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8-K - FORM 8-K - GEN PROBE INCa58712e8vk.htm
Exhibit 99.1
(GEN-PROBE LOGO)
Contact:
Michael Watts
Vice president, investor relations and
corporate communications
858-410-8673
For Immediate Release
Gen-Probe Reports Financial Results for the Fourth Quarter and Full Year 2010
— In Fourth Quarter, Company Generates Record Non-GAAP EPS of $0.61,
17% Higher than in the Prior Year Period, and GAAP EPS of $0.56 —
— For Full Year 2010, Total Revenues of $543.3 Million Grow by 9%,
Non-GAAP EPS of $2.19 Increase by 12% —
SAN DIEGO, CA, February 15, 2011 — Gen-Probe Incorporated (NASDAQ: GPRO) today reported financial results for the fourth quarter and full year 2010, highlighted by record non-GAAP earnings per share (EPS) of $0.61 in the quarter, 17% higher than in the prior year period.
“In the fourth quarter of 2010, Gen-Probe generated record clinical diagnostics sales and an all-time high in earnings per share despite macroeconomic headwinds and unusually strong sales of influenza products a year ago,” said Carl Hull, the Company’s president and chief executive officer. “At the same time, we took important steps to accelerate our future growth by filing US regulatory applications for the APTIMA® human papillomavirus (HPV) and trichomonas products, and by acquiring GTI Diagnostics.”
Key financial results for the fourth quarter of 2010 were ($ in millions, except EPS):
                                                 
    Non-GAAP     GAAP  
    2010     2009     Change     2010     2009     Change  
     
Product sales
  $ 131.1     $ 135.5       -3 %   $ 131.1     $ 135.5       -3 %
Total revenues
  $ 136.7     $ 138.9       -2 %   $ 136.7     $ 138.9       -2 %
Operating profit
  $ 40.1     $ 37.4       +7 %   $ 36.8     $ 34.9       +5 %
Net income
  $ 29.4     $ 25.8       +14 %   $ 27.2     $ 24.0       +13 %
EPS
  $ 0.61     $ 0.52       +17 %   $ 0.56     $ 0.48       +17 %
Key financial results for the full year 2010 were ($ in millions, except EPS):
                                                 
    Non-GAAP     GAAP  
    2010     2009     Change     2010     2009     Change  
     
Product sales
  $ 522.7     $ 483.8       +8 %   $ 522.7     $ 483.8       +8 %
Total revenues
  $ 543.3     $ 498.3       +9 %   $ 543.3     $ 498.3       +9 %
Operating profit
  $ 149.4     $ 131.0       +14 %   $ 137.8     $ 120.1       +15 %
Net income
  $ 107.5     $ 99.8       +8 %   $ 106.9     $ 91.8       +16 %
EPS
  $ 2.19     $ 1.95       +12 %   $ 2.18     $ 1.79       +22 %

 


 

Revenue Detail
Clinical diagnostics product sales established a new record in the fourth quarter of 2010, with growth driven by the APTIMA Combo 2® assay for detecting Chlamydia and gonorrhea. Increased APTIMA sales offset lower sales of PRODESSE influenza assays, which were unusually strong in the prior year period due to the H1N1 pandemic. Foreign exchange fluctuations reduced clinical diagnostics sales by an estimated $0.5 million, or less than 1%, compared to the prior year period.
Blood screening product sales decreased in the fourth quarter of 2010, as expected, due to lower sales of TIGRIS® instruments to Novartis, the Company’s blood screening collaboration partner. Sales of blood screening assays were flat compared to the prior year period. Foreign exchange fluctuations reduced blood screening sales by an estimated $0.7 million, or 1%, compared to the prior year period.
Sales of research products and services in the fourth quarter of 2010 declined mainly due to the divestiture of the BioKits food testing business late in 2009, and foreign exchange effects.
Fourth quarter product sales were ($ in millions):
                                 
