Exhibit 99.1

MARKETAXESS REPORTS THIRD QUARTER 2011 RECORD REVENUES OF $46.6
MILLION, RECORD PRE-TAX INCOME OF $22.3 MILLION AND DILUTED EPS OF $0.34

Third Quarter Financial Highlights^*

•

Record revenues of $46.6 million, up 24.5%

•

Record pre-tax income of $22.3 million, up 64.9%

•

Record pre-tax margin of 47.9%, up from 36.1%

•

EBITDA of $24.1 million, up 59.6%

•

Net income of $13.4 million, up 56.1%

NEW YORK, October 26, 2011 — MarketAxess Holdings Inc. (Nasdaq: MKTX), the operator of a leading electronic trading platform for U.S. and European high-grade corporate bonds, emerging markets bonds and other types of fixed-income securities, today announced results for the third quarter ended September 30, 2011.

“We are very pleased to report another record quarter of revenues, pre-tax income and operating margin,” said Richard M. McVey, chairman and chief executive officer of MarketAxess. “This represents the 10th consecutive quarter of record results and has been driven by strong U.S. high grade market share gains and continued expense discipline.”

Third Quarter Results

Total revenues for the third quarter of 2011 increased 24.5% to a record $46.6 million, compared to $37.4 million for the third quarter of 2010. Pre-tax income was a record $22.3 million, compared to $13.5 million for the third quarter of 2010, an increase of 64.9%. Pre-tax margin was 47.9%, compared to 36.1% for the third quarter of 2010. Net income totaled $13.4 million, or $0.34 per share on a diluted basis, compared to $8.6 million, or $0.22 per share on a diluted basis, for the third quarter of 2010.

Commission revenue for the third quarter of 2011 totaled $39.8 million on total trading volume of $131.7 billion, compared to $31.2 million in commission revenue on total trading volume of $100.5 billion for the third quarter of 2010. U.S. high-grade trading volume as a percentage of FINRA’s high-grade TRACE trading volume increased to an estimated 11.6%, compared to an estimated 8.3% for the third quarter of 2010.

Technology products and services revenue, which includes revenue for technology licenses, support and professional services, increased 9.4% to $3.8 million for the third quarter of 2011, compared to $3.5 million for the third quarter of 2010. Other revenue, which consists of information and user access fees, investment income and other revenue, increased 5.6% to $3.0 million, compared to $2.8 million for the third quarter of 2010.

Total expenses for the third quarter of 2011 increased 1.6% to $24.3 million, compared to $23.9 million for the third quarter of 2010. The increase in expenses during the third quarter of 2011 was primarily due to higher marketing and advertising expense of $0.6 million. During the third quarter of 2011, the Company’s Compensation Committee modified the cash incentive bonus accrual methodology to reflect lower than expected staffing levels and higher than expected operating income. Without the adjustment, employee compensation costs for the quarter would have been approximately $1.9 million higher. For the first nine months of 2011, the total cash bonus provision is approximately 18% higher compared to the first nine months of 2010.

The effective tax rate for the third quarter of 2011 was 39.7%, compared to 36.3% for the third quarter of 2010.

Employee headcount as of September 30, 2011 was 233, compared to 223 as of September 30, 2010.

Dividend

The Company’s board of directors declared a quarterly cash dividend of $0.09 per share of common stock outstanding or issuable upon conversion of outstanding shares of non-voting common stock, to be paid on November 24, 2011 to stockholders of record as of the close of business on November 10, 2011.

Share Repurchase Program

The Company’s board of directors approved a $35.0 million share repurchase program, which authorizes the Company to repurchase shares of its common stock in the open market or in privately negotiated transactions, at times and prices considered appropriate by the Company.

Balance Sheet Data

As of September 30, 2011, total assets were $339.2 million and included $237.8 million in cash, cash equivalents and securities. Total stockholders’ equity as of September 30, 2011 was $305.8 million.

Guidance for 2011

The Company previously expected that its full year 2011 expenses would be at the high end of the guidance range of $101.0 million to $107.0 million. Due principally to the modification in the incentive bonus accrual methodology and lower than expected staffing levels, the Company now expects full year 2011 expenses to be at the lower end of this range.

