Exhibit 10.29

FIRST AMENDMENT TO CONSENT TO SUBLEASE

THIS FIRST AMENDMENT TO CONSENT TO SUBLEASE (this “First Amendment”), dated as of September 1, 2011, is made with reference to that certain Sublease Agreement (the “Sublease”) dated as of February 28, 2011, by and between ACCELERON PHARMA, INC. a Delaware corporation with an address of 128 Sidney Street, Cambridge, Massachusetts 02139 (“Sublandlord”), and AVEO PHARMACEUTICALS, INC., a Delaware corporation with an address of 75 Sidney Street, Cambridge, MA 02139 (“Subtenant”), and is entered into by and among Sublandlord, Subtenant and MASSACHUSETTS INSTITUTE OF TECHNOLOGY, a Massachusetts charitable corporation with an address c/o MIT Investment Management Company, 238 Main Street, Suite 200, Cambridge, MA 02142 (“Prime Landlord”), with reference to the following facts:

NOW, THEREFORE, in consideration of the covenants herein reserved and contained, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged and agreed, Prime Landlord, Sublandlord and Subtenant hereby agree as follows:

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signatures on following page]

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EXECUTED as an instrument under seal as of the date first written above.

PRIME LANDLORD: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

By:     MIT Investment Management Company, its authorized agent

SUBLANDLORD: ACCELERON PHARMA, INC.

SUBTENANT: AVEO PHARMACEUTICALS, INC.

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EXHIBIT A

First Amendment to Sublease

[Attach fully-executed copy of First Amendment to Sublease]

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FIRST AMENDMENT TO SUBLEASE

This First Amendment to Sublease (this “First Amendment to Sublease”) is made as of the 1st day of September, 2011 (“Execution Date”), by and between ACCELERON PHARMA, INC., a Delaware corporation with an address of 128 Sidney Street, Cambridge MA 02139 (“Sublandlord”) and AVEO PHARMACEUTICALS, INC., a Delaware corporation with an address of 75 Sidney Street, Cambridge, MA 02139 (“Subtenant”).

W I T N E S S E T H

WHEREAS, Sublandlord and Subtenant are the current parties to that certain Sublease Agreement dated as of February 28, 2011 (the “Sublease”), pursuant to which Sublandlord is leasing to Subtenant the Sublease Premises (as defined in the Sublease) in the building known as 12 Emily Street, Cambridge (the “Building”).

WHEREAS, pursuant to Section 2(g) of the Sublease, Subtenant leases twenty-one (21) parking spaces from Sublandlord, eleven (11) of which parking spaces are located on the south side of the Building and ten (10) of which parking spaces are located in the 128 Sidney Street parking lot; and

WHEREAS, the parties desire to amend Section 2(g) of the Sublease;

NOW, THEREFORE, in consideration of the covenants herein reserved and contained, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Sublandlord and Subtenant hereby agree as follows:

Effective as of the Execution Date, Section 2(g) of the Sublease is deleted and the following is substituted in its place:

“Subtenant shall lease thirty-one (31) parking spaces from the Sublandlord at the then current market rates (currently, as of the date hereof, $190 per space per month but subject to adjustment in accordance with Section 1.4(b) of the Master Lease) and such parking fees shall be payable by Subtenant to Sublandlord on a monthly basis. Eleven (11) of the parking spaces shall be initially located on the south side of the Building and twenty (20) parking spaces shall be located in the 128 Sidney Street parking lot.”

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IN WITNESS WHEREOF, duly authorized representatives of the parties have duly executed this First Amendment to Sublease effective as of the Execution Date.

SUBLANDLORD:

ACCELERON PHARMA, INC.,

a Delaware corporation

Date Signed: September 16, 2011

SUBTENANT:

AVEO PHARMACEUTICALS, INC.,

a Delaware corporation

Date Signed:                     

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