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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549
------------------------
FORM 10-K
(X) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d)
OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended: December 31, 2004

OR
( ) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF
THE SECURITIES EXCHANGE ACT OF 1934
COMMISSION FILE NUMBER 1-10173

------------------------

LIFE SCIENCES RESEARCH INC.

(EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
MARYLAND
(JURISDICTION OF INCORPORATION OR ORGANIZATION)
52-2340150
IRS Employer Identification No.
PO BOX 2360, METTLERS ROAD, EAST MILLSTONE, NJ 08875-2360
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)
REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: 732 649-9961
SECURITIES REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT:
None
SECURITIES REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT:

- ------------------------------------- ------------------------------------
TITLE OF EACH CLASS NAME OF EACH EXCHANGE ON WHICH
REGISTERED
Voting Common Stock $0.01 par value OTCBB

Indicate by check mark whether the Registrant (1) has filed all reports required
to be filed by Section 13 or Section 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such report), and (2) has been subject to such
filing requirements for the past 90 days.

Yes X No __


Indicate by check mark if disclosure of delinquent filers pursuant to Item 405
of Regulation S-K is not contained herein, and will not be contained, to the
best of the registrant's knowledge, in definitive proxy or information
statements incorporated by reference in Part III of this Form 10-K or any
amendment of this Form 10-K. [ x ]

Indicate by check mark whether the registrant is an accelerated filer (as
defined in Rule 12b-2 of the Act)

Yes _ No X

The aggregate market value of the Voting Common Stock held by non-affiliates of
the Registrant was $49,811,748 on June 30, 2004, the last business day of
Registrant's most recently completed second fiscal quarter.

Indicate the number of outstanding shares of each of the Registrant's classes of
common stock as of the latest practicable date.

As of March 24, 2005 the Registrant had outstanding 12,464,339 shares
of Voting Common Stock







TABLE OF CONTENTS


ITEM PAGE

PART I


1. Business ........................................................................ 3

2. Properties ...................................................................... 13

3. Legal Proceedings ............................................................... 13

4. Submission of Matters to a Vote of Security Holders.............................. 13

PART II

5. Market For Registrant's Common Equity, Related Stockholder Matters and
Issuer Purchases of Equity Securities............................................ 14

6. Selected Consolidated Financial Data ............................................ 19

7. Management's Discussion and Analysis of Financial Condition and Results
of Operation .................................................................... 21

7A. Quantitative and Qualitative Disclosures About Market Risk....................... 34

8. Financial Statements and Supplementary Data ..................................... 35

9. Changes in and Disagreements with Accountants on Accounting and Financial
Disclosure ...................................................................... 64

9(a) Controls and Procedures ......................................................... 64

PART III

10. Directors and Executive Officers of the Registrant............................... 65

11. Executive Compensation .......................................................... 67

12. Security Ownership of Certain Beneficial Owners and Management
and Related Stockholder Matters................................................. 73

13. Certain Relationships and Related Transactions .................................. 74

14. Principal Accountant Fees and Services .......................................... 75

PART IV

15. Exhibits and Financial Statements Schedules...................................... 76






PART I

ITEM 1. BUSINESS

INTRODUCTION

Life Sciences Research, Inc. ("LSR") and subsidiaries (collectively, the
"Company") is a global contract research organization, offering worldwide
pre-clinical and non-clinical testing for biological safety evaluation research
services to pharmaceutical, biotechnology, agrochemical and industrial chemical
companies. The Company serves the rapidly evolving regulatory and commercial
requirements to perform safety evaluations on new pharmaceutical compounds and
chemical compounds contained within the products that humans use, eat and are
otherwise exposed to. In addition, the Company tests the effect of such
compounds on the environment and also performs work on assessing the safety and
efficacy of veterinary products.

As the Company continues to build on improving fundamentals, we have the
following strategy and goals:

o To grow to significant profitability and improved return on investment for
our shareholders.
o To be appreciated as the listening, understanding and reliable partner in
creative compound development and safety assessment and to be the first
choice for the industries we serve.
o To provide our employees with the opportunity for individual development in
a caring, rewarding and safe working environment.
o To be recognized positively in the local communities in which we operate.

LSR was incorporated on July 19, 2001 as a Maryland corporation. It was formed
specifically for the purpose of making a recommended all share offer (the
"Offer") for Life Sciences Research Ltd (LSR Ltd) formerly Huntingdon Life
Sciences Group plc ("Huntingdon"). The Offer was made on October 16, 2001 and
was declared unconditional on January 10, 2002, at which time LSR acquired
approximately 89% of the outstanding ordinary shares of Huntingdon in exchange
for approximately 5.3 million shares of LSR Voting Common Stock. The subsequent
offer period expired on February 7, 2002, by which time approximately 92% of the
outstanding ordinary shares had been offered for exchange. LSR completed its
compulsory purchase under UK law of the remaining outstanding ordinary shares of
Huntingdon on March 26, 2002 at which time Huntingdon became a wholly owned
subsidiary of LSR, in exchange for a total of approximately 5.9 million shares
of LSR Voting Common Stock (the "Exchange Offer").

Under accounting principles generally accepted in the United States ("US GAAP"),
the Company whose stockholders retain the majority interest in a combined
business must be treated as the acquirer for accounting purposes. Accordingly,
the Exchange Offer is accounted for as a reverse acquisition for financial
reporting purposes. The reverse acquisition is deemed a capital transaction and
the net assets of Huntingdon (the accounting acquirer) are carried forward to
LSR (the legal acquirer and the reporting entity) at their carrying value before
the combination. Although Huntingdon was deemed to be the acquiring corporation
for financial accounting and reporting purposes, the legal status of LSR as the
surviving corporation does not change. The relevant acquisition process utilizes
the capital structure of LSR and the assets and liabilities of Huntingdon are
recorded at historical cost. The equity of LSR is the historical equity of
Huntingdon, retroactively restated to reflect the number of shares issued in the
Exchange Offer.

LSR's executive office is based at the Princeton Research Center in East
Millstone, New Jersey.

HISTORY

Huntingdon was originally incorporated in the UK in 1951 as a limited liability
company to provide contract research services to the UK pharmaceutical,
agrochemical and food industries. In 1964 it was acquired by the US company,
Becton Dickinson. Over the next 20 years it successfully established itself as a
leading Contract Research Organization (CRO) with business across a number of
sectors and with a number of leading pharmaceutical and agrochemical companies.
In April 1983, Huntingdon was re-registered as a public limited company and in
1988 it was floated on the London Stock Exchange. In early 1989 Huntingdon
obtained a listing for its ADR's on the New York Stock Exchange.

In 1995, it acquired the toxicology business of APBI, which included
laboratories near Princeton, New Jersey and Newcastle and Eye, Suffolk in the UK
for a total consideration of $43 million. Immediately upon acquisition, the
toxicology business of APBI in the UK was merged with that of Huntingdon
Research Center Limited and the name of that company changed to Huntingdon Life
Sciences Limited. The US business acquired operates as Huntingdon Life Sciences
Inc.

In the first half of 1997, allegations were made relating to animal care and
Good Laboratory Practice (GLP) against Huntingdon's operating subsidiaries in
the UK and US. Those allegations and the UK Government's subsequent statement in
the House of Commons in July 1997 about its investigation into those allegations
caused the cancellation of booked orders and a decline in new orders.
Significant trading losses and cash outflows resulted during the period from mid
1997 through 1998. Given the medium to long term element of many of Huntingdon's
activities and the reluctance of clients to place new work until its finances
were stabilized, Huntingdon required a substantial injection of finance to both
initially restore confidence and then to fund operations during the period until
it returned to profitability.

On September 2, 1998 a group of new investors, led by Andrew Baker, subscribed
(pound)15 million ($25 million) for 120 million ordinary shares while existing
shareholders and institutional investors took up a further 57 million shares,
contributing (pound)7.1 million ($11.8 million). After expenses of (pound)1.7
million ($2.9 million), the issue of shares raised (pound)20.4 million ($33.9
million). On the same date Huntingdon's bankers agreed to continue Huntingdon's
credit facilities at (pound)24.5 million ($40.8 million) until August 31, 2000
and this amount remained fully drawn down. This debt was refinanced on January
20, 2001 by means of a loan from HLSF LLC, a subsidiary company of the Stephens
Group Inc., a related party at the time, which has since transferred the debt to
an unrelated third party. It is now repayable on June 30, 2006.

Since the involvement of the new investor group in 1998, the management team,
led by Brian Cass, believes that LSR has successfully addressed many of the
Company's past difficulties. Relationships with customers have been restored and
sales are growing at an encouraging rate.

In November 1999, a new so called "animal rights" group known as "Stop
Huntingdon Animal Cruelty" (SHAC) was formed in the UK with Huntingdon as its
target. Since then, activists in both the UK and the US have continued focusing
on Huntingdon (now LSR), its staff and directors, but also many other
stakeholders in the business, including shareholders, financial institutions,
suppliers and customers. For further details see Other Information Pertaining to
the Company - Animal Rights Activism, below.

In October 2001, LSR commenced the Offer for Huntingdon, which was completed in
March 2002 with Huntingdon becoming a wholly owned subsidiary of LSR. The effect
of the Offer was to re-domicile Huntingdon's corporate and legal existence to
the US. As a US company incorporated in Maryland, LSR benefits from a more
hospitable corporate environment, including corporate governance and privacy
rules and regulations that benefit LSR security holders. Moreover, the
investment community in the US is more familiar with the CRO industry, since
most publicly traded CRO's are domiciled in the US.

In March 2002, LSR completed a private placement of approximately 5.1 million
shares of Voting Common Stock at a per share subscription price of $1.50 per
share.

In April 2002, LSR began trading its common stock on the US Over the Counter
Bulletin Board (OTCBB).

DESCRIPTION OF BUSINESS

The Company provides pre-clinical and non-clinical biological safety evaluation
research services to most of the world's leading pharmaceutical, biotechnology,
agrochemical and industrial chemical companies. The purpose of this safety
evaluation is to identify risks to humans, animals or the environment resulting
from the use or manufacture of a wide range of chemicals, which are essential
components of our clients' products. The Company's services are designed to meet
the regulatory requirements of governments around the world.

The Company's aim is to develop its business within these markets, principally
in the pharmaceutical sector, and through organic growth. In doing so, the
Company expects to benefit from strong drug pipelines in the pharmaceutical
industry and a growing trend towards outsourcing as clients focus more internal
resources on research in the search for new compounds.

The Company's sales and marketing functions are specifically focused on two main
groups, pharmaceutical and non-pharmaceutical customers. As much of the research
activity conducted for these two customer groups is similar, the Company
believes it is appropriate, operationally, to view this as one business.

Pharmaceuticals and Biopharmaceuticals

The pharmaceutical research and development pathway is shown below:



- ----------------------------- ---------------------------------------------------------------------- ----------------

DRUG DISCOVERY DRUG DEVELOPMENT MARKETING
- ----------------------------- ---------------------------------------------------------------------- ----------------
NON-CLINICAL CLINICAL
Pre-Clinical
Toxicology
Pharmacology
Drug Metabolism
Pharmacokinetics
Chemical Synthesis Phase I Phase II Phase III Phase IV
Safety Efficacy Long Term Post marketing
efficacy surveillance
------------------ --------------- -------------
LONG TERM SAFETY STUDIES

----------------------------------------------------------------------



The Company performs non-clinical testing in support of the drug development
process. This primarily consists of pre-clinical outsourcing from the
pharmaceutical industry, as well as further longer term non-clinical safety
testing that is performed in parallel to human clinical testing (such as
carcinogenicity studies and safety studies relating to reproductive
implications). Essentially all of this work is performed as a result of
regulatory requirements that seek to minimize the risks associated with the
ultimate testing and use of these compounds in humans. Pre-clinical testing
includes studies conducted prior to the compound's exposure to humans. This
helps to evaluate both how the drug affects the body as well as how the body
affects the drug. Utilizing advanced laboratory and toxicological evaluations,
this work helps assess safe and appropriate dose regimens. Non-clinical testing,
which includes longer term studies often conducted concurrently with clinical
(human) testing, can focus on identifying and avoiding the longer term cancer
implications of exposure to the compound, or relating to the potential of
possible reproductive implications. Over 80% of the Company's orders are derived
from this pharmaceutical sector. The Company views its non-clinical market as
extending to "proof of concept" in man (Phase 2A) and to analytical chemistry
support for clinical trials. Since 1999, the Company has had collaborative
relationships with a number of Phase I clinical trial units and offers
centralized clinical laboratory services in support of clinical trials.

The Company has also actively pursued opportunities to extend its range of
capabilities supporting late stage drug discovery, focused around invitro and
invivo models for lead candidate drug characterization and optimization. This
growing range of biological services is intended to position the Company to take
advantage of the increasing demand for a greater understanding of the physical,
chemical and biological properties of intended therapeutics prior to the
commencement of pre-clinical and clinical testing.

The outsourced market for the late stage clinical trials (Phase 3 and beyond) is
also relevant to the Company. While the Company does not preclude entering this
market in the future, it has no plan to do so in the foreseeable future, as it
is a very different business and one in which a number of major companies are
already firmly established.

Market Growth

It is estimated that the pharmaceutical industry annual research and development
(R & D) spending is over $50 billion per year and is growing at around 10% per
annum. Approximately 20% of this is devoted solely to pre-clinical testing and a
further 10% to central laboratory services. The Company believes that
approximately 20-25% of the pre-clinical is outsourced and almost all the
central laboratory which means that the Company is today competing in a market
which exceeds $3 billion. It is widely believed that this market will continue
to grow for the foreseeable future, both in absolute dollar amount and in the
percentage of pre-clinical work that is outsourced.

The market for these services is growing, among other things, due to the
following:

o New drug discovery is growing fueled by new technologies and strong
profits. The information obtained from the Human Genome Project has led to
the greater understanding of the pathways underlying the mechanism of
disease. This has, in turn, led to a growth in the use and understanding of
the `omics (genomics, proteomics, etc.) and increased focus on target
receptor based discovery.

o Preclinical development services should experience the higher growth first,
as they are at the front end to receive the anticipated wave of new drug
candidates generated by advances in drug discovery technologies.

o The need to replace earnings from drugs coming off patent, and anticipated
decreasing price flexibility in key markets, is driving an increase in the
number of drugs being put into development.

o It is estimated there has been a 30% increase in the numbers of projects in
pre-clinical development in the last four years.

o There is also a growing trend towards the outsourcing of development work
as clients focus more internal resource on discovery research in the search
for new lead compounds.

o The biotechnology industry has become a significant source of business for
the Company. The number of drugs produced by the biotechnology industry,
which require US Food and Drug Administration (FDA) approval has grown
substantially over the past decade. Many biotechnology companies have
strategically chosen not to invest in asset intensive development and
regulatory safety evaluation, but rather to outsource major areas of R & D
and utilize CROs to perform these services. This frees them from the
inefficient utilization of in-house capabilities due to their sporadic and
varied demand for these capabilities.

o The process of consolidation within the pharmaceutical industry is also
accelerating the move towards outsourcing. While there is a short-term
negative impact from mergers with development pipelines being rationalized
and a focus on integration rather than development, longer-term resources
are increasingly invested in in-house facilities for discovery and lead
optimization rather than development and regulatory safety evaluation.
Undertaking development work and safety evaluation is the Company's core
business.

As a result of these, amongst other factors, it is believed that the overall
market for outsourced services is estimated to be growing at a rate at least
equal to the growth of research and development expenditure by the
pharmaceutical industry.

Non-Pharmaceuticals

The Company currently generates approximately 20% of its orders from safety and
efficacy testing of compounds for the agrochemical, industrial chemical, and
veterinary and food industries. During 2004 non-pharmaceutical revenues were
approximately the same as the prior year and a declining percent of total
revenues, which is predicted to continue. The work involved has many
similarities and often uses many of the same facilities, equipment, and
scientific disciplines to those employed in pre-clinical testing of
pharmaceutical compounds.

The Company's business in these areas is again driven by governmental regulatory
requirements. The Company's services address safety concerns surrounding a
diverse range of products, spanning such areas as agricultural herbicides and
other pesticides, medical devices, veterinary medicines, and specialty chemicals
used in the manufacture of pharmaceutical intermediates, and manufactured
foodstuffs and products. The Company believes it is a clear market leader in
programs designed to assess the safety, environmental impact and efficacy of
agricultural chemicals as well as in programs to take new specialty chemicals to
market.




Market Growth

It is estimated that the worldwide market for outsourced contract research from
non-pharmaceutical industries is approximately $300 million. The growth in the
non-pharmaceutical business is driven both by the introduction of novel
compounds, and by legislation concerning the safety and environmental impact of
existing products.

The Company believes that this segment is likely to experience relatively low
growth in the next few years, although a number of market segments included in
this broad area of business have the potential for some growth in the future due
to the following:

o Continued implementation of testing requirements for `high production
volume' (HPV) chemical products in Europe and the US.
o Introduction of new legislation for the notification of new and existing
chemicals that are in use within the European Union (REACH).
o Safety testing of specific formulations of crop protection products on a
country-by-country basis within the European Union (91/414).
o More stringent regulations affecting compounds, which have the potential to
adversely affect the environment, (e.g. biocides and endocrine disrupters).
o Growth in concerns over food safety, (e.g. additives and genetically
modified foods, and the introduction of `nutraceuticals').

Safety testing in these industries is also more likely to be outsourced as,
unlike the pharmaceutical industry, fewer companies have comprehensive internal
laboratory facilities. While overall R & D is not growing, we believe that
increased outsourcing could provide business opportunities in this market.

Customers

The Company offers worldwide pre-clinical and non-clinical testing for
biological safety evaluation research services to pharmaceutical, biotechnology,
agrochemical and industrial chemical companies. In 2004 the Company received
orders from companies ranging from the largest in their industries to small and
start-up organizations. 37 clients placed over $1 million of orders with the
Company and the ten largest clients accounted for approximately 45% of orders.
No single client accounted for more than 10% of net revenues for 2004.

For net revenues from clients, assets attributable to each of the Company's
business segments, other segment information and a geographical analysis of
revenues from clients (based on the location of the client) for each of the last
three fiscal years, see note 13 to the audited consolidated financial statements
included elsewhere in this Annual Report.

Backlog

The majority of the Company's net revenues are earned under contracts, which
generally range in duration from a few months to three years. Revenue from these
contracts is generally recognized over the term of the contract as services are
rendered. The Company maintains an order backlog to track anticipated net
revenues for work that has yet to be earned. Aggregate backlog at December 31,
2004 was $119 million compared to $93.5 million at December 31, 2003, which
represents an increase of 14% exclusive of the impact of foreign exchange.



COMPETITION

Competition in both the pharmaceutical and non-pharmaceutical market segments
ranges from the in-house R&D divisions of large pharmaceutical, agrochemical and
industrial chemical companies who perform their own safety assessments, to "full
service" providers - CROs like LSR, who provide a full range of non-clinical
safety services to the industries (such as Covance Inc., and Charles River
Laboratories International, Inc., which acquired Inveresk Research in 2004) and
"niche" suppliers focusing on specific services, geographic areas, or industries
(such as MDS, WIL Research, or SafePharm Labs).

GOVERNMENT REGULATION OF OPERATIONS

Regulatory agencies

Since the services provided by the Company are used to support pharmaceutical,
biotechnological, chemical or agrochemical product approval applications, its
laboratories are subject to both formal and informal inspections by appropriate
regulatory and supervisory authorities, as well as by representatives from
client companies. The Company is regularly inspected by US, Japan and UK
governmental agencies because of the number and complexities of the studies it
undertakes. In 1979, the US Food and Drug Administration (FDA) promulgated the
Good Laboratory Practice (GLP) regulations, defining the standards under which
biological safety evaluations are to be conducted. Other governmental agencies
such as the Environmental Protection Agency (EPA), the Japanese Ministry Of
Health and Welfare, the Japanese Ministry of Agriculture, Forestry and
Fisheries, and the UK Department of Health, have introduced
compliance-monitoring programs with similar GLP standards. During 2004 the
Company in the UK had 2 GLP inspections; and in the US an EPA (Environmental
Protection Agency) inspection. The Company has had numerous such inspections
since 1995.

The Company's laboratory in the US is subject to the United States Department of
Agriculture (USDA) Animal Welfare Regulations (Title 9, Code of Federal
Regulations, Subchapter A). The laboratory is regularly inspected by USDA
officials for compliance with these regulations. Compliance is assured through
an Institutional Animal Care and Use Committee, comprising staff from a broad
range of disciplines within the Company and including external representation.
Furthermore, in the US there is a voluntary certification program run by an
independent and internationally recognized organization, the Association for
Assessment and Accreditation of Laboratory Animal Care (AAALAC). The Company's
laboratories in both the US and UK are accredited under this program. The
Company's pre-clinical services are subject to industry standards for the
conduct of research and development studies that are embodied in the regulations
for GLP. The FDA and other regulatory authorities require the test results
submitted to such authorities be based on studies conducted in accordance with
GLP. The Company must also maintain reports for each study for specified periods
for auditing by the study sponsor and by FDA or other regulatory authorities.

The Company's operations in the UK are regulated by the Animals (Scientific
Procedures) Act 1986. This legislation, administered by the UK Home Office,
provides for the control of scientific procedures carried out on animals and
regulation of their environment. Personal licenses (the Company has
approximately 240 licensees) are issued by the UK Home Office to personnel who
are competent to perform regulated procedures and each program of work must be
authorized in advance by a Project Licensee. Premises where procedures are
carried out must also be formally designated by the UK Home Office.
Consultations and inspections are regularly undertaken in order to ensure
continued compliance with regulatory and legislative requirements, the Company
had 18 such visits in 2004.

At each of its research centers, the Company ensures the availability of
suitably experienced and qualified veterinary staff backed by a 24-hour call out
system.

COMPLIANCE WITH ENVIRONMENTAL REGULATIONS

While the Company conducts its business to comply with certain environmental
regulations, compliance with such regulations does not impact significantly on
its earnings or competitive position. Management believes that its operations
are currently in material compliance with all applicable environmental
regulations.

OTHER INFORMATION PERTAINING TO THE COMPANY

Human Resources

The Company's most important resource is its people. They have created the
Company's knowledge base, its expertise and its excellent scientific reputation.
Scientists from the Company are represented at the highest levels in several US,
UK and international committees on safety and toxicity testing. Several staff
members are considered leaders in their respective fields. They frequently
lecture at scientific seminars and regularly publish articles in scientific
journals. This recognition has resulted in frequent assignments from clients for
consultation services. Some of the Company's staff serve by invitation or
election on a number of scientific and industrial advisory panels and groups of
certain organizations and agencies such as the FDA, the EPA, the UK Department
of Health, and the World Health Organization.

