014, by dialing (855) 859-2056 from the U.S. or (404) 537-3406 from abroad. The audio webcast will also be available in the investor section of the Company’s website, www.visionsciences.com.

Use of Non-GAAP Financial Measures

Non-GAAP gross profit, non-GAAP operating loss, non-GAAP net loss, and non-GAAP net loss per share excludes non-cash or non-operational activities. As a result, the Company uses these measures to assess and analyze its operational results and trends and to make financial and operations decisions. The Company also believes these non-GAAP financial measures are useful to investors, because they provide greater transparency regarding the Company’s operating performance. These non-GAAP financial measures should not be considered measures of the Company’s liquidity. In addition, these non-GAAP financial measures are unlikely to be comparable with non-GAAP information provided by other companies. Reconciliations between non-GAAP financial measures and GAAP financial measures for gross profit, operating loss, net loss, and net loss per share are included in a table accompanying this press release after the unaudited condensed consolidated financial statements.

About Vision-Sciences, Inc.

Vision-Sciences, Inc. designs, develops, manufactures and markets products for flexible endoscopy. The Company’s unique product lines feature a streamlined visualization system and proprietary sterile disposable microbial barrier, known as EndoSheath technology, providing users with efficient and cost effective endoscope turnover while enhancing patient safety. Information about Vision-Sciences’ products is available at www.visionsciences.com.

Vision-Sciences owns the registered trademarks Vision Sciences^®, EndoSheath^®, EndoWipe^®, Slide-On^®, and The Vision System^®.

Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995: This press release contains forward-looking statements, which are any statements that are not historical facts. These forward-looking statements are based on Vision-Sciences’ current expectations, and should not be relied upon as representing its views as of any subsequent date. Forward-looking statements are subject to a variety of risks and uncertainties that could cause the Company’s actual results to differ materially from the statements contained herein; risk factors are detailed in the Company’s most recent annual report and other filings with the U.S. Securities and Exchange Commission. There is no assurance that any future results or events discussed in these statements will be achieved. The Company does not assume any obligation to update any forward-looking statements as a result of new information or future events or developments, except as may be required by law.

Exhibit 99.1

(Financial tables follow)

Exhibit 99.1

Vision-Sciences, Inc. and Subsidiaries

Condensed Consolidated Statements of Operations

(In thousands, except per share amounts)

Exhibit 99.1

Vision-Sciences, Inc. and Subsidiaries

Condensed Consolidated Balance Sheets

(In thousands, except per share amounts)

Exhibit 99.1

Vision-Sciences, Inc. and Subsidiaries

Condensed Consolidated Statements of Cash Flows

(In thousands, except per share amounts)

Exhibit 99.1

Vision-Sciences, Inc. and Subsidiaries

Non-GAAP Financial Measures and Reconciliation

(In thousands, except per share amounts)

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