FIRST AMENDMENT TO FIRST AMENDED AND RESTATED SECURED TERM LOAN AGREEMENT

THIS FIRST AMENDMENT TO FIRST AMENDED AND RESTATED SECURED TERM LOAN AGREEMENT (“Amendment”) is made as of March 31, 2010 (the “Effective Date”), by and among BIOMED REALTY, L.P., a Maryland limited partnership (“Borrower” or “Operating Partnership”), KEYBANK NATIONAL ASSOCIATION, a national banking association (“KeyBank”), each lender whose name is set forth on the signature pages of this Amendment (collectively, together with KeyBank, the “Lenders” and, individually, a “Lender”) and KEYBANK NATIONAL ASSOCIATION, not individually but as “Administrative Agent”.

RECITALS

A. Borrower, Administrative Agent, KeyBank and the Lenders entered into that certain First Amended and Restated Secured Term Loan Agreement dated as of August 1, 2007 (the “Loan Agreement”) for the purposes described therein, pursuant to which Lenders made a TWO HUNDRED FIFTY MILLION and NO/100THS DOLLARS ($250,000,000.00) loan (“Loan”) to Borrower. All of the documents evidencing, securing or executed in connection with the Loan, as the same may be amended from time to time pursuant to the terms hereof, are collectively referred to as the “Loan Documents.”

B. Concurrently herewith, pursuant to Section 3.1(e) of the Loan Agreement, Borrower desires to make a voluntarily prepayment of the Loan, reducing the outstanding balance of the Loan by $100,000,000.00.

C. In connection with the current voluntary partial prepayment of $100,000,000.00, Borrower hereby desires that the Lenders agree to remove and release, and the Lenders hereby agree to remove and release, the following Projects as “Subject Properties” under the Loan Agreement: (i) 3240, 3260, 3280 Bayshore Boulevard, Brisbane, California, (ii) 9885 Towne Centre Drive, San Diego, California, and (iii) 3450 Monte Villa Parkway, Seattle, Washington.

D. In addition to the removal and release of the above-referenced Projects as Subject Properties under the Loan Agreement, Borrower and the Lenders hereby desire to further amend the Loan Agreement to permit future Subject Property Releases (as defined below) provided that certain conditions precedent are satisfied.

E. The parties hereto desire to provide for an amendment to the Loan Agreement to address such changes in the removal and release provisions relating to Subject Properties and to make such other amendments and revisions to the Loan Agreement as are more particularly set forth hereinbelow.

TERMS AND CONDITIONS

NOW, THEREFORE, with reference to the foregoing Recitals, all of which are incorporated herein by this reference, for valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows:

1. The following Definition from Article I of the Loan Agreement is hereby deleted in its entirety:

(a) “Bayshore Project”.

2. Additional Definitions. The following Definitions are hereby added to Article I of the Loan Agreement:

“Minimum Release Price” for each Subject Property shall have the value ascribed to each such Subject Property on Schedule 1.3 attached hereto and made a part hereof.

“Release Price” for each Subject Property shall mean, respectively, a cash amount reasonably determined by the Administrative Agent that is equal to the greater of: (i) the Minimum Release Price for each such Subject Property, or (ii) that portion of the then-current Gross Asset Value attributable to the applicable Subject Property less the outstanding principal balance of the corresponding Subject Property Indebtedness as of the end of the most recent Fiscal Quarter for which financial results have been reported.

“Subject Property Release” means the removal and release of an Income-Producing Project or a Project or any portion thereof as a “Subject Property” under this Agreement.

3. Voluntary Partial Prepayment. Concurrently herewith Borrower has made a voluntary partial prepayment of the Loan to the Lenders in the aggregate amount of $100,000,000.00. From and after the date hereof, the current aggregate principal amount of the Loan outstanding is $150,000,000.00.

