Under the License Agreement, InSite exclusively licensed to Inspire certain intellectual property in connection with the development and commercialization of topical anti-infective products containing azithromycin as the sole active ingredient for human ocular or ophthalmic indications (each a "Subject Product") in the United States and Canada and their respective territories and possessions (the "Territory").

    The Amendment also grants Inspire the exclusive option, but not the obligation, to re-acquire the exclusive right to develop and commercialize AzaSite Xtra in the Territory from InSite (the "AzaSite Xtra Option"). The AzaSite Xtra Option can be exercised during the period commencing on the effective date of the Amendment and ending on the date that is ten (10) business days following the first regulatory approval of AzaSite Xtra in the United States, unless the License Agreement is earlier terminated or has expired in accordance with its terms. Upon exercise of the AzaSite Xtra Option, Inspire is required to pay InSite a one-time payment. In addition, in the event that Inspire exercises the AzaSite Xtra Option, Inspire will be obligated to pay InSite royalties on net sales of AzaSite Xtra consistent with the terms of the License Agreement for so long as InSite remains indebted under certain Senior Secured Notes. In the event that InSite is no longer indebted under the Senior Secured Notes, InSite has agreed to negotiate in good faith a separate royalty buy-down agreement with Inspire with respect to AzaSite Xtra; provided that any modification to royalty payment obligations with respect to AzaSite Xtra would be subject to InSite and Inspire reaching a subsequent agreement.

    InSite and Inspire agreed that within thirty (30) days after the effective date of the Amendment, they will establish a committee to manage their interactions regarding the development by InSite of AzaSite Xtra (the "Steering Committee"). InSite has the final decision-making authority with respect to the development of and regulatory strategy for AzaSite Xtra in the Territory unless and until Inspire exercises the AzaSite Xtra Option.