Exhibit 10.2

THIS FIRST AMENDMENT TO LEASE (“First Amendment”), is made and entered into this 15^th day of March, 2007, by and between FAWN INDUSTRIAL LLC, a Delaware limited liability company and 1881 INDUSTRIAL LLC, a Delaware limited liability company (successors in interest to 3929 Westpoint Industrial, LLC), hereinafter collectively referred to as “Landlord” and TENGION, INC., a Delaware corporation, hereinafter referred to as “Tenant”. Tenant leases from Landlord approximately 25,600 square feet (the “Premises”) known as Suite G, located at 3929 Westpoint Boulevard, Forsyth County, North Carolina.

W I T N E S S E T H:

WHEREAS, Landlord’s predecessor 3929 Westpoint Industrial, LLC and Tenant entered into a Lease dated on or about June 6, 2005 for the Premises (the “Lease”); and

WHEREAS, Landlord’s predecessor 3929 Westpoint Industrial, LLC duly assigned its interests in the Lease to Landlord; and

WHEREAS, Landlord and Tenant desire to amend the Lease to provide for, among other things, the exercise by Tenant of its Right of First Refusal set forth in Section 30(a) of the Lease with respect to approximately 12,800 square feet of space in the Building known as Suite F on the terms and conditions set forth in this First Amendment.

NOW THEREFORE, based on the mutual promises and covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which is acknowledged, the parties hereto agree to amend the Lease as follows:

“Fifty-three (53) spaces for Tenant’s use at or near the front entrance of the Premises. Tenant shall also be permitted to designate parking spaces near the rear of the Building (the “Designated Rear Parking Area”) directly behind the Premises as shown on

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Exhibit A-1 to the Lease and in Tenant’s Plans as described in the Workletter attached as Addendum Number One to the Lease (the “Workletter”). Landlord shall have no obligation to monitor or enforce Tenant’s parking rights herein.”

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Notwithstanding the fact that there are separate Base Rent schedules for the original Premises and the Expansion Space, the Base Rent due for the Premises as a whole shall be deemed to be a single cumulative amount which is the total of the Base Rent due for the original Premises set forth in Section 1(e) of the Lease and the Base Rent due for the Expansion Space as set forth in the above Base Rent Schedule.

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During the term hereof, Landlord shall notify Tenant of its proportionate share due for such Common Area Expenses. Landlord shall have the option through the Lease term to require Tenant’s reimbursement on either a monthly, quarterly or annual basis, at Landlord’s sole discretion, to become due and payable as additional rent within ten (10) days, if invoiced monthly or thirty days (30) days, if invoiced quarterly or annually, from the date of invoice. Provided Tenant is not then in monetary default under this Lease, Tenant and/or its qualified professional advisers shall have the right, upon prior written notice to Landlord, and at its sole cost and expense, to inspect and/or audit Landlord’s books and records at Landlord’s office or at the office of Landlord’s managing agent within 180 days following receipt of a summary schedule of Common Area Expenses. If after such inspection and/or audit Tenant disputes the amount of operating expenses, a certification as to the proper amount shall be made by Landlord’s independent certified public accountant in consultation with Tenant’s professional, which certification shall be final and conclusive. If such audit reveals that operating expenses were overstated in the calendar year audited Landlord shall within thirty (30) days after the certification pay to Tenant the amount of any overstatement which it had collected from Tenant. If the

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operating expense certification shows that the operating expenses were overstated by more than 7% in the calendar year audited, then Landlord shall pay the reasonable costs of Tenant’s audit, but not including however any travel charges related to such audit. However, if such certification does not show that Landlord had made such an overstatement then Tenant shall pay both the costs of its professional as well as the reasonable charges of Landlord’s independent certified public accountant (but not including however any of its travel charges) engaged to determine the correct amount of operating expenses. If the certification shows that Landlord has undercharged Tenant then Tenant shall within thirty (30) days pay to Landlord the amount of any undercharge.

Books and records necessary to accomplish any audit permitted under this Section shall be retained for twelve months after the end of each calendar year, and on receipt of notice of Tenant’s intent to inspect and/or audit the operating expenses shall be made available to Tenant to conduct the inspection and/or audit at the location set forth above.

In the event that the Tenant elects to have a professional audit Landlord’s operating expenses as provided in this Lease, such audit must be conducted by an independent nationally or regionally recognized accounting firm that is not being compensated by Tenant on a contingency fee basis. All information obtained through such audit as well as any compromise, settlement or adjustment reached as a result of such audit shall be held in strict confidence by Tenant and its officers, agents, and employees and as a condition to such audit, the Tenant’s auditor shall execute a written agreement agreeing that the auditor is not being compensated on a contingency fee basis and that all information obtained through such audit as well as any compromise, settlement or adjustment reached as a result of such audit, shall be held in strict confidence and shall not be revealed in any manner to any person other than to Tenant and Tenant’s professional advisers except upon the prior written consent of the Landlord, which consent shall not be unreasonably withheld, or if required pursuant to any litigation between Landlord and Tenant.

No subtenant shall have any right to conduct an audit.

THE NEXT PAGE IS THE SIGNATUARE PAGE.

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IN WITNESS WHEREOF, the parties hereto have executed this First Amendment to Lease or have caused their duly authorized representatives to execute same in four (4) original counterparts, as of the day and year first above written.

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