    Three Months Ended Dec. 31,     Change  
    2010     2009     As Reported     Constant Currency  
         
Clinical Diagnostics
  $ 80.1     $ 77.6       +3 %     +4 %
Blood Screening
  $ 47.6     $ 53.4       -11 %     -10 %
Research Products and Services
  $ 3.4     $ 4.4       -23 %     -21 %
         
Total Product Sales
  $ 131.1     $ 135.5       -3 %     -2 %
 
Product sales for the full year 2010 were ($ in millions):
                                 
    12 Months Ended Dec. 31,     Change  
    2010     2009     As Reported     Constant Currency  
         
Clinical Diagnostics
  $ 305.8     $ 274.2       +12 %     +12 %
Blood Screening
  $ 203.1     $ 197.5       +3 %     +3 %
Research Products and Services
  $ 13.8     $ 12.0       +15 %     +17 %
         
Total Product Sales
  $ 522.7     $ 483.8       +8 %     +8 %
Collaborative research revenues in the fourth quarter of 2010 were $3.7 million, compared to $2.0 million in the prior year period, an increase of 85% that resulted primarily from increased funding from Novartis associated with the development of the fully automated PANTHER™ instrument and the PROCLEIX® ULTRIO® Plus assay for the blood screening market.
Royalty and license revenues in the fourth quarter of 2010 were $1.9 million, compared to $1.4 million in the prior year period, an increase of 36% that resulted primarily from higher royalties received from Novartis and Ventana.

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GAAP Income Statement Details
Gross margin on product sales was 69.4% in the fourth quarter of 2010, compared to 67.2% in the prior year period. This increase resulted mainly from decreased sales of low-margin instruments.
Acquisition-related amortization expenses were $2.2 million in the fourth quarter of 2010, compared to $1.9 million in the prior year period, an increase of 16% that resulted mainly from the October 2009 acquisition of Prodesse and its related intangible assets.
Research and development (R&D) expenses in the fourth quarter of 2010 were $26.9 million, compared to $27.4 million in the prior year period, a decrease of 2% that resulted primarily from lower clinical trial expenses.
Marketing and sales expenses in the fourth quarter of 2010 were $15.0 million, similar to $15.3 million in the prior year period.
G&A expenses were $15.6 million in the fourth quarter of 2010, compared to $14.9 million in the prior year period, an increase of 5% that resulted mainly from expenses associated with the consolidation of United Kingdom operations and the acquisition of GTI Diagnostics.
Total other income was $1.2 million in the fourth quarter of 2010, compared to $2.3 million in the prior year period. This decrease of 48% resulted primarily from lower realized gains from the sale of marketable securities, lower yields on the Company’s municipal bond portfolio, and lower investment balances due to share repurchases, acquisitions and strategic investments.
Income tax expense was $10.8 million in the fourth quarter of 2010, corresponding to a tax rate of 28%. Income tax expense benefited from the reinstatement of the federal R&D tax credit, which was retroactive to the beginning of 2010.
Non-GAAP Income Statement Details
Excluding $0.1 million of acquisition-related depreciation expense, gross margin on product sales in the fourth quarter of 2010 was 69.5%, compared to 67.3% in the prior year period.
Excluding transaction-related costs, general and administrative (G&A) expenses in the fourth quarter of 2010 were $14.7 million, similar to $14.5 million in the prior year period.
Excluding a $0.4 million non-cash gain on a change in the fair value of contingent consideration, total other income in the fourth quarter of 2010 was $0.8 million, compared to $2.3 million in the prior year period.
Excluding adjustments to contingent consideration that largely are not taxable, income tax expense in the fourth quarter of 2010 was $11.4 million, corresponding to a tax rate of 28%.
Cash Flows and Balance Sheet
In the fourth quarter of 2010, Gen-Probe generated net cash of $43.8 million from operating activities, and spent $8.6 million on property, plant and equipment, leading to free cash flow of $35.2 million. The Company repurchased approximately 245,000 shares of its stock in the fourth quarter for $11.9 million, thereby completing its $100 million buyback program. In a separate press release today, Gen-Probe announced a new, $150 million stock repurchase program.
Gen-Probe continues to have a strong balance sheet. As of December 31, 2010, the Company had $489.7 million of cash, cash equivalents and marketable securities, and $240.0 million of short-term debt. The Company pays interest on this debt at a rate 0.6% above the one-month London Interbank Offered Rate (LIBOR), which has been below 0.3%.

