Exhibit 99.1

HANSEN MEDICAL REPORTS FOURTH QUARTER AND FULL YEAR 2010 RESULTS

Record Procedure Growth and Catheter Sales;

Development Milestones Continue Toward 2011 Vascular Robotic System Launch in U.S. and Europe

MOUNTAIN VIEW, CA. – February 23, 2011 – Hansen Medical, Inc. (Nasdaq: HNSN), a global leader in flexible medical robotics and the developer of robotic technology for accurate 3D control of catheter movement, today reported business highlights and financial results for the fourth quarter and full year ended December 31, 2010.

Fourth Quarter Summary and Recent Business Highlights

Full Year 2010 Summary

“2010 was a transformational year for Hansen Medical, as we delivered on the foundational elements that we believe are necessary to reach commercial excellence in the coming year and beyond,” said Bruce Barclay, president and chief executive officer of Hansen Medical. “In fulfillment of several commitments made early in my tenure, we launched new products, including our new Lynx irrigated ablation catheter, received unconditional approval for an IDE study for Atrial Fibrillation (AF), completed a first-in-man clinical study with our flexible catheter vascular system, expanded our relationship with key business partners that included deepening our relationship with Philips, expanded our intellectual property portfolio, and appointed talented industry executives to execute on our strategic initiatives. We are beginning 2011 with positive momentum and a strengthened balance sheet, excited about the approaching commercial launch of our flexible catheter vascular system which we expect will accelerate market adoption of flexible robotics and expand our customer base over the coming 12 months.”

2010 Fourth Quarter Financial Results

Total revenue for the fourth quarter ended December 31, 2010 was $3.5 million compared to revenue of $7.2 million in the same period in 2009. Procedures performed in the period with company products grew to a record 647 worldwide. During the fourth quarter, the company recognized revenue on two Sensei Robotic Systems as well as shipment of 666 catheters. The company shipped a total of three systems all of which will be recognized as revenue as they are installed and physicians are trained. As of December 31, 2010, the company had a total deferred revenue balance of $11.6 million that includes shipment of 16 Sensei systems that have not been recognized as revenue.

Cost of revenues for this year’s fourth quarter was $3.5 million and included non-cash stock compensation expense of $202,000. As a result, gross profit for the quarter was $(59,000) and gross margin was negative 1.7 percent. This compares to gross profit of $2.4 million and gross margin of 33.2 percent for the same period in 2009, which included non-cash stock compensation expense of $170,000.

Research and development expenses for the fourth quarter 2010, including non-cash stock compensation expense of $401,000, were $3.2 million, compared to $4.3 million for the same period in 2009, which included non-cash stock compensation expense of $503,000. The decrease in research and development expenses was primarily the result of an offset to the company’s research and development costs arising from the financial accounting for the company’s receipt of a product development milestone payment under the joint development agreement with Philips.

Selling, general and administrative expenses for the fourth quarter of 2010, including non-cash stock compensation expense of $807,000, were $7.6 million, compared to $9.4 million for the same period in 2009, which included non-cash stock compensation expense of $577,000. The decrease in selling, general and administrative expenses was primarily due to decreased employee-related expenses and a decrease in legal costs primarily associated with the Luna litigation in 2009.

Net loss for the fourth quarter 2010, including total non-cash stock compensation expense of $1.4 million, was $11.0 million, or $0.20 loss per share, based on average shares outstanding of 53.8 million shares. This compares favorably with a net loss for the fourth quarter of 2009, including non-cash stock compensation expense of $1.3 million, of $11.7 million, or $0.31 loss per share, based on average shares outstanding of 37.5 million shares.

Cash, cash equivalents and short-term investments as of December 31, 2010 were $28.0 million, compared to $28.3 million as of December 31, 2009. The flat cash balance is due primarily to the net proceeds of approximately $29.8 million raised from the public offering completed in April 2010 largely offset by the expenses of the company’s operations during 2010.

2010 Full-Year Financial Results

Total revenue for the year ended December 31, 2010 was $16.6 million, compared to $22.2 million for 2009. The company shipped 16 Sensei Robotic Catheter Systems, 2,439 catheters and recorded 2,474 Sensei procedures in 2010 compared to 26 Sensei Robotic Catheter Systems, 2,243 catheters and 1,652 Sensei procedures in 2009. The company’s net loss for 2010, including non-cash stock compensation expense of $5.0 million, was $37.9 million, or $0.78 loss per basic and diluted share, based on an average basic and diluted shares outstanding of 48.9 million. This compares favorably to a net loss of $52.4 million, or $1.55 loss per basic and diluted share, based on an average basic and diluted shares outstanding of 33.9 million, for 2009, which included non-cash stock compensation expense of $7.4 million.

