UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): October 8, 2013

EVOKE PHARMA, INC.

(Exact Name of Registrant as Specified in its Charter)

Registrant’s telephone number, including area code: (760) 487-1255

(Former Name or Former Address, if Changed Since Last Report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

On October 8, 2013, Evoke Pharma, Inc. (the “Company”) closed the full exercise of the over-allotment option granted to the representative of the underwriters to purchase an additional 315,000 shares of its common stock, at a price to the public of $12.00 per share, in connection with the Company’s recently announced underwritten initial public offering (the “Offering”). This exercise brings the total shares of common stock issued in the Offering to 2,415,000, and total gross proceeds from the Offering to $28,980,000, before underwriting discounts and commissions and offering expenses payable by the Company. Aegis Capital Corp. acted as sole book-running manager for the Offering. Cantor Fitzgerald & Co. and Feltl and Company, Inc. acted as co-managers for the Offering.

A registration statement relating to these securities was declared effective by the Securities and Exchange Commission on September 24, 2013.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.