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2011 Financial Guidance
“We anticipate 2011 will be a good year financially for Gen-Probe,” said Herm Rosenman, the Company’s senior vice president and chief financial officer. “As we said in our recent analyst day, we forecast continued, high-single-digit growth in product sales, even as instrument sales decline. We also expect improving gross and operating margins to drive solid earnings growth, despite increased legal expenses and lower non-operating income.” Gen-Probe’s 2011 financial guidance is described in the table below:
                 
    Non-GAAP     GAAP  
     
Total revenues
    $570 to $595 million       $570 to $595 million  
Product gross margins
  68% to 69.5%     68% to 69.5%  
Acquisition-related amortization and other transaction expense
  N/A       $13 to 14 million  
Operating margin
  27% to 29%     25% to 27%  
Tax rate
  32% to 33%     32% to 33%  
Diluted shares
    48 to 49 million       48 to 49 million  
EPS
    $2.28 to $2.40       $2.06 to $2.20  
Notes on Presentation
In this press release, all per share amounts are calculated on a fully diluted basis. Some totals may not foot due to rounding. Certain prior year amounts have been reclassified to conform to the current year presentation.
About Non-GAAP Financial Measures
To supplement Gen-Probe’s financial results for the fourth quarter of 2010 and its 2011 financial guidance, in each case presented in accordance with GAAP, Gen-Probe uses the following financial measures defined as non-GAAP by the SEC: non-GAAP net income, non-GAAP gross margin, non-GAAP marketing and sales expenses, non-GAAP G&A expenses, non-GAAP operating margin, non-GAAP income tax rate, and non-GAAP EPS. Gen-Probe’s management does not, nor does it suggest that investors should, consider such non-GAAP financial measures in isolation from, or as a substitute for, financial information prepared and presented in accordance with GAAP. Gen-Probe’s management believes that these non-GAAP financial measures provide meaningful supplemental information regarding the Company’s performance by excluding certain expenses and adjustments that may not be indicative of core business results. Gen-Probe believes that both management and investors benefit from referring to these non-GAAP financial measures in assessing Gen-Probe’s performance and when planning, forecasting and analyzing future periods. These non-GAAP financial measures also facilitate management’s internal comparisons to Gen-Probe’s historical performance and our competitors’ operating results. Gen-Probe believes these non-GAAP financial measures are useful to investors in allowing for greater transparency with respect to supplemental information used by management in its financial and operational decision making. Further, our reconciliations of non-GAAP to GAAP operating results, which are included on the attached tables, are presented in the format of consolidated statements of income solely to assist a reader in understanding the impact of the various adjustments to our GAAP operating results, individually and in the aggregate, and are not intended to place any undue prominence on our non-GAAP operating results.
Webcast Conference Call
A live webcast of Gen-Probe’s fourth quarter 2010 conference call for investors can be accessed at http://www.gen-probe.com beginning at 4:30 p.m. Eastern Time today. The webcast will be archived for at least 90 days. A telephone replay of the call will be available for approximately 24 hours. Call 800-294-4406 (US) or 203-369-3231 (international).