Full Year 2011 Outlook

The company will continue to focus on its three strategic initiatives in 2011: growing the electrophysiology (EP) business, developing and launching the vascular platform, and achieving operational excellence. The company has already delivered on one of its previously communicated 2011 outlook items, namely the execution of new agreements with Philips for the FOSSL technology. While the company anticipates Sensei system shipments in 2011, given the uncertainty of timing of those shipments, the company will not currently be providing specific guidance. The company expects continued good growth in catheter shipments and procedures in 2011, continuing the positive trends shown in the prior year. Overall operating expense levels are not expected to change significantly in 2011 from the prior year. The company expects to receive regulatory clearance in the US and Europe for the flexible catheter vascular robotic system and to offer the system for commercial sale in the second half of 2011. Finally, the current cash position, including anticipated cash flows from the company’s last milestone payment under its joint development agreement with Philips, is expected to be sufficient to fund the company’s operations through the launch of the next generation flexible catheter vascular robotic technology in 2012.

“We are very encouraged about our EP procedural growth as it testifies to the continued market adoption, safety and clinical relevance of our Sensei system and the value that it delivers to patients, physicians, hospitals and payors,” said Barclay. “Our 2011 business plan is focused on achieving key strategic initiatives, and establishing a unique and differentiated value proposition for our vascular system that we believe represents a ten-fold increase in market opportunity from our currently addressable market and includes a new set of physician customers.”

Hansen Medical Conference Call

Company management will hold a conference call to discuss its 2010 fourth quarter and year end results today, February 23, 2011, at 2:00 p.m. Pacific (5:00 p.m. Eastern). Investors are invited to listen to the call live via the Internet using the link available within the “Investor Relations” section of Hansen Medical’s website at www.hansenmedical.com. A replay of the webcast will be available approximately one hour after the completion of the live call. Additionally, participants can dial into the live conference call by calling 877-941-2322 or 480-629-9715. An audio replay will be available approximately one hour after the completion of the conference call through March 2, 2011, by calling 877-870-5176 or 858-384-5517, and entering access code 4409948.

About Hansen Medical, Inc.

Hansen Medical, Inc., based in Mountain View, California, develops products and technology using robotics for the accurate positioning, manipulation and control of catheters and catheter-based technologies. The company’s Sensei® system and its Sensei X Robotic Catheter System were cleared by the U.S. Food and Drug Administration for manipulation and control of certain mapping catheters in EP procedures. This robotic catheter system is compatible with fluoroscopy, ultrasound, 3D surface map and patient electrocardiogram data. In the United States, the Sensei System is not approved for use in guiding ablation procedures; this use remains experimental. The U.S. product labeling therefore provides that the safety and effectiveness of the Sensei and Sensei X systems for use with cardiac ablation catheters in the treatment of cardiac arrhythmias, including atrial fibrillation (AF), have not been established during EP procedures, such as guiding catheters in the treatment of AF. In the European Union, the Sensei and the Sensei X systems are cleared for use during EP procedures, such as guiding catheters in the treatment of AF and the Lynx ® robotic catheter is cleared for the treatment of AF. The flexible catheter vascular robotic system requires regulatory filings and approval and is not commercially available. Additional information can be found at www.hansenmedical.com.

Forward-Looking Statements

This press release contains forward-looking statements that involve risks, uncertainties, assumptions and other factors which, if they do not materialize or prove correct, could cause Hansen’s results to differ materially from those expressed or implied by such forward-looking statements. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including statements containing the words “plan,” “expects,” “believes,” “goal,” “estimate,” and similar words. Hansen Medical intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Exchange Act and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements about the expectations for commercializing our vascular robotic system and the FOSSL technology, expectations regarding procedure and shipment trends, expectations around operating expense levels and the sufficiency of cash to support the launch of a second generation flexible catheter robotic system. Important factors that could cause actual results to differ materially from those indicated by forward-looking statements include, among others, that the development of new products and applications of technology are subject to design, engineering and manufacturing challenges that could delay clinical studies, regulatory filings and commercialization, potential safety and regulatory issues that could delay, suspend or terminate clinical studies, regulatory approvals or sales, uncertain timelines, costs and results of clinical trials and development new products, our ability to plan and manage cost-reduction or operational efficiency initiatives, the scope and validity of intellectual property rights applicable to products being developed, and our ability to remediate material weaknesses in internal controls over financial reporting. These and other risks are described in greater detail under the heading “Risk Factors” contained in our periodic SEC filings, including our Quarterly Report on Form 10-Q filed with the SEC on November 9, 2010. Given these uncertainties, you should not place undue reliance on the forward-looking statements in this press release. We undertake no obligation to revise or update information herein to reflect events or circumstances in the future, even if new information becomes available.

Hansen Medical, Heart Design, Hansen Medical & Heart Design, Sensei, and Lynx are registered trademarks, and Artisan is a trademark of Hansen Medical, Inc. in the United States and other countries.

EnSite Velocity is a trademark of St. Jude Medical.

TABLES FOLLOW

HANSEN MEDICAL

Condensed Consolidated Statements of Operations

(unaudited)

(in thousands, except per share data)

HANSEN MEDICAL

Condensed Consolidated Balance Sheets

(unaudited)

(in thousands)

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