PDL BIOPHARMA, INC. - FORM 8-K - EX-99.1 - EXHIBIT 99.1

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8-K - PDL BIOPHARMA, INC 8-K 5-11-2011 - PDL BIOPHARMA, INC.	form8k.htm

Exhibit 99.1

Bank of America Merrill Lynch 2011 Health
Care Conference

May 11, 2011

Forward Looking Statements

This presentation contains forward-looking statements, including PDL’s expectations with respect to its future royalty
revenues, expenses, net income, and cash provided by operating activities.

Each of these forward-looking statements involves risks and uncertainties. Actual results may differ materially from those,
express or implied, in these forward-looking statements. Factors that may cause differences between current expectations
and actual results include, but are not limited to, the following:

▪ The expected rate of growth in royalty-bearing product sales by PDL’s existing licensees;

• The relative mix of royalty-bearing Genentech products manufactured and sold outside the U.S. versus manufactured
or sold in the U.S.;

• The ability of PDL’s licensees to receive regulatory approvals to market and launch new royalty-bearing products and
whether such products, if launched, will be commercially successful;

• Changes in any of the other assumptions on which PDL’s projected royalty revenues are based;

• Changes in foreign currency rates;

• Positive or negative results in PDL’s attempt to acquire royalty-related assets;

• The outcome of pending litigation or disputes, including PDL’s current dispute with Genentech related to ex-U.S. sales
of Genentech licensed products; and

• The failure of licensees to comply with existing license agreements, including any failure to pay royalties due.

Other factors that may cause PDL’s actual results to differ materially from those expressed or implied in the forward-
looking statements in this presentation are discussed in PDL’s filings with the SEC, including the "Risk Factors" sections
of its annual and quarterly reports filed with the SEC. Copies of PDL’s filings with the SEC may be obtained at the
"Investors" section of PDL’s website at www.pdl.com. PDL expressly disclaims any obligation or undertaking to release
publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in PDL’s
expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are
based for any reason, except as required by law, even as new information becomes available or other events occur in the
future. All forward-looking statements in this presentation are qualified in their entirety by this cautionary statement.

Overview of PDL BioPharma

Company Overview

• PDL pioneered the humanization of monoclonal antibodies
which enabled the discovery of a new generation of
targeted treatments for cancer and immunologic diseases

• PDL’s primary assets are its antibody humanization patents
and royalty assets which consist of its Queen et al. patents
and license agreements

• Licensees consist of large biotechnology and
pharmaceutical companies including Roche/Genentech/
Novartis, Elan/BiogenIdec, Pfizer/Wyeth/J&J and Chugai

Antibody Humanization Technology

• Antibodies are naturally produced by humans to
fight foreign substances, such as bacteria and
viruses

• In the 1980’s, scientists began creating antibodies in
non-human immune systems, such as those of
mice, that could target specific sites on cells to fight
various human diseases

• However, mouse derived antibodies are recognized
by the human body as foreign substances and may
be rejected by the human immune system

• PDL’s technology allows for the “humanization” of mouse derived antibodies by moving
the important binding regions from the mouse antibody onto a human framework

• PDL’s humanization technology is important because the humanized antibodies retain the
binding and activity levels from the original mouse antibody

• PDL’s technology has been incorporated into antibodies to treat cancer, eye diseases,
arthritis, multiple sclerosis and other health conditions with aggregate annual sales of over
$17 billion

Mission Statement

• Queen et al. Patents

▪ Manage patent portfolio

▪ Manage license agreements

• Purchase new royalty generating assets

▪ Assets that improve shareholder return

▪ Commercial stage assets

▪ Prefer biologics with strong patent protection

• Optimize return for shareholders

Corporate Governance

Management

• John McLaughlin
President & CEO

• Christine Larson
VP & CFO

• Christopher Stone
VP, General Counsel &
Secretary

• Caroline Krumel
VP of Finance

• Danny Hart
Associate General Counsel

Board of Directors

• Fred Frank
Lead Director

• Jody Lindell

• John McLaughlin

• Paul Sandman

• Harold Selick

Licensed Products and Royalty Revenue

1. As reported to PDL by its licensee 2. As reported by Roche; assume 1.155 CHF/USD

How Long will PDL Receive Royalties from
Queen et al. Patents?