4


 

About Gen-Probe
Gen-Probe is a global leader in the development, manufacture and marketing of rapid, accurate and cost-effective molecular diagnostic products and services that are used primarily to diagnose human diseases, screen donated human blood, and ensure transplant compatibility. Gen-Probe has approximately 28 years of expertise in nucleic acid testing (NAT), and received the 2004 National Medal of Technology, America’s highest honor for technological innovation, for developing NAT assays for blood screening. Gen-Probe is headquartered in San Diego and employs approximately 1,400 people. For more information, go to www.gen-probe.com.
Trademarks
APTIMA, APTIMA COMBO 2, PANTHER, PRODESSE and TIGRIS are trademarks of Gen-Probe. All other trademarks are the property of their owners.
Caution Regarding Forward-Looking Statements
Any statements in this news release about our expectations, beliefs, plans, objectives, assumptions or future events or performance, including those under the heading “ 2011 Financial Guidance,” are not historical facts and are forward-looking statements. These statements are often, but not always, made through the use of words or phrases such as believe, will, expect, anticipate, estimate, intend, plan and would. For example, statements concerning Gen-Probe’s financial condition, possible or expected results of operations, the development and commercialization of new products, regulatory approvals, future milestones, growth opportunities, and plans of management are all forward-looking statements. Forward-looking statements are not guarantees of performance. They involve known and unknown risks, uncertainties and assumptions that may cause actual results, levels of activity, performance or achievements to differ materially from those expressed or implied. Some of these risks, uncertainties and assumptions include but are not limited to: (i) the risk that we may not achieve our expected 2011 financial targets, (ii) the risk that we may not integrate acquisitions, such as Tepnel, Prodesse and GTI Diagnostics, successfully, (iii) the possibility that the market for the sale of our new products, such as our PANTHER instrument system and PROGENSA PCA3, APTIMA HPV and APTIMA trichomonas assays, may not develop as expected, (iv) the enhancement of existing products and the development of new products may not proceed as planned, (v) the risk that investigational products, including those now in US clinical trials, may not be approved by regulatory authorities or become commercially available in the time frame we anticipate, or at all, (vi) the risk that we may not be able to compete effectively, (vii) the risk that we may not be able to maintain our current corporate collaborations and enter into new corporate collaborations or customer contracts, (viii) our dependence on Novartis and other third parties for the distribution of some of our products, (ix) our dependence on a small number of customers, contract manufacturers and single source suppliers of raw materials, (x) changes in third-party reimbursement policies regarding our products could adversely affect sales, (xi) changes in government regulation or tax policy affecting our diagnostic products could harm our sales, increase our development costs or increase our taxes, (xii) the risk that our intellectual property may be infringed by third parties or invalidated, and (xiii) our involvement in patent and other intellectual property and commercial litigation could be expensive and could divert management’s attention. This list includes some, but not all, of the factors that could affect our ability to achieve results described in any forward-looking statements. For additional information about risks and uncertainties we face and a discussion of our financial statements and footnotes, see documents we file with the SEC, including our most recent annual report on Form 10-K and all subsequent periodic reports. We assume no obligation and expressly disclaim any duty to update forward-looking statements to reflect events or circumstances after the date of this news release or to reflect the occurrence of subsequent events.
# # #

5


 

Gen-Probe Incorporated
Consolidated Balance Sheets — GAAP
(In thousands, except share and per share data)
                 
    December 31,     December 31,  
    2010     2009  
    (unaudited)          
Assets
               
Current assets:
               
Cash and cash equivalents, including restricted cash of $16 and $17 at December 31, 2010 and December 31, 2009, respectively
  $ 59,690     $ 82,616  
Marketable securities
    170,648       402,990  
Trade accounts receivable, net of allowance for doubtful accounts of $355 and $516 at December 31, 2010 and December 31, 2009, respectively
    54,739       55,305  
Accounts receivable — other
    5,493       4,707  
Inventories
    66,416       61,071  
Deferred income tax
    13,634       13,959  
Prepaid income tax
    2,993       7,317  
Prepaid expenses
    11,672       14,526  
Other current assets
    5,148       4,708  
 
           
Total current assets
    390,433       647,199  
Marketable securities, net of current portion
    259,317       15,472  
Property, plant and equipment, net
    160,863       157,437  
Capitalized software, net
    13,981       12,560  
Patents, net
    12,450       1,556  
Goodwill
    150,308       122,680  
Purchased intangibles, net
    120,270       108,015  
License, manufacturing access fees and other assets, net
    60,175       63,266  
 