4. Subject Property Releases.

(a) As of the Effective Date, the following Projects are hereby released and removed as “Subject Properties” under the Loan Agreement:

	(i)		3240, 3260, 3280 Bayshore Boulevard, Brisbane, California,
	(ii)		9885 Towne Centre Drive, San Diego, California, and
	(iii)		3450 Monte Villa Parkway, Seattle, Washington.

(b) Concurrently herewith, the Administrative Agent shall execute such documents or instruments and take all other actions necessary or advisable on behalf of the Lenders to release the related security interests (including without limitation releases of any pledged Equity Interests) evidenced by any Security Documents pertaining to the Projects referenced in Section 4(a)(i)-(iii) above, and to release the corresponding Subsidiary Guarantors relating to such aforementioned Projects from any continuing obligations under the Subsidiary Guaranty.

5. Schedule of Subsidiary Guarantors. As of the Effective Date, Schedule 1.2 to the Loan Agreement (Schedule of Subsidiary Guarantors) is hereby deleted in its entirety and replaced with the attached Schedule 1.2.

6. Schedule of Subject Properties. As of the Effective Date, Schedule 1.3 to the Loan Agreement (Schedule of Subject Properties) is hereby deleted in its entirety and replaced with the attached Schedule 1.3.

7. Schedule of Subsidiaries and Projects. As of the Effective Date, Schedule 4.4 (Subsidiaries) and Schedule 4.19 (Projects) to the Loan Agreement are hereby deleted in their entirety and replaced with the attached Schedule 4.4 and Schedule 4.19.

8. Sale of a Subject Property. The provisions set forth in Section 2A.3 of the Loan Agreement are hereby amended, restated and wholly replaced in their entirety by the following:

“2A.3 Sale of a Subject Property. Provided that no Default or Event of Default shall have occurred hereunder or under the other Loan Documents and be continuing (or would exist immediately after giving effect to the transactions contemplated by this Section 2A.3), a Subject Property Owner (or Borrower or another applicable Subsidiary) may engage in a Subject Property Sale upon the following terms and conditions:

(a) Borrower shall deliver to the Administrative Agent written notice of the desire to consummate such Subject Property Sale on or before the date that is five (5) Banking Days prior to the date on which the Subject Property Sale is to be effected;

(b) On the date of the proposed Subject Property Sale, Borrower shall make a principal prepayment of the Loan to Administrative Agent on behalf of the Lenders equal to the Release Price for the Project that is the subject of the proposed Subject Property Sale;

(c) On or before the date that is five (5) Banking Days prior to the date the Subject Property Sale is to be effected, Borrower shall submit to the Administrative Agent a Certificate, which shall be subject to the Administrative Agent’s review and reasonable approval, setting forth the Subject Properties Leverage Ratio on a pro forma basis as of the date of the Subject Property Sale (the “Pro Forma Subject Properties Leverage Ratio”), giving effect to (in addition to other changes to the Subject Properties Leverage Ratio during the intervening period (e.g., any reductions to the outstanding principal balance of the Subject Property Indebtedness)): (A) the Subject Property Sale and the corresponding payment to Administrative Agent on behalf of the Lenders of the applicable Release Price for such Subject Property being sold, and (B) any other Projects that became or are becoming a Subject Property prior to the date of the Subject Property Sale;

(d) If the Pro Forma Subject Properties Leverage Ratio exceeds the Target Subject Properties Leverage Ratio, Borrower shall, concurrently or before the closing of the Subject Property Sale and in addition to the payment of the Release Price, pay to the Administrative Agent for the account of the Lenders, which payment shall be applied to reduce the Outstanding Loan Amount, the amount necessary to make the Pro Forma Subject Properties Leverage Ratio no greater than the Target Subject Properties Leverage Ratio; and

(e) Upon the occurrence of the Subject Property Sale, the underlying Project shall no longer be a Subject Property, and the Administrative Agent shall execute such documents or instruments and take all other actions necessary or advisable on behalf of the Lenders to release the related security interests (including without limitation releases of any pledged Equity Interests) evidenced by any Security Documents and to release the related Subsidiary Guarantor(s), if applicable, from any obligations under the Subsidiary Guaranty.”