• PDL’s revenues consist of royalties generated on sales of licensed products

▪ Sold before the expiration of the Queen et al. patents in mid-2013 through end of 2014

▪ Made prior to the expiration of the Queen et al. patents and sold anytime thereafter

Example of Antibody Formulation, Fill and Finish Schedule

½ month

1 month

½ month

2-3 months

Thaw, Formulation
& Vial Filling

Quality
Release

Packaging
& Quality

Inventory

Example of Antibody Bulk Manufacturing Schedule

Cell

Culture

Quality Release
Testing

Bulk Frozen Storage

1 mo

3 mos

5 mos

10 mos

15 mos

20 mos

27 mos

3 mos

2-18 months

1mo

Purification to Concentrated Bulk/Frozen

Genentech Product Made or Sold in U.S.
Net Sales up to $1.5 Billion	3.0%
Net Sales Between $1.5 Billion and $2.5 Billion	2.5%
Net Sales Between $2.5 Billion and $4.0 Billion	2.0%
Net Sales Over $4.0 Billion	1.0%
Genentech Product Made and Sold Ex-U.S.
All Sales	3.0%

Queen et al Patents - Royalty Rates

• Tysabri and Actemra

§ Flat, low single-digit royalty

• Genentech Products (Avastin, Herceptin, Lucentis1 and Xolair)

§ Tiered royalties on product made or sold in US

§ Flat, 3% royalty on product made and sold outside US

§ Blended global royalty rate on Genentech Products in 2010 was 1.9%

§ Blended royalty rate on Genentech Products in 2010 made or sold in US
was 1.5%

1. As part of a settlement with Novartis, which commercializes Lucentis outside US, PDL agreed to pay to Novartis certain
amounts based on net sales of Lucentis made by Novartis during calendar year 2011 and beyond. The amounts to be paid are
less than we receive in royalties on such sales and we do not currently expect such amount to materially impact our total
annual revenues.

Shift of Manufacturing Sites = Higher Royalties

• Roche is moving some manufacturing ex-US which may result in higher royalties
to PDL due to the flat 3% royalty for Genentech Products made and sold ex-US

▪ Current production at Penzburg (Herceptin) and Basel (Avastin) plants

▪ Two new plants in Singapore (CHO = antibody and e. coli = antibody fragment)

- E. coli (Lucentis) and CHO (Avastin) plants are approved for commercial supply to the US

- E. coli and CHO plants are expected to be approved for commercial supply to the EU in 2011

- Currently, all Lucentis is made in the US

Percent of Total Worldwide Sales1

1. As reported to PDL by its licensee

Royalty Revenue & Licensed Products

Royalties by Product

($ in millions)

Royalty Products - Approved

Royalty Products - Avastin

Licensee	Product	Status	Indications
Roche (Genentech)	Avastin	Approved sBLA Phase 3	Colorectal Cancer NSCLC Metastatic Renal Cell Glioblastoma Metastatic Breast HER2- 1st Line Metastatic Breast HER2- 2nd Line Ovarian Cancer Gastric

ü On December 16, 2010, FDA notified Roche/Genentech of its intention to withdraw
Avastin’s approval as first line treatment for HER2- breast cancer in combination with
paclitaxel.

ü In response to request from Genentech, FDA scheduled a hearing on June 28-29, 2011 to
allow Genentech to present why Avastin should remain FDA-approved for HER2- breast
cancer.

ü On December 16, 2010, EMEA narrowed, but did not withdraw Avastin’s approval for first
line treatment of HER2- breast cancer in combination with paclitaxel.

ü Roche lowered its estimate of peak annual sales from of Avastin from CHF8 - CHF9 billion
to CHF7 billion.

