UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

PURSUANT TO SECTION 13 OR 15(d)

OF THE SECURITIES EXCHANGE ACT OF 1934

Date of report (Date of earliest event reported): July 16, 2013

OXiGENE, INC.

(Exact name of registrant as specified in its charter)

701 Gateway Boulevard, Suite 210, South San Francisco, CA 94080

(Address of principal executive offices)

Registrant’s telephone number, including area code: (650) 635-7000

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the obligation of the registrant under any of the following provisions:

(a) On July 17, 2013, OXiGENE, Inc. (the “Company”) filed a Certificate of Amendment to its Restated Certificate of Incorporation, a copy of which is attached hereto as Exhibit 3.1 and incorporated herein by reference, with the Secretary of State of Delaware. The Certificate of Amendment, effective as of July 17, 2013, decreases from 100,000,000 shares to 70,000,000 shares the aggregate number of shares of common stock authorized to be issued by the Company.

(a) The 2013 annual meeting of the stockholders of the Company was held on July 16, 2013 at the Company’s offices in South San Francisco, California. Of the 2,274,453 shares of the Company’s common stock entitled to vote at the meeting, 1,334,614 shares were represented at the meeting in person or by proxy, constituting a quorum. Each of the nominees for director were duly elected and each of the other proposals described below were approved. The voting results are presented below.

(b)

1. The Company’s stockholders elected five members to the Board of Directors to hold office until the 2014 annual meeting of stockholders and until their successors are duly elected and qualified. The votes regarding the election of directors were as follows:

2. Amendment to the Company’s 2005 Stock Plan to increase the number of shares of common stock reserved for issuance under the 2005 Stock Plan, from 333,333 shares to 833,333 shares, and to increase the limit on the number of stock-based awards issuable to a participant in the 2005 Stock Plan in any fiscal year from 16,666 to 200,000.

3. Amendment of the Company’s Restated Certificate of Incorporation to decrease from 100,000,000 shares to 70,000,000 shares the aggregate number of shares of common stock authorized to be issued by the Company.

4. Ratification of the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2013.

5. Approval, on an advisory basis, of the compensation of the Company’s named executive officers.

6. Approval, on an advisory basis, the frequency of future votes on the compensation of the Company’s named executive officers.

(d) After considering the results of the advisory stockholder vote on the frequency of future votes on the compensation of the Company’s named executive officers and consistent with a plurality of the votes cast with respect to this matter, the Board of Directors has decided to hold future advisory stockholder votes to approve the compensation paid to the Company’s named executive officers every three years until the next required vote on the frequency of such advisory votes.

(d) Exhibits

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.