           
Total assets
  $ 1,167,797     $ 1,128,185  
 
           
Liabilities and stockholders’ equity
               
Current liabilities:
               
Accounts payable
  $ 14,614     $ 20,455  
Accrued salaries and employee benefits
    26,825       24,775  
Other accrued expenses
    13,935       24,755  
Income tax payable
    634        
Short-term borrowings
    240,000       240,127  
Deferred revenue
    1,166       3,527  
 
           
Total current liabilities
    297,174       313,639  
Non-current income tax payable
    8,315       5,958  
Deferred income tax
    29,775       23,220  
Deferred revenue, net of current portion
    2,500       1,978  
Other long-term liabilities
    6,654       16,215  
Commitments and contingencies
               
Stockholders’ equity:
               
Preferred stock, $0.0001 par value per share; 20,000,000 shares authorized, none issued and outstanding
           
Common stock, $0.0001 par value per share; 200,000,000 shares authorized, 47,966,156 and 49,143,798 shares issued and outstanding at December 31, 2010 and December 31, 2009, respectively
    5       5  
Additional paid-in capital
    195,820       242,615  
Accumulated other comprehensive income
    678       4,616  
Retained earnings
    626,876       519,939  
 
           
Total stockholders’ equity
    823,379       767,175  
 
           
Total liabilities and stockholders’ equity
  $ 1,167,797     $ 1,128,185  
 
           

6


 

Gen-Probe Incorporated
Consolidated Statements of Income — GAAP
(In thousands, except per share data)
(Unaudited)
                                 
    Three Months Ended     Twelve Months Ended  
    December 31,     December 31,  
    2010     2009     2010     2009  
Revenues:
                               
Product sales
  $ 131,093     $ 135,470     $ 522,709     $ 483,759  
Collaborative research revenue
    3,708       2,049       14,518       7,911  
Royalty and license revenue
    1,893       1,351       6,100       6,632  
         
Total revenues
    136,694       138,870       543,327       498,302  
Operating expenses:
                               
Cost of product sales (excluding acquisition-related intangible amortization)
    40,104       44,454       169,222       152,393  
Acquisition-related intangible amortization
    2,231       1,894       8,847       4,144  
Research and development
    26,885       27,428       111,103       105,970  
Marketing and sales
    15,016       15,306       59,492       53,853  
General and administrative
    15,610       14,925       56,818       61,828  
         
Total operating expenses
    99,846       104,007       405,482       378,188  
         
Income from operations
    36,848       34,863       137,845       120,114  
Other income/(expense):
                               
Investment and interest income
    1,401       1,923       11,765       21,603  
Interest expense
    (535 )     (392 )     (2,216 )     (1,857 )
Gain on contingent consideration
    399             7,994        
Other income/(expense), net
    (95 )     769       (177 )     (58 )
         
Total other income, net
    1,170       2,300       17,366       19,688  
         
Income before income tax
    38,018       37,163       155,211       139,802  
Income tax expense
    10,780       13,138       48,274       48,019  
         
Net income
  $ 27,238     $ 24,025     $ 106,937     $ 91,783  
         
Net income per share:
                               
Basic
  $ 0.57     $ 0.49     $ 2.20     $ 1.82  
         
Diluted
  $ 0.56     $ 0.48     $ 2.18     $ 1.79  
         
Weighted average shares outstanding:
                               
Basic
    47,827       48,923       48,560       50,356  
         
Diluted
    48,455       49,458       49,033       50,965  
         

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Gen-Probe Incorporated
Consolidated Statements of Income — Non-GAAP Reconciliations
(In thousands, except per share data)
(Unaudited)
                                                 
    Three Months Ended     Three Months Ended  
    December 31, 2010     December 31, 2009  
    Non-GAAP     Adjustments     GAAP     Non-GAAP     Adjustments     GAAP  
         