ü On April 15, 2011, Roche announced that CHMP issued a positive opinion for the use of
Avastin in combination with Xeloda for 1st-line HER 2- breast cancer.

ü Based on our internal model, we project Avastin for treatment of metastatic HER2- breast
cancer represents slightly more than 2% of total PDL royalty revenue.

Royalty Products - Avastin

Licensee	Product	Status	Indications
Roche (Genentech)	Avastin	Approved sBLA Phase 3	Colorectal Cancer NSCLC Metastatic Renal Cell Glioblastoma Metastatic Breast HER2- 1st Line Metastatic Breast HER2- 2nd Line Ovarian Cancer Gastric

ü On February 7, 2011, Genentech reported that Phase 3 trial in women with previously
treated (recurrent), platinum-sensitive ovarian cancer showed an improvement in
progression free survival in those patients treated with Avastin in combination with
chemotherapy (carboplatin and gemcitabine) followed by continued use of Avastin alone
compared to those treated with chemotherapy alone.

ü Two previous Phase 3 studies in women with newly diagnosed ovarian cancer
demonstrated that front-line Avastin in combination with standard chemotherapy
(carboplatin and paclitaxel), followed by the continued use of Avastin alone, significantly
increased progression free survival compared to treatment with chemotherapy alone.

ü Roche has submitted an application for approval for first line treatment in EU and expects
a decision later in 2011.

ü Genentech expects to file an application for approval in US in 2011.

Royalty Products - Avastin


		Phase 2 ISP	Adjuvant settings Retinopathy of Prematurity
	Herceptin	Approved	Breast HER2+ Cancer HER2+ Stomach and Gastro-Esophageal cancers
	Lucentis	Approved Approved Phase 3	AMD RVO DME
	Xolair	Approved sBLA	Moderate-Severe Asthma Pediatric Asthma
Elan	Tysabri	Approved	Multiple Sclerosis
Roche (Chugai)	Actemra	Approved	Rheumatoid Arthritis

ü On February 16, Research to Prevent Blindness Foundation and the U.S. National Eye
Institute announced results from a trial showing that just 4% of the infants who developed
retinopathy of prematurity and were treated with Avastin suffered a recurrence of the
disease compared to 22% of those babies with the disease who received laser treatment.

ü Retinopathy of prematurity is a disease that harms the retina and is the most common
cause of blindness in infants.

ü Because the trial was not sponsored by Genentech/Roche, it is not clear whether they will
seek approval for this indication.

ü The publication of this data in the February 17 issue of the New England Journal of
Medicine should result in significant off-label use in this disease.

Royalty Products - Lucentis




	Lucentis	Approved Approved Phase 3 (US)	AMD RVO DME
	Xolair	Approved sBLA	Moderate-Severe Asthma Pediatric Asthma
Elan	Tysabri	Approved	Multiple Sclerosis
Roche (Chugai)	Actemra	Approved	Rheumatoid Arthritis

ü On January 7, Novartis announced that Lucentis has been approved in the EU for the
treatment of visual impairment due to diabetic macular edema (DME).

§ DME is a leading cause of blindness in the working-age population in most
developed countries.

ü On February 11, 2011, Genentech announced that one of two Phase 3 studies evaluating
in patients with DME showed that a significantly higher percentage of patients receiving
monthly dosing of Lucentis achieved an improvement in vision of at least 15 letters on the
eye chart at 24 months compared to those in a control group, who received a placebo
injection.




	Lucentis	Approved Approved Phase 3	AMD RVO DME
	Xolair	Approved sBLA	Moderate-Severe Asthma Pediatric Asthma
Elan	Tysabri	Approved	Multiple Sclerosis
Roche (Chugai)	Actemra	Approved	Rheumatoid Arthritis

ü On November 22, 2010, Regeneron and its partner, Bayer, reported top line data from two
Phase 3 trials investigating its VEGF Trap in age-related macular degeneration (AMD)
patients which suggest that it may be injected into the eye every other month with safety
and efficacy comparable to that of monthly dosing of Lucentis.

