Exhibit 99.1

MARKETAXESS REPORTS FOURTH QUARTER 2013 REVENUES OF $60.4 MILLION, PRE-TAX INCOME OF $24.8 MILLION AND DILUTED EPS FROM CONTINUING OPERATIONS OF $0.41

Company Announces Increase of Regular Quarterly Dividend to $0.16 per Share, up from $0.13

Fourth Quarter Financial Highlights^*

Full Year 2013 Financial Highlights^**

NEW YORK, January 29, 2014 – MarketAxess Holdings Inc. (Nasdaq: MKTX), the operator of a leading electronic trading platform for fixed-income securities, and the provider of market data and post-trade services for the global fixed-income markets, today announced results for the fourth quarter and full year ended December 31, 2013.

“2013 was a year of continued strong growth for MarketAxess, combined with an accelerated investment in new opportunities. Our record revenues and earnings were driven by market share growth and record volumes in all three of our core products – high-grade, high yield and emerging markets,” said Richard M. McVey, Chairman and Chief Executive Officer of MarketAxess. “Last year was also an inflection point for Open Trading, with increased engagement from investors and dealers in our all-to-all trading protocols.”

Fourth Quarter Results From Continuing Operations

Total revenues for the fourth quarter of 2013 increased 24.4% to $60.4 million, compared to $48.6 million for the fourth quarter of 2012. Pre-tax income was $24.8 million, compared to $22.2 million for the fourth quarter of 2012, an increase of 11.8%. Pre-tax margin was 41.0%, compared to 45.7% for the fourth quarter of 2012. Net income totaled $15.5 million, or $0.41 per share on a diluted basis, compared to $20.9 million, or $0.56 per share for the fourth quarter of 2012. The fourth quarter 2012 results include a favorable income tax adjustment of $6.7 million, or $0.18 per share, relating to certain previously unrecognized tax benefits. Excluding this income tax adjustment, net income for the fourth quarter of 2012 totaled $14.2 million, or $0.38 per share on a diluted basis.

Commission revenue for the fourth quarter of 2013 totaled $50.5 million on total trading volume of $171.3 billion, compared to $44.2 million in commission revenue on total trading volume of $149.1 billion for the fourth quarter of 2012. U.S. high-grade trading volume as a percentage of FINRA’s high-grade TRACE trading volume increased to an estimated 13.9%, compared to an estimated 13.6% for the fourth quarter of 2012.

All other revenue, which consists of information and post-trade services, technology products and services, investment income and other revenue, increased to $10.0 million, compared to $4.3 million for the fourth quarter of 2012. The increase in all other revenue was principally due to information and post-trade services revenue generated by Xtrakter Limited (“Xtrakter”) totaling $5.6 million for the fourth quarter of 2013. The Company completed the acquisition of Xtrakter on February 28, 2013.

Total expenses for the fourth quarter of 2013 increased 35.1% to $35.6 million, compared to $26.4 million for the fourth quarter of 2012. The increase in total expenses was largely due to approximately $6.8 million of Xtrakter operating expenses incurred during the fourth quarter of 2013. Excluding Xtrakter operating expenses, the $2.4 million increase in total expenses from the fourth quarter of 2012 of approximately 9.2% was principally attributable to higher salaries and variable incentive compensation due to an increase in profitability and headcount, higher depreciation and amortization resulting from an increase in software development and other capital expenditures and an increase in occupancy costs principally driven by a loss on the sublease of office space in London.

The effective tax rate for the fourth quarter of 2013 was 37.6%, compared to 5.7% for the fourth quarter of 2012. Excluding the impact of the non-recurring favorable income tax adjustment, the effective tax rate for the fourth quarter of 2012 was 35.9%.

Employee headcount from continuing operations was 293 as of December 31, 2013, compared to 206 as of December 31, 2012. The increase was mainly due to personnel increases associated with the Xtrakter acquisition.

