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S-1/A - AMENDMENT NO. 1 TO FORM S-1 - Cara Therapeutics, Inc.d605125ds1a.htm

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated October 4, 2013, in Pre-effective Amendment No. 1 to the Registration Statement (Form S-1 No. 333-192230) and related Prospectus of Cara Therapeutics, Inc. for the registration of shares of its common stock.

/s/ Ernst & Young LLP

Boston, MA

December 27, 2013