(State or other jurisdiction

of incorporation)

(IRS Employer

Identification No.)

One Amgen Center Drive

Thousand Oaks, California

Reducing the multiple used to determine the lump sum cash severance payment for senior vice presidents and above from “3 times” to “2 times” a participant’s annual base salary and targeted annual bonus (determined in accordance with the Amended and Restated Plan);

Eliminating the excise tax reimbursement feature of the Plan (sometimes referred to as a “partial gross-up”) with the result that there are now no tax gross-ups provided under the Amended and Restated Plan;

Simplifying the calculation of the lump sum cash severance payment under the Plan by including in the severance formula only a participant’s targeted annual bonus for the year in which their termination occurs, instead of the higher of such targeted annual bonus or the actual average annual bonus for the three years preceding the Change of Control;

Removing the stock option acceleration value offset by which a participant’s lump sum cash severance payment is offset by the value of any stock option acceleration (as determined in accordance with Section 280G of the Internal Revenue Code of 1986, as amended from time to time) resulting from the Change of Control;

Removing the provision of in-kind health and welfare benefits under the Plan, with the exception of offering Company-paid coverage under the Consolidated Omnibus Reconciliation Act of 1985, as amended, for group health and dental care for up to 18 months; and

Adding a component to the Amended and Restated Plan’s retirement benefit to reflect the implementation of the Amgen Inc. Retiree Medical Savings Account Plan, Effective July 1, 2009, and modifying the method of providing the retirement benefit to a contribution to the Amgen Inc. Supplemental Retirement Plan, Amended and Restated Effective January 1, 2009, or a lump sum cash payment, in the Company’s discretion.

Exhibit

No.

Document Description