ü On December 20, 2010, Regeneron has also reported positive Phase 3 data in the
treatment of retinal vein occlusion (RVO) for which Lucentis is approved.

§ Unlike the AMD trial, monthly administration was used in the RVO trial, which does
not afford a dosing advantage with respect to Lucentis.

ü On February 22, 2011, Regeneron and its partner, Bayer, filed an application for approval
of its VEGF Trap for treatment of AMD with a PDUFA date of August 20, 2011 based on
priority review.

ü Regeneron filed suit in February 2011 seeking a summary judgment that it does not
infringe Genentech’s patents.

ü Genentech filed a countersuit in April 2011 asserting that Regeneron is willfully infringing
Genentech’s patents, seeking treble damages and asking for injunctive relief.

Royalty Products - Lucentis

Licensee	Product	Status	Indications

			HER2+ Stomach and Gastro-Esophageal cancers
	Lucentis	Approved Approved Phase 3	AMD RVO DME
	Xolair	Approved sBLA	Moderate-Severe Asthma Pediatric Asthma
Elan	Tysabri	Approved	Multiple Sclerosis
Roche (Chugai)	Actemra	Approved	Rheumatoid Arthritis

ü On April 4, 2011, Genentech and Johns Hopkins University reported results of a review of
files of 77,886 patients with AMD who received either Avastin off-label or Lucentis.

ü Patients receiving Avastin off-label had an 11% increased risk of overall mortality, 57%
increased risk of hemorrhagic cerebrovascular accident, 80% more likely to have ocular
inflammation and 11% more likely to have cataract surgery following treatment than
Lucentis treated patients.

ü Authors of the study note that it is limited due to incomplete information on confounding
factors such as smoking, lipid and blood pressure levels, etc.

Royalty Products - Lucentis



			HER2+ Stomach and Gastro-Esophageal cancers
	Lucentis	Approved Approved Phase 3	AMD RVO DME
	Xolair	Approved sBLA	Moderate-Severe Asthma Pediatric Asthma
Elan	Tysabri	Approved	Multiple Sclerosis
Roche (Chugai)	Actemra	Approved	Rheumatoid Arthritis

ü On April 28, 2011, New England Journal of Medicine reported the results from the NEI’s
CATT study comparing Lucentis and Avastin on fixed and variable schedules in the
treatment of AMD.

ü Efficacy results from the first year of the two year study showed that, with respect to the
primary endpoint of mean change in visual acuity (number of lines of letters on an eye
chart) at 12 months, less expensive Avastin was not inferior to Lucentis.

§ It is estimated that off label use of Avastin in the U.S. was 60% prior to the results of
the CATT trial.

ü At 12 months, serious adverse events (primarily hospitalizations) occurred at a 24 percent
rate for patients receiving Avastin and a 19 percent rate for patients receiving Lucentis.
However, preliminary 24 month safety data showed no difference between Lucentis and
Avastin treated patients in terms of death, stroke and all arteriothrombotic events.

Royalty Products - Tysabri

Licensee	Product	Status	Indications



	Xolair	Approved sBLA	Moderate-Severe Asthma Pediatric Asthma
Elan	Tysabri	Approved	Multiple Sclerosis
Roche (Chugai)	Actemra	Approved	Rheumatoid Arthritis

ü Biogen Idec and Elan made regulatory filings with FDA and EMA to update the label of
Tysabri to reflect that anti-JC virus antibody status could be used to stratify the risk of
progressive multifocal leukoencephalopathy (PML).

§ On April 18, 2011, CHMP recommended inclusion of JC virus (JCV) status as a risk
factor the product label for Tysabri in the EU.

§ The CHMP also recommended a five-year renewal of the Tysabri’s Marketing
Authorization in the EU.

ü On April 22, 2011, FDA disclosed the estimated risk of PML infection in Tysabri treated
patients is 0.3 per 1,000 patients during the first two years of treatment, 1.5 per 1,000
patients during months 25 to 36, and 0.9 per 1,000 after three years. Limited data is
available beyond four years.