To ensure that this experience and expertise is transmitted throughout the
organization, the Company conducts training programs. For example, the Company's
study director training programs train graduate staff in all phases of
toxicology. Also, in conjunction with the Institute of Animal Technology, the
Company maintains what it believes to be one of the largest animal technician
training programs in the world. The Company employs approximately 240 licensed
personnel.

The number of employees in the Company at December 31, 2004 and 2003 were as
follows:

2004 2003
US ............. 247 223
UK ............. 1,129 1,233
Japan .......... 11 11
----------- -----------
1,387 1,467
----------- -----------

The reduction in the UK headcount is a result of the restructuring of the
business in the first quarter of 2004, arising from a consolidation of duplicate
facilities in response to changes in the market, particularly for
non-pharmaceutical services.

Management and Labor Relations

The Company's labor force is non-union and there has never been any disruption
of the business through strikes or other employee action. The Company regularly
reviews its pay and benefits packages and believes that its labor relations,
policies and practices and management structure are appropriate to support its
competitive position.

Acquisition of Huntingdon Life Sciences KK (HLS KK)

HLSKK has acted as the Company's marketing representative in Japan since 1996.
This Company was a joint venture, 50% of which was owned by Huntingdon. On July
1, 2003, the remaining 50% of the shares in HLS KK, not previously owned by
Huntingdon, was purchased, resulting in HLS KK becoming a wholly owned
subsidiary of Huntingdon. The purchase price is payable over a three year
period, and is equal to the greater of (a) $1 million or (b) the commission
which would have been paid if the purchase had not happened at rates of between
2.5% and 4.5% of billings generated. Payments during that three year period
shall be made at the rate which had been in effect for commissions prior to the
acquisition, and is payable semi-annually. The amount paid in 2004 was $577,000
(there were no payments made in 2003 that pertained to the purchase of the final
50% interest).

Prior to July 1, 2003, the shares owned by Huntingdon in HLS KK were held as an
investment, as the day to day control of HLS KK was not exercised by the
Company.



Research and Development

In addition to experience gained through research activities performed for
clients, the Company engages in research in order to respond to the changing
needs of clients and to maintain competitiveness within the industries in which
it operates. Most of the research undertaken, however, is an inherent part of
the research carried out on behalf of clients in completing studies and as such
it is not identified separately.

Know-how and Patents

The Company believes that its proprietary know-how plays an important role in
the success of its business. Where the Company considers it appropriate, steps
are taken to protect its know-how through confidentiality agreements and
protection through registration of title or use. However the Company has no
patents, trademarks, licenses, franchises or concessions which are material and
upon which any of the services offered are dependent.

Quality Assurance

The Company maintains extensive quality assurance programs, designed to ensure
that all testing programs meet client requirements, as well as all relevant
codes, standards and regulations. Based on a Master Schedule, periodic
inspections are conducted as testing programs are performed to assure adherence
to project specifications or protocols and final reports are extensively
inspected to ensure consistency with data collected.

Animal Rights Activism

In parallel with an increase in so called "animal rights" activity
internationally targeting organizations in the CRO, academic, and medical
research community, a new campaign group (Stop Huntingdon Animal Cruelty or
SHAC) was formed in the UK during November 1999 with Huntingdon as its target.
SHAC's broad aim is to end all animal research, while its immediate and publicly
stated goal at that time was to "shut HLS down within three years". During 2000,
this campaign intensified with any stakeholder in Huntingdon becoming a
potential target; this included staff, directors, institutional and personal
shareholders, customers, financial institutions and other suppliers. The
protests took many forms, including demonstrations outside the Company's
facilities and in local towns; distribution of propaganda; abuse, intimidation
and threats directed at many of the stakeholders listed above; and in some cases
violence.

During 2001 and 2002 the incidents of violent protest in the UK appeared to
partly diminish. However, activists increased the focus of protest activities on
the Company's financial institutions, in unsuccessful attempts to deprive
Huntingdon of its bank financing and to defeat the re-domiciling transaction to
the US. During the same period, in large part due to the successful US
re-domiciling, animal rights activities of SHAC and the other groups expanded to
the US, with a focus on the Company's stakeholders and suspected stakeholders,
market makers and senior staff and directors.

To counter this "animal rights" campaign, the Company has adopted a strategy of
openness and direct cooperation with all its stakeholders, the media and the
local communities. The Company has taken every opportunity to promote the value
of the work it does in helping its customers bring to market safe and effective
products. Members of the media, schools, local groups and national bodies have
visited the Company's facilities, toured the animal facilities and laboratories,
and talked with staff. These visitors have been consistently impressed with the
Company's ethics, standards of animal welfare and the professionalism of its
staff. As a consequence of the Company's high profile public relations
activities and the irrationality of the "animal rights" messages, media coverage
has become increasingly positive throughout the duration of the campaign. In
both the US and the UK the media has consistently condemned the actions of the
SHAC campaign.

As a result of and in conjunction with the Company's leadership on this issue,
there has been a marked increase in communication campaigns to educate the
general population about the valuable benefits of animal based research, the
commitment to and progress in development of non-animal based alternatives, and
the high standard of animal welfare in which this work is conducted. Our
clients' recognition for our scientific and professional integrity and
leadership was evident in the granting in October 2001 of the prestigious UK
Pharma Industry Individual Achievement Award to Brian Cass, the Company's
President and Managing Director. In June 2002, in further recognition of his
contribution to science and professional achievements, Mr. Cass was appointed as
a Commander in the Most Excellent Order of the British Empire (CBE). The highly
prestigious CBE is awarded on merit, for exceptional achievement or service; it
is recommended by the Prime Minister of England but decided by the Queen of
England.

In the UK the Company has successfully lobbied politicians and the British
parliament, with great support from industry trade bodies such as the
Association of the British Pharmaceutical Industry, Bioindustry Association, and
Research Defence Society. As a result, the British Government has made very
positive statements in support of the Company and has been extremely critical of
the illegal acts of some "animal rights" supporters. The Government has
introduced legislation to offer more protection to those targeted and is
encouraging the police and courts to ensure the law is enforced. This national
initiative continues to develop, particularly as the government and police deal
with protecting other animal rights targets in the UK, including academic
institutions. Of particular note, in January 2005 the UK Department of Trade and
Industry announced proposed amendments to the previously introduced Serious
Organized Crime and Police Bill that would create a new crime of "economic
sabotage" by animal rights extremists. The new measures are designed to tackle
the intimidation of businesses by animal rights extremists by protecting firms
doing business with animal research facilities. These new measures are in
addition to other provisions of the bill introduced in 2004 that would create a
new offense of protesting outside someone's home in such a way that causes
harassment, alarm or distress to residents; provide additional police power to
direct protestors to leave home protests; and extend the Protection from
Harassment Act to cover various types of harassment by animal rights extremists.

In April 2003 the Company obtained from the London High Court of Justice a
groundbreaking legal injunction protecting its employees against harassment from
SHAC and similar animal rights activists. The order, obtained under the
Protection from Harassment Act, bans protesters from approaching within 50 yards
of employees homes and sets up similar exclusion zones around the Company's two
UK research centers. Several months later, a group of five large Japanese
pharmaceutical companies followed a similar course in obtaining protective
injunctions for their employees who were being harassed. Since then, other
companies similarly targeted by animal rights extremists have obtained
injunctions of this type. Notably during 2004, Oxford University became the
target of animal rights extremists attempting to halt the construction of
on-campus animal research facilities. The University also successfully obtained
a broad-ranging injunction against such protests.

Although the animal rights movement is more recent and less developed in the US
and appears to enjoy less public support than in the UK, the Company is
addressing it proactively with actions similar to those it has utilized in the
UK. These steps include a strategy of openness and media cooperation;
legislative and regulatory lobbying in association with industry trade bodies
such as Americans for Medical Progress, National Association for Biomedical
Research and the Foundation for Biomedical Research; and legal actions including
close cooperation with law enforcement authorities at all levels. For example,
following incidents of vandalism at or following home protests against the
Company's US employees, the Company obtained orders of the New Jersey Superior
Court, the New York Supreme Court and the California Supreme Court placing
restrictions on home protests by animal rights activists as well as limits on
the scope of protests at the Company's Princeton Research Center. During 2002,
criminal indictments were brought against SHAC extremists in New York City and
Boston. In the New York prosecution, felony convictions, including prison terms,
have been handed down. In Washington D.C., legislation was enacted in May 2002
which significantly increased the penalties under the Animal Enterprise
Terrorism Act for acts of vandalism against medical research and animal based
research facilities. In May 2004, seven leading US animal rights extremists,
including Kevin Kjonas, the President of SHAC-USA, were arrested and criminally
indicted by the New Jersey US Attorney's Office on federal charges of animal
enterprise terrorism, interstate stalking and conspiracy to engage in interstate
stalking. Each of the charges carries a maximum penalty of three to five years
in federal prison and a $250,000 fine for each count. An additional criminal
charge of conspiracy to anonymously utilize a telecommunications device to
abuse, threaten and harass persons was added to the indictment in September
2004. A trial date of June 1, 2005 has been set.


Management recognizes that there has long been, and expects that there will
continue to be, individuals with strong views that animals should not be used
under any circumstances for the betterment of humanity, including for animal
based research. Regardless of whether there continues to be a direct impact from
this political issue on the Company's business, the Company remains committed to
continuing its initiatives to educate the community to the value of animal based
medical research, to advancing the important strides our industry has made in
animal welfare, and to supporting with state of the art science and techniques
our clients' desire to maximize the safety of vital new compounds being
developed for the betterment of society.

Available Information

Our Internet website is located at http://www.lsrinc.net. The reference to our
Internet website does not constitute incorporation by reference of the
information contained on or hyperlinked from our Internet website and should not
be considered part of this document.

The public may read and copy any materials we file with the Securities and
Exchange Commission ("SEC") at the SEC's Public Reference Room at 450 Fifth
Street, N.W.. Washington, D.C. 20549. The public may obtain information on the
operation of the Public Reference Rooms by calling the SEC at 1-800-SEC-0330.
The SEC also maintains an Internet website that contains reports, proxy and
information statements and other information regarding issuers that file
electronically with the SEC. The SEC's Internet website is located at
http://www.sec.gov.


ITEM 2. PROPERTIES

The Company's head office is situated within the Princeton Research Center in
New Jersey.

The Company believes that its facilities, described below, are adequate for its
operations and that suitable additional space will be available if and when
needed.

The following table shows the location of the facilities of the Company,
approximate size, based on occupancy, and the principal activities conducted at
such facilities each of which is owned by the Company.



Laboratories
Location and Offices Size Principal Activities
- -------- ----------- ---- --------------------

Princeton Research Center, East 150,000 sq.ft. 53.5 acres Laboratories, animal accommodation and
Millstone, NJ, US offices
Huntingdon Research Center, 559,000 sq.ft. 80 acres Laboratories, animal accommodation and
Huntingdon, England offices
Eye Research Center, Eye, England 257,000 sq.ft. 28 acres Laboratories, animal accommodation and
offices



ITEM 3. LEGAL PROCEEDINGS

The Company is party to certain legal actions arising out of the normal course
of its business. In management's opinion, none of these actions will have a
material effect on the Company's operations, financial condition or liquidity.
No form of proceedings has been brought, instigated or is known to be
contemplated against the Company by any governmental agency.


ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

The Company's 2004 annual meeting of stockholders was held on December 2, 2004.
The only matter submitted for a vote of stockholders was the election of
directors for a one-year term. All five of the Company's directors at the time
were re-elected for an additional one-year term:


Name For Withheld

Andrew Baker 9,078,505 518
Gabor Balthazar 9,078,990 1,003
Brian Cass 9,078,505 488
Afonso Junqueiras 9,078,051 5,102
Yaya Sesay 9,078,551 16,302


In addition, 2,760 shares abstained from voting.




PART II

ITEM 5. MARKET FOR REGISTRANT'S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND
ISSUER PURCHASES OF EQUITY SECURITIES

LSR's Voting Common Stock trades on the Over the Counter Bulletin Board (OTCBB)
Market under the symbol "LSRI". The closing market price of the Voting Common
Stock on March 24, 2005 was $12.65 per share.

Until January 24, 2002 Huntingdon's Ordinary Shares were listed on the London
Stock Exchange Ltd., under the Stock Exchange Automated Quotation symbol "HTD".
The company completed its re-domiciling from the UK to the US on March 26, 2002
with a conversion ratio of 50:1 for the HTD common shares to LSR common shares
(or a ratio of 2 HTD ADRs per 1 LSR common share). LSR common stock commenced
trading on the OTCBB on April 8, 2002.

The Company's common stock traded on the OTCBB during 2003 and 2004. The high
and low quarterly sales price of LSR's common stock on the OTCBB for the two
years to December 31, 2004 were as follows:

HIGH SALES LOW SALES
QUARTER ENDED PRICE PRICE
- -------------
------------------ -----------------
$ $
March 31, 2003 2.80 1.80
June 30, 2003 2.90 1.80
September 30, 2003 3.50 1.80
December 31, 2003 2.70 1.50
March 31, 2004 2.80 1.75
June 30, 2004 5.00 1.60
September 30, 2004 7.15 4.00
December 31, 2004 12.50 6.95

The Company has not paid any cash dividends in the two most recent fiscal years
and does not expect to declare or pay cash dividends on the Company's Voting
Common Stock in the near future. The Board of Directors will determine the
extent to which legally available funds will be used to pay dividends. In making
decisions regarding dividends, the Board will exercise its business judgment and
will take into account such matters as results of operations and financial
condition and any then-existing or proposed commitments for the use of available
funds.

See Item 7 for discussion of restrictions impacting the export or import of
capital or that affect the remittance of dividends or other payments to
non-resident holders of the Company's equity.

As of March 24, 2005, LSR had 2,202 holders of record of Voting Common Stock.

On March 28, 2002, LSR closed the sale in a private placement of an aggregate of
5,085,334 shares of voting Common Stock at a price of $1.50 per share. Of the
aggregate proceeds of approximately $7.6 million, $4.4 million was in cash, $2.4
million represented conversion into equity of debt owed to Mr. Baker ($2.1
million) and Focused Healthcare Partners ("FHP") ($0.3 million) and $825,000 was
paid with promissory notes. $128,000 of such promissory notes have been repaid
to the end of 2004.

Equity Incentive Plans

LSR 2001 Equity Incentive Plan (the "LSR 2001 Equity Incentive Plan")

The LSR Board has adopted the LSR 2001 Equity Incentive Plan. Adoption of the
LSR 2001 Equity Incentive Plan enables LSR to use stock options (and other
stock-based awards) as a means to attract, retain and motivate key personnel.
This stock option plan was approved by the shareholders of LSR, prior to the
acquisition of Huntingdon.

Awards under the LSR 2001 Equity Incentive Plan (which has designated the
Compensation Committee for such purpose) may be granted by a committee
designated by the LSR Board pursuant to the terms of the LSR 2001 Equity
Incentive Plan and may include: (i) options to purchase shares of LSR Voting
Common Stock, including incentive stock options ("ISOs"), non-qualified stock
options or both; (ii) stock appreciation rights ("SARs"), whether in conjunction
with the grant of stock options or independent of such grant, or stock
appreciation rights that are only exercisable in the event of a change in
control or upon other events; (iii) restricted stock consisting of shares that
are subject to forfeiture based on the failure to satisfy employment-related
restrictions; (iv) deferred stock, representing the right to receive shares of
stock in the future; (v) bonus stock and awards in lieu of cash compensation;
(vi) dividend equivalents, consisting of a right to receive cash, other awards,
or other property equal in value to dividends paid with respect to a specified
number of shares of LSR Voting Common Stock or other periodic payments; or (vii)
other awards not otherwise provided for, the value of which are based in whole
or in part upon the value of the LSR Voting Common Stock. Awards granted under
the LSR 2001 Equity Incentive Plan are generally not assignable or transferable
except pursuant to a will and by operation of law.

The flexible terms of the LSR 2001 Equity Incentive Plan are intended to, among
other things, permit the Compensation Committee to impose performance conditions
with respect to any award, thereby requiring forfeiture of all or part of any
award if performance objectives are not met or linking the time of
exercisability or settlement of an award to the attainment of performance
conditions. For awards intended to qualify as "performance-based compensation"
within the meaning of Section 162(m) of the United States Internal Revenue Code
such performance objectives shall be based solely on (i) annual return on
capital; (ii) annual earnings or earnings per share; (iii) annual cash flow
provided by operations; (iv) changes in annual revenues; (v) stock price; and/or
(vi) strategic business criteria, consisting of one or more objectives based on
meeting specified revenue, market penetration, geographic business expansion
goals, cost targets, and goals relating to acquisitions or divestitures.

LSR's Compensation Committee, which administers the 2001 LSR Equity Incentive
Plan, has the authority, among other things, to: (i) select the directors,
officers and other employees and independent contractors entitled to receive
awards under the 2001 LSR Equity Incentive Plan; (ii) determine the form of
awards, or combinations of awards, and whether such awards are to operate on a
tandem basis or in conjunction with other awards; (iii) determine the number of
shares of LSR Voting Common Stock or units or rights covered by an award; and
(iv) determine the terms and conditions of any awards granted under the 2001 LSR
Equity Incentive Plan, including any restrictions or limitations on transfer,
any vesting schedules or the acceleration of vesting schedules, any forfeiture
provision or waiver of the same and including any terms and conditions necessary
or desirable to ensure the optimal tax result for participating personnel and
the Company including by way of example to ensure that there is no tax on the
grant of the rights and that such tax only arises on the exercise of rights or
otherwise when the LSR Voting Common Stock unconditionally vests and is at the
disposal of such participating personnel. The exercise price at which shares of
LSR Voting Common Stock may be purchased pursuant to the grant of stock options
under the 2001 LSR Equity Incentive Plan is to be determined by the option
committee at the time of grant in its discretion, which discretion includes the
ability to set an exercise price that is below the fair market value of the
shares of LSR Voting Common Stock covered by such grant at the time of grant.

The number of shares of LSR Voting Common Stock that may be subject to
outstanding awards granted under the 2001 LSR Equity Incentive Plan (determined
immediately after the grant of any award) may not exceed 20 percent of the
aggregate number of shares of LSR Voting Common Stock then outstanding.

The 2001 LSR Equity Incentive Plan may be amended, altered, suspended,
discontinued, or terminated by the LSR Board without LSR Voting Common
Stockholder approval unless such approval is required by law or regulation or
under the rules of any stock exchange or automated quotation system on which LSR
Voting Common Stock is then listed or quoted. Thus, LSR Voting Common
Stockholder approval will not necessarily be required for amendments, which
might increase the cost of the plan or broaden eligibility. LSR Voting Common
Stockholder approval will not be deemed to be required under laws or regulations
that condition favorable tax treatment on such approval, although the LSR Board
may, in its discretion, seek LSR Voting Common Stockholder approval in any
circumstances in which it deems such approval advisable.



The LSR Board has designated the Compensation Committee of the Board to serve as
the stock option committee. LSR made grants under the LSR 2001 Equity Incentive
Plan on March 1, 2002 to certain directors and key employees at the time.

Grants to Directors
- -------------------
Name Number Granted
Gabor Balthazar 20,000
John Caldwell 20,000
Kirby Cramer 40,000

Grants to Named Executive Officers
- ----------------------------------
Name Number Granted
- ---- --------------
Andrew Baker 200,000
Brian Cass 200,000
Frank Bonner 35,000
Julian Griffiths 60,000
Richard Michaelson 90,000

All such options have ten-year terms; 50% of the shares subject to grant are
immediately exercisable with the remaining 50% exercisable one year after the
grant date (meaning all such options fully vested as of March 1, 2003); and all
have an exercise price of $1.50 per share, the price at which the Company sold
shares of Common Stock in the Private Placement. Options to purchase an
aggregate of 1,188,000 shares of LSR Common Stock (including those specified
above) were granted during the two years 2002 and 2003 to employees and
directors, on the terms set forth above, are listed below.

Date of Grant Numbers Granted Exercise Price
- ------------- --------------- --------------
March 1, 2002 1,142,000 $1.50
September 3, 2002 20,000 $2.40
October 21, 2002 15,000 $2.03
February 14, 2003 11,000 $1.80

In 2004, in addition to the options granted under the 2004 LTIP referred to
below, options to purchase an aggregate of 67,100 shares of LSR Common Stock
were issued, all at exercise prices equal to the market price at the date of
grant, on the terms set forth in the previous paragraph, are listed below.

Date of Grant Numbers Granted Exercise Price
- ------------- --------------- --------------
April 12, 2004 37,100 $1.85
October 28, 2004 17,400 $7.70
December 15, 2004 12,600 $9.52

2004 Long Term Incentive Plan

Effective June 1, 2004 the Company adopted the 2004 Long Term Incentive Plan
("2004 LTIP"), pursuant to the terms of the 2001 Equity Incentive Plan. The 2004
LTIP has two components: a grant of stock options, with a vesting date of March
31, 2007, and a cash bonus to be awarded in 2007 based on 2006 Company financial
performance.

Options to purchase an aggregate of 362,663 shares of common stock were granted
to 32 key employees of the Company as of June 1, 2004 under the 2004 LTIP;
55,500 of such options were granted to Andrew Baker, the Company's Chairman and
CEO, 55,500 of such options were granted to Brian Cass, the Company's Managing
Director and President, 30,303 of such options were granted to Richard
Michaelson, the Company's CFO and Secretary, and 27,750 of such options were
granted to Julian Griffiths, the Company's UK Director of Operations. The
exercise price of all such options is $3.30, the market price of LSR common
stock on June 1, 2004. All such options have ten-year terms and are exercisable
in full on March 31, 2007. At December 31, 2004, 356,419 shares under the 2004
LTIP option plan were outstanding and none were exercisable.

The following table summarizes stock option activity under the Company's option
plans.



Shares Wtd Avg.Ex Price Number of securities remaining
(000) available for future issuance

Outstanding - December 31, 2003 1,188 $1.52
Granted 430 $3.54
Lapsed (105) $1.78
Exercised (127) $1.51
----------- ------------------ --------------------------------
Outstanding - December 31, 2004 1,386 $2.13 814,000
----------- ------------------ --------------------------------
Exercisable at end of year 996
Weighted average fair value per
option granted in 2004 was $3.44


Huntingdon Life Sciences Group plc Stock Option Plans

Huntingdon Life Sciences Group plc issued options prior to December 31, 1997
pursuant to several stock option plans. However, the ability to exercise options
under all such Huntingdon plans lapsed on March 26, 2002 in connection with
LSR's acquisition of Huntingdon, except for those granted under the Unapproved
Stock Option Plan (the "Unapproved Plan"). Under the Unapproved Plan, some
options technically remain outstanding. However, such options are exercisable
only for shares of Huntingdon, a 100% wholly owned subsidiary of LSR, and as
such are considered to have no value.