Full Year 2013 Results From Continuing Operations

Total revenues for the year ended December 31, 2013 increased 25.1% to a record $238.7 million, compared to $190.8 million for 2012. Pre-tax income was a record $107.3 million, compared to $89.4 million for 2012, an increase of 20.0%. Pre-tax margin was 44.9%, compared to 46.8% for 2012. Net income totaled $68.6 million, or $1.81 per share on a diluted basis, compared to $61.8 million, or $1.64 per share for 2012. Excluding the income tax adjustment, net income for 2012 totaled $55.1 million, or $1.46 per share on a diluted basis.

Commission revenue for the year ended December 31, 2013 increased 16.9% to $203.7 million, compared to $174.2 million for 2012. Variable transaction fees increased 23.9% to $142.3 million on total trading volume of $693.7 billion, compared to variable transaction fees of $114.9 million on total trading volume of $589.6 billion for 2012.

All other revenue increased 110.8% to $35.1 million, compared to $16.6 million for 2012. The increase in all other revenue was principally due to information and post-trade services revenue generated by Xtrakter totaling $18.4 million for the year ended December 31, 2013.

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Total expenses for the year ended December 31, 2013 increased 29.5% to $131.5 million, compared to $101.5 million for 2012. The increase in total expenses was largely due to approximately $19.7 million of Xtrakter operating expenses incurred during 2013. Excluding Xtrakter operating expenses, the $10.3 million increase in total expenses from full year 2012 of approximately 10.2% was principally attributable to higher depreciation and amortization, professional and consulting fees, salaries and benefits and occupancy costs. Capital spending for the year ended December 31, 2013 was $23.3 million compared to $10.4 million in 2012.

The effective tax rate for 2013 was 36.1%, compared to 30.9% for 2012. Excluding the income tax adjustment, the effective tax rate for 2012 was 38.4%.

Discontinued Operations

As previously reported, the Company completed the sale of its Greenline Financial Technologies, Inc. (“Greenline”) subsidiary in October 2013. The aggregate purchase price was $11.0 million in cash. Greenline’s results have been classified as discontinued operations in the Consolidated Statement of Operations for all periods presented and, accordingly, are not included in the period to period comparisons of continuing operations. The Company recorded an accounting gain on the sale of Greenline in the fourth quarter of 2013 of $7.6 million, or $0.20 per share on a diluted basis.

Dividend

The Company’s board of directors declared a quarterly cash dividend of $0.16 per share of common stock outstanding, to be paid on February 27, 2014 to stockholders of record as of the close of business on February 13, 2014. This represents an increase of $0.03 per share in the quarterly cash dividend.

Share Repurchase Program

In January 2014, the Company’s board of directors approved a $35.0 million share repurchase program, which authorizes the Company to repurchase shares of its common stock in the open market or in privately negotiated transactions, at times and prices considered appropriate by the Company.

Balance Sheet Data

As of December 31, 2013, total assets were $351.6 million and included $200.4 million in cash, cash equivalents and securities available-for-sale. Total stockholders’ equity as of December 31, 2013 was $310.4 million.

Guidance for 2014

The Company expects total expenses for 2014 to be in the range of $150.0 million to $157.0 million and its full year 2014 capital spending to be in the range of $17.0 million to $20.0 million. The Company also anticipates that the overall effective tax rate for 2014 will be between 37% and 40%.

Non-GAAP Financial Measures

EBITDA, adjusted net income and adjusted diluted earnings per share are non-GAAP financial measures. The Company believes that these non-GAAP financial measures, when taken into consideration with the corresponding GAAP financial measures, are important in understanding the Company’s operating results. See the attached schedules for reconciliations of GAAP to the corresponding non-GAAP measure.