Licensee	Product	Status	Indications
Roche (Genentech)	Avastin	Approved	Colorectal Cancer NSCLC

		Phase 3	DME
	Xolair	Approved sBLA	Moderate-Severe Asthma Pediatric Asthma
Elan	Tysabri	Approved	Multiple Sclerosis
Roche (Chugai)	Actemra	Approved	Rheumatoid Arthritis

Royalty Products - Actemra

ü On January 5, 2011, Roche announced that FDA expanded the Actemra label to include
inhibition and slowing of structural joint damage, improvement of physical function, and
achievement of major clinical response in adult patients with moderately to severely active
rheumatoid arthritis.

ü On April 18, 2011, FDA approved Actemra to treat patients age 2 and older with active
systemic juvenile idiopathic arthritis (SJIA).

§ It is the first and only approved treatment for SJIA, a rare and severe form of arthritis
affecting children.

Future Royalty Products - Development Stage

Licensee	Product	Status	Indications
Roche (Genentech)	T-DM1	Phase 2 & 3	Breast HER2+ Cancer
	Ocrelizumab	Phase 2b	Relapsing Remitting Multiple Sclerosis
	Pertuzumab	Phase 3	Metastatic HER2+ Breast Cancer
Roche	Afutuzumab	Phase 3	Chronic Lymphocytic Leukemia
Elan/J&J/Pfizer	Bapineuzumab	Phase 3	Alzheimer’s Disease
Lilly	Solanezumab	Phase 3	Alzheimer’s Disease
Merck	Datoluzumab	Phase 2	Metastatic Colorectal Cancer
Abbott/Biogen Idec	Daclizumab	Phase 3	Relapsing Remitting Multiple Sclerosis

Future Royalty Products - T-DM1

ü On October 13, 2010, Roche/Genentech announced preliminary, six month results from a
Phase 3 trial in second line HER2+ breast cancer patients which showed that 48% of
women treated with T-DM1 had their tumors shrink compared with 41% of those taking
the combination of Herceptin and Taxotere.

§ Among the women taking the standard therapy, 75% had side effects of grade 3 or
higher on a 5-point scale, compared with 37% of those getting T-DM1.

Future Royalty Products - Pertuzumab

Licensee	Product	Status	Indications
Roche (Genentech)	T-DM1	Phase 2 & 3	Breast HER2+ Cancer
	Ocrelizumab	Phase 2b	Relapsing Remitting Multiple Sclerosis
	Pertuzumab	Phase 3	Metastatic HER2+ Breast Cancer
Roche	Afutuzumab	Phase 3	Chronic Lymphocytic Leukemia
Elan/J&J/Pfizer	Bapineuzumab	Phase 3	Alzheimer’s Disease
Lilly	Solanezumab	Phase 3	Alzheimer’s Disease
Merck	Datoluzumab	Phase 2	Metastatic Colorectal Cancer
Abbott/Biogen Idec	Daclizumab	Phase 3	Relapsing Remitting Multiple Sclerosis
Eisai	Farletuzumab	Phase 3	Ovarian Cancer

ü On December 10, 2010, Roche/Genentech reported the results from a Phase 2 trial
investigating the neoadjuvant (prior to surgery) use of pertuzumab and Herceptin plus
chemotherapy for the treatment of early-stage, HER2+ breast cancer.

ü Treatment significantly improved the rate of complete tumor disappearance in the breast
by more than half compared to Herceptin plus docetaxel, p=0.014.

ü Roche expects a global regulatory filing of pertuzumab at the end of 2011.