Warrants

On October 9, 2001, on behalf of Huntingdon, LSR issued to Stephens Group Inc.
warrants to purchase up to 704,425 shares of LSR Voting Common Stock at a
purchase price of $1.50 per share. Stephens Group Inc. subsequently sold the
warrants to independent third parties. The LSR warrants are exercisable at any
time and will expire on October 9, 2011. These warrants arose out of
negotiations regarding the refinancing of the bank loan by the Stephens Group
Inc., (Stephens' Loan) in January 2001. In accordance with APB Opinion No. 14,
Accounting for Convertible Debt and Debt Issued with Stock Purchase Warrants
("APB 14") the warrants were recorded at their pro rata fair values in relation
to the proceeds received on the date of issuance. As a result, the value of the
warrants was $430,000. 154,425 of such warrants were exercised in 2004.

On June 11, 2002 LSR issued to FHP warrants to purchase up to 410,914 shares of
LSR Voting Common Stock at a purchase price of $1.50 per share. The LSR warrants
are exercisable at any time and will expire on June 11, 2012. These warrants
arose out of negotiations regarding the provision of the $2.9 million loan
facility made available to the Company on September 25, 2000 by Mr. Baker, who
controls FHP. In accordance with APB 14 the loan and warrants were recorded at
their pro rata fair values in relation to the proceeds received. As a result,
the value of the warrants was $250,000.

On July 25, 2002, 100,000 warrants were issued at the deemed market price on the
day of $1.50 (the same price at which the Private Placement had been completed).
On October 15, 2003, 100,000 warrants were issued, 75,000 of which were at an
exercise price of $2.50, the market price on the day, and 25,000 of which were
issued at an exercise price of $5.00 per share. On October 24, 2003, 100,000
warrants were issued at the market price on the day of $2.05. In all three
cases, these warrants were issued to independent consultants in connection with
financial and strategic advice.



A summary of warrants outstanding at December 31, 2004 is as follows:

Warrants Exercise Price Expiration Date
October 9, 2001 550,000 $1.50 October 9, 2011
June 11, 2002 410,914 $1.50 June 11, 2012
October 24, 2003 100,000 $2.05 October 24, 2013

Share purchase loan

Brian Cass, President and Managing Director of LSR, acquired 400,000 shares of
LSR Common Stock in the Private Placement. Mr Cass acquired such shares through
the delivery of two promissory notes. Both such promissory notes, each in the
amount of (pound)211,679 ($406,403), are due on March 28, 2007; bear interest at
the rate of 5% per annum; and are secured by the 200,000 shares of LSR Common
Stock purchased with the proceeds of each such loan. The due date of each
promissory note would be accelerated if Mr Cass voluntarily resigned from his
employment with LSR or had his employment terminated. Repayment of one of the
promissory notes will be made by automatic deduction of (pound)44,000 ($84,476)
per year from the (pound)66,000 ($126,713) per year pension contribution made by
the Company to a pension plan established by Mr Cass. The other note is further
collateralized by the (pound)214,500 ($412,000) accrued in such pension account.
In addition, one-third of any yearly bonus received by Mr. Cass will be used to
reduce the principal of the promissory notes. Total amount of this loan as of
December 31, 2004 is (pound)363,000 ($697,000 at year-end foreign exchange
rates).

Julian Griffiths, a former director of LSR and current Director of Operations of
Huntingdon, acquired 50,000 shares of LSR Common Stock in the Private Placement.
Mr Griffiths acquired such shares through the delivery of a promissory note in
the principal amount of (pound)52,817 ($101,403), which was due on March 28,
2007; bore interest at the rate of 5% per annum; and was secured by the 50,000
shares of LSR Common Stock purchased with the proceeds of the loan. This loan
was paid in full in 2003.

Repurchase of equity securities

The Company did not repurchase any equity securities during 2004.




ITEM 6. SELECTED CONSOLIDATED FINANCIAL DATA

The selected consolidated financial data presented below should be read in
conjunction with the "Management's Discussion and Analysis of Financial
Condition and Results of Operations", included elsewhere in this report. For the
purpose of this report, it is assumed that LSR is the ultimate parent company
for periods prior to July 19, 2001, since before this date, LSR had no
substantive operations on a stand-alone basis.

The selected consolidated financial information as of December 31, 2004, 2003,
2002 and 2001 and for each of the four years in the period ended December 31,
2004 has been derived from LSR's audited consolidated financial statements and
the related notes included in this Annual Report on Form 10-K beginning on page
34. Such financial statements have been prepared in accordance with US GAAP.

The selected consolidated financial information as of December 31, 2000 has been
derived from Huntingdon's audited consolidated financial statements including
Huntingdon's Annual Report on Form 10-K for the period ended December 31, 2000.
Such financial statements have been prepared in accordance with US GAAP.


As of and for the year ended December 31


------------- --------------- -------------- ------------- --------------
2004 2003 2002 2001 2000
-------------------------------------------------------------------------
($000, except per share data)

Statement of Operations Data
Revenues $157,551 $132,434 $115,742 $99,206 $95,964
Cost of revenues (117,061) (104,798) (93,403) (84,133) (80,740)
------------- --------------- -------------- ------------- --------------
Gross profit 40,490 27,636 22,339 15,073 15,224
Selling, general and administrative (24,666) (20,867) (18,075) (15,966) (15,140)
------------- --------------- -------------- ------------- --------------
Operating income/(loss) before
other operating income/(expense) 15,824 6,769 4,264 (893) 84
Other operating income/(expense) - (3,522) - (750) -
------------- --------------- -------------- ------------- --------------
Operating income/(loss) 15,824 3,247 4,264 (1,643) 84
Interest expense (net) (6,521) (5,990) (6,238) (6,510) (7,204)
Other income/(expense)
Foreign exchange gain/(loss) on
Convertible Capital Bonds 3,345 4,760 4,977 (1,386) (3,544)
Gain on repurchase of
Convertible Capital Bonds
Capital Bonds - 602 1,191 - -
Cost of currency hedge contract (455) - - - -
Merger/Offer costs - - (1,246) (2,868) -
Refinancing costs - - - (217) (1,819)
------------- --------------- -------------- ------------- --------------
Income/(loss) before income taxes 12,193 2,619 2,948 (12,624) (12,483)
Income tax benefit/(expense) 5,401 1,109 (251) 2,996 2,720
------------- --------------- -------------- ------------- --------------
Net income/(loss) 17,594 $3,728 $2,697 ($9,628) ($9,763)
------------- --------------- -------------- ------------- --------------
Income/(loss) per share
- basic $1.45 $0.31 $0.25 ($1.64) ($1.68)
- diluted $1.29 $0.29 $0.24 ($1.64) ($1.68)
Weighted average number of
Common stock (000)
- basic 12,153 11,958 10,679 5,868 5,824
- diluted 13,607 12,700 11,083 5,868 5,824

Balance Sheet Data
Working capital* $1,800 $(3,911) $(844) $(1,896) $(33,214)
Total assets 200,075 156,273 148,410 133,964 146,107
Long term debt and related party loans 89,685 87,560 84,075 88,123 50,209
Total shareholders deficit (2,064) (8,446) (7,804) (4,724) 4,066
Common stock and paid in capital 75,796 75,221 75,217 66,094 65,330
Book value per share ($0.17) ($0.71) ($0.73) ($0.81) $0.70


Other Financial Data
Depreciation and amortization $9,530 $9,049 $8,108 $8,307 $9,093
Capital expenditure 11,096 8,716 4,177 3,295 3,648
Cash generated/(used) in the year 16,070 2,627 12,404 (1,046) (5,189)
Net days sales outstanding (DSO) 4 8 9 47 36
Gross profit % 25.7 20.9% 19.3% 15.2% 15.9%
Operating income/(expense) before
other operating income/(expense)% 10.0% 5.1% 3.7% (0.9)% 0.1%
Operating income/(expense) % 10.0% 2.5% 3.7% (1.7)% 0.1%
Net income/(loss) % 11.2% 2.8% 2.3% (9.7)% (10.2)%
Other operating income/(expense) is comprised of:
Restructuring costs - ($3,551) - - -
Animal rights costs - (575) - (400) -
Recovery/bad debt relating to
bankruptcy of an exchange broker - 396 - (350) -
Share of associate company income - 208 - - -
------------- --------------- -------------- ------------- --------------
- (3,522) - (750) -
------------- --------------- -------------- ------------- --------------


*Working capital is defined as current assets less current liabilities.






ITEM 7. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

GENERAL

The following should be read in conjunction with the consolidated financial
statements of LSR as presented in "Item 8, Financial Statements and
Supplementary Data".

The Company is a global provider of pre-clinical and non-clinical safety testing
services to the pharmaceutical, agrochemical and industrial chemical industries.
The Company provides those services under contracts, which may range from one
day to three years. Income from these contracts is recognized as services are
rendered towards the preparation of the final report. Contracts are generally
terminable upon notice by the client with the client being responsible for
reimbursing the Company for the value of work performed through the date of
cancellation plus the value of work required to wind down a study on an orderly
basis.

The Company's business is characterized by high fixed costs, in particular staff
and facility related costs. Such a high proportion creates favorable conditions
for the Company as excess capacity is utilized, such as has been the case during
the last three years. However, during periods of declining revenue, careful
planning is required to reduce costs without impairing revenue-generating
activities.

RESULTS OF OPERATIONS

Year ended December 31, 2004 compared with year ended December 31, 2003

Revenues in the year ended December 31, 2004 were $157.6 million, an increase of
19% on revenues of $132.4 million for the year ended December 31, 2003. The
underlying increase, after adjusting for the impact of the movement in exchange
rates was 8.5%; with the UK showing a 8.6% increase and the US an 8.4% increase.
Orders for the year ended December 31, 2004, at constant exchange rates of
$179.4 million were 24% above the previous year. At December 31, 2004 backlog
(booked-on work) amounted to approximately $119 million, an increase of 27%
above the level at December 31, 2003 (14% net of foreign currency effect). This
reflected strong demand in the industry as companies invested in their early
stage pipelines together with LSR's success in winning new studies due to its
scientific expertise and focus on customer service.

Cost of sales in the year ended December 31, 2004 were $117.1 million (74.3% of
revenue), an increase of 11.7% on cost of sales of $104.8 million (79.1% of
revenue) for the year ended December 31, 2003. This increase was partly due to
exchange rate movements, which increased cost of sales in the year by $10.0
million. Without these movements cost of sales would have increased by 2.2%. In
the UK cost increases in sterling were only 2%, which is lower than the revenue
growth as capacity is filled without the corresponding increase in fixed costs.
The main increase was in direct material costs reflecting the higher revenues,
offset by a reduction in labor costs as a result of the restructuring completed
in the first quarter. Increases in costs in the US were 3.3%, mainly due to
increases in labor costs offset by a reduction in direct material costs compared
to the previous year.

Selling, general and administrative expenses rose by 18.2% to $24.7 million for
the year ended December 31, 2004 (15.7% of revenue) from $20.9 million (15.8% of
revenue) in the year ended December 31, 2004. Of this increase, $2.1 million
related to exchange rate movements. This growth was due to a continuation of the
build-up of the sales activity during the year and higher labor costs, including
bonuses paid or accrued to senior employees.

Other operating expenses in the year ended December 31, 2003 were $3.5 million.
These comprised $0.6 million in connection with specific legal actions taken
against animal rights groups and $3.5 million in respect of a restructuring of
the business. These restructuring costs comprise redundancy (severance) payments
and asset write downs in the UK arising from a consolidation of duplicate
facilities in response to changes in the market, particularly for non
pharmaceutical services and a closure of excess and outdated toxicology
capacity. This restructuring was effected to improve the efficiency of the
Company's operations without impairing its ability to service clients' needs.
These expenses were offset by income of $0.2 million representing the Group's
share of an associated company's income (recognized following its acquisition in
June 2003) and $0.4 million from the recovery of funds, written off in 2001
following the bankruptcy of an exchange broker.

Net interest expense increased by 8.9% to $6.5 million for the year ended
December 31, 2004 from $6.0 million in the year ended December 31, 2003.
Excluding the effect of exchange rate movements, there was a net decline of $0.2
million, reflecting the full year impact of loans and bonds repaid during 2003.

Other income of $2.9 million for the year ended December 31, 2004 comprised $3.3
million from the non-cash foreign exchange remeasurement gain on the Capital
Bonds denominated in US dollars (the functional currency of the financing
subsidiary that holds the bonds is UK sterling), offset by $0.4 million relating
to the cost of a currency hedge contract. In the year ended December 31, 2003
there was other income of $5.4 million which was comprised of a non-cash foreign
exchange remeasurement gain on the Capital Bonds of $4.8 million and a $0.6
million gain made on the partial repurchase of the Capital Bonds.

Taxation benefit on income for the year ended December 31, 2004 was $5.4 million
representing a benefit at 44% compared to a taxation benefit of $1.1 million
representing a benefit at 42% for the year ended December 31, 2003. A
reconciliation between the US statutory tax rate and the effective rate of
income tax benefit on losses before income taxes for the year ended December 31,
2004 and December 31, 2003 is shown below:

% of income before
income taxes
2004 2003
% %
US statutory rate 35 35
Foreign rate differential (6) (3)
UK R & D credit and non-deductible items (36) 13
State taxes 1 2
Change in estimate (38) (89)
---------------- --------------
Effective tax rate (44) (42)
---------------- --------------

The main reason for the change in estimate above relates to the Huntingdon 2002
and 2003 tax provisions. The UK government from April 1, 2002 introduced a new
tax allowance, `Research and Development (R & D) Tax Credit', for large
companies. At the end of 2002, it was not certain how this would apply to
Huntingdon. When submitting Huntingdon's 2002 corporation tax computation, and
following discussions with the UK Inland Revenue, Huntingdon made a claim for
the R & D Tax Credit, which has now been accepted. The 2003 provision has been
included in the current year benefit as a change in estimate. The 2004 claim is
part of the non-deductible items above.

The overall net income for the year ended December 31, 2004 was $17.6 million
compared to $3.7 million in the year ended December 31, 2003. The diluted income
per share for the year ended December 31, 2004 was $1.29 compared to $0.29 for
the year ended December 31, 2003.

Earnings before interest, taxes, depreciation and amortization, other
income/(expense) and other operating expenses in 2003 ("EBITDA") was 25.4
million for 2004, or 16.1% of revenues, compared with 14.6 million, or 11.0% of
revenues for 2003.

The Company believes that EBITDA information, which for this Company excludes
other income/(expense) and other operating expenses, enhances an investor's
understanding of our financial performance and our ability to satisfy principal
and interest obligations with respect to our indebtedness. However, EBITDA
should not be considered in isolation or viewed as a substitute for net income,
cash flow from operations or other measures of performance as defined by
generally accepted accounting principles in the United States. We understand
that while securities analysts, lenders and others in their evaluation of
companies frequently use EBITDA, EBITDA as used herein is not necessarily
comparable to other similarly titled captions of other companies due to
potential inconsistencies in the method of calculation. Our management uses
EBITDA to assess financial performance and debt service capabilities. In
assessing financial performance, our management reviews EBITDA as a general
indicator of economic performance compared to prior periods. Because EBITDA
excludes interest, income tax, depreciation and amortization, other
income/(expense) and other operating expenses, EBITDA provides an indicator of
general economic performance that is not affected by changes in debt levels,
fluctuations in interest rates or effective tax rates, levels of depreciation
and amortization, exchange rate movements on the Capital Bonds or one off
operating expenses. Our management believes this type of measurement is useful
for comparing general operating performance from period to period and making
certain management decisions. Nevertheless, our management recognizes that there
are material limitations associated with the use of EBITDA as compared to n et
income, which reflects overall financial performance, including the effects of
interest, taxes, depreciation, amortization, other income/(expense) and other
operating expenses.

Year ended December 31, 2003 compared with the year ended December 31, 2002

Revenues in the year ended December 31, 2003 were $132.4 million, an increase of
14% on revenues of $115.7 million for the year ended December 31, 2002. The
underlying increase, after adjusting for the impact of the movement in exchange
rates was 7%; with the UK showing a 6% increase and the US a 12% increase.
Orders for the year ended December 31, 2003, at constant exchange rates, were 8%
below the previous year. A weakening in the market for toxicology services due
to extra capacity coming on stream at competitors, combined with a reduction in
non pharmaceutical work in Europe, were responsible for this fall. After a
record growth in orders in 2002, backlog at December 31, 2002 amounted to
approximately $95 million and this sustained the growth in revenues.

Cost of sales in the year ended December 31, 2003 were $104.8 million, an
increase of 12% on cost of sales of $93.4 million for the year ended December
31, 2002. This increase was partly due to exchange rate movements, which
increased cost of sales in the year by $6.4 million. Without these movements
cost of sales would have increased by 5%. In the UK cost increases in sterling
were only 5%, which is lower than the revenue growth as capacity is filled
without the corresponding increase in fixed costs. The main increase was in
labor costs reflecting increases in staffing. Increases in costs in the US were
only 6%, mainly due to lower increases in direct materials costs compared to the
UK.

Selling, general and administrative expenses rose by 15% to $20.9 million for
the year ended December 31, 2003 from $18.1 million in the year ended December
31, 2002. Of this increase, $1.3 million related to exchange rate movements.
This growth was due to a continuation of the build-up of the sales activity
during the year and higher labor costs.

Other operating expenses in the year ended December 31, 2003 were $3.5 million
compared with $0 in the year ended December 31, 2002. In the year ended December
31, 2003, other operating expenses comprised $0.6 million in connection with
specific legal actions taken against animal rights groups and $3.5 million in
respect of a restructuring of the business. These restructuring costs comprise
redundancy (severance) payments and asset write downs in the UK arising from a
consolidation of duplicate facilities in response to changes in the market,
particularly for non pharmaceutical services and a closure of excess and
outdated toxicology capacity. This restructuring was effected in order to
improve the efficiency of the Company's operations without impairing its ability
to service clients' needs. These expenses were offset by income of $0.2 million
representing the Group's share of an associated company's income (recognized
following its acquisition in June 2003) and $0.4 million from the recovery of
funds, written off in 2001 following the bankruptcy of an exchange broker.

Interest expense declined by 5% to $6.0 million for the year ended December 31,
2003 from $6.3 million in the year ended December 31, 2002. The main reasons for
this reduction were the repayment of the former Stephens loan and Baker loan,
and the repurchase of $1.4 million (principal amount) of the bonds, together
with lower interest rates on the non-bank debt (down from an average in 2002 of
5.77% to 5.5% in 2003).

Other income of $5.4 million for the year ended December 31, 2003 comprised $4.8
million from the non-cash foreign exchange remeasurement gain on the Capital
Bonds denominated in US dollars (the functional currency of the financing
subsidiary that holds the bonds is UK sterling) and a $0.6 million gain on the
partial repurchase of the Capital Bonds. In the year ended December 31, 2002
there was other income of $4.9 million which was comprised of a non-cash foreign
exchange remeasurement gain on the Capital Bonds of $5.0 million and a $1.2
million gain made on the partial repurchase of the Capital Bonds; offset against
a $1.3 million charge relating to the finalization of the 2001 US redomiciling
Exchange Offer.



Taxation benefit on income for the year ended December 31, 2003 was $1.1 million
representing a benefit at 42% compared to a taxation expense of $0.3 million
representing expense at 8% for the year ended December 31, 2002. A
reconciliation between the US statutory tax rate and the effective rate of
income tax benefit on losses before income taxes for the year ended December 31,
2003 and December 31, 2002 is shown below:

% of income before
income taxes
2003 2002
% %
US statutory rate 35 35
Foreign rate differential (3) (9)
Non-deductible items 13 (31)
State taxes 2 2
Change in estimate (89) 11
---------------- --------------
Effective tax rate (42) 8
---------------- --------------

The main reason for the change in estimate above relates to the Huntingdon 2002
tax provision. The UK government from April 1, 2002 introduced a new tax
allowance, `Research and Development (R & D) Tax Credit', for large companies.
At the end of 2002, it was not certain how this would apply to Huntingdon. When
submitting Huntingdon's 2002 corporation tax computation, and following
discussions with the UK Inland Revenue, Huntingdon has made a claim for the R &
D Tax Credit and this has been included in the change in estimate figures for
2003 above. Pending the outcome of the 2002 claim, the 2003 provision has
excluded any further allowance.

The overall net income for the year ended December 31, 2003 was $3.7 million
compared to $2.7 million in the year ended December 31, 2002. The diluted income
per share for the year ended December 31, 2003 was $0.29 compared to $0.24 for
the year ended December 31, 2002.

Earnings before interest, taxes, depreciation and amortization, other
income/(expense) and other operating expenses (EBITDA) in 2003 was $14.6 million
or 11.0% of revenues, compared with $12.4 million or 10.7% of revenues in 2002.


SEGMENT ANALYSIS

The analysis of the Company's revenues and operating loss between segments for
the three years ended December 31, 2004 is as follows:

The performance of each segment is measured by revenues and operating
income/(loss) before other operating expenses.



Company 2004 2003 2002
$000 $000 $000


Revenues
UK 127,148 104,324 90,851
US 30,403 28,110 24,891
--------------- ---------------- ----------------
$157,551 $132,434 $115,742
--------------- ---------------- ----------------
Operating income/(loss) before other operating expenses
UK 18,716 9,282 7,562
US 3,861 2,085 781
Corporate (6,753) (4,598) (4,079)
--------------- ---------------- ----------------

$15,824 $6,769 $4,264
--------------- ---------------- ----------------
Other operating expense
UK - (3,155) -
US - - -
Corporate - (367) -
--------------- ---------------- ----------------
$- $(3,522) $-
--------------- ---------------- ----------------
Operating income/(loss)
UK 18,716 6,127 7,562
US 3,861 2,085 781
Corporate (6,753) (4,965) (4,079)
--------------- ---------------- ----------------
$15,824 $3,247 $4,264
--------------- ---------------- ----------------



UK

2004 v 2003

Revenues increased by 21.9% in the year ended December 31, 2004 compared with
the year ended December 31, 2003. After allowing for the effect of exchange rate
movements the increase was 8.6%. Orders for the year ended December 31, 2004 at
constant exchange rates were 23.7% above the previous year and 11.7% above
revenues for the year.

Costs increased by 14.0% in the year ended December 31, 2004 compared with the
year ended December 31, 2003. After allowing for the effect of exchange rate
movements, the increase was 2.8%. The main increase was in direct material costs
reflecting the increase in revenues; however, this was offset by a reduction in
labor as a result of the restructuring undertaken in the first quarter.

The operating income before other operating expenses for the year ended December
31, 2004 was $18.7 million compared with $9.3 million in the year to December
31, 2003.

