Exhibit 31.3

CERTIFICATIONS

I, Mark G. Foletta, certify that:

1.         I have reviewed this Amendment No. 1 to Form 10-K of Amylin Pharmaceuticals, Inc.; and

2.         Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.