Genentech / Roche - Product Pipeline

2011

2012

2013

Post 2013

Avastin

Lucentis

Diabetic Macular Edema (US)

Pertuzumab1

mBC HER2+ 1st Line

Avastin + Herceptin

mBC HER+ 2nd Line

Avastin

Relapsed Ovarian Cancer

Actemra

RA DMARD H2H (EU)

Actemra

Ankylosing Spondylitis

Herceptin

Subcutaneous Formulation

Avastin & Herceptin

HER2+ mBC 1st Line

Avastin

mCRC TML

Actemra

SC Formulation (EU)

Afutuzumab (GA101)

Chronic Lymphocytic Leukemia

Avastin

BC Adjuvant HER2+

Avastin

BC Adj Triple Negative

Herceptin

BC HER 2+ Adj 2 Year

Avastin

Glioblastoma 1st Line

Avastin

HER 2- BC adj

Avastin

NSCLC adj

1. Not a licensed product; source Roche investor update, April 14, 2011

US & EU Filings Calendar

Financial Update

Financial Overview

1. Includes $92.5 million one time legal settlement to MedImmune. Net interest expense
includes $17.6 million loss on convertible note retirement.

2. Includes $10.0 million one time legal settlement from UCB.

New 2015 Convertible Notes

• Terms

▪ $135 million convertible, non-callable senior notes due May 2015

- Option for the bankers to purchase an additional ~$20 million within 13 days after
first issuance of the Notes

▪ Coupon rate is 3.75%

▪ Conversion price is $7.92/share

▪ 50% hedge effectively increases conversion price to $9.31½ /share

• Timing

▪ Transaction was priced on Tuesday, May 10th

▪ Transaction expected to close on Monday, May 16th

• Use of Proceeds

▪ Repurchase or redeem from time to time PDL’s convertible notes
due in February 2012 with a current principle balance of $133 million

▪ Pay cost of convertible note hedge transactions

▪ General corporate purposes

$497 Million Debt

• $250 million 2.00% convertible senior notes due February 2012; current
principal amount $133 million

▪ Conversion rate is 144.474 shares / $1,000 face amount ($6.92/share)

• $180 million 2.875% convertible senior notes due February 2015 placed
November 1, 2010

▪ Conversion rate is 144.474 shares / $1,000 face amount ($6.92/share)

• $300 million 10.25% secured non-recourse notes; current principal amount
$184 million

▪ Distributed $200 million of proceeds as special dividend of $1.67/share in December
2009

▪ Approximately 40% of Genentech royalties dedicated to quarterly principal and interest
payments; principal repayment fluctuates in relation to royalties received

▪ Anticipated final maturity is September 2012; legal maturity is March 2015

▪ After final maturity, securitized Genentech royalties will be retained by PDL

• In order to pay a dividend, PDL must first satisfy a net assets test at the
time of dividend declaration by Board of Directors

Legal Matters

Recent Resolution of Legal Disputes

• PDL has resolved all challenges to the Queen et al. Patents in the
U.S. Patent and Trademark Office (USPTO) and the European
Patent Office (EPO) as well as its dispute with MedImmune

▪ UCB Pharma

- PDL received $10 million from UCB and PDL agreed not to sue UCB for any royalties
related to Cimzia

- UCB terminated patent interference proceedings before the USPTO and withdrew its
opposition appeal in the EPO

▪ MedImmune

- PDL paid MedImmune $65 million on February 15, 2011 and will pay them an additional
$27.5 million by February 2012

- MedImmune ceased support of any party in the EPO opposition appeal

▪ Novartis

- PDL dismissed its claims against Novartis in its Nevada lawsuit

- Novartis withdrew its opposition appeal to PDL’s European patent in EPO

- PDL will pay Novartis an amount based on Novartis’ net ex-U.S. sales of Lucentis during
calendar year 2011 and beyond

▪ BioTransplant

- PDL acquired BioTransplant, a bankrupt company and instructed BioTransplant to
withdraw its opposition appeal in the EPO

Pending Dispute with Genentech and Roche

• In August 2010, Genentech sent a fax on behalf of Roche and Novartis
asserting its products do not infringe PDL’s supplementary protection
certificates (SPCs)

▪ Products include Avastin, Herceptin, Lucentis and Xolair

▪ SPCs are extensions of patent term in Europe that are issued on a country-by-country
and product-by-product basis

