UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 8-K

Current Report

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

April 26, 2011

Date of Report (Date of earliest event reported)

CEPHEID

(Exact name of Registrant as specified in its charter)

(408) 541-4191

(Registrant’s telephone number, including area code)

Not Applicable

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligations of the registrant under any of the following provisions (see General Instruction A.2 below):

Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

(b) As previously reported on a current report on Form 8-K filed on February 14, 2011, Mitchell D. Mroz retired from, and did not stand for reelection to, Cepheid’s Board of Directors. Mr. Mroz’s term as a Class III director ended on April 26, 2011. There were no disagreements between Mr. Mroz and Cepheid.

(a) Cepheid held its Annual Meeting of Shareholders on April 26, 2011 (the “Annual Meeting”). Proxies for the Annual Meeting were solicited pursuant to Regulation 14A of the Securities Exchange Act of 1934, as amended.

(b) The matters described below were voted on at the Annual Meeting and the number of votes cast with respect to each matter was as indicated:

(1) Holders of Cepheid’s common stock voted to elect three directors, each to serve until his successor has been elected and qualified or until his earlier resignation or removal as follows:

(2) Holders of Cepheid’s common stock voted to ratify the appointment of Ernst & Young LLP as its independent registered public accounting firm for the fiscal year ending December 31, 2011:

(3) Holders of Cepheid’s common stock voted to approve the non-binding advisory resolution on compensation paid to Cepheid’s named executive officers, as disclosed pursuant to Item 402 of Regulation S-K, including compensation discussion and analysis, compensation tables and narrative discussion:

(4) Holders of Cepheid’s common stock voted to approve the non-binding advisory resolution that every year will be the preferred frequency with which Cepheid holds a non-binding advisory shareholder vote regarding the compensation of Cepheid’s named executive officers:

(d) Following the vote of holders of Cepheid’s common stock to approve the non-binding advisory resolution that every year is the preferred frequency with which Cepheid holds a non-binding advisory shareholder vote regarding its executive compensation, Cepheid will include a non-binding advisory shareholder vote on its executive compensation every year until the next vote on the frequency of shareholder votes on the compensation of executives.

On April 26, 2011, as a result of the retirement of Mitchell D. Mroz and the approval of Dr. Glenn D. Steele as a new director, Cepheid’s Board of Directors appointed the following individuals to serve on the Audit Committee, Compensation Committee and Nominating and Governance Committee, effective immediately, to serve until his or her successor is duly appointed, or such individual ceases to be a member of such committee or by death, resignation or removal:

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.