The Company now expects its full year 2011 capital spending to be in the range of $7.0 million to $8.0 million.

Non-GAAP Financial Measure

EBITDA is a non-GAAP financial measure. The Company believes that this non-GAAP financial measure, when taken into consideration with the corresponding GAAP financial measure, is important in understanding the Company’s operating results. See the attached schedule for a full reconciliation of GAAP net income to EBITDA.

Webcast and Conference Call Information

Richard M. McVey, Chairman and Chief Executive Officer, and Antonio L. DeLise, Chief Financial Officer, will host a conference call to discuss the Company’s financial results and outlook on October 26, 2011, at 10:00 a.m. Eastern time. To access the conference call, please dial 866-804-6925 (U.S.) or 857-350-1671 (international). The passcode for all callers is 34061897. The Company will also host a live audio Webcast of the conference call on the Investor Relations section of the Company’s website at http://www.marketaxess.com. A replay of the call will be made available by dialing 888-286-8010 (U.S.) or 617-801-6888 (international) for one week after the announcement. The passcode for replay callers is 12683250. The Webcast will also be archived on http://www.marketaxess.com for 90 days following the announcement.

About MarketAxess

MarketAxess operates a leading electronic trading platform that enables investment industry professionals to efficiently trade corporate bonds and other types of fixed-income instruments. MarketAxess’ patented trading technology allows institutional investor clients to request competitive, executable bids or offers from multiple broker-dealers simultaneously, and to execute trades with the broker-dealer of their choice. Over 850 institutional investors are active users of the MarketAxess trading platform, accessing the global liquidity provided by MarketAxess’ 80 broker-dealer clients in U.S. high-grade corporate bonds, European bonds, high yield and emerging markets bonds, agency bonds, asset-backed and preferred securities and credit default swaps. MarketAxess also offers a number of trading-related products and services, including: market data to assist clients with trading decisions; connectivity solutions that facilitate straight-through processing; technology services to optimize trading environments; and execution services for exchange-traded fund managers and other clients.

MarketAxess maintains its headquarters in New York and has offices in London, Chicago and Salt Lake City. For more information, please visit www.marketaxess.com.

Cautionary Note Regarding Forward-Looking Statements

This press release may contain forward-looking statements, including statements about the outlook and prospects for Company and industry growth, as well as statements about the Company’s future financial and operating performance. These and other statements that relate to future results and events are based on MarketAxess’ current expectations. Actual results in future periods may differ materially from the those currently expected or desired because of a number of risks and uncertainties, including: the level and intensity of competition in the fixed-income electronic trading industry and the pricing pressures that may result; the variability of our growth rate; the rapidly evolving nature of the electronic financial services industry; the level of trading volume transacted on the MarketAxess platform; the absolute level and direction of interest rates and the corresponding volatility in the corporate fixed-income market; our ability to develop new products and offerings and the market’s acceptance of those products; our exposure to risks resulting from non-performance by counterparties to transactions executed between our clients in which we act as an intermediary in matching back-to-back trades; our dependence on our broker-dealer clients; our ability to enter into strategic alliances and to acquire other businesses and successfully integrate them with our business; our future capital needs and our ability to obtain capital when needed; and other factors. The Company’s actual results and financial condition may differ, perhaps materially, from the anticipated results and financial condition in any such forward-looking statements. The Company undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. More information about these and other factors affecting MarketAxess’ business and prospects is contained in MarketAxess’ periodic filings with the Securities and Exchange Commission and can be accessed at www.marketaxess.com.