• PDL Response

▪ Genentech’s assertions are without merit

▪ PDL disagrees with Genentech’s assertions of non-infringement

▪ Genentech had waived its rights to challenge our patents, including SPCs in its 2003
Settlement Agreement with PDL

• 2003 Settlement Agreement

▪ Resolved intellectual property disputes between the two companies at that time

▪ Limits Genentech’s ability to challenge infringement of PDL’s patent rights, including
SPCs, and waives Genentech’s right to challenge or assist other in challenging the
validity of our patent rights

Nevada Lawsuit Against Genentech/Roche

• PDL filed a lawsuit against Genentech and Roche in Nevada
state court

▪ Lawsuit states that fax constitutes a breach of 2003 Settlement
Agreement because Genentech assisted Roche in challenging PDL’s
patents and SPCs

▪ Complaint seeks compensatory damages, including liquidated damages
and other monetary remedies set forth in the 2003 Settlement
Agreement, punitive damages and attorney’s fees

• In November 2010, Genentech and Roche filed two motions
to dismiss

▪ They contend that 2003 Settlement Agreement applies only to PDL’s
U.S. patent rights

▪ They asserted that the Nevada court lacks personal jurisdiction over
Roche

▪ On April 21, 2011, Nevada court heard arguments on two Genentech
and Roche motions

▪ If case proceeds, trial is not yet scheduled and not expected until 2012

Optimizing Stockholder Return

Business Strategy

• Purchase new royalty assets and
ladder like a bond portfolio

▪ Continue to reinvest in new royalty
assets and pay dividends

▪ Debt repaid by end of 2015

▪ Company continues as long as it
can generate satisfactory return

• If unable to acquire royalty assets
on attractive terms, build cash
reserves to

▪ Repay debt

▪ Use all excess cash to pay
dividends to enhance shareholder
return

▪ Wind-up company in 2016
timeframe

• Queen et al. patents expire end of 2014;
royalties will likely continue to ~ 2016

• There are two possible pathways
forward for PDL

Optimizing Stockholder Return

• Continuously evaluating alternatives

▪ Dividends

▪ Capital restructure

▪ Share repurchase

▪ Company sale

▪ Purchase of commercial stage, royalty
generating assets

Investment Highlights

• Strong historic revenue growth from approved products

• Potential for additional indications from existing
products, new product approvals and purchase of new
royalty assets

• Potential to grow and diversify revenues with the
addition of new royalty assets

• Significantly reduced expenses with no R&D burn

• Liquidity - volume averages 3 million shares/day

• Return to stockholders

▪ In 2011, $0.60/share to be paid in quarterly regular dividends of
$0.15/share in March 15, June 15, September 15 and
December 15

Appendix

Avastin

• Licensor

▪ Genentech (US) and Roche (ex-US)

• Mechanism

▪ As a tumor grows, it exceeds the ability of the local
blood supply to nourish it

▪ Tumor causes up regulation of vascular endothelial
growth factor (VEGF) stimulating angiogenesis or the
growth of leaky blood vessels to nourish the tumor

▪ Avastin targets and inhibits VEGF reduction in blood
vessels “starving” the tumor

• Approvals

▪ Metastatic colorectal cancer, advanced non-small cell
lung cancer, renal cancer, metastatic HER2- breast
cancer and glioblastoma

• Sales

▪ 2010 worldwide net sales of $6.4 billion1

- US is reviewing approval for metastatic HER2- breast cancer and EU
has narrowed this label, resulting in drop in sales for this indication

Treatment with Avastin
reduces vascularization
or blood supply of tumor

1. As reported to PDL by its licensee

Herceptin

• Licensor

▪ Genentech (US) and Roche (ex-US)

• Mechanism

▪ Some breast cancer cells make too many (over-express)
copies of a particular gene known as HER2 that causes
rapid growth of the breast cancer cell

▪ Herceptin works by attaching itself to the HER2
receptors on the surface of breast cancer cells, blocking
them from receiving growth signals and slowing or
stopping the growth of the breast cancer cell