Revenues:
                                               
Product sales
  $ 131,093     $     $ 131,093     $ 135,470     $     $ 135,470  
Collaborative research revenue
    3,708             3,708       2,049             2,049  
Royalty and license revenue
    1,893             1,893       1,351             1,351  
         
Total revenues
    136,694             136,694       138,870             138,870  
Operating expenses:
                                               
Cost of product sales (excluding acquisition-related intangible amortization)
    40,013       91       40,104       44,361       93       44,454  
Acquisition-related intangible amortization
          2,231       2,231             1,894       1,894  
Research and development
    26,885             26,885       27,428             27,428  
Marketing and sales
    15,016             15,016       15,209       97       15,306  
General and administrative
    14,670       940       15,610       14,479       446       14,925  
         
Total operating expenses
    96,584       3,262       99,846       101,477       2,530       104,007  
         
Income from operations
    40,110       (3,262 )     36,848       37,393       (2,530 )     34,863  
Other income/(expense):
                                               
Investment and interest income
    1,401             1,401       1,923             1,923  
Interest expense
    (535 )           (535 )     (392 )           (392 )
Gain on contingent consideration
          399       399                    
Other income/(expense), net
    (95 )           (95 )     769             769  
         
Total other income, net
    771       399       1,170       2,300             2,300  
         
Income before income tax
    40,881       (2,863 )     38,018       39,693       (2,530 )     37,163  
Income tax expense
    11,437       (657 )     10,780       13,890       (752 )     13,138  
         
Net income
  $ 29,444     $ (2,206 )   $ 27,238     $ 25,803     $ (1,778 )   $ 24,025  
         
Net income per share:
                                               
Basic
  $ 0.61     $ (0.04 )   $ 0.57     $ 0.53     $ (0.04 )   $ 0.49  
         
Diluted
  $ 0.61     $ (0.05 )   $ 0.56     $ 0.52     $ (0.04 )   $ 0.48  
         
Weighted average shares outstanding:
                                               
Basic
    47,827               47,827       48,923               48,923  
 
                                       
Diluted
    48,455               48,455       49,458               49,458  
 
                                       

8


 

Gen-Probe Incorporated
Consolidated Statements of Income — Non-GAAP Reconciliations
(In thousands, except per share data)
(Unaudited)
                                                 
    Twelve Months Ended     Twelve Months Ended  
    December 31, 2010     December 31, 2009  
    Non-GAAP     Adjustments     GAAP     Non-GAAP     Adjustments     GAAP  
         
Revenues:
                                               
Product sales
  $ 522,709     $     $ 522,709     $ 483,759     $     $ 483,759  
Collaborative research revenue
    14,518             14,518       7,911             7,911  
Royalty and license revenue
    6,100             6,100       6,632             6,632  
         
Total revenues
    543,327             543,327       498,302             498,302  
Operating expenses:
                                               
Cost of product sales (excluding acquisition-related intangible amortization)
    168,860       362       169,222       152,118       275       152,393  
Acquisition-related intangible amortization
          8,847       8,847             4,144       4,144  
Research and development
    111,103             111,103       105,970             105,970  
Marketing and sales
    59,492             59,492       53,756       97       53,853  
General and administrative
    54,491       2,327       56,818       55,497       6,331       61,828  
         
Total operating expenses
    393,946       11,536       405,482       367,341       10,847       378,188  
         
Income from operations
    149,381       (11,536 )     137,845       130,961       (10,847 )     120,114  
Other income/(expense):
                                               
Investment and interest income
    11,765             11,765       21,603             21,603  
Interest expense
    (2,216 )           (2,216 )     (1,857 )           (1,857 )
Gain on contingent consideration
          7,994       7,994                    
Other income/(expense), net
    (177 )           (177 )     (58 )           (58 )
         
Total other income, net
    9,372       7,994       17,366       19,688             19,688  
         