# # #

Media and Investor Relations Contacts:

Tony DeLise		William McBride
MarketAxess Holdings Inc.		William McBride & Associates
+1-212-813-6017		+1-917-239-6726
Florencia Panizza
MarketAxess Holdings Inc.
+1-212-813-6029

MarketAxess Holdings Inc.
Consolidated Statements of Operations

		Three Months Ended								Nine Months Ended
		September 30,								September 30,
		2011				2010				2011				2010
		($ in thousands, except per share data)
		(unaudited)
Revenues
Commissions
U.S. high-grade		$	28,017			$	21,537			$	81,225			$	61,562
Eurobond			4,443				4,075				13,666				14,236
Other			7,362				5,540				21,792				14,121
Total commissions			39,822				31,152				116,683				89,919
Technology products and services			3,779				3,455				10,871				9,870
Information and user access fees			1,831				1,603				5,239				4,959
Investment income			303				301				912				907
Other			829				902				2,259				1,968
Total revenues			46,564				37,413				135,964				107,623
Expenses
Employee compensation and benefits			13,707				14,326				45,079				42,448
Depreciation and amortization			1,799				1,560				4,988				4,798
Technology and communications			2,772				2,543				7,996				7,313
Professional and consulting fees			2,247				2,241				7,784				6,369
Occupancy			721				706				2,195				2,351
Marketing and advertising			1,280				679				3,502				2,066
General and administrative			1,742				1,834				4,553				5,813
Total expenses			24,268				23,889				76,097				71,158
Income before taxes			22,296				13,524				59,867				36,465
Provision for income taxes			8,852				4,913				23,706				13,984
Net income		$	13,444			$	8,611			$	36,161			$	22,481
Per Share Data:
Earnings per share:
Basic		$	0.36			$	0.24			$	0.98			$	0.61
Diluted		$	0.34			$	0.22			$	0.91			$	0.57
Cash dividends declared per common share		$	0.09			$	0.07			$	0.27			$	0.21
Weighted-average common shares:
Basic			37,126				32,945				36,798				33,434
Diluted			39,828				38,743				39,539				39,187

MarketAxess Holdings Inc.
Consolidated Condensed Balance Sheet Data

		September 30, 2011				December 31, 2010
		($ in thousands)
		(unaudited)
Assets
Cash and cash equivalents		$	157,622			$	124,994
Securities available-for-sale			80,200				72,552
Deferred tax assets, net			9,589				19,813
All other assets			91,789				82,162
Total assets		$	339,200			$	299,521
Liabilities and Stockholders’ Equity
Total liabilities		$	33,367			$	34,730
Series B Preferred Stock			—				30,315
Total stockholders’ equity			305,833				234,476
Total liabilities and stockholders’ equity		$	339,200			$	299,521

MarketAxess Holdings Inc.
Reconciliation of Non-GAAP Financial Measures

		Three Months Ended								Nine Months Ended
		September 30,								September 30,
		2011				2010				2011				2010
		($ in thousands)
		(unaudited)
Net income		$	13,444			$	8,611			$	36,161			$	22,481
Add back:
Interest expense			14				19				46				60
Provision for income taxes			8,852				4,913				23,706				13,984
Depreciation and amortization			1,799				1,560				4,988				4,798
Earnings before interest, taxes, depreciation and amortization (EBITDA)		$	24,109			$	15,103			$	64,901			$	41,323

MarketAxess Holdings Inc.
Volume Statistics

		Total Trading Volume
		Three Months Ended								Nine Months Ended
		September 30,								September 30,
		2011				2010				2011				2010
		($ in millions)
		(unaudited)
U.S. high-grade — multi dealer 1
fixed-rate		$	79,233			$	59,222			$	238,577			$	173,716
floating-rate			2,761				1,165				9,524				6,352
Eurobond			7,580				10,712				28,891				39,470
Other1			42,092				29,351				122,814				78,395
Total		$	131,666			$	100,450			$	399,806			$	297,933

		Average Daily Volume
		Three Months Ended								Nine Months Ended
		September 30,								September 30,
		2011				2010				2011				2010
		($ in millions)
		(unaudited)
U.S. high-grade1		$	1,281			$	944			$	1,313			$	958
Eurobond			117				165				154				209
Other1			658				459				650				417
Total		$	2,056			$	1,568			$	2,116			$	1,584
Number of U.S. Trading Days 2			64				64				189				188
Number of U.K. Trading Days 3			65				65				188				189