9. Future Subject Property Release Provisions. The following shall be added as new Section 2A.5 to the Loan Agreement:

“2A.5 Release of a Subject Property. Provided that no Default or Event of Default shall have occurred hereunder or under the other Loan Documents and be continuing (or would exist immediately after giving effect to the transactions contemplated by this Section 2A.5), a Subject Property Owner (or Borrower or another applicable Subsidiary) may engage in a Subject Property Release upon the following terms and conditions:

(a) Borrower shall deliver to the Administrative Agent written notice of the desire to consummate such Subject Property Release on or before the date that is five (5) Banking Days prior to the date on which the Subject Property Release is to be effected;

(b) On the date of the proposed Subject Property Release, Borrower shall make a principal prepayment of the Loan to Administrative Agent on behalf of the Lenders equal to the Release Price for the Project that is the subject of the proposed Subject Property Release;

(c) On or before the date that is five (5) Banking Days prior to the date the Subject Property Release is to be effected, Borrower shall submit to the Administrative Agent a Certificate, which shall be subject to the Administrative Agent’s review and reasonable approval, setting forth the Pro Forma Subject Properties Leverage Ratio as of the date of the Subject Property Release giving effect to (in addition to other changes to the Subject Properties Leverage Ratio during the intervening period (e.g., any reductions to the outstanding principal balance of the Subject Property Indebtedness)): (A) the Subject Property Release and the corresponding payment to Administrative Agent on behalf of the Lenders of the applicable Release Price for such Subject Property being released, and (B) any other Projects that became or are becoming a Subject Property prior to the date of the Subject Property Release;

(d) If the Pro Forma Subject Properties Leverage Ratio exceeds the Target Subject Properties Leverage Ratio, Borrower shall, concurrently or before the closing of the Subject Property Release and in addition to the payment of the Release Price, pay to the Administrative Agent for the account of the Lenders, which payment shall be applied to reduce the Outstanding Loan Amount, the amount necessary to make the Pro Forma Subject Properties Leverage Ratio no greater than the Target Subject Properties Leverage Ratio; and

(e) Upon the occurrence of the Subject Property Release, the underlying Project shall no longer be a Subject Property, and the Administrative Agent shall execute such documents or instruments and take all other actions necessary or advisable on behalf of the Lenders to release the related security interests (including without limitation releases of any pledged Equity Interests) evidenced by any Security Documents and to release the related Subsidiary Guarantor(s), if applicable, from any obligations under the Subsidiary Guaranty.”

10. Full Force and Effect. Except as amended hereby, the terms and provisions of the Loan Agreement and the Loan Documents remain unchanged, are and shall remain in full force and effect unless and until modified or amended in writing in accordance with their terms, and are hereby ratified and confirmed. Except as expressly provided herein, this Amendment shall not constitute an amendment, waiver, consent or release with respect to any provision of any Loan Document, a waiver of any default or Event of Default under any Loan Document, or a waiver or release of any of the Lenders’ rights and remedies (all of which are hereby reserved). The Borrower expressly ratifies and confirms the confession of judgment (if applicable) and waiver of jury trial provisions contained in the Loan Documents.

11. References to Loan Documents; Capitalized Terms. Any and all references to any Loan Document in any other Loan Document shall be deemed to refer to such Loan Document as amended by this Amendment. This Amendment is deemed incorporated into each of the Loan Documents. Any initially capitalized terms used in this Amendment without definition shall have the meanings assigned to those terms in the Loan Documents. To the extent that any term or provision of this Amendment is or may be inconsistent with any term or provision in any Loan Document, the terms and provisions of this Amendment shall control.

12. Successors and Assigns. This Amendment will be binding upon and inure to the benefit of the Borrower and the Lenders and their respective heirs, executors, administrators, successors and assigns.

13. Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State of New York.