Income before income tax
    158,753       (3,542 )     155,211       150,649       (10,847 )     139,802  
Income tax expense
    51,303       (3,029 )     48,274       50,825       (2,806 )     48,019  
         
Net income
  $ 107,450     $ (513 )   $ 106,937     $ 99,824     $ (8,041 )   $ 91,783  
         
Net income per share:
                                               
Basic
  $ 2.21     $ (0.01 )   $ 2.20     $ 1.98     $ (0.16 )   $ 1.82  
         
Diluted
  $ 2.19     $ (0.01 )   $ 2.18     $ 1.95     $ (0.16 )   $ 1.79  
         
Weighted average shares outstanding:
                                               
Basic
    48,560               48,560       50,356               50,356  
 
                                       
Diluted
    49,033               49,033       50,965               50,965  
 
                                       

9


 

Gen-Probe Incorporated
Consolidated Statements of Cash Flows — GAAP
(In thousands)
(Unaudited)
                 
    Twelve Months Ended  
    December 31,  
    2010     2009  
     
Operating activities:
               
Net income
  $ 106,937     $ 91,783  
Adjustments to reconcile net income to net cash provided by operating activities:
               
Depreciation and amortization
    44,529       40,382  
Amortization of premiums on investments, net of accretion of discounts
    9,573       5,868  
Stock-based compensation
    24,075       23,420  
Excess tax benefit from employee stock-based compensation
    (3,692 )     (2,005 )
Deferred revenue
    (1,808 )     812  
Deferred income tax
    (3,745 )     (5,786 )
Gain on contingent consideration
    (7,994 )      
Gain on sale of food safety business
          (291 )
Loss on disposal of property and equipment
    1,065       221  
Changes in assets and liabilities:
               
Trade and other accounts receivable
    2,649       (11,303 )
Inventories
    (1,154 )     2,315  
Prepaid expenses
    3,055       1,218  
Other current assets
    (360 )     1,912  
Other long-term assets
    (559 )     (4,123 )
Accounts payable
    (6,265 )     3,500  
Accrued salaries and employee benefits
    (133 )     (676 )
Other accrued expenses
    (4,417 )     (806 )
Income tax payable
    7,688       (2,371 )
Other long-term liabilities
    122       961  
     
Net cash provided by operating activities
    169,566       145,031  
     
Investing activities:
               
Proceeds from sales and maturities of marketable securities
    427,821       438,601  
Purchases of marketable securities
    (401,434 )     (419,019 )
Proceeds from sale of property, plant and equipment
    82        
Purchases of property, plant and equipment
    (30,716 )     (32,364 )
Purchase of capitalized software
    (3,891 )     (1,290 )
Purchases of intangible assets, including licenses and manufacturing access fees
    (2,513 )     (7,341 )
Net cash paid for business combinations
    (53,000 )     (183,725 )
Proceeds from sale of food safety business
          6,357  
Cash paid for investment in Pacific Biosciences
    (50,000 )      
Other
    (820 )     403  
     
Net cash used in investing activities
    (114,471 )     (198,378 )
     
Financing activities:
               
Repurchase and retirement of common stock
    (99,935 )     (174,847 )
Proceeds from issuance of common stock and employee stock purchase plan
    31,830       10,923  
Payment of contingent consideration
    (10,000 )      
Repurchase and retirement of restricted stock for payment of taxes
    (1,257 )     (1,716 )
Excess tax benefit from employee stock-based compensation
    3,692       2,005  
Borrowings, net
    (228 )     238,450  
     
Net cash (used in) provided by financing activities
    (75,898 )     74,815  
     
Effect of exchange rate changes on cash and cash equivalents
    (2,123 )     1,026  
     
Net increase in cash and cash equivalents
    (22,926 )     22,494  
Cash and cash equivalents at the beginning of period
    82,616       60,122  
     
Cash and cash equivalents at the end of period
  $ 59,690     $ 82,616  
     

10