Exhibit 4.2

SECOND AMENDMENT TO WARRANTS

SECOND AMENDMENT TO WARRANTS, dated December     , 2012 (this “Amendment”), by and among University General Health System, Inc., a Nevada corporation (the “Company”), and each party listed on the signature pages hereto (collectively, the “Holders”).

WHEREAS, the Company entered into the Securities Purchase Agreement, dated April 30, 2012 (the “Securities Purchase Agreement”), with the Holders;

WHEREAS, pursuant to the Securities Purchase Agreement, on May 2, 2012, the Company issued to each of the Holders a Common Stock Purchase Warrant (the “Warrants”);

WHEREAS, on December     , 2012, the Warrants were amended pursuant to the First Amendment to Warrants, by and among the Company and the Holders (the “First Amendment to Warrants”);

WHEREAS, Section 5(l) of each Warrant provides that written consent of the holder thereof and the Company shall be required for any amendment to such Warrant; and

WHEREAS, on the terms and subject to the conditions set forth herein, the Company and the Holders hereby consent to amend the terms of the Warrants as set forth below.

NOW, THEREFORE, in consideration of the premises and the mutual agreements, provisions and covenants contained herein and in the Warrants, the parties hereby agree as follows:

Section 1 Definitions. Unless otherwise specified herein, all capitalized terms used and not defined herein shall have the meanings ascribed to them in the Warrants.

Section 2 Representations and Warranties. The Company has the requisite corporate power and authority to enter into and to consummate this Amendment. The execution and delivery of this Amendment has been duly authorized by all necessary action on the part of the Company and no further action is required by the Company, the Board of Directors or the Company’s stockholders in connection herewith. This Amendment has been duly executed by the Company and, when delivered in accordance with the terms hereof, will constitute the valid and binding obligation of the Company enforceable against the Company in accordance with its terms, except: (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors’ rights generally and (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies.

Section 3 Amendments.

(a) Section 2(b) shall be amended and restated in its entirety to read as follows:

“b) Exercise Price. In the event this Warrant is exercised on or before December 31, 2012, the exercise price per share of the Common Stock under this Warrant shall be $0.15 (the “2012 Exercise Price”). In the event this Warrant is exercised on or after January 1, 2013 and before the Termination Date, the exercise price per share of the Common Stock under this Warrant shall be $0.26, subject to adjustment hereunder (the “Post-2012 Exercise Price”; the 2012 Exercise Price or the Post 2012 Exercise Price, as applicable, is referred to herein as the “Exercise Price”). For the avoidance of doubt, (i) the Post-2012 Exercise Price has been adjusted hereunder to $0.24 as of January 1, 2013 and (ii) notwithstanding any other provision of this Warrant, the 2012 Exercise Price shall not be subject to adjustment hereunder under any circumstances.”

Section 4 Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Amendment shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof.

Section 5 Effectiveness and Counterparts. The Amendment shall become effective when, and only when, the Company and the Holders shall have executed and delivered this Amendment. This Amendment may be executed in two or more counterparts, each of which will be deemed an original but all of which together will constitute one and the same instrument.

Section 6 Headings. The headings used in this Warrant are for the convenience of reference only and shall not, for any purpose, be deemed a part of this Warrant.

Section 7 Prior Agreements. This Amendment and the other agreements contemplated hereby constitute the entire agreement between the parties concerning the subject matter hereof and supersede any prior representations, understandings or agreements. There are no representations, warranties, agreements, conditions or covenants, of any nature whatsoever (whether express or implied, written or oral) between the parties hereto with respect to such subject matter except as expressly set forth herein and in the other agreements contemplated hereby.

Section 8 Severability. Wherever possible, each provision of this Amendment shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Amendment shall be prohibited by or invalid under applicable law, such provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions or the remaining provisions of this Amendment.

Section 9 Amendments. Any amendments or modifications must be executed in writing by all parties hereto.

Section 10 No Further Effect. Except as explicitly modified by this Amendment and the First Amendment to Warrants, the Warrants shall remain in full force and effect in accordance with their terms.

[Signature Page Follows]

2

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.

IN WITNESS WHEREOF, the parties have duly executed this Second Amendment to Warrants as of the date first above written.