In the year ended December 31, 2003, other operating expenses of $3.2 million
comprised $3.5 million in respect of a restructuring of the business. These
restructuring costs comprise redundancy (severance) payments and asset write
downs arising from a consolidation of duplicate facilities in response to
changes in the market, particularly for non pharmaceutical services, and a
closure of excess and outdated toxicology capacity. These expenses were offset
by income of $0.3 million from the recovery of funds, written off in 2001,
following the bankruptcy of an exchange broker.

The operating income for the year ended December 31, 2004 was $18.7 million
compared with $6.1 million in the previous year.

2003 v 2002

Revenues increased by 15% in the year ended December 31, 2003 compared with the
year ended December 31, 2002. After allowing for the effect of exchange rate
movements the increase was 6%. Orders for the year ended December 31, 2003 at
constant exchange rates were 9.8% below the previous year and 2.3% below
revenues for the year. The Company believes that a weakening in the market for
toxicology services due to extra capacity coming on stream at competitors,
combined with a decline in work being outsourced by the Agrochemical industry,
both on new chemical entities and as re-registration work under European
Directive 91/414/EEC diminished, were responsible for this fall. Backlog at
December 31, 2002 was 29% higher than a year previously and this sustained the
growth in revenues.

Costs increased by 14% in the year ended December 31, 2003 compared with the
year ended December 31, 2002. After allowing for the effect of exchange rate
movements, the increase was 4.5%. The main cost increases were in labor where
staff numbers were built up in response to the growth in orders in 2002. With
the softness in orders in 2003 steps were taken to reduce staffing levels in the
second half of the year, but the average headcount for the year was 28 higher
than in 2002. Changes to Social Security charges, which took effect from April
1, 2003, also added to labor costs.

The operating income before other operating expenses for the year ended December
31, 2003 was $9.3 million compared with $7.6 million in the year to December 31,
2002.

Other operating expenses in the year ended December 31, 2003, were $3.1 million
compared with $0 in the year ended December 31, 2002. In the year ended December
31, 2003, other expenses comprised $3.5 million in respect of a restructuring of
the business. These restructuring costs comprise redundancy (severance) payments
and asset write downs arising from a consolidation of duplicate facilities in
response to changes in the market, particularly for non pharmaceutical services,
and a closure of excess and outdated toxicology capacity. These expenses were
offset by income of and $0.4 million from the recovery of funds, written off in
2001, following the bankruptcy of an exchange broker.

The operating income for the year ended December 31, 2003 was $6.1 million
compared with $7.6 million in the previous year.

US

2004 v 2003

Revenues increased by 8.4% in the year ended December 31, 2004 as compared to
the year ended December 31, 2003. Orders for the year ended December 31, 2003
were 25.1% above the previous year and 21.5% above revenues for the year.

Costs increased by 2% in the year ended December 31, 2004 as compared with the
year ended December 31, 2003. This cost increase was mainly due to higher direct
materials as a result of the higher revenues.

The operating income for the year ended December 31, 2004 was $3.9 million
compared with an operating income of $2.1 million in the previous year.

2003 v 2002

Revenues increased by 13% in the year ended December 31, 2003 as compared to the
year ended December 31, 2002. Orders for the year ended December 31, 2003 were
4% below the previous year, but 6.9% above revenues for the year. A weakening in
the market for toxicology services was responsible for the fall in orders, but
the level of orders combined with the high level of backlog at December 31, 2002
sustained the growth in revenues.

Costs increased by 8% in the year ended December 31, 2003 as compared with the
year ended December 31, 2002. This cost increase was mainly driven by the
increase in revenues; however, there were also additional costs due to the
increase in sales activity.

The operating income for the year ended December 31, 2003 was $2.1 million
compared with $0.8 million in the previous year.

Corporate

2004 v 2003

Corporate costs for the year ended December 31, 2004 were $6.8 million, an
increase of 47% on corporate costs for the year ended December 31, 2003 of $4.6
million. Excluding the effects of exchange rate movements the increase was 42%.
The main reasons for the increase are the discretionary bonus plan relating to
those senior employees in the Company's corporate headquarters of $1.5 million,
together with general increases in labor costs and legal and professional fees.

In the year ended December 31, 2003, other operating expenses were $0.4 million
for specific legal action taken against animal rights groups.

The operating loss for the year ended December 31, 2004 was $6.8 million
compared with an operating loss for the year ended December 31, 2003 of $5.0
million.

2003 v 2002

Corporate costs for the year ended December 31, 2003 were $4.6 million, an
increase of 13% on corporate costs for the year ended December 31, 2002 of $4.1
million. Excluding the effects of exchange rate movements, the increase was 10%.
The main reasons for the increase were general increases in labor costs and
legal and professional fees.

In the year ended December 31, 2003, other operating expenses were $0.6 million
for specific legal action taken against animal rights groups, offset by income
of $0.2 million representing the Group's share of an associated company's income
(recognised following its acquisition in June 2003).

The operating loss for the year ended December 31, 2003 was $5.0 million
compared with an operating loss of $4.1 million for the year ended December 31,
2002.

LIQUIDITY AND CAPITAL RESOURCES

Bank Loan and Non-Bank Loans

On January 20, 2001, the Company's net non-bank loan of (pound)22.6 million
(approximately $43.4 million), was refinanced by Stephens' Group Inc. and other
parties. The loan was transferred from Stephens Group Inc., to an unrelated
third party effective February 11, 2002. It is now repayable on June 30, 2006
and interest is payable quarterly at LIBOR plus 1.75%. At the same time the
Company was required to take all reasonable steps to sell off such of its real
estate assets through sale/leaseback transactions and/or obtaining mortgage
financing secured by the Company's real estate assets to discharge this loan.
The loan is held by LSR Ltd., and is secured by the guarantees of wholly owned
subsidiaries of the Company including, LSR Ltd, Huntingdon Life Sciences Ltd,
and Huntingdon Life Sciences Inc., and collateralized by all the assets of these
companies.

On October 9, 2001, on behalf of Huntingdon, LSR issued to Stephens Group Inc.
warrants to purchase up to 704,425 shares of LSR Voting Common Stock at a
purchase price of $1.50 per share. These warrants were subsequently transferred
to an unrelated third party. These LSR warrants are exercisable at any time and
will expire on October 9, 2011. These warrants arose out of negotiations
regarding the refinancing of the bank loan by the Stephens Group Inc., in
January 2001. In accordance with APB Opinion No. 14, Accounting for Convertible
Debt and Debt Issued with Stock Purchase Warrants ("APB 14") the warrants were
recorded at their pro rata fair values in relation to the proceeds received on
the date of issuance. As a result, the value of the warrants was $430,000.
154,425 of such warrants were exercised in 2004.


Convertible Capital Bonds

The remainder of the Company's long term financing is provided by Convertible
Capital Bonds repayable in September 2006. At the time of the issue in 1991,
these bonds were for $50 million par and at December 31, 2004, $46.2 million
were outstanding. They carry interest at a rate of 7.5% per annum, payable
biannually in March and September. During 2002, the Company repurchased and
cancelled $2,410,000 principal amount of such bonds resulting in a $1.2 million
gain recorded in other income/expense. In 2003 the Company further repurchased
and cancelled $1,345,000 principal amount of such bonds resulting in a gain of
$0.6 million recorded in other income/expense. At the current conversion rate,
the number of shares of Voting Common Stock to be issued on conversion and
exchange of each unit of $10,000 comprised in a Bond would be 49. The conversion
rate is subject to adjustment in certain circumstances.

Related Party Loans

Financing which totaled $5.7 million was provided to the company in 2000 and
2001 and was fully repaid in 2002. This financing had been provided in part by a
$2.9 million loan facility made available on September 25, 2000 by the Company's
Chairman and CEO, Mr. Baker. In connection with this financing, the company
authorized, subject to shareholder approval, the issuance of warrants to
purchase 410,914 shares of LSR Voting Common Stock at a purchase price of $1.50
per share to FHP, a company controlled by Mr. Baker. Such shareholder approval
was granted on June 12, 2002. Additionally, other financing also included a $2.8
million facility from the Stephens Group Inc. made available on July 19, 2001.
Effective February 11, 2002 the Stephens Group Inc. debt was transferred to an
unrelated third party. $550,000 of the loan from Mr. Baker was transferred to
and assumed by FHP in March 2001. On March 28, 2002, $2.1 million of Mr. Baker's
loan was converted into 1,400,000 shares of LSR Voting Common Stock and $300,000
of FHP's loan was converted into 200,000 shares of LSR Voting Common Stock; in
each case as part of LSR's private placement of approximately 5.1 million shares
of Voting Common Stock. The remaining principal amounts were repaid in full to
Mr. Baker and FHP, inclusive of 10% interest, respectively, in 2002. The other
$2.8 million facility was also repaid in full as of October 1, 2002.

As noted above, on June 11, 2002 LSR issued to FHP warrants to purchase up to
410,914 shares of LSR Voting Common Stock at a purchase price of $1.50 per
share. These LSR warrants are exercisable at any time and will expire on June
11, 2012. These warrants arose out of negotiations regarding the provision of
the $2.9 million loan facility made available to the Company on September 25,
2000 by Mr. Baker, who controls FHP. In accordance with APB 14 the loan and
warrants were recorded at their pro rata fair values in relation to the proceeds
received. As a result, the value of the warrants was $250,000.

Common Shares

On January 10, 2002, LSR issued 99,900 shares of Voting Common Stock and 900,000
shares of Non-Voting Common Stock at a price of $1.50 per share (or an aggregate
of $1.5 million). Effective July 25, 2002, all of the 900,000 shares of the
Non-Voting Common Stock were converted into 900,000 shares of Voting Common
Stock.

On March 28, 2002, LSR closed the sale in a private placement of an aggregate of
5,085,334 shares of Voting Common Stock at a price of $1.50 per share. Of the
aggregate proceeds of approximately $7.6 million, $4.4 million was in cash, $2.4
million represented conversion into equity of debt owed to Mr. Baker ($2.1
million) and FHP ($0.3 million) and $825,000 was paid with promissory notes.
$128,000 of such promissory notes have been repaid through December 31, 2004.


Cash flows

During the year ended December 31, 2004 funds generated were $16.0 million,
increasing cash on hand and on short-term deposit from $17.3 million at December
31, 2003 to $33.3 million at December 31, 2004. The cash generated from
operating, investing and financing activities were generated as follows (in
millions):



2004 2003 2002
---- ---- ----

Operating income before other operating expense $15.8 $6.8 $4.3
Depreciation and loss on disposal of fixed assets 9.5 9.3 8.1
Impairment of fixed assets - 2.0 -
Working capital movement 10.1 (0.6) 9.0
Interest (5.9) (6.0) (6.1)

Capital expenditure (11.1) (8.7) (4.2)
Cash acquired on business acquisition - 1.9 -
Other (expense)/income (2.6) (1.5) (1.2)
Loan repayments net of shares issued (0.1) (1.1) 1.7
Effect of exchange rate changes on cash 0.3 0.6 0.8
---------- ---------- ----------
16.0 $2.7 $12.4
---------- ---------- ----------


Net days sales outstanding (DSOs) at December 31, 2004 were 4 days, an
improvement from the 8 days at December 31, 2003. DSO is calculated as a sum of
accounts receivable, unbilled receivables and fees in advance over total
revenue. The impact on liquidity from a one-day change in DSO is approximately
$357,000.

At December 31, 2004, the Company had a working capital surplus of $1.8 million.
The Company believes that projected cash flow from operations will satisfy its
contemplated cash requirements for at least the next 12 months.

Commitment and Contingencies

2004 2003 2002
$000 $000 $000
Operating lease expenses were as follows:
Hire of plant and equipment 291 451 904
Other operating leases 405 410 392

The Company leases certain equipment under various non-cancelable operating and
capital leases. Future minimum lease payments required under operating and
capital leases are as follows:



Total 2-3 4-5 After
1 year years years 5 years
$000 $000 $000 $000 $000

Capital lease obligations 715 275 336 104 -
Operating leases 801 508 268 25 -
------------- ------------- ----------- ----------- -----------
1,516 783 604 129 -
------------- ------------- ----------- ----------- -----------


All operating leases are for Plant & Equipment

The total cost of equipment capitalized under these capital leases is $981,000
and $546,000, at December 31, 2004 and 2003, respectively. Depreciation on these
capital leases amounted to $192,000 and $68,000 and $5,000 for the years ended
December 31, 2004, 2003 and 2002, respectively. Accumulated depreciation on the
capital leases amounted to $114,000, $87,000 and $20,000 for the years ended at
December 31, 2004, 2003 and 2002, respectively.


Contingencies

The Company is party to certain legal actions arising in the normal course of
its business. In management's opinion, none of these actions will have a
material effect on the Company's operations, financial condition or liquidity.
No form of proceedings has been brought, instigated or is known to be
contemplated against the Company by any government agency.

ORDERS

New business signings totaled $179.4 million for the year ended December 31,
2004, an increase of 24% exclusive of the impact of movements in exchange rates
from the prior year. 2003 saw a rapid growth in business from the Pharmaceutical
industry and this growth in business was maintained in 2004, with particularly
strong order growth in toxicology testing as companies invested in their early
stage pipelines. However there was a decline in the amount of work outsourced
from the Agrochemical industry, both on new chemical entities and as
registration work under European Directive 91/414/EEC diminished.

EXCHANGE RATE FLUCTUATIONS AND EXCHANGE CONTROLS

The Company operates on a worldwide basis and generally invoices its clients in
the currency of the country in which the Company operates. Thus, for the most
part, exposure to exchange rate fluctuations is limited as sales are denominated
in the same currency as costs. Trading exposures to currency fluctuations do
occur as a result of certain sales contracts, performed in the UK for US
clients, which are denominated in US dollars and contribute approximately 9% of
total revenues. Management has decided not to hedge against this exposure.

Also, exchange rate fluctuations may have an impact on the relative price
competitiveness of the Company vis a vis competitors who trade in currencies
other than sterling or dollars. Such fluctuations also have an impact on the
translation of the 7.5% Convertible Capital Bonds payable in September 2006.

The Company has debt denominated in both USD and GBP, each of which have
repayment dates in 2006. Whereas the Company's functional currency is the UK
pound sterling, which results in the Company recording other income/loss
associated with USD debt as a function of relative changes in foreign exchange
rates, no decision has been made as to which currency might be chosen as the
basis for replacement financing. The Company recognizes that there has recently
been volatility in exchange rates which could have an impact on such
refinancing. To manage the volatility relating to these exposures, from time to
time, the Company may enter into certain derivative transactions. The Company
holds and issues derivative financial instruments for economic hedging purposes
only. In December 2004 the Company purchased a currency hedge against the UK
pound sterling. The call amount of the hedge was (pound)15.4 million and the put
amount was $30 million.

Finally, the consolidated financial statements of LSR are denominated in US
dollars. Changes in exchange rates between the UK pound sterling and the US
dollar will affect the translation of the UK subsidiary's financial results into
US dollars for the purposes of reporting the consolidated financial results. The
process by which each foreign subsidiary's financial results are translated into
US dollars is as follows: income statement accounts are translated at average
exchange rates for the period; balance sheet asset and liability accounts are
translated at end of period exchange rates; and equity accounts are translated
at historical exchange rates. Translation of the balance sheet in this manner
affects the stockholders' equity account referred to as the accumulated other
comprehensive loss account. Management has decided not to hedge against the
impact of exposures giving rise to these translation adjustments as such hedges
may impact upon the Company's cash flow compared to the translation adjustments
which do not affect cash flow in the medium term.

Exchange rates for translating sterling into US dollars were as follows:

At December 31 Average rate (1)
2001 1.4554 1.4403
2002 1.6099 1.5039
2003 1.7857 1.6354
2004 1.9199 1.8321

(1) Based on the average of the exchange rates on the last day of each month
during the period. On March 24, 2005 the noon buying rate for sterling was
(pound)1.00 = $1.8709.

The Company has not experienced difficulty in transferring funds to and
receiving funds remitted from those countries outside the US or UK in which it
operates and management expects this situation to continue.

While the UK has not at this time entered the European Monetary Union, the
Company has ascertained that its financial systems are capable of dealing with
Euro denominated transactions.

The following table summarizes the financial instruments denominated in
currencies other than the US dollar held by LSR and its subsidiaries as of
December 31, 2004:



Expected Maturity Date
2004 2005 2006 2007 2008 Thereafter Total Fair Value

(In US Dollars, amounts in thousands)

Cash - Pound Sterling 19,880 - - - - - 19,880 19,880
- Euro 1,691 - - - - - 1,691 1,691
- Japanese Yen 2,550 - - - - - 2,550 2,550
Accounts
receivable - Pound Sterling 19,453 - - - - - 19,453 19,453
- Euro 520 - - - - - 520 520
- Japanese Yen 1,862 - - - - - 1,862 1,862

Debt - Pound Sterling - - 43,086 - - - 43,086 43,086
- Japanese Yen 499 60 - - - - 559 559


COMPETITION

Competition in both the pharmaceutical and non-pharmaceutical market segments
ranges from in-house research and development divisions of large pharmaceutical,
agrochemical and industrial chemical companies, who perform their own safety
assessments to contract research organizations like the Company, who provide a
full range of services to the industries and niche suppliers focusing on
specific services or industries.

This competition could have a material adverse effect on the Company's net
revenues and net income, either through in-house research and development
divisions doing more work internally to utilize capacity or through the loss of
studies to other competitors. As the Company operates on an international basis,
movements in exchange rates, particularly against sterling, can have a
significant impact on its price competitiveness.

CONSOLIDATION WITHIN PHARMACEUTICAL INDUSTRY

The process of consolidation within the pharmaceutical industry continues to
accelerate the move towards outsourcing work to contract research organizations
in the longer term as resources are increasingly invested in in-house facilities
for discovery and lead optimization, rather than development and regulatory
safety evaluation. However, in the short-term, there is a negative impact with
development pipelines being rationalized and a focus on integration rather than
development. This can have a material adverse impact on the Company's net
revenues and net income.

ANIMAL RIGHTS ACTIVISM

Please refer to the detailed discussion under Item 1, on pages 10 to 12.

INFLATION

While most of the Company's net revenues are earned under fixed price contracts,
the effects of inflation do not generally have a material adverse effect on its
operations or financial condition as only a minority of the contracts have
duration in excess of one year.


CRITICAL ACCOUNTING POLICIES

Management's Discussion and Analysis of Financial Condition and Results of
Operations discusses the Company's consolidated financial statements, which have
been prepared in accordance with US GAAP. The Company considers the following
accounting policies to be critical accounting policies.

Revenue recognition

The majority of the Company's net revenues have been earned under contracts,
which generally range in duration from a few months to three years. Revenue from
these contracts is generally recognized over the term of the contracts as
services are rendered. Contracts may contain provisions for renegotiation in the
event of cost overruns due to changes in the level of work scope. Renegotiated
amounts are included in net revenue when earned and realization is assured.
Provisions for losses to be incurred on contracts are recognized in full in the
period in which it is determined that a loss will result from performance of the
contractual arrangement. Most service contracts may be terminated for a variety
of reasons by the Company's customers, either immediately or upon notice of a
future date. The contracts generally require payments to the Company to recover
costs incurred, including costs to wind down the study, and payment of fees
earned to date, and in some cases to provide the Company with a portion of the
fees or income that would have been earned under the contract had the contract
not been terminated early.

Unbilled receivables are recorded for revenue recognized to date that is
currently not billable to the customer pursuant to contractual terms. In
general, amounts become billable upon the achievement of certain aspects of the
contract or in accordance with predetermined payment schedules. Unbilled
receivables are billable to customers within one year from the respective
balance sheet date. Fees in advance are recorded for amounts billed to customers
for which, revenue has not been recognized at the balance sheet date (such as
upfront payments upon contract authorization, but prior to the actual
commencement of the study).

If the Company does not accurately estimate the resources required or the scope
of work to be performed, or does not manage its projects properly within the
planned periods of time or satisfy its obligations under the contracts, then
future margins may be significantly and negatively affected or losses on
existing contracts may need to be recognized. While such errors have not
historically been significant, any such resulting reductions in margins or
contract losses could be material to the Company's results of operations.

Use of estimates

The preparation of financial statements in conformity with US GAAP requires
management to make estimates and assumptions that affect the reported amounts of
assets and liabilities and disclosure of contingent assets and liabilities as of
the dates of the financial statements and the results of operations during the
reporting periods. These also include management estimates in the calculation of
pension liabilities covering discount rates, return on plan assets and other
actuarial assumptions. Although these estimates are based upon management's best
knowledge of current events and actions, actual results could differ from those
estimates.

Taxation

The Company accounts for income taxes under the provisions of Statement of
Financial Accounting Standards ("SFAS") No. 109, "Accounting For Income Taxes"
("SFAS 109"). SFAS 109 requires recognition of deferred tax assets and
liabilities for the estimated future tax consequences of events attributable to
differences between the financial statement carrying amounts of existing assets
and liabilities and their respective tax bases and operating loss and tax credit
carry forwards. Deferred tax assets and liabilities are measured using enacted
rates in effect for the year in which the differences are expected to be
recovered or settled. The effect on deferred tax assets and liabilities of
changes in tax rates is recognized in the statement of operations in the period
in which the enactment rate changes. Deferred tax assets and liabilities are
reduced through the establishment of a valuation allowance at such time as,
based on available evidence, it is more likely than not that the deferred tax
assets will not be realized. While the Company has considered future taxable
income and ongoing prudent and feasible tax planning strategies in assessing the
need for the valuation allowance, in the event that the Company were to
determine that it would not be able to realize all or part of its net deferred
tax assets in the future, an adjustment to the deferred tax assets would be
charged to income in the period such determination was made. Likewise, should
the Company determine that it would be able to realize its deferred tax assets
in the future in excess of its net recorded amount, an adjustment to the
deferred tax assets would increase income in the period such determination was
made.

FORWARD LOOKING STATEMENTS

Statements in this Management's Discussion and Analysis of Financial Condition
and Results of Operations, as well as in certain other parts of this Annual
Report on Form 10-K (as well as information included in oral statements or other
written statements made or to be made by the Company) that look forward in time,
are forward looking statements made pursuant to the safe harbor provisions of
the Private Litigation Reform Act of 1995. Forward looking statements include
statements concerning plans, objectives, goals, strategies, future events or
performance, expectations, predictions, and assumptions and other statements
which are other than statements of historical facts. Although the Company
believes such forward-looking statements are reasonable, it can give no
assurance that any forward-looking statements will prove to be correct. Such
forward-looking statements are subject to, and are qualified by, known and
unknown risks, uncertainties and other factors that could cause actual results,
performance or achievements to differ materially from those expressed or implied
by those statements. These risks, uncertainties and other factors include, but
are not limited to the Company's ability to estimate the impact of competition
and of industry consolidation and risks, uncertainties and other factors set
forth in the Company's filings with the Securities and Exchange Commission,
including without limitation this Annual Report on Form 10-K.


ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

LSR is subject to market risks arising from changes in interest rates and
foreign currency exchange rates.

The Company has debt denominated in both USD and GBP, each of which have
repayment dates in 2006. Whereas the Company's functional currency is the UK
pound sterling, which results in the Company recording other income/loss
associated with USD debt as a function of relative changes in foreign exchange
rates, no decision has been made as to which currency might be chosen as the
basis for replacement financing. The Company recognizes that there has recently
been volatility in exchange rates which could have an impact on such
refinancing. To manage the volatility relating to these exposures, from time to
time, we might enter into certain derivative transactions. We hold and issue
derivative financial instruments for economic hedging purposes only. In December
2004 the Company purchased a currency hedge against the UK pound sterling. The
call amount of the hedge was (pound)15.4 million and the put amount was $30.0
million.

Non-Bank Loans

The Company's (pound)22.6 million ($43.4 million) credit facility is UK pound
sterling denominated and does not contribute to transaction gains and losses on
the income statement due to the fact that, under US GAAP, the Company's
functional currency is sterling. Interest on all outstanding borrowings under
this credit facility is based upon LIBOR plus a margin, approximately 6.28% per
annum for the year ended December 31, 2004. At December 31, 2004 this credit
facility was fully drawn down.

In the year ended December 31, 2004, a 1% change in LIBOR would have resulted in
a fluctuation in interest expense of $414,000.

Revenue

For the year ended December 31, 2004, approximately 81% of the Company's net
revenues were from outside the US.

Convertible Capital Bonds

The Company's $46.2 million principal amount of Convertible Capital Bonds are US
dollar denominated, but are held by a non-US subsidiary of the Company. As a
result, with respect to these bonds, the Company experiences exchange related
gains and losses which only has a non-cash impact on the financial statements,
based on the movement of exchange rates. The Company is unable to predict
whether it will experience future gains or future losses from such
exchange-related risks on the bonds.

See Management's Discussion and Analysis of Financial Condition and Results of
Operations.



ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS Page


Independent Auditors' Report - December 31, 2004 and 2003 36

Independent Auditors' Report - December 31, 2002 37

Consolidated Statements of Operations-
Years ended December 31, 2004, 2003 and 2002 38

Consolidated Balance Sheets - December 31, 2004 and 2003 39

Consolidated Statements of Shareholders' (Deficit)/Equity and
Comprehensive Income/(Loss) - Years ended December 31, 2004, 2003
and 2002 41

Consolidated Statements of Cash Flows - Years ended December 31, 2004,
2003 and 2002 43

Notes to Consolidated Financial Statements 44





REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM


To the Board of Directors and Stockholders of
Life Sciences Research, Inc. and Subsidiaries

We have audited the accompanying consolidated balance sheets of Life Sciences
Research, Inc. and Subsidiaries (the "Company") as of December 31, 2004 and
2003, and the related consolidated statements of operations, shareholders'
equity (deficit) and comprehensive income/(loss), and cash flows for each of the
years then ended. These financial statements are the responsibility of the
Company's management. Our responsibility is to express an opinion on these
financial statements based on our audits. The financial statements of the
Company as of December 31, 2002 and for the year then ended were audited by
other auditors whose report dated March 26, 2003 expressed an unqualified
opinion on those statements.

We conducted our audits in accordance with the standards of the Public Company
Accounting Oversight Board (United States of America). Those standards require
that we plan and perform the audit to obtain reasonable assurance about whether
the financial statements are free of material misstatement. An audit includes
examining, on a test basis, evidence supporting the amounts and disclosures in
the financial statements. An audit also includes assessing the accounting
principles used and significant estimates made by management, as well as
evaluating the overall financial statement presentation. We believe that our
audits provide a reasonable basis for our opinion.

In our opinion, the consolidated financial statements referred to above present
fairly, in all material respects, the financial position of the Company as of
December 31, 2004 and 2003, and the results of its operations and its cash flows
for each of the years in the two year period ended December 31, 2004 in
conformity with accounting principles generally accepted in the United States of
America.



/s/Hugh Scott, P.C.
Lakewood, New Jersey

March 7, 2005





REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of Life Sciences Research, Inc. and
Subsidiaries, East Millstone, New Jersey

We have audited the accompanying consolidated balance sheet of Life Sciences
Research, Inc. and Subsidiaries (the "Company") as of December 31, 2002, and the
related consolidated statements of operations, shareholders' (deficit)/equity
and comprehensive loss, and cash flows for the year ended December 31, 2002.
These financial statements are the responsibility of the Company's management.
Our responsibility is to express an opinion on these financial statements based
on our audit.

We conducted our audit in accordance with auditing standards of the Public
Company Accounting Oversight Board (United States).. Those standards require
that we plan and perform the audit to obtain reasonable assurance about whether
the financial statements are free of material misstatement. An audit includes
examining, on a test basis, evidence supporting the amounts and disclosures in
the financial statements. An audit also includes assessing the accounting
principles used and significant estimates made by management, as well as
evaluating the overall financial statement presentation. We believe that our
audit provides a reasonable basis for our opinion.

In our opinion, such consolidated financial statements present fairly, in all
material respects, the financial position of Life Sciences Research, Inc. and
Subsidiaries as of December 31, 2002, and the results of their operations and
their cash flows for the year ended December 31, 2002, in conformity with
accounting principles generally accepted in the United States of America.

/s/Deloitte & Touche LLP

Princeton, New Jersey
March 26, 2003





Life Sciences Research Inc. and Subsidiaries
Consolidated Statements of Operations
Dollars in (000's), except per share amounts


Year Ended December 31,
2004 2003 2002

Revenues $157,551 $132,434 $115,742
Cost of sales (117,061) (104,798) (93,403)
------------------- ----------------- ---------------
Gross profit 40,490 27,636 22,339
Selling, general and administrative expenses (24,666) (20,867) (18,075)
Other operating expense - (3,522) -
------------------- ----------------- ---------------
Operating income 15,824 3,247 4,264
Interest income 114 94 66
Interest expense (6,635) (6,084) (6,304)
Other income 2,890 5,362 4,922
------------------- ----------------- ---------------
Income before income taxes 12,193 2,619 2,948
Income tax benefit/(expense) 5,401 1,109 (251)
------------------- ----------------- ---------------
Net income $17,594 $3,728 $2,697
=================== ================= ===============
Income per share
-basic $1.45 $0.31 $0.25
-diluted $1.29 $0.29 $0.24

Weighted average number of common stock outstanding
-basic 12,153,105 11,957,760 10,678,890
-diluted 13,607,308 12,699,576 11,083,416



The accompanying notes are an integral part of these consolidated financial
statements.







Life Sciences Research Inc. & Subsidiaries
Consolidated Balance Sheets
Dollars in (000's), except per share amounts


December 31,
ASSETS 2004 2003

Current assets:
Cash and cash equivalents $33,341 $17,271
Accounts receivable, net of allowance of $255
and $561 in 2004 and 2003, respectively 27,841 17,515
Unbilled receivables 11,516 8,246
Inventories 2,024 1,901
Prepaid expenses and other current assets 2,929 4,610
------------- --------------
Total current assets $77,651 $49,543
------------- --------------
Property and equipment, net 109,999 $101,547
Goodwill 901 832
Unamortized capital bonds issue costs 271 429
Deferred income taxes 11,253 3,922
------------- --------------
Total assets $200,075 $156,273
------------- --------------
LIABILITIES AND SHAREHOLDERS' EQUITY/(DEFICIT)
Current liabilities:
Accounts payable $13,547 $12,508
Accrued payroll and other benefits 4,024 4,152
Accrued expenses and other liabilities 19,987 13,695
Short-term debt 719 338
Fees invoiced in advance 37,574 22,761
------------- --------------
Total current liabilities $75,851 $53,454
------------- --------------
Long-term debt 89,685 $87,560
Pension liabilities 36,603 21,414
Deferred income taxes - 2,291
------------- --------------

Total liabilities $202,139 $164,719
------------- --------------

(Continued)







Life Sciences Research Inc. & Subsidiaries
Consolidated Balance Sheets (Continued)
Dollars in (000's), except per share amounts



December 31,
LIABILITIES AND SHAREHOLDERS' EQUITY/(DEFICIT) (Continued) 2004 2003

Commitments and contingencies - -
Shareholders' equity/(deficit)
Preferred Stock, $0.01 par value. Authorized: 5,000,000
Issued and outstanding: None - -
Non-Voting Common Stock, $0.01 par value. Authorized: 5,000,000
Issued and outstanding: None - -
Voting Common Stock, $0.01 par value. Authorized: 50,000,000
Issued and outstanding at December 31, 2004: 12,441,281
(December 31, 2003: 12,034,883) 125 120
Paid in capital 75,671 75,101
Less: Promissory notes for issuance of common stocks (697) (661)
Accumulated comprehensive loss (34,724) (22,973)
Accumulated deficit (42,439) (60,033)
-------------- ------------
Total shareholders' (deficit) $(2,064) $(8,446)
-------------- -------------
Total liabilities and shareholders' equity/(deficit) $200,075 $156,273
------------- --------------


The accompanying notes are an integral part of the consolidated financial
statements.








Life Sciences Research Inc. and Subsidiaries
Consolidated Statements of Shareholders' (Deficit)/Equity and Comprehensive
Income/(Loss)
Dollars in (000's), except per share amounts


Common Common Promissory Additional Accum-ulatedAccumulated Total
Stock Stock Notes for Paid in Deficit Other
at Par Issuance of Capital Compre-hensive
Common Stock Loss

Balance, December 31, 2001 5,847 $59 $- $66,035 $(66,458) $(4,360) $(4,724)

Issue of Shares 5,585 55 - 8,384 - - 8,439
Promissory notes for issuance
of common stock 500 5 (684) 679 - - -
Accumulated
comprehensive loss:
- - Net income for the - - - - 2,697 - -
year
- - Minimum pension
liability, net of $5,903
tax -Deficiency on UK
defined benefit pension
plan. - - - - - (13,507)
- - Translation
adjustments, - - - - - (709) -
net of $569 tax - - - - - (11,519)
Total Comprehensive Loss
-----------------------------------------------------------------------------------------
Balance, December 31, 2002 11,932 $119 $(684) $75,098 $(63,761) $(18,576) $(7,804)
Issue of shares 103 1 - 3 - - 4
Repayment of Promissory notes
- - 23 - - - 23
Accumulated comprehensive loss:
Net income for the year - - - - 3,728 - -
Minimum pension liability,
net of $971 deferred tax -
Deficiency on UK defined
benefit pension plan - - - - - (2,265) -

Translation adjustments,
net of $123 tax - - - - - (2,132) -
Total comprehensive loss - - - - - - (669)

-----------------------------------------------------------------------------------------

Balance, December 31, 2003 12,035 $120 $(661) $75,101 $(60,033) $(22,973) $(8,446)







Life Sciences Research Inc. and Subsidiaries
Consolidated Statements of Shareholders' (Deficit)/Equity and Comprehensive
Income/(Loss)
Dollars in (000's), except per share amounts



Common Common Promissory Additional Accum-ulatedAccumulated Total
Stock Stock Notes for Paid in Deficit Other
at Par Issuance of Capital Compre-hensive
Common Stock Loss


Balance, December 31, 2003 12,035 $120 $(661) $75,101 $(60,033) $(22,973) $(8,446)
Issue of shares 406 5 - 570 - - 575
Increase in value net of
repayment of Promissory notes
- - (36) - - - (36)
Accumulated comprehensive loss:
Net income for the year - - - - 17,594 - -
Minimum pension liability,
net of $4,385 deferred tax
- Deficiency on UK defined
benefit pension plan
- - - - - (10,233) -

Translation adjustments,
net of $232 tax - - - - - (1,518) -
Total comprehensive income
- - - - - - 5,843
-----------------------------------------------------------------------------------------
Balance, December 31, 2004 12,441 125 (697) 75,671 (42,439) (34,724) (2,604)
-----------------------------------------------------------------------------------------



The accompanying notes are an integral part of these consolidated financial
statements.








Life Sciences Research Inc. and Subsidiaries
Consolidated Statements of Cash Flows
Dollars in (000's) except per share amounts


Year Ended December 31,
2004 2003 2002

Cash flows from operating activities:
Net income $17,594 $3,728 $2,697
Adjustments to reconcile net income to net cash from operating
activities
Depreciation 9,530 9,049 8,108
Impairment of fixed assets - 2,014 -
Loss on disposals of fixed assets - 271 -
Foreign exchange gain on Capital Bonds (3,345) (4,760) (4,977)
Deferred income tax( benefit)/expense (5,512) (1,234) 188
Gain on repurchase of Capital Bonds - (602) (1,191)
Share of profit on acquisition - (208) -
Provision for losses on accounts receivable (302) 244 123
Amortization of capital bonds issue costs 179 165 191
Amortization of warrants 179 290 156
Changes in operating assets and liabilities:
Accounts receivable, unbilled receivables and prepaid expenses (8,974) 5,063 4,605
Inventories - (157) (127)
Accounts payable, accrued expenses and other liabilities 4,841 2,048 (1,728)
Fees invoiced in advance 12,776 (5,972) 5,988
------------ ------------ ------------
Net cash provided by operating activities $26,966 $9,939 $14,033
------------ ------------ ------------
Cash flows from investing activities:
Purchase of property, plant and equipment (11,096) (8,716) (4,177)
Cash acquired with Subsidiary - 1,893 -
------------ ------------ ------------
Net cash used in investing activities $(11,096) $(6,823) $(4,177)
------------ ------------ ------------

Cash flows from financing activities:
Proceeds from issue of common shares 539 27 6,039
Proceeds from long-term borrowings - 444 334
Repayments of long-term borrowings - (1,328) (4,627)
Repayments of short term borrowings (651) (253) -
------------ ------------ ------------
Net cash (used)/provided by financing activities $(112) $(1,110) $1,746
------------ ------------ ------------

Effect of exchange rate changes on cash and cash equivalents 312 621 802
------------ ------------ ------------
Increase in cash and cash equivalents 16,070 2,627 12,404
Cash and cash equivalents at beginning of year 17,271 14,644 2,240
------------ ------------ ------------
Cash and cash equivalents at end of year $33,341 $17,271 $14,644
------------ ------------ ------------
Supplementary disclosures:
Interest paid $5,928 $5,544 $6,110
Non-cash transactions:
Conversion of debt to equity $- $- $2,400
Issuance of common stocks for promissory notes $- $- $684


The accompanying notes are an integral part of these consolidated financial statements





1. THE COMPANY AND ITS OPERATIONS

Life Sciences Research Inc. ("LSR") and subsidiaries (collectively, the
"Company") is a global contract research organization, offering worldwide
pre-clinical and non-clinical testing for biological safety evaluation research
services to pharmaceutical, biotechnology, agrochemical and industrial chemical
companies. The Company serves the rapidly evolving regulatory and commercial
requirements to perform safety evaluations on new pharmaceutical compounds and
chemical compounds contained within the products that humans use, eat, and are
otherwise exposed to. In addition, it tests the effect of such compounds on the
environment and also performs work on assessing the safety and efficacy of
veterinary products.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

A summary of the significant accounting policies, is set out below:

Basis of Presentation

These financial statements are prepared in conformity with the accounting
principles generally accepted in the United States of America ("US GAAP"). Under
US GAAP, the company whose stockholders retain the majority interest in a
combined business must be treated as the acquirer for accounting purposes.
Accordingly, the Exchange Offer is accounted for as a "reverse acquisition" for
financial reporting purposes. The reverse acquisition is deemed a capital
transaction and the net assets of Huntingdon Life Sciences Group plc
("Huntingdon") (the accounting acquirer) are carried forward to LSR (the legal
acquirer and the reporting entity) at their carrying value before the
combination. Although Huntingdon was deemed to be the acquiring corporation for
financial accounting and reporting purposes, the legal status of LSR as the
surviving corporation does not change. The relevant acquisition process utilizes
the capital structure of LSR and the assets and liabilities of Huntingdon are
recorded at historical cost. In these financial statements, Huntingdon is the
operating entity for financial reporting purposes and the financial statements
for all periods presented represent Huntingdon's financial position and results
of operations. The equity of LSR is the historical equity of Huntingdon,
retroactively restated to reflect the number of shares issued in the Exchange
Offer. Certain reclassifications and eliminations have been recorded in the
current year presentation to retroactively consolidate Huntingdon and LSR.

Principles of Consolidation

The consolidated financial statements incorporate the accounts of LSR and each
of its subsidiaries. All inter-company balances have been eliminated upon
consolidation.

Cash and Cash Equivalents

Cash and cash equivalents include all highly liquid investments with an original
maturity date of three months or less at the date of purchase.

Allowance for Uncollectible Accounts

The Company establishes an allowance for uncollectible accounts which it
believes is adequate to cover anticipated losses on the collection of all
outstanding trade receivable balances. The adequacy of the uncollectible account
allowance is based on historical information, a review of customer accounts and
related receivable balances, and management's assessment of current economic
conditions. The Company reassesses the allowance for uncollectible accounts
annually.

Inventories

Inventories are valued on a FIFO (first-in, first out) method at the lower of
cost, or market value. They comprise materials and supplies.

Property, Plant and Equipment

Property, plant and equipment, stated at cost, is depreciated over the estimated
useful lives of the assets on a straight-line basis. Estimated useful lives are
as follows:

Buildings and facilities 15 - 50 years
Plant and equipment 4 - 25 years
Vehicles 5 years
Computers and software 3 - 5 years

Amounts spent to repair and maintain these assets arising out of the normal
course of business are expensed in the period incurred.

Concentration of Credit Risk

The Company maintains cash and cash equivalents in US financial institutions,
which, at times, may exceed federally insured limits. Based on the nature of the
financial instruments and/or historical realization of these instruments, the
Company believes they bear minimal risk.

Income Taxes

The Company accounts for income taxes under the provisions of SFAS No. 109,
"Accounting For Income Taxes" ("SFAS 109"). SFAS 109 requires recognition of
deferred tax assets and liabilities for the estimated future tax consequences of
events attributable to differences between the financial statement carrying
amounts of existing assets and liabilities and their respective tax bases and
operating loss and tax credit carry forwards. Deferred tax assets and
liabilities are measured using enacted rates in effect for the year in which the
differences are expected to be recovered or settled. The effect on deferred tax
assets and liabilities of changes in tax rates is recognized in the statement of
operations in the period in which the enactment rate changes. Deferred tax
assets and liabilities are reduced through the establishment of a valuation
allowance at such time as, based on available evidence, it is more likely than
not that the deferred tax assets will not be realized.

Revenue Recognition

The majority of the Company's net revenues have been earned under contracts,
which generally range in duration from a few months to three years. Revenue from
these contracts is recognized over the term of the contracts as services are
rendered. Contracts may contain provisions for renegotiation in the event of
cost overruns due to changes in the level of work scope. Renegotiated amounts
are included in net revenue when earned and realization is assured. Provisions
for losses to be incurred on contracts are recognized in full in the period in
which it is determined that a loss will result from performance of the
contractual arrangement. Most service contracts may be terminated for a variety
of reasons by the Company's customers either immediately or upon notice at a
future date. The contracts generally require payments to the Company to recover
costs incurred, including costs to wind down the study, and payment of fees
earned to date, and in some cases to provide the Company with a portion of the
fees or profits that would have been earned under the contract had the contract
not been terminated early. Unbilled receivables are recorded for revenue
recognized to date that is currently not billable to the customer pursuant to
contractual terms. In general, amounts become billable upon the achievement of
certain aspects of the contract or in accordance with predetermined payment
schedules. Unbilled receivables are billable to customers within one year from
the respective balance sheet date. Fees in advance are recorded for amounts
billed to customers for which revenue has not been recognized at the balance
sheet date (such as upfront payments upon contract authorization, but prior to
the actual commencement of the study).



Foreign Currencies

Transactions in currencies other than the functional currency of the entity are
recorded at the rates of exchange at the date of the transaction. Monetary
assets and liabilities in currencies other than the functional currency are
translated at the rates of exchange at the balance sheet date and the related
transaction gains and losses are reported in the statements of operations.
Exchange gains and losses on foreign currency transactions are recorded as other
income or expense. Certain intercompany loans are determined to be of a
long-term investment nature. The Company records gains and losses from
re-measuring such loans as a component of other comprehensive income.

Upon consolidation, the results of operations of subsidiaries and associates
whose functional currency is other than the US dollar are translated into US
dollars at the average exchange rate and assets and liabilities are translated
at year-end exchange rates and capital accounts are translated at historical
exchange rates, and retained earnings are translated at the weighted average of
historical rates. Translation adjustments are presented as a separate component
of other accumulated comprehensive loss in the financial statements.

Goodwill and Other Intangible Assets

Effective 2003, the Company adopted SFAS No. 142, "Goodwill and Other Intangible
Assets," which establishes financial accounting and reporting standards for
acquired goodwill and other intangible assets (Note 4). In accordance with SFAS
No. 142, goodwill and indefinite-lived intangible assets are no longer amortized
but are reviewed at least annually for impairment. Separate intangible assets
that have finite useful lives continue to be amortized over their estimated
useful lives.

SFAS No. 142 requires that goodwill be tested annually for impairment using a
two-step process. The first step is to identify a potential impairment. The
second step of the impairment test measures the amount of the impairment loss.
The Company, after completing the first step of the process, concluded there was
no impairment of goodwill at December 31, 2004.

Impairment of Long-Lived Assets

The Company adopted the provisions of SFAS No. 144, "Accounting for the
Impairment or Disposal of Long-lived Assets". The Company evaluates long-lived
assets whenever events or changes in circumstances indicate that the carrying
amount of an asset may not be recoverable. An impairment loss would be
recognized when estimated undiscounted future cash flows expected to result from
the use of the asset and its eventual disposal are less than its carrying
amount. In such instances, the carrying value of long-lived assets is reduced to
the estimated fair value, as determined using an appraisal or discounted cash
flows, as appropriate.

Restructuring Costs

The Company recognizes obligations associated with restructuring activities in
accordance with SFAS No. 146, "Accounting for Costs Associated with Exit or
Disposal Activities." The Company adopted the provisions of SFAS No. 146 as of
the beginning of fiscal 2003, which generally requires a liability for costs
associated with an exit or disposal activity be recognized and measured
initially at its fair value in the period in which the liability is incurred.
The overall purpose of the Company's restructuring actions is to lower overall
operating costs and improve profitability by reducing excess capacities.
Restructuring costs (Note 8) are typically recorded in other operating expenses
in the period in which the plan is approved by the Company's senior management
and, where material, the Company's Board of Directors, and when the liability is
incurred.

Leased Assets

Assets held under the terms of capital leases are included in property and
equipment and are depreciated on a straight-line basis over the lesser of the
useful life of the asset or the term of the lease. Obligations for future lease
payments, less attributable finance charges are shown within liabilities and are
analyzed between amounts falling due within and after one year. Operating lease
rentals are charged to the Consolidated Statement of Operations as incurred.

Pension Costs

During the year the Company had two defined contribution plans. One of the
defined contribution pension plans covers all employees in the US; the other,
employees in the UK. Prior to December 31, 2002, a defined benefit pension plan
provided benefits to employees in the UK based on their final pensionable
salary. As of December 31, 2002, the defined benefit pension plan was curtailed.
The gain on curtailment was recognized in the Statement of Operations according
to SFAS No. 88, "Employees' Accounting for Settlements and Curtailments of
Deferred Benefit Pension Plan and for Termination Benefits". The pension cost of
the plan is accounted for in accordance with SFAS No. 87, "Employers' Accounting
For Pensions". Pension information is presented in accordance with the currently
required provisions of SFAS No. 132, "Employers' Disclosures About Pensions And
Other Post Retirement Benefits". The net asset at transition, prior service cost
and net (loss)/gain subject to amortization, outside the corridor, are being
amortized on a straight-line basis over periods of 15 years, 10 years and 10
years respectively. The Company recognized all actuarial gains and losses
immediately for the purposes of its minimum pension liability.

Use of Estimates

The preparation of financial statements in conformity with accounting principles
generally accepted in the United States requires management to make estimates
and assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingent assets and liabilities as of the dates of the financial
statements and the results of operations during the reporting periods. Although
these estimates are based upon management's best knowledge of current events and
actions, actual results could differ from those estimates.

Income Per Share

Income per share is computed in accordance with SFAS No. 128, "Earnings Per
Share". Basic income per share is computed by dividing net income available to
common stockholders by the weighted average number of common shares outstanding
during the year. The computation of diluted income per share is similar to the
computation of basic income per share, except that the denominator is increased
to include the number of additional common shares that would have been
outstanding if the dilutive potential common shares had been issued. Diluted
income per share reflects the potential dilution that could occur if dilutive
securities and other contracts to issue common stock were exercised or converted
into common shares or resulted in the issuance of common shares that then shared
in the income of the Company.

Segment Analysis

In accordance with the Statement of Financial Accounting Standards No. 131,
"Disclosures About Segments of an Enterprise and Related Information" (SFAS
131), the Company discloses financial and descriptive information about its
reportable operating segments. Operating segments are components of an
enterprise about which separate financial information is available and regularly
evaluated by the chief operating decision maker in deciding how to allocate
resources and in assessing performance.

Loans and Warrants

In accordance with Accounting Principles Board ("APB") Opinion No. 14
"Accounting for Convertible Debt and Debt issued with Share Purchase Warrants",
loans and warrants are recorded at their pro-rata fair values in relation to the
proceeds received with the portion allowable to the warrants accounted for as
paid-in-capital. The costs of raising long-term financing are capitalized as an
asset and are amortized, using the effective interest method, over the term of
the debt.


Stock-Based Compensation

The Company accounts for its stock option and stock-based compensation
arrangements plans using the intrinsic-value method. Under the intrinsic value
method, the difference between the amount the employee will pay the Company for
stock acquired under the Company's incentive plans and the stock's fair value on
the date of grant is charged to expense. Since employees must pay the Company
the grant date fair value for stock options, no expense is recorded for stock
options. (Alternatively, if employees did not have to pay for stock issued for
deferred stock units granted, their grant date fair value would be recorded as
expense).

The following table reconciles net income and earnings per common stock (EPS),
as reported, to pro forma net income and EPS, as if the Company had expensed the
grant date fair value of both stock options and deferred stock units as
permitted by SFAS No. 123, "Accounting for Stock Based Compensation" ("SFAS
123"). These pro forma amounts may not be representative of the initial impact
of adopting SFAS 123 since, as amended, it permits alternative methods of
adoption.





Year ended December Year ended Year Ended
31, 2004 December 31, 2003 December 31, 2002
------------------------ --------------------- ----------------------
$000 $000 $000

Net income As Reported $17,594 $3,728 $2,697
Less: Pro forma expense as
if stock options were
charged against net
income, net of tax
(281) (67) (59)

Pro forma 17,313 $3,661 $2,638
Basic and Diluted EPS: As Reported $1.45 and $1.29 $0.31 and $0.29 $0.25 and $0.24
Pro forma $1.42 and $1.27 $0.31 and $0.29 $0.25 and $0.24


The weighted average fair value at the date of grant for options granted during
2004, 2003 and 2002 was $3.44, $1.03 and $0.87 respectively. The options granted
prior to 2002 are considered to have no value. These fair values were estimated
using the Black-Scholes option-pricing model, based on the following
assumptions:



2004 2003 2002

Dividend yield 0% 0% 0%
Volatility 135% 40% 40%
Risk-free interest rate 4.63% 3.72% 3.72%
Expected term of options (in years) 10 years 10 years 10 years





3. PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment as of December 31 consisted of the following:



2004 2003
$000 $000

Property, plant and equipment at cost:
Building and facilities 128,395 116,981
Plant, equipment, vehicles, computers and software 110,005 108,658
Assets in the course of construction 330 1,045
-------------- ---------------
238,730 226,684
Less: Accumulated depreciation (128,731) (125,137)
-------------- ---------------
Property and equipment, net $109,999 $101,547
-------------- ---------------


Depreciation expense aggregated $9,530,000, $9,049,000 and $8,108,000 for 2004,
2003 and 2002 respectively.

The net book value of assets held under capital leases and included above is as
follows:

Cost Depreciation Net book
Value
$000 $000 $000
At December 31, 2004 981 114 867
At December 31, 2003 546 87 459

4. GOODWILL AND INTANGIBLE ASSETS

In June 2001, the FASB issued Statement of Financial Accounting Standards No.
141, "Business Combinations", which eliminates the pooling of interests method
of accounting for business combinations and addresses the initial recognition
and measurement of goodwill and other intangible assets acquired in a business
combination. In June 2001, the FASB issued Statement of Financial Accounting
Standards No. 142, "Goodwill and Other Intangible Assets", or SFAS No. 142. The
Company adopted SFAS No. 142 as of January 1, 2003. SFAS No. 142 addresses the
financial accounting and reporting standards for the acquisition of intangible
assets outside of a business combination, and for goodwill and other intangible
assets subsequent to their acquisition. This statement requires that goodwill be
separately disclosed from other intangible assets in the statement of financial
position, and no longer be amortized but tested for impairment on a periodic
basis.

On July 1, 2003, the remaining 50% of the shares in HLS KK, not previously owned
by Huntingdon, was purchased, resulting in HLS KK becoming a wholly owned
subsidiary of Huntingdon. The purchase price is payable over a three year
period, and is equal to the greater of (a) $1 million or (b) the commission
which would have been paid if the purchase had not happened. Payments during
that three year period shall be made at the rate which had been in effect for
commissions prior to the acquisition, and is payable semi-annually. Goodwill on
purchase was Japanese Yen 99,500,000 ($901,000 at year end rates).

Prior to this date, the shares owned by Huntingdon in HLS KK were held as an
investment, as the day to day control of HLS KK was not exercised by the
Company.


5. INCOME TAXES

The components of income before taxes and the related benefit/(expense) for tax
for the years ended December 31 are as follows:



Income/(loss) before taxes 2004 2003 2002
$000 $000 $000

United Kingdom 13,761 1,452 4,110
United States (1,669) 887 (1,162)
Japan 101 280 -
------------- ------------- -------------
$12,193 $2,619 $2,948
------------- ------------- -------------

The benefit/(expense)for income taxes by location 2004 2003 2002
of the taxing jurisdiction for the years ended $000 $000 $000
December 31, consisted of the following:
Current Taxation:
- - State Taxes - US (72) (39) (63)
- - Corporate Tax - Japan (44) (86) -
Deferred taxation:
- - United Kingdom 4,864 2,263 (45)
- - United States 651 (1,029) (143)
- - Japan 2 - -
------------- ------------- -------------
$5,401 $1,109 $(251)
------------- ------------- -------------


Reconciliation between the US statutory rate and the effective rate is as
follows:

% of income/(loss) before income
taxes
2004 2003 2002
% % %

US statutory rate 35 35 35
Foreign rate differential (6) (3) (9)
UK R & D credit and non-deductible items (36) 13 (31)
State taxes 1 2 2
Change in estimate (38) (89) 11
------------ ---------- ----------
Effective tax rate (44) (42) 8
------------ ---------- ----------

The main reason for the change in estimate above relates to the Huntingdon 2002
and 2003 tax provisions. The UK government introduced a new tax allowance,
`Research and Development (R & D) Tax Credit, for large companies from April 1,
2002. At the end of 2002, it was not certain how this would apply to Huntingdon.
When submitting Huntingdon's 2002 corporation tax computation, and following
discussions with the UK Inland Revenue, Huntingdon has made a claim for the R &
D Tax Credit, which has now been accepted and the 2003 provision included in the
2004 change in estimate. The 2004 claim is part of the non-deductible items
above.


The tax effects of temporary differences that give rise to significant portions
of deferred tax assets and liabilities as of December 31 are as follows:

2004 2003
$000 $000
Current deferred tax assets:
Accrued liabilities - -
---------- -----------
$- $-
---------- -----------
Non-current deferred tax assets:
Net operating losses - US 5,189 4,827
Net operating losses - UK 20,801 17,624
Net operating losses - Japan 27 -
Net pension plan minimum liability adjustment - UK 10,968 6,423
Capital losses - UK 16,373 15,228
Valuation allowance - UK (16,373) (15,228)
---------- -----------
Net non-current deferred tax assets $36,985 $28,874
---------- -----------


Non-current deferred tax liabilities:
Property and equipment - US 554 929
- UK 25,178 26,314
---------- -----------
Total $25,732 $27,243
---------- -----------
Net non-current deferred tax assets $11,253 $3,922

Net non-current deferred tax liabilities $- $2,291

In accordance with SFAS No. 109, the Company nets all current and non-current
assets and liabilities by tax jurisdiction.

Of the gross amount of net operating losses in the US of $12,613,000, $2,817,000
expires in 2012, $6,163,000 expires in 2018, $523,000 expires in 2019,
$1,087,000 expires in 2021, $492,000 expires in 2022, $3,000 expires in 2023 and
$1,528,000 expires in 2024. The gross amount of net operating losses in the UK
of $67,218,000 have no expiration date. The Company has not provided a valuation
allowance on the net operating loss carry forwards because it believes that it
is more likely than not that those amounts will be realized through taxable
income from future operations. A full valuation allowance has been recorded for
the total benefit of capital losses incurred in prior years, as the Company does
not anticipate that the benefit will be realized in the foreseeable future
through the recognition of capital gains.



6. LONG-TERM DEBT AND RELATED PARTY LOANS

2004 2003
$000 $000
Non-bank loans 43,114 40,965
Capital leases, net of current 376 400
portion
Convertible Capital Bonds 46,195 46,195
----------------- ---------------
$89,685 $87,560
----------------- ---------------



Repayment Schedule Total 2006 2007 2008 2009 Thereafter
$000 $000 $000 $000 $000 $000

Non bank loan 43,114 43,114 - - - -
Capital leases 376 160 118 98 - -
Convertible Capital Bonds 46,195 46,195 - - - -
------------- ------------- ------------ ------------- ------------- --------------
$89,685 $89,469 $118 $98 $- $-
------------- ------------- ------------ ------------- ------------- --------------


Bank Loans and Non-Bank Loans

On January 20, 2001, the Company's non-bank loan of (pound)22.6 million
($43.4million approximately), was refinanced by Stephens Group Inc. and other
parties. The loan was transferred from Stephens Group Inc. to an unrelated third
party effective February 11, 2002. It is now repayable on June 30, 2006 and
interest is payable quarterly at LIBOR plus 1.75%. At the same time the Company
was required to take all reasonable steps to sell off such of its real estate
assets through sale/leaseback transactions and/or obtaining mortgage financing
secured by the Company's real estate assets to discharge this loan. The Company
is taking all reasonable steps to conduct these transactions. The loan is held
by LSR Ltd and is secured by the guarantees of the wholly owned subsidiaries of
the Company including LSR Ltd., Huntingdon Life Sciences Ltd and Huntingdon Life
Sciences Inc., and collateralized by all the assets of these companies.

On October 9, 2001, on behalf of Huntingdon, LSR issued to Stephens Group Inc.
warrants to purchase up to 704,425 shares of LSR Voting Common Stock at a
purchase price of $1.50 per share. These warrants were subsequently transferred
to an unrelated third party. The LSR warrants are exercisable at any time and
will expire on October 9, 2011. These warrants arose out of negotiations
regarding the refinancing of the bank loan by the Stephens Group Inc., in
January 2001. In accordance with APB Opinion No. 14, Accounting for Convertible
Debt and Debt Issued with Stock Purchase Warrants ("APB 14") the warrants were
recorded at their pro rata fair values in relation to the proceeds received on
the date of issuance and treated as a debt discount. The value of the warrants
was $430,000. 154,425 of such warrants were exercised in 2004.

Convertible Capital Bonds

The remainder of the Company's long term financing is provided by Convertible
Capital Bonds repayable in September 2006. At the time of the issue in 1991,
these bonds were for $50 million par and at December 31, 2004 and 2003 $46.2
million was outstanding. They carry interest at a rate of 7.5% per annum,
payable biannually in March and September. During 2002, the Company repurchased
and cancelled $2,410,000 principal amount of such bonds resulting in a $1.2
million gain recorded in other income/expense. In January 2003, the Company
further repurchased and cancelled $1,345,000 principal amount of such bonds
resulting in a gain of $0.6 million. At the current conversion rate, the number
of shares of Voting Common Stock to be issued on conversion and exchange of each
unit of $10,000 comprised in a Bond would be 49. The conversion rate is subject
to adjustment in certain circumstances.



Related Party Loans

Financing which totaled $5.7 million was provided to the Company in 2000 and
2001 and was fully repaid in 2002. This financing had been provided in part by a
$2.9 million loan facility made available on September 25, 2000 by the Company's
Chairman and CEO, Mr. Baker. In connection with this financing, the company
authorized, subject to shareholder approval, the issuance of warrants to
purchase 410,914 shares of LSR Voting Common Stock at a purchase price of $1.50
per share to FHP, a company controlled by Mr. Baker. Such shareholder approval
was granted on June 12, 2002. Additionally, other financing also included a $2.8
million facility from the Stephens Group Inc. made available on July 19, 2001.
Effective February 11, 2002 the Stephens Group Inc. debt was transferred to an
unrelated third party. $550,000 of the loan from Mr. Baker was transferred to
and assumed by FHP in March 2001. On March 28, 2002, $2.1 million of Mr. Baker's
loan was converted into 1,400,000 shares of LSR Voting Common Stock and $300,000
of FHP's loan was converted into 200,000 shares of LSR Voting Common Stock; in
each case as part of LSR's private placement of approximately 5.1 million shares
of Voting Common Stock. The remaining principal amounts were repaid in full to
Mr. Baker and FHP, inclusive of 10% interest, respectively, in 2002. The other
$2.8 million facility was repaid in full as of October 1, 2002.

As noted above, on June 11, 2002 LSR issued to FHP warrants to purchase up to
410,914 shares of LSR Voting Common Stock at a purchase price of $1.50 per
share. These LSR warrants are exercisable at any time and will expire on June
11, 2012. These warrants arose out of negotiations regarding the provision of
the $2.9 million loan facility made available to the Company on September 25,
2000 by Mr. Baker, who controls FHP. In accordance with APB 14 the loan and
warrants were recorded at their pro rata fair values in relation to the proceeds
received. As a result, the value of the warrants was $250,000.



7. FAIR VALUE OF FINANCIAL INSTRUMENTS

The Company's principal financial instruments comprise cash and cash
equivalents, accounts receivables, unbilled receivables and long-term debt. The
Company does not hold financial instruments for trading purposes.

The estimated fair value of the Company's financial instruments as of December
31, 2004 and 2003 is summarized below. Certain estimates and judgments were
required to develop the fair value amounts. The fair value amounts shown below
are not necessarily indicative of the amounts that the Company would realize
upon disposition nor do they indicate the Company's intent or ability to dispose
of the financial instrument.



2004 2003
Carrying Estimated Carrying Estimated
Value Fair Value Value Fair Value
$000 $000 $000 $000
Primary financial instruments held or issued
to finance the Company's operations:


Cash and cash equivalents $33,341 $33,341 $17,271 $17,271
Accounts receivable 27,841 27,841 17,515 17,515
Short-term debt 719 719 338 338
Accounts payable 13,547 13,547 12,508 12,508
Fees invoiced in advance 37,574 37,574 22,761 22,761
Long-term debt (excluding the Convertible Capital
Bond) 43,490 43,490 41,365 41,365
Convertible Capital Bond 46,195 46,195 46,195 36,956



The following methods and assumptions were used by the Company in estimating its
fair value disclosure for financial instruments:

Cash and cash equivalents, capital leases - short term, accounts payable and
fees invoiced in advance: The estimated fair value of these financial
instruments approximates their carrying values due to their short maturities.

Accounts receivables: The estimated fair value of these financial instruments
approximates their carrying value due to their short maturities, less any
provision for bad debt.

Long-term debt: The carrying value of these financial instruments approximates
the fair value due to their variable interest rates.

Convertible Capital Bond: The estimated fair values of the Company's Convertible
Capital Bond is based on market prices at year-end.

8. RESTRUCTURING COSTS

During the fourth quarter of 2003, the Company recorded restructuring charges of
$3,551,000 including impairment of fixed assets of $2,014,000, and employee
severance of $1,537,000 associated with the UK facilities. These charges arose
from the consolidation of duplicate facilities in response to changes in the
market, particularly for non-pharmaceutical services, and the closure of excess
and outdated toxicology capacity. This restructuring will improve the efficiency
of the Company's operations and will not impair its ability to service clients'
needs.



9. OTHER INCOME/(EXPENSE)



2004 2003 2002
$000 $000 $000


Exchange gain/(loss) on capital bonds 3,345 4,760 4,977
Gain on partial repurchase of Capital Bonds - 602 1,191
Cost of currency hedge contract (455) - -
Exchange offer costs - - (1,246)
--------------- ----------- -----------
$2,890 $5,362 $4,922
--------------- ----------- -----------


10. COMMITMENTS AND CONTINGENCIES

Leases

Operating lease expenses were as follows:
2004 2003 2002
$000 $000 $000
Plant and equipment 291 451 904
Other operating leases 405 410 392

The Company leases certain equipment under various non-cancelable operating and
capital leases. Future minimum lease payments required under operating and
capital leases are as follows:



Operating Leases Capital Leases
For the years ended December 31,
$000 $000

2005 508 275
2006 208 198
2007 60 138
2008 25 104
2009 - -
2010 and thereafter - -
----------------- ----------------
Total minimum lease payments 801 715
=================

Less amounts representing interest (120)
----------------
Present value of net minimum lease payments 595
Less current portion of capital lease obligations (219)
----------------
Non-current portion of capital lease obligations 376
================



The total cost of equipment capitalized under these capital leases is $981,000
and $546,000 at December 31, 2004 and 2003, respectively. Depreciation on these
capital leases amounted to $192,000, $68,000, and $5,000 for the years ended at
December 31, 2004, 2003 and 2002, respectively. Accumulated depreciation on the
capital leases amounted to $114,000, $87,000 and $20,000 for the years ended at
December 31, 2004, 2003 and 2002, respectively.

Contingencies

The Company is party to certain legal actions arising out of the normal course
of its business. In management's opinion, none of these actions will have a
material effect on the Company's operations, financial condition or liquidity.
No form of proceedings has been brought, instigated or is known to be
contemplated against the Company by any government agency.



11. SHAREHOLDERS' EQUITY

Common Stock

As of December 31, 2004 and 2003 LSR had outstanding 12,441,281 and 12,034,883
shares of Voting Common Stock of par value of $0.01 each respectively.

Share option plans

LSR 2001 Equity Incentive Plan (the "LSR 2001 Equity Incentive Plan")

The LSR 2001 Equity Incentive Plan was adopted effective October 4, 2001.
Adoption of the LSR 2001 Equity Incentive Plan enables LSR to use stock options
(and other stock-based awards) as a means to attract, retain and motivate key
personnel. This stock option plan was approved by the shareholders of LSR, prior
to the acquisition of Huntingdon.

Awards under the LSR 2001 Equity Incentive Plan may be granted by a committee
designated by the LSR Board pursuant to the terms of the LSR 2001 Equity
Incentive Plan (which has designated the Compensation Committee for such
purpose) and may include: (i) options to purchase shares of LSR Voting Common
Stock, including incentive stock options ("ISOs"), non-qualified stock options
or both; (ii) stock appreciation rights ("SARs"), whether in conjunction with
the grant of stock options or independent of such grant, or stock appreciation
rights that are only exercisable in the event of a change in control or upon
other events; (iii) restricted stock consisting of shares that are subject to
forfeiture based on the failure to satisfy employment-related restrictions; (iv)
deferred stock, representing the right to receive shares of stock in the future;
(v) bonus stock and awards in lieu of cash compensation; (vi) dividend
equivalents, consisting of a right to receive cash, other awards, or other
property equal in value to dividends paid with respect to a specified number of
shares of LSR Voting Common Stock or other periodic payments; or (vii) other
awards not otherwise provided for, the value of which are based in whole or in
part upon the value of the LSR Voting Common Stock. Awards granted under the LSR
2001 Equity Incentive Plan are generally not assignable or transferable except
pursuant to a will and by operation of law.

The flexible terms of the LSR 2001 Equity Incentive Plan are intended to, among
other things, permit the Compensation Committee to impose performance conditions
with respect to any award, thereby requiring forfeiture of all or part of any
award if performance objectives are not met or linking the time of
exercisability or settlement of an award to the attainment of performance
conditions. For awards intended to qualify as "performance-based compensation"
within the meaning of Section 162 (m) of the United States Internal Revenue Code
such performance objectives shall be based solely on (i) annual return on
capital; (ii) annual earnings or earnings per share; (iii) annual cash flow
provided by operations; (iv) changes in annual revenues; (v) stock price; and/or
(vi) strategic business criteria, consisting of one or more objectives based on
meeting specified revenue, market penetration, geographic business expansion
goals, cost targets, and goals relating to acquisitions or divestitures.

LSR's Compensation Committee, which administers the 2001 LSR Equity Incentive
Plan, has the authority, among other things, to: (i) select the directors,
officers and other employees and independent contractors entitled to receive
awards under the 2001 LSR Equity Incentive Plan; (ii) determine the form of
awards, or combinations of awards, and whether such awards are to operate on a
tandem basis or in conjunction with other awards; (iii) determine the number of
shares of LSR Voting Common Stock or units or rights covered by an award; and
(iv) determine the terms and conditions of any awards granted under the 2001 LSR
Equity Incentive Plan, including any restrictions or limitations on transfer,
any vesting schedules or the acceleration of vesting schedules, any forfeiture
provision or waiver of the same and including any terms and conditions necessary
or desirable to ensure the optimal tax result for participating personnel and
the Company including by way of example to ensure that there is no tax on the
grant of the rights and that such tax only arises on the exercise of rights or
otherwise when the LSR Voting Common Stock unconditionally vests and is at the
disposal of such participating personnel. The exercise price at which shares of
LSR Voting Common Stock may be purchased pursuant to the grant of stock options
under the 2001 LSR Equity Incentive Plan is to be determined by the Compensation
Committee at the time of grant in its discretion, which discretion includes the
ability to set an exercise price that is below the fair market value of the
shares of LSR Voting Common Stock covered by such grant at the time of grant.

The number of shares of LSR Voting Common Stock that may be subject to
outstanding awards granted under the 2001 LSR Equity Incentive Plan (determined
immediately after the grant of any award) may not exceed 20 percent of the
aggregate number of shares of LSR Voting Common Stock then outstanding.

The 2001 LSR Equity Incentive Plan may be amended, altered, suspended,
discontinued, or terminated by the LSR Board without LSR Common Stockholder
approval unless such approval is required by law or regulation or under the
rules of any stock exchange or automated quotation system on which LSR Voting
Common Stock is then listed or quoted. Thus, LSR Common Stockholder approval
will not necessarily be required for amendments, which might increase the cost
of the plan or broaden eligibility. LSR Common Stockholder approval will not be
deemed to be required under laws or regulations that condition favorable tax
treatment on such approval, although the LSR Board may, in its discretion, seek
LSR Common Stockholder approval in any circumstances in which it deems such
approval advisable.

The LSR Board has designated the Compensation Committee of the Board to serve as
the Stock Option Committee. LSR made grants under the LSR 2001 Equity Incentive
Plan on March 1, 2002 to certain directors and key employees at that time.

Grants to Directors
Name Number Granted
- ---- --------------
Gabor Balthazer 20,000
John Caldwell 20,000
Kirby Cramer 40,000

Grants to Named Executive Officers
Name Number Granted
- ---- --------------
Andrew Baker 200,000
Brian Cass 200,000
Frank Bonner 35,000
Julian Griffiths 60,000
Richard Michaelson 90,000




All such options have ten-year terms; 50% of the shares subject to grant are
immediately exercisable with the remaining 50% exercisable one year after the
grant date (meaning all such options fully vested as of March 1, 2003); and all
have an exercise price of $1.50 per share, the price at which the Company sold
shares of Common Stock in the Private Placement. Options to purchase an
aggregate of 1,188,000 shares of LSR Common Stock (including those specified
above) were granted during the two years 2002 and 2003 to employees and
directors, on the terms set forth above, are listed below:

Date of Grant Numbers Granted Exercise Price
- ------------- --------------- --------------
March 1, 2002 1,142,000 $1.50
September 3, 2002 20,000 $2.40
October 21, 2002 15,000 $2.03
February 14, 2003 11,000 $1.80

In 2004, in addition to the options granted under the 2004 LTIP referred to
below, options to purchase an aggregate of 67,100 shares of LSR Common Stock
were issued, all at exercise prices equal to the market price at the date of
grant, on the terms set forth in the previous paragraph, are listed below.

Date of Grant Numbers Granted Exercise Price
- ------------- --------------- --------------
April 12, 2004 37,100 $1.85
October 28, 2004 17,400 $7.70
December 15, 2004 12,600 $9.52

2004 Long Term Incentive Plan

Effective June 1, 2004 the Company adopted the 2004 Long Term Incentive Plan
("2004 LTIP"), pursuant to the terms of the 2001 Equity Incentive Plan. The 2004
LTIP has two components: a grant of stock options, with a vesting date of March
31, 2007, and a cash bonus to be awarded in 2007 based on 2006 Company financial
performance.

Options to purchase an aggregate of 362,663 shares of common stock were granted
to 32 key employees of the Company as of June 1, 2004 under the 2004 LTIP;
55,500 of such options were granted to Andrew Baker, the Company's Chairman and
CEO, 55,500 of such options were granted to Brian Cass, the Company's Managing
Director and President, 30,303 of such options were granted to Richard
Michaelson, the Company's CFO and Secretary, and 27,750 of such options were
granted to Julian Griffiths, the Company's UK Director of Operations.The
exercise price of all such options is $3.30, the market price of LSR common
stock on June 1, 2004. All such options have ten-year terms and are exercisable
in full on March 31, 2007. At December 31, 2004, 356,419 shares under the 2004
LTIP option plan were outstanding and none were exercisable.

The following table summarizes stock option activity under the Company's option
plans.



Shares Wtd Avg. Ex Price Number of securities remaining
(000) available for future issuance

Outstanding - December 31, 2003 1,188 $1.52

Granted 430 $3.54
Lapsed (105) $1.78
Exercised (127) $1.51
----------- ------------------ ------------------------------------
Outstanding - December 31, 2004 1,386 $2.13 814,000
----------- ------------------ ------------------------------------
Exercisable at end of year 996
Weighted average fair value per
option granted in 2004 was $3.44


Huntingdon Life Sciences Group plc Stock Option Plan

Huntingdon Life Sciences Group plc issued options prior to December 31, 1997
pursuant to several stock option plans. However, the ability to exercise options
under all such Huntingdon plans lapsed on March 26, 2002 in connection with
LSR's acquisition of Huntingdon, except for those granted under the Unapproved
Stock Option Plan (the "Unapproved Plan"). Under the Unapproved Plan, some
options technically remain outstanding. However, such options are exercisable
only for shares of Huntingdon, a 100% wholly owned subsidiary of LSR, and are
therefore considered to have no value.

Warrants

On October 9, 2001, on behalf of Huntingdon, LSR issued to Stephens Group Inc.
warrants to purchase up to 704,425 shares of LSR Voting Common Stock at a
purchase price of $1.50 per share. Stephens Group Inc. subsequently sold the
warrants to independent third parties. The LSR warrants are exercisable at any
time and will expire on October 9, 2011. These warrants arose out of
negotiations regarding the refinancing of the bank loan by the Stephens Group
Inc., in January 2001. In accordance with APB Opinion No. 14, Accounting for
Convertible Debt and Debt Issued with Stock Purchase Warrants ("APB 14") the
warrants were recorded at their pro rata fair values in relation to the proceeds
received on the date of issuance. As a result, the value of the warrants was
$430,000. 154,425 of such warrants were exercised in 2004.

On June 11, 2002 LSR issued to FHP warrants to purchase up to 410,914 shares of
LSR Voting Common Stock at a purchase price of $1.50 per share. The LSR warrants
are exercisable at any time and will expire on June 11, 2012. These warrants
arose out of negotiations regarding the provision of the $2.9 million loan
facility made available to the Company on September 25, 2000 by Mr. Baker, who
controls FHP. In accordance with APB 14 the loan and warrants were recorded at
their pro rata fair values in relation to the proceeds received. As a result,
the value of the warrants was $250,000.

On July 25, 2002, 100,000 warrants were issued at the deemed market price on the
day of $1.50 (the same price at which the Private Placement had been completed).
On October 15, 2003, 100,000 warrants were issued 75,000 of which were at an
exercise price of $2.50, the market price on the day, and 25,000 of which were
issued at an exercise price of $5.00 per share. On October 24, 2003, 100,000
warrants were issued at the market price on the day of $2.05. In all three
cases, these warrants were issued to independent consultants in connection with
financial and strategic advice.

A summary of warrants outstanding at December 31, 2004 is as follows:

Date of issue Warrants Exercise price Expiration Date
October 9, 2001 550,000 $1.50 October 9, 2011
June 11, 2002 410,914 $1.50 June 11, 2012
October 24, 2003 100,000 $2.05 October 24, 2013



12. EMPLOYEE BENEFITS

Prior to December 31, 2002, the Company operated the Huntingdon Life Sciences
Pension and Life Assurance Scheme (the "HLS Defined Benefit Pension Plan") a
funded pension plan providing benefits, based on final pensionable salary, for
certain Company employees in the UK. The Plan had been closed to new entrants
from April 5, 1997 and as of December 31, 2002, the accumulation of plan
benefits of employees in the plan was permanently suspended, and therefore, the
HLS Defined Benefit Pension Plan was curtailed. This suspension of benefits
resulted in a gain on curtailment of $8.4 million at December 31, 2002, which
has been recorded as a reduction of the Company's unrecognized net actuarial
loss.

The components of the net periodic benefit cost of the HLS Defined Benefit
Pension Plan for the years ended December 31, are as follows:



2004 2003 2002
$000 $000 $000

Service cost, benefits earned during the year - - $1,466
Interest cost on projected benefit obligation $7,294 $6,101 5,581
Expected return on plan assets (8,298) (7,279) (6,455)
Amortization of transition asset (145) (277) (238)
Amortization of actuarial loss 854 710 -
------------- ------------ -------------
Net periodic (benefit)/cost $(295) $(745) $354
------------- ------------ -------------

The major assumptions used in calculating the pension expense were:

2004 2003 2002
Discount rate 5.5% 5.5% 5.75%
Rate of increase of future compensation N/A N/A N/A
Long-term rate of return on plan assets 8.0% 8.0% 8.25%

A reconciliation of the projected benefit obligation for the HLS Defined Benefit
Pension Plan to the accrued pension expense recorded as of December 31 is as
follows:

2004 2003 2002
$000 $000 $000
Projected benefit obligation $(154,613) $(123,892) $(99,068)
Plan assets at market value 118,054 102,483 81,356
------------ ------------- --------------

Funded status $(36,559) $(21,409) $(17,712)
Unrecognized net actuarial loss/(gain) 41,211 24,875 19,678
Adjustment for minimum liability - pretax (41,211) (24,734) (19,296)
Unrecognized net asset at transition - (141) (382)
------------ ------------- --------------
(Accrued)/prepaid pension expense $(36,559) $(21,409) $(17,712)
------------ ------------- --------------
Change in plan assets
Fair value of assets, beginning of year $102,483 $81,356 $86,492
Foreign currency changes 7,702 8,884 8,238
Actual gain/(loss) on plan assets 11,308 16,202 (13,299)
Employer contributions 768 809 1,654
Employee contributions - - 752
Benefit payments (4,207) (4,768) (2,481)
------------ ------------ --------------
Fair value of assets, end of year $118,054 $102,483 $81,356
------------ ------------ --------------
Change in projected benefits obligation
Projected benefit obligation, beginning of year $123,892 $99,068 $91,467
Foreign currency changes 9,311 10,819 10,013
Service cost - - 1,466
Interest cost 7,643 6,216 5,581
Actuarial (gains)/losses 17,974 12,557 681
Gain on curtailment - - (8,411)
Employee contributions - - 752
Benefit payments (4,207) (4,768) (2,481)
------------ ------------ --------------
Projected benefit obligation, end of year $154,613 $123,892 $99,068
------------ ------------ --------------




On April 6, 1997 the Company established a defined contribution plan, the Group
Personal Pension Plan, for Company employees in the UK. Additionally, a defined
contribution plan (401-K plan) is also available for employees in the US. The
retirement benefit expense for these plans for the year ended December 31, 2004,
2003 and 2002 were $3.6 million, $2.5 million and $1.3million respectively.



13. GEOGRAPHICAL ANALYSIS

During each of the years ended December 31, 2004, 2003 and 2002, the Company
operated from within two segments based on geographical markets, the United
Kingdom and the United States. The Company had one continuing activity, Contract
Research, throughout these periods.

The accounting policies of the operating segments are the same as those
described in the summary of significant accounting policies. Transactions
between segments, which are immaterial, are carried out on an arms-length basis.
Interest income, interest expense and income taxes are also not reported on an
operating segment basis because they are not considered in the performance
evaluation by the Company's chief operating decision-maker. Geographical segment
information is as follows:



US UK Corporate Total
$000 $000 $000 $000


2004 Revenues $30,403 $127,148 $- $157,551
Operating income before other operating
income/(expense) 3,861 18,716 (6,753) 15,824
Operating (loss)/income 3,861 18,716 (6,753) 15,824
Long-lived assets (A) 19,567 143,143 3,753 166,463
Property and equipment, net 9,941 100,035 23 109,999
Depreciation and amortization 1,307 8,213 10 9,530
Capital expenditure 2,066 9,023 7 11,096
Total assets 25,521 169,939 4,615 200,075

2003 Revenues $28,110 $104,324 $- $132,434
Operating income before other operating
expense 2,085 9,282 (4,598) 6,769
Operating income 1,914 6,127 (4,794) 3,247
Long-lived assets (A) 15,091 119,282 4,200 138,573
Property and equipment, net 9,395 92,126 26 101,547
Depreciation & amortization 1,896 9,431 7 11,334
Capital expenditure 1,904 6,804 8 8,716
Total assets 17,588 132,731 5,954 156,273

2002 Revenues $24,891 $90,851 $- $115,742
Operating income before other expense/income
781 7,562 (4,079) 4,264
Operating income 781 7,562 (4,079) 4,264
Long-lived assets (A) 20,192 108,857 4,154 133,203
Property and equipment, net 9,611 84,928 35 94,574
Depreciation & amortization 1,334 6,768 6 8,108
Capital expenditure 991 3,181 5 4,177
Total assets 21,908 120,455 6,047 148,410



(A) Long-lived assets exclude cash and cash equivalents and unamortized costs
of raising long-term debt.





Revenues from customers (based on location of customers)

2004 2003 2002
$000 $000 $000
United States 44,530 38,820 37,316
Europe 78,277 61,110 51,551
Rest of World 34,744 32,534 26,875
-------------- ------------- ------------
$157,551 $132,464 $115,742
-------------- ------------- ------------


14. ALLOWANCE FOR UNCOLLECTIBLE ACCOUNTS



Balance as of Exchange Charged to Accounts Balance as
beginning of Adjustment operations written off of end of
period period
$000 $000 $000 $000 $000

Allowance for uncollectible accounts
deducted from trade debtors

December 31, 2004 561 15 (94) (227) 255
December 31, 2003 287 29 250 (5) 561
December 31, 2002 164 17 294 (188) 287



15. OTHER RELATED PARTY TRANSACTIONS

Share purchase loan

Brian Cass, President and Managing Director of LSR, acquired 400,000 shares of
LSR Common Stock in the Private Placement. Mr. Cass acquired such shares through
the delivery of two promissory notes. Both such promissory notes, each in the
amount of (pound)211,679 ($406,403), are due on March 28, 2007; bear interest at
the rate of 5% per annum; and are secured by the 200,000 shares of LSR Common
Stock purchased with the proceeds of each such loan. The due date of each
promissory note would be accelerated if Mr. Cass voluntarily resigned from his
employment with LSR or had his employment terminated. Repayment of one of the
promissory notes will be made by automatic deduction of (pound)44,000 ($84,476)
per year from the (pound)66,000 ($126,713) per year pension contribution made by
the Company to a pension plan established by Mr. Cass. The other note is further
collateralized by the (pound)214,500 ($412,000) accrued in such pension account.
In addition, one-third of any yearly bonus received by Mr. Cass will be used to
reduce principal of the promissory notes. Total amount of this loan as of
December 31, 2004 is (pound)363,000 ($697,000 at year-end foreign exchange
rates).

Julian Griffiths, a former director of LSR and current Director of Operations of
Huntingdon, acquired 50,000 shares of LSR Common Stock in the Private Placement.
Mr. Griffiths acquired such shares through the delivery of a promissory note in
the principal amount of (pound)52,817 ($101,403), which is due on March 28,
2007; bears interest at the rate of 5% per annum; and is secured by the 50,000
shares of LSR Common Stock purchased with the proceeds of the loan. This loan
was totally repaid during 2003.



16. UNAUDITED QUARTERLY FINANCIAL INFORMATION

The following is a summary of unaudited quarterly financial information for the
12 months ended December 31, 2004 and December 31, 2003.




Year ended December 31, 2004 Quarter Ended
March 31 June 30 September 30 December 31
$000 $000 $000 $000


Revenues $37,236 $38,315 $40,855 $41,145
Cost of sales (29,435) (28,111) (29,674) (29,841)
--------------------------------------------------------------------------
Gross profit 7,801 10,204 11,181 11,304
Selling and administrative expenses (5,485) (6,201) (6,659) (6,321)
Other operating (expense)/income - - - -
--------------------------------------------------------------------------
Operating income 2,316 4,003 4,522 4,983
Interest income 14 14 13 73
Interest expense (1,576) (1,593) (1,689) (1,777)
Other income/(expense) 1,355 (625) (105) 2,265
--------------------------------------------------------------------------
Income/(Loss) before taxes 2,109 1,799 2,741 5,544
Income tax (expense)/benefit (716) (597) (945) 7,659
--------------------------------------------------------------------------
Net income $1,393 $1,202 $1,796 $13,203
--------------------------------------------------------------------------

Earnings per share $0.12 $0.10 $0.15 $1.07

Quarter Ended
Year ended December 31, 2003 March 31 June 30 September 30 December 31
$000 $000 $000 $000


Revenues $31,901 $32,663 $32,723 $35,147
Cost of sales (25,373) (25,442) (26,164) (27,819)
--------------------------------------------------------------------------
Gross profit 6,528 7,221 6,559 7,328
Selling and administrative costs (4,921) (5,395) (5,189) (5,362)
Other operating(expense)/income - (132) 387 (3,777)
--------------------------------------------------------------------------
Operating income/(loss) 1,607 1,694 1,757 (1,811)
Interest income 16 23 10 45
Interest expense (1,708) (1,444) (1,464) (1,468)
Other (expense)/income (450) 2,179 308 3,325
--------------------------------------------------------------------------
(Loss)/income before taxes (535) 2,452 611 91
Income tax benefit/(expense) 177 (592) (215) 1,739
--------------------------------------------------------------------------
Net (loss)/income $(358) $1,860 $396 $1,830
--------------------------------------------------------------------------

(Loss)/earnings per share $(0.03) $0.16 $0.03 $0.15




ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
FINANCIAL DISCLOSURES

None

ITEM 9(a) CONTROLS AND PROCEDURES

Evaluation of disclosure controls and procedures. The Company's Principal
Executive Officer (the CEO) and Principal Financial Officer (the CFO) have
reviewed and evaluated the effectiveness of the Company's disclosure controls
and procedures as of the end of the period covered in this report. Based on that
evaluation, the Principal Executive Officer and the Principal Financial Officer
have concluded that the Company's current disclosure controls and procedures are
effective. There have been no significant changes in the Company's internal
controls or in the other factors that significantly affect those controls.





PART III

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

The table below sets forth certain information with respect to the current
directors and executive officers of LSR.

Name Age Office Held

Andrew Baker 56 Director
Chairman of the Board and Chief Executive Officer
Gabor Balthazar 63 Director
Brian Cass 57 Director, Managing Director/President
Afonso Junqueiras 48 Director
Richard Michaelson 53 Chief Financial Officer & Secretary
Yaya Sesay 62 Director

(a) Identification of Directors and Executive Officers

Andrew Baker became a director and Chairman and Chief Executive Officer of LSR
on January 10, 2002. He was appointed to the Board of Huntingdon as Executive
Chairman in September 1998. He is a chartered accountant and has operating
experience in companies involved in the delivery of healthcare ancillary
services. He spent 18 years until 1992 with Corning Incorporated ("Corning") and
held the posts of President and CEO of MetPath Inc., Corning's clinical
laboratory subsidiary, from 1985 to 1989. He became President of Corning
Laboratory Services Inc. in 1989, which at the time controlled MetPath Inc. (now
trading as part of Quest Diagnostics Inc.), and Hazleton Corporation,
G.H.Besselaar Associates and SciCor Inc., all three now trading as part of
Covance Inc. Since leaving Corning in 1992, Mr. Baker has focused on investing
in and developing companies in the healthcare sector including Unilab
Corporation, a clinical laboratory services provider in California, and Medical
Diagnostics Management, a US based provider of radiology and clinical laboratory
services to health care payers. In 1997, he formed Focused Healthcare Partners
("FHP"), an investment partnership that acts as general partner for healthcare
startup and development companies.

Gabor Balthazar became a director of LSR on January 10, 2002. He was appointed
to the Board of Huntingdon as the Senior Independent Non-Executive Director in
March 2000. He has been active in international marketing and management
consulting for almost 30 years. He was a founding Board member of Unilab
Corporation, serving as President from 1989 to 1992, and continuing to sit on
Unilab's Board until November 1999. From 1985 to 1997, Mr. Balthazar served as a
consultant to Frankfurt Consult, the merger/acquisition subsidiary of BHF-Bank,
Frankfurt, Germany and to Unilabs Holdings SA, a Swiss clinical laboratory
testing holding company, from 1987 to 1992. He is a graduate of the Columbia Law
School and the Columbia Business School in New York City.

Brian Cass, FCMA, CBE, became a director and Managing Director/President of LSR
on January 10, 2002. He was appointed to the Board of Huntingdon as Managing
Director/Chief Operating Officer in September 1998. Prior to joining Huntingdon
he was a Vice President of Covance Inc. and Managing Director of Covance
Laboratories Ltd., (previously Hazleton Europe Ltd) for nearly 12 years, having
joined the company in 1979 as Controller. Brian Cass worked at Huntingdon
Research Center between 1972 and 1974 and has previous experience with other
companies in the electronics and heavy plant industries. He has also held
directorships with North Yorkshire Training & Enterprise Council Ltd and
Business Link North Yorkshire Ltd. In June 2002, Mr. Cass was also appointed as
a Commander in the Most Excellent Order of the British Empire (CBE).

Afonso Junqueiras became a director of LSR on January 15, 2003. He is a civil
engineer and has been President and a director of a South American private civil
engineering firm since 1997.

Richard Michaelson became Chief Financial Officer and Secretary of LSR effective
January 10, 2002. Mr. Michaelson was Director of Strategic Finance of Huntingdon
from September 1998 to December 2001. He served as Senior Vice President of
Unilab Corporation, a clinical laboratory testing company based in Los Angeles,
California, from September 1997 to December 1997, Senior Vice President-Finance,
Treasurer and Chief Financial Officer of Unilab from February 1994 to September
1997, and Vice President-Finance, Treasurer and Chief Financial Officer of
Unilab from November 1993 to February 1994. Mr. Michaelson also served as Vice
President of Unilab beginning in October 1990. Mr. Michaelson joined MetPath,
Inc., the clinical laboratory subsidiary of Corning Incorporated, in 1980 and
served as Vice President of MetPath from 1983 and Treasurer of Corning Lab
Services, Inc. from 1990 through, in each case, September 1992.

Yaya Sesay, served as a senior government official of an African nation for
approximately 25 years, culminating in his service as Financial Secretary of the
Ministry of Finance for three years. For the past five years, Mr. Sesay has been
an international businessman with an interest in the development of
pharmaceutical products.

The Articles of Amendment and Restatement of LSR provide that the directors
shall be not less than one in number and there shall be no maximum number of
directors. Any director appointed by the board of directors holds office only
until the next following annual meeting, at which time he shall be eligible for
re-election by the stockholders. Directors may be removed from office only for
cause.

No director or executive officer has a family relationship with any other
director or executive officer.

(b) Code of Ethics

The Company has adopted a Senior Officer and Financial Personnel Code of Ethics.
A copy of such Code of Ethics is filed as Exhibit 14 in this Form 10-K.



ITEM 11. EXECUTIVE COMPENSATION

In the 12 months ended December 31, 2004 and 2003 the aggregate compensation of
the Executive Officers and key employees as a group, paid or accrued, was
$3,322,247 and $1,584,541 respectively.

Employment Agreements

Andrew Baker

The services of Mr. Baker are provided for not less than 100 days per year
through a management services contract between Huntingdon and FHP. Mr. Baker
controls FHP. Under the contract, FHP agrees to provide the services of Mr.
Baker as Chairman and CEO of the Company. The management services contract will
continue until terminated on 12 months' written notice from either party.

Under the management services contract FHP is paid an annual fee of
(pound)300,000. Mr. Baker receives health and medical insurance benefits from
the company. He is also entitled to a non-pensionable car allowance of up to
(pound)1,000 per month. Mr. Baker receives contributions to his private pension
arrangements, equivalent to 33 percent of this basic annual fee. The management
services contract may be terminated if either FHP or Mr. Baker is guilty of
serious misconduct or is in material breach of the terms of the contract, among
other reasons. In the event of termination without "cause" following a "change
in control", as defined, FHP would receive a payment equal to 2.99 times this
annualized fee plus an amount equal to 2.99 times all incentive compensation
earned or received by FHP or Mr. Baker during the 12 months prior to
termination.

Both FHP and Mr. Baker are bound by confidentiality restrictions and a
restriction preventing Mr. Baker from holding any interests conflicting with
those of the Company, without the Company's consent. Mr. Baker has undertaken to
the Company that, during the continuance of the management services contract, he
will not without the prior consent of the Company, be concerned or interested in
any business, which competes, or conflicts with the business of the Company.

Brian Cass

The services of Mr. Cass are provided through a service agreement between
Huntingdon Life Sciences Limited (a wholly owned subsidiary of Huntingdon) and
Mr. Cass, which appoints Mr. Cass as President/Managing Director of the Company.
Mr. Cass' service agreement can be terminated on two years' written notice from
either party.

Mr. Cass receives a gross salary of (pound)300,000 per annum. Under the service
agreement, Mr. Cass is also entitled to health insurance, life insurance,
personal accident insurance and medical expenses insurance. Mr. Cass receives
contributions to his private pension arrangements, equivalent to 33 percent of
his basic annual salary. He is also entitled to a non-pensionable car allowance
of (pound)1,000 gross per month and (pound)2,000 per month as relocation
allowance. Mr. Cass' service agreement also provides for payment to Mr. Cass of
a bonus, at the absolute discretion of the Company's Board. In the event of
termination without "cause" following a "change in control", as defined, Mr.
Cass would receive a payment equal to 2.99 times his annual salary plus an
amount equal to 2.99 times all incentive compensation earned or received by Mr.
Cass during the 12 months prior to termination.

Mr. Cass' service agreement may be terminated if Mr. Cass is guilty of serious
misconduct or is in material breach of the terms of the service agreement or is
in breach of the model code for securities transactions by directors of listed
companies, among other reasons.

Mr. Cass is bound by confidentiality restrictions and a restriction preventing
him from being engaged, concerned or interested in any business that conflicts
with the business of the Company or any subsidiary unless either the Company's
Board otherwise consents or the interest is limited to a holding or other
interest of no more than 5 percent of the total amount of shares or securities
of any company quoted on a recognized investment exchange.



Richard Michaelson

The services of Mr. Michaelson are provided through a service agreement between
him and Huntingdon Life Sciences Inc. (a wholly owned subsidiary of Huntingdon).
The service agreement appoints Mr. Michaelson as Chief Financial Officer and
Secretary of the Company. Mr. Michaelson's service agreement will continue until
terminated by Mr. Michaelson on thirty days' written notice or by Huntingdon
Life Sciences Inc. on 12 months' written notice. In the event of termination
without "cause" following a "change in control", as defined, Mr. Michaelson
would receive a payment equal to 2.99 times his annual salary plus an amount
equal to 2.99 times all incentive compensation earned or received by Mr.
Michaelson during the 12 months prior to termination.

Mr. Michaelson receives an annual salary of $300,000 gross and is entitled to
health insurance, life insurance, personal accident insurance, medical expenses
insurance and participation in the 401(k) Plan of Huntingdon Life Sciences Inc.
Mr. Michaelson's service agreement also provides for the payment of a bonus to
Mr. Michaelson in the absolute discretion of the Company's Board.

In addition, Mr. Michaelson is entitled to a car allowance of $1,000 gross per
month.

The agreement may be terminated if Mr. Michaelson is guilty of serious
misconduct or is in material breach of the terms of the service agreement,
amongst other reasons.

Mr. Michaelson is bound by confidentiality restrictions and a restriction
preventing him from being engaged, concerned or interested in any business
conflicting with the business of the Company or any subsidiary unless the Board
otherwise consents or the interest is limited to a holding or other interest of
no more than 5 percent of the total amount of shares or securities of any
company quoted on a recognized investment exchange.

Discretionary bonus plan

The Company operates a discretionary bonus plan for executive officers and key
managers based upon improvements to operating income and achievement of
pre-defined targets. No bonus awards were made in respect of 2001, 2002 or 2003.
In accordance with the Company performance provisions established in June 2004
by the Compensation Committee, aggregate bonus awards of $1,910,000 are expected
to be paid to 31 senior employees of the Company in March 2005 as a result of
the Company's achievement of specified fiscal year 2004 performance goals
established by the Compensation Committee.



The following table shows the remuneration of Executive Officers and key
employees in the 12 months ended December 31, 2004, 2003, and 2002:



Annual Compensation Long Term Compensation
Awards

Name And Principal Year Salary Bonus Other Annual Number Of Shares
Position Compensation Underlying Options



Andrew Baker 2004 427,489 576,000 141,805 55,500
Chairman and Chief 2003 327,050 - 108,918 -
Executive Officer 2002 300,780 - 100,160 200,000

Brian Cass 2004 427,489 576,000 218,691 55,500
President 2003 327,080 - 175,843 -
2002 300,780 - 160,327 200,000

Richard Michaelson 2004 287,952 150,000 42,108 30,303
Chief Financial Officer 2003 222,108 - 18,633 -
and 2002 196,923 - 11,917 90,000
Secretary


Julian Griffiths 2004 266,667 137,408 70,638 27,750
Director of Operations 2003 204,425 - 44,692 -
of Huntingdon 2002 187,988 - 54,547 60,000

Frank Bonner 2004 - - - -
Former Director of 2003 141,945 - 13,817 -
Science &
Technology of Huntingdon 2002 221,073 - 20,053 35,000



Note - the bonuses were paid in March 2005



Messrs. Baker, Bonner, Cass and Griffiths are paid in UK pounds sterling. The
amounts have been converted at the rate of 2004: $1.8321, 2003: $1.6354, and
2002: $1.5039, to (pound)1.00 for the purposes of the above table.

The Officers' pension contributions are privately invested.

EQUITY INCENTIVE PLANS

LSR 2001 Equity Incentive Plan (the "LSR 2001 Equity Incentive Plan")

The LSR Board has adopted the LSR 2001 Equity Incentive Plan. Adoption of the
LSR 2001 Equity Incentive Plan enables LSR to use stock options (and other
stock-based awards) as a means to attract, retain and motivate key personnel.
This stock option plan is approved by the shareholders.

Awards under the LSR 2001 Equity Incentive Plan may be granted by a committee
designated by the LSR Board pursuant to the terms of the LSR 2001 Equity
Incentive Plan (which has designated the Compensation Committee for such
purpose) and may include: (i) options to purchase shares of LSR Voting Common
Stock, including incentive stock options ("ISOs"), non-qualified stock options
or both; (ii) stock appreciation rights ("SARs"), whether in conjunction with
the grant of stock options or independent of such grant, or stock appreciation
rights that are only exercisable in the event of a change in control or upon
other events; (iii) restricted stock consisting of shares that are subject to
forfeiture based on the failure to satisfy employment-related restrictions; (iv)
deferred stock, representing the right to receive shares of stock in the future;
(v) bonus stock and awards in lieu of cash compensation; (vi) dividend
equivalents, consisting of a right to receive cash, other awards, or other
property equal in value to dividends paid with respect to a specified number of
shares of LSR Voting Common Stock or other periodic payments; or (vii) other
awards not otherwise provided for, the value of which are based in whole or in
part upon the value of the LSR Voting Common Stock. Awards granted under the LSR
2001 Equity Incentive Plan are generally not assignable or transferable except
pursuant to a will and by operation of law.

The flexible terms of the LSR 2001 Equity Incentive Plan are intended to, among
other things, permit the Compensation Committee to impose performance conditions
with respect to any award, thereby requiring forfeiture of all or part of any
award if performance objectives are not met or linking the time of
exercisability or settlement of an award to the attainment of performance
conditions. For awards intended to qualify as "performance-based compensation"
within the meaning of Section 162(m) of the United States Internal Revenue Code
such performance objectives shall be based solely on (i) annual return on
capital; (ii) annual earnings or earnings per share; (iii) annual cash flow
provided by operations; (iv) changes in annual revenues; (v) stock price; and/or
(vi) strategic business criteria, consisting of one or more objectives based on
meeting specified revenue, market penetration, geographic business expansion
goals, cost targets, and goals relating to acquisitions or divestitures.

LSR's Compensation Committee, which will administer the 2001 LSR Equity
Incentive Plan, will have the authority, among other things, to: (i) select the
directors, officers and other employees and independent contractors entitled to
receive awards under the 2001 LSR Equity Incentive Plan; (ii) determine the form
of awards, or combinations of awards, and whether such awards are to operate on
a tandem basis or in conjunction with other awards; (iii) determine the number
of shares of LSR Voting Common Stock or units or rights covered by an award; and
(iv) determine the terms and conditions of any awards granted under the 2001 LSR
Equity Incentive Plan, including any restrictions or limitations on transfer,
any vesting schedules or the acceleration of vesting schedules, any forfeiture
provision or waiver of the same and including any terms and conditions necessary
or desirable to ensure the optimal tax result for participating personnel and
the Company including by way of example to ensure that there is no tax on the
grant of the rights and that such tax only arises on the exercise of rights or
otherwise when the LSR Voting Common Stock unconditionally vests and is at the
disposal of such participating personnel. The exercise price at which shares of
LSR Voting Common Stock may be purchased pursuant to the grant of stock options
under the 2001 LSR Equity Incentive Plan is to be determined by the option
committee at the time of grant in its discretion, which discretion includes the
ability to set an exercise price that is below the fair market value of the
shares of LSR Voting Common Stock covered by such grant at the time of grant.

The number of shares of LSR Voting Common Stock that may be subject to
outstanding awards granted under the 2001 LSR Equity Incentive Plan (determined
immediately after the grant of any award) may not exceed 20 per cent of the
aggregate number of shares of LSR Voting Common Stock then outstanding.

The 2001 LSR Equity Incentive Plan may be amended, altered, suspended,
discontinued, or terminated by the LSR Board without LSR Voting Common
Stockholder approval unless such approval is required by law or regulation or
under the rules of any stock exchange or automated quotation system on which LSR
Voting Common Stock is then listed or quoted. Thus, LSR Voting Common
Stockholder approval will not necessarily be required for amendments, which
might increase the cost of the plan or broaden eligibility. LSR Voting Common
Stockholder approval will not be deemed to be required under laws or regulations
that condition favorable tax treatment on such approval, although the LSR Board
may, in its discretion, seek LSR Voting Common Stockholder approval in any
circumstances in which it deems such approval advisable.

The LSR Board has designated the Compensation Committee of the Board to serve as
the stock option committee.

LSR made grants under the LSR 2001 Equity Incentive Plan on March 1, 2002 to
certain directors as of that date, and employees, including the Named Executive
Officers:

Grants to Directors
- -------------------
Name Number Granted
- ---- --------------
Gabor Balthazar 20,000
John Caldwell 20,000
Kirby Cramer 40,000

Grants to Named Executive Officers
- ----------------------------------
Name Number Granted
- ---- --------------
Andrew Baker 200,000
Brian Cass 200,000
Frank Bonner 35,000
Julian Griffiths 60,000
Richard Michaelson 90,000

All such options have ten-year terms; 50% of the shares subject to grant are
immediately exercisable with the remaining 50% exercisable one year after the
grant date (meaning all such options, fully vested as of March 1, 2003); and all
have an exercise price of $1.50 per share, the price at which the Company sold
shares of Common Stock in the Private Placement. Options to purchase an
aggregate of 1,188,000 shares of LSR Common Stock (including those specified
above) were granted in the two years 2002 and 2003 to employees and directors,
on the terms set forth above, are listed below:

Date of Grant Numbers Granted Exercise Price
- ------------- --------------- --------------
March 1, 2002 1,142,000 $1.50
September 3, 2002 20,000 $2.40
October 21, 2002 15,000 $2.03
February 14, 2003 11,000 $1.80

In 2004, in addition to the options granted under the 2004 LTIP referred to
below, options to purchase an aggregate of 67,100 shares of LSR Common Stock
were issued, all at exercise prices equal to the market price at the date of
grant, on the terms set forth in the previous paragraph, are listed below.

Date of Grant Numbers Granted Exercise Price
- ------------- --------------- --------------
April 12, 2004 37,100 $1.85
October 28, 2004 17,400 $7.70
December 15, 2004 12,600 $9.52

2004 Long Term Incentive Plan

Effective June 1, 2004 the Company adopted the 2004 Long Term Incentive Plan
("2004 LTIP"), pursuant to the terms of the 2001 Equity Incentive Plan. The 2004
LTIP has two components: a grant of stock options, with a vesting date of March
31, 2007, and a cash bonus to be awarded in 2007 based on 2006 Company financial
performance.

Options to purchase an aggregate of 362,663 shares of common stock were granted
to 32 key employees of the Company as of June 1, 2004 under the 2004 LTIP;
55,500 of such options were granted to Andrew Baker, the Company's Chairman and
CEO, 55,500 of such options were granted to Brian Cass, the Company's Managing
Director and President, 30,303 of such options were granted to Richard
Michaelson, the Company's CFO and Secretary, and 27,750 of such options were
granted to Julian Griffiths, the Company's UK Director of Operations. The
exercise price of all such granted options is $3.30, the market price of LSR
common stock on June 1, 2004. All such options have ten-year terms and are
exercisable in full on March 31, 2007. At December 31, 2004, 356,419 shares
under the 2004 LTIP option plan were outstanding and none were exercisable.

The following table summarizes stock option activity under the Company's option
plans.



Shares Wtd Avg. Ex Price Number of securities remaining
(000) available for future issuance

Outstanding - December 31, 2003 1,188 $1.52
Granted 430 $3.54
Lapsed (105) $1.78
Exercised 127 $1.51
----------- ------------------ ----------------------------------
Outstanding - December 31, 2004 1,386 $2.13 814,000
----------- ------------------ ----------------------------------
Exercisable at end of year 996
Weighted average fair value per
option granted in 2004 was $3.44



Huntingdon Life Sciences Group plc Stock Option Plans

Huntingdon Life Sciences Group plc issued options prior to December 31, 1997
pursuant to several stock option plans. However, the ability to exercise options
under all such Huntingdon plans lapsed on March 26, 2002 in connection with
LSR's acquisition of Huntingdon, except for those granted under the Unapproved
Stock Option Plan (the "Unapproved Plan"). Under the Unapproved Plan, some
options technically remain outstanding. However, such options are exercisable
only for shares of Huntingdon, a 100% wholly owned subsidiary of LSR, and as
such are considered to have no value.

Warrants

On October 9, 2001, on behalf of Huntingdon, LSR issued to Stephens Group Inc.
warrants to purchase up to 704,425 shares of LSR Voting Common Stock at a
purchase price of $1.50 per share. Stephens Group Inc. subsequently sold the
warrants to independent third parties. The LSR warrants are exercisable at any
time and will expire on October 9, 2011. These warrants arose out of
negotiations regarding the refinancing of the bank loan by the Stephens Group
Inc., (Stephens' Loan) in January 2001. In accordance with APB Opinion No. 14,
Accounting for Convertible Debt and Debt Issued with Stock Purchase Warrants
("APB 14") the warrants were recorded at their pro rata fair values in relation
to the proceeds received on the date of issuance. As a result, the value of the
warrants was $430,000. 154,425 of such warrants were exercised in 2004.

On June 11, 2002 LSR issued to FHP warrants to purchase up to 410,914 shares of
LSR Voting Common Stock at a purchase price of $1.50 per share. The LSR warrants
are exercisable at any time and will expire on June 11, 2012. These warrants
arose out of negotiations regarding the provision of the $2.9 million loan
facility made available to the Company on September 25, 2000 by Mr. Baker, who
controls FHP. In accordance with APB 14 the loan and warrants were recorded at
their pro rata fair values in relation to the proceeds received. As a result,
the value of the warrants was $250,000.

On July 25, 2002, 100,000 warrants were issued at the deemed market price on the
day of $1.50 (the same price at which the Private Placement had been completed).
On October 15, 2003, 100,000 warrants were issued; 75,000 of which were at an
exercise price of $2.50, the market price on the day, and 25,000 of which were
issued at an exercise price of $5.00 per share. On October 24, 2003, 100,000
warrants were issued at the market price on the day of $2.05. In all three
cases, these warrants were issued to independent consultants in connection with
financial and strategic advice.

A summary of warrants outstanding at December 31, 2004 is as follows:

Warrants Exercise price Expiration Date
October 9, 2001 550,000 $1.50 October 9, 2011
June 11, 2002 410,914 $1.50 June 11, 2012
October 24, 2003 100,000 $2.05 October 24, 2013



ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND
RELATED STOCKHOLDER MATTERS

The following table sets forth, as of March 24, 2005, certain information
regarding the beneficial ownership of the shares of LSR common stock, by (a)
each person or entity who is known by LSR to own beneficially 5% or more of its
outstanding shares of Common Stock (none other than Mr. Baker and Mr. Cass, who
are each a Director and Executive Officer of LSR); (b) each Director or
Executive Officer of LSR or principal subsidiary; and (c) all Directors and
Executive Officers as a group.



Name Number of Shares Percent of Outstanding Shares


Andrew Baker 2,311,060 (1) 17.9%
Gabor Balthazar 20,000 (2) *
Brian Cass 620,000 (3) 5.1%

Afonso Junqueiras -- --
Richard Michaelson 330,390 (4) 2.6%
Yaya Sesay -- --
All Directors and Executive Officers
as a Group 3,281,450 24.8%


* Signifies less than 1%. All percentages calculated on the basis of 12,441,281
outstanding shares of Voting Common Stock outstanding at December 31, 2004.
Shares subject to issuance upon presently exercisable options or Warrants
are included in the number of outstanding shares for purposes of
calculating that holder's percentage interest, as well as the aggregate
percentage interest of all directors and Executive Officers as a group.

(1) Includes presently exercisable options to purchase 200,000 shares and
presently exercisable warrants to purchase 410,914 shares. 1,604,001 of
such shares are beneficially owned by Focused Healthcare Partners Ltd, a
Bahamas corporation that is controlled by Mr. Baker. 490,914 of such shares
(including the 410,914 shares subject to presently exercisable warrants
noted above) are beneficially owned by Focused Healthcare Partners LLC, a
New Jersey limited liability company that is controlled by Mr. Baker.

(2) Includes presently exercisable options to purchase 20,000 shares

(3) Includes presently exercisable options to purchase 200,000 shares

(4) Includes presently exercisable options to purchase 90,000 shares




From time to time US depositary institutions hold shares on behalf of their
clients to enable a market to be made in the LSR's shares. No holdings of 5% or
more have been reported by those institutions at March 24, 2005.




ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

(1) A $2,910,800 ((pound)2,000,000) facility was made available to the Company
on September 25, 2000 by the Company's Chairman and CEO, Mr. Baker. This
had been drawn down in full. The loan was repayable on demand, although it
was subordinate to the bank loan, it was unsecured and interest was payable
monthly at a rate of 10% per annum. By Amendment No. 2 to that loan
facility, dated March 20, 2001, FHP became party to the loan and $550,000
of the amount loaned was transferred to FHP. On March 28, 2002 $2.1 million
of Mr. Baker's loan was converted into 1,400,000 shares of LSR Voting
Common Stock and $300,000 of FHP's loan was converted into 200,000 shares
of LSR Voting Common Stock. The remaining principal amounts were repaid in
full to Mr. Baker and FHP, respectively, in 2002.

(2) On January 20, 2001 the Company's bank loan was refinanced by means of a
loan from HLSF, LLC a subsidiary company of the Stephens Group Inc., a
related party at the time, and the other two banks that were part of the
original loan syndicate. That loan was transferred to an unrelated third
party effective February 11, 2002. The loan is now repayable on June 30,
2006 and interest is payable in quarterly breaks at a rate of "LIBOR" plus
1.75% per annum. The loan is secured by guarantees from LSR, Inc., LSR Ltd,
Huntingdon Life Sciences Limited and Huntingdon Life Sciences Inc.,
collateralized by all the assets of those companies.

(3) In accordance with the terms of a facility agreement dated July 19, 2001
and as amended on October 5, 2001, the Stephens Group Inc. made $2,910,800
((pound)2,000,000) available to the Company, which was available for a
period of one year from July 19 2001. That loan was transferred to another
party effective February 11, 2002. This amount, which is secured and
subordinated to the bank debt, was drawn down in full. Interest was payable
monthly at a rate of 10% per annum. With the consent of the bank lender,
one half of the facility was repaid on July 1, 2002, and the remainder was
repaid on October 1, 2002.

(4) In October 2001 the Company issued to Stephen Group Inc., warrants to
purchase up to 704,425 shares of Common Voting Stock at a purchase price of
$1.50 per share. These warrants arose out of the refinancing of the bank
loan by the Stephens Group Inc. in January 2001. These warrants were
subsequently transferred to an unrelated third party. These warrants are
exercisable at any time and will expire on October 9, 2011. 154,425 of such
warrants were exercised in 2004.

In addition at the June 11, 2002 shareholders meeting, shareholders
approved the issuance to FHP of warrants to purchase up to 410,914 shares
of Common Voting Stock at a purchase price of $1.50 per share. These