UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 8-K

CURRENT REPORT

PURSUANT TO SECTION 13 OR 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of earliest event reported): November 27, 2013 (November 21, 2013)

UNILIFE CORPORATION

(Exact name of Registrant as Specified in Charter)

Registrant’s telephone number, including area code: (717) 384-3400

Not Applicable

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the Registrant under any of the following provisions:

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Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On November 21, 2013, the board of directors of the Company promoted the Company’s Chief Operating Officer, Dr. Ramin Mojdeh, to the position of President. Dr. Mojdeh will also retain his position as Chief Operating Officer. Dr. Mojdeh’s compensation and benefits will remain the same as described in the Company’s Proxy Statement filed with the Securities and Exchange Commission (“SEC”) on October 7, 2013 (the “Proxy Statement”).

Information required by Items 401(b), (d), (e) and Item 404(a) of Regulation S-K for Dr. Mojdeh has been included in either the Proxy Statement or the Company’s Annual Report on Form 10-K filed with the SEC on September 13, 2013 and such information is incorporated herein by reference.

Item 5.07 Submission of Matters to a Vote of Security Holders

On November 21, 2013, Unilife Corporation held its annual meeting of stockholders in New York City, at which the following proposals were submitted to a vote of stockholders. The results of the votes are provided below.

Proposal No. 1 – The election of the persons named below as directors to hold office until our annual meeting of stockholders to be held in 2014 and until his or her successor is duly elected and qualified or until his or her earlier resignation or removal

All director nominees were elected and the votes were cast as follows:

Proposal No. 2 – Ratification of the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending June 30, 2014

The appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending June 30, 2014 was ratified and the votes were cast as follows:

Proposal No. 3 – Advisory vote regarding the approval of compensation paid to certain executive officers

The compensation of the Company’s named executive officers was approved, on an advisory basis, and the votes were cast as follows:

Proposal No. 4 - For the purposes of ASX Listing Rule 10.14 and for all other purposes, to approve the grant of up to 105,000 securities to Slavko James Joseph Bosnjak (which Mr. Bosnjak may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement

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The grant of up to 105,000 securities to Slavko James Joseph Bosnjak (which Mr. Bosnjak may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement was approved and the votes were cast as follows:

Proposal No. 5 - For the purposes of ASX Listing Rule 10.14 and for all other purposes, to approve the grant of up to 105,000 securities to Jeff Carter (which Mr. Carter may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement

The grant of up to 105,000 securities to Jeff Carter (which Mr. Carter may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement was approved and the votes were cast as follows:

Proposal No. 6 - For the purposes of ASX Listing Rule 10.14 and for all other purposes, to approve the grant of up to 105,000 securities to William Galle (which Mr. Galle may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement

The grant of up to 105,000 securities to William Galle (which Mr. Galle may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement was approved and the votes were cast as follows:

Proposal No. 7 - For the purposes of ASX Listing Rule 10.14 and for all other purposes, to approve the grant of up to 105,000 securities to John Lund (which Mr. Lund may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement

The grant of up to 105,000 securities to John Lund (which Mr. Lund may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement was approved and the votes were cast as follows:

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Proposal No. 8 - For the purposes of ASX Listing Rule 10.14 and for all other purposes, to approve the grant of up to 105,000 securities to Mary Katherine Wold (which Ms. Wold may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement

The grant of up to 105,000 securities to Mary Katherine Wold (which Ms. Wold may elect to take in the form of shares of restricted stock or restricted stock units) on the terms set out in the Proxy Statement was approved and the votes were cast as follows:

Proposal No. 9 - For the purposes of ASX Listing Rule 10.14 and for all other purposes, to approve a special grant of 52,500 securities to William Galle in the form of restricted stock units on the terms set out in the Proxy Statement

The grant of 52,500 securities to William Galle in the form of restricted stock units on the terms set out in the Proxy Statement was approved and the votes were cast as follows:

Proposal No. 10 - For the purposes of ASX Listing Rule 7.4 and for all other purposes, to ratify the issuance and sale by the Company of 3,512,153 shares of commons stock (equivalent to 21,072,918 CHESS Depositary Interests (“CDIs”)) under the Controlled Equity Offering Sales Agreement the Company entered into with Cantor Fitzgerald & Co. dated October 3, 2013, pursuant to a registration statement filed by the Company with the SEC, and the accompanying prospectus supplement that we filed with the SEC on October 4, 2012

The issuance and sale by the Company of 3,512,153 shares of commons stock (equivalent to 21,072,918 CHESS Depositary Interests (“CDIs”)) under the Controlled Equity Offering Sales Agreement the Company entered into with Cantor Fitzgerald & Co. dated October 3, 2013, pursuant to a registration statement filed by the Company with the SEC, and the accompanying prospectus supplement that the Company filed with the SEC on October 4, 2012 was ratified and the votes were cast as follows:

Item 8.01 Other Events

During the annual meeting of stockholders on November 21, 2013, Alan Shortall, the Company’s Chief Executive Officer, made a PowerPoint presentation. The presentation is attached hereto as Exhibit 99.1.

Item 9.01 Financial Statements and Exhibits

(d) Exhibits

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed on its behalf by the undersigned hereunto duly authorized.

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EXHIBIT INDEX

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