▪ Herceptin also fights breast cancer by alerting the
immune system to destroy cancer cells onto which it is
attached

• Approvals

▪ Metastatic HER2+ breast cancer, metastatic HER2+
stomach cancer

• Sales

▪ 2010 worldwide net sales of $5.4 billion1

Without Herceptin treatment,
cell surface receptors signal
into the HER2+ breast cancer
cell to proliferate

Herceptin binds to cell surface
receptors inhibiting
intracellular signals thus
preventing cancer cell
proliferation and signaling the
immune system to “kill” the
cancer cell

1. As reported to PDL by its licensee

Lucentis

• Licensor

▪ Genentech (US) and Novartis (ex-US)

• Mechanism

▪ A form of VEGF known as VEGF-A causes the
formation of leaky blood vessels result in the
swelling in the macula and vision loss

▪ Lucentis binds to and inhibits VEGF-A before it
can cause the formation of the leaky blood vessels
preserving and sometimes improving vision

• Approvals

▪ Wet age-related macular degeneration (AMD),
macular edema or swelling following retinal vein
occlusion, diabetic macular edema

• Sales

▪ 2010 worldwide net sales of $3.0 billion1

- Recent NIH study comparing safety and effectiveness
of Lucentis finds less expensive Avastin equally
efficacious - will adversely affect future Lucentis sales
for AMD

- It’s estimated that in the U.S. 60% of AMD patients are
already treated with off-label Avastin

Cross
section of
normal
macula at
back of eye

Cross
section of
macula with
AMD causing
loss of vision

Amsler Grid as
seen through
normal eyes

Amsler Grid as
seen through
eyes with AMD

1. As reported to PDL by its licensee

Xolair

• Licensor

▪ Genentech (US) and Novartis (ex-US)

• Mechanism

▪ IgE plays a role in allergic disease by
causing the release of inflammatory
mediators from mast cells that result in
sneezing, wheezing and asthma

▪ Xolair binds to and neutralizes circulating
IgE by preventing IgE from binding to its
mast-cell receptor

• Approvals

▪ Moderate-to-severe persistent asthma

• Sales

▪ 2010 worldwide net sales of $1.0 billion1

Xolair antibody (yellow) binds to IgE
(blue) preventing IgE from binding to
mast cell. Otherwise, IgE binding to
mast cell would result in wheezing,
sneezing and asthma.

1. As reported to PDL by its licensee

Tysabri

▪ EU authorities have recommended renewal of
Tysabri’s approval for the typical five year
period

In MS, the body’s
autoimmune system is
inappropriately activated,
resulting in it attacking
the body. Here, defense
cells, known as T cells,
are activated.

Activated T cells are able
to cross the blood brain
barrier affording them
access to nerve cells.

Activated T cells attack,
and recruit other defense
cells known as
macrophages, to attack
and consume the myelin
sheath or insulation
surrounding nerve fibers.
The resulting holes in the
myelin slow the
transmission of impulses
along the nerve and
cause the symptoms of
MS.

1. As reported to PDL by its licensee

Actemra

• Licensor

▪ Roche and Chugai

• Mechanism

▪ Rheumatoid arthritis (RA) is an autoimmune disease in
which the body's immune system attacks itself

▪ One of the defense mechanisms inappropriately
activated in RA is IL-6, which can result in destruction of
the cartilage between joints causing the symptoms of
RA

▪ Actemra binds to and neutralizes IL-6 preventing it from
destroying cartilage thereby blocking one of the causes
of RA

• Approvals

▪ Treatment of signs and symptoms in moderate-to-
severe adult RA patients, slowing of structural damage
to joints caused by RA and preservation physical
function of joints afflicted by RA

• Sales

▪ 2010 worldwide net sales of $459 million1

It is the degradation and
eventual destruction of this
cartilage that causes the
symptoms of RA.

1. As reported by Roche; assume 1.155 CHF/USD

Attached files

PDL BIOPHARMA, INC. Reports

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