14. Counterparts. This Amendment may be executed in any number of counterparts, all of which taken together shall constitute one agreement, and any of the parties hereto may execute this Amendment by signing any such counterpart.

[Signature page follows.]

IN WITNESS WHEREOF, the Borrower, the Lenders and the Administrative Agent have executed this Agreement as of the date first above written.

Address:

2001 Ross Avenue, Suite 4900
Dallas, Texas 75201
Telephone: 214-979-2740
Facsimile: 214-979-2727
Attn: Chuck Butterworth

Signature Page to Amendment
S-4

Address:

BBVA Compass
15 South 20^th Street
Suite 1504
Birmingham, Alabama 35233
Telephone: 205-297-5920
Facsimile: 205-297-3901
Attn: Keely W. McGee, Senior Vice President

Signature Page to Amendment
S-5

Address:

405 Park Avenue
New York, New York 10022
Telephone: 212-515-6762
Facsimile: 212-339-8325
Attn: Douglas S. Marron
Attn: Brian Deegan

Signature Page to Amendment
S-6

Address:

710 Carillon Parkway
St. Petersburg, Florida 33716
Telephone: 727-567-4196
Facsimile: 727-567-8830
Attn: Thomas Scott, Senior Vice President

Signature Page to Amendment
S-7

Address:

c/o Babson Capital Management, LLC
1500 Main Street, Floor 21, Tower Square
Springfield, MA 01115
Attn: Richard F. McKeever, Managing Director
Telephone: 413-226-1432
Facsimile: 413-226-2432

Signature Page to Amendment
S-8

Address:

c/o PB Capital Corporation
230 Park Avenue
New York, NY 10169
Attn: Andrew E. Woodtli, Assistant Vice President
Telephone: 212-756-5608
Facsimile: 212-765-5536

Signature Page to Amendment
S-9

Address:

RBS Citizens, N.A. d/b/a Charter One
1215 Superior Avenue, OHS675
Cleveland, OH 44114
Phone: 216-277-0051
Facsimile: 216-277-4600
Attn: Erin L. Mahon, Assistant Vice President

Signature Page to Amendment
S-10

Address:

Wells Fargo Bank, N.A.
301 S. College Street, 4th Floor
Mailcode D1053-04R
Charlotte, NC 28202
Telephone: 704-383-4013
Facsimile: 704-383-6205
Attn: Anand Jobanputra, Relationship Manager

Signature Page to Amendment
S-11

Signature Page to Amendment
S-12

Address:

75 State Street MA1 SST04-11
Boston, Massachusetts 02109
Telephone: 617-757-5578
Facsimile: 617-757-5652
Attn: T. Gregory Donohue, Senior Vice President

Signature Page to Amendment
S-13

Address:

TD Bank, N.A.
370 Main Street, 2nd Floor
Worcester, MA 01608
Telephone:: 508-368-6921
Facsimile: 508-368-6520
Attn: David Yesue, Assistant Vice President

Signature Page to Amendment
S-14

Address:

Grosse Bleiche 46
55116 Mainz, Germany
Phone: +49 6131 9280 7263
Facsimile: +49 6131 9280 7308
Attn: Armin Gemmerich, Executive Director

Signature Page to Amendment
S-15

Address:

People’s United Bank
850 Main Street, 12^th Floor
Bridgeport, CT 06604
Phone: 203-338-7375
Facsimile: 203-338-7344
Attn: Maurice Fry, Vice President

Signature Page to Amendment
S-16

Address:

PNC Real Estate
1900 E. Ninth Street — 22nd Floor
(Mail Stop: B7-YB13-22-1)
Cleveland, OH 44114
Telephone: 216-222-6032
Facsimile: 216-222-6070
Attn: John E. Wilgus, II

 Senior Vice President

 Real Estate Banking

Signature Page to Amendment
S-17

Address:

65 Liberty Street
New York, NY 10005
Telephone: 212-815-9168
Facsimile: 212-766-5006
Attn: Nae-Yee Lung, Executive Vice President and General Manager