Attached files
Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the use in this Registration Statement on Form S-1 of Emisphere Technologies, Inc. of
our reports dated March 31, 2011, relating to our audits of the financial statements, as of
December 31, 2010 and 2009 and for the years then ended and of internal control over financial
reporting as of December 31, 2010, appearing in the Prospectus, which is part of this Registration
Statement. Our report dated March 31, 2011, relating to the financial statements includes an
emphasis paragraph relating to an uncertainty as to the Company’s ability to continue as a going
concern.
Our report dated March 31, 2011, on the effectiveness of internal control over financial reporting
as of December 31, 2010, expressed an opinion that Emisphere Technologies, Inc. had not maintained
effective internal control over financial reporting as of December 31, 2010, based on criteria
established in Internal Control — Integrated Framework issued by the Committee of Sponsoring
Organizations of the Treadway Commission.
We also consent to the reference to our firm under the caption “Experts” in such Prospectus.
/s/
McGladrey & Pullen, LLP
New York, New York
July 26, 2011
New York, New York
July 26, 2011