Webcast and Conference Call Information

Richard M. McVey, chairman and chief executive officer, and Antonio L. DeLise, chief financial officer, will host a conference call to discuss the Company’s financial results and outlook on Wednesday, January 29, 2014, at 10:00 a.m. Eastern time. To access the conference call, please dial +1 855 425 4206 (U.S.) or +1 484 756 4249 (international). The Company will also host a live audio Webcast of the conference call on the Investor Relations section of the Company’s website at http://investor.marketaxess.com. A replay of the call will be made available by dialing +1 855 859 2056 (U.S.) or +1 404 537 3406 (international) for one week after the announcement. The Webcast will also be archived on http://investor.marketaxess.com for 90 days following the announcement.

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About MarketAxess

MarketAxess operates a leading electronic trading platform that enables fixed-income market participants to efficiently trade corporate bonds and other types of fixed-income instruments using MarketAxess’ patented trading technology. Over 1,000 institutional investor and broker-dealer firms are active users of the MarketAxess trading platform, accessing global liquidity in U.S. high-grade corporate bonds, European bonds, high-yield and emerging markets bonds, agency bonds, asset-backed and preferred securities and credit default swaps. MarketAxess SEF Corporation has received temporary registration from the U.S. Commodity Futures Trading Commission to operate a swap execution facility. MarketAxess also offers a number of trading-related products and services, including: market data to assist clients with trading decisions; connectivity solutions that facilitate straight-through processing; technology services to optimize trading environments; and execution services for exchange-traded fund managers and other clients. Through its Xtrakter subsidiary, MarketAxess also offers a range of pre- and post-trade services, including trade matching, regulatory transaction reporting and market and reference data, across a range of fixed-income products.

MarketAxess maintains its headquarters in New York and has offices in London, Boston, Chicago, Los Angeles, Salt Lake City, São Paulo and Singapore. For more information, please visit www.marketaxess.com.

Cautionary Note Regarding Forward-Looking Statements

This press release may contain forward-looking statements, including statements about the outlook and prospects for Company and industry growth, as well as statements about the Company’s future financial and operating performance. These and other statements that relate to future results and events are based on MarketAxess’ current expectations. Actual results in future periods may differ materially from those currently expected or desired because of a number of risks and uncertainties, including: the volatility of financial services markets generally; the level of trading volume transacted on the MarketAxess platform; the absolute level and direction of interest rates and the corresponding volatility in the corporate fixed-income market; the level and intensity of competition in the fixed-income electronic trading industry and the pricing pressures that may result; the variability of our growth rate; the rapidly evolving nature of the electronic financial services industry; our ability to introduce new fee plans and our clients’ response; our exposure to risks resulting from non-performance by counterparties to transactions executed between our clients in which we act as an intermediary in matching back-to-back trades; our dependence on our broker-dealer clients; the loss of any of our significant institutional investor clients; our ability to develop new products and offerings and the market’s acceptance of those products; the effect of rapid market or technological changes on us and the users of our technology; our ability to successfully maintain the integrity of our trading platform and our response to system failures, capacity constraints and business interruptions; our vulnerability to cyber security risks; our ability to protect our intellectual property rights or technology and defend against intellectual property infringement or other claims; our ability to enter into strategic alliances and to acquire other businesses and successfully integrate them with our business; our ability to comply with new laws, rules and regulations both domestically and internationally; our ability to maintain effective compliance and risk management methods; the strain of growth initiatives on management and other resources; our future capital needs and our ability to obtain capital when needed; limitations on our operating flexibility contained in our credit agreement; and other factors. The Company’s actual results and financial condition may differ, perhaps materially, from the anticipated results and financial condition in any such forward-looking statements. The Company undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. More information about these and other factors affecting MarketAxess’ business and prospects is contained in MarketAxess’ periodic filings with the Securities and Exchange Commission and can be accessed at www.marketaxess.com.

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Media and Investor Relations Contacts:

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MarketAxess Holdings Inc.

Consolidated Statements of Operations

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MarketAxess Holdings Inc.

Consolidated Condensed Balance Sheet Data

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MarketAxess Holdings Inc.

Reconciliation of Non-GAAP Financial Measures

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MarketAxess Holdings Inc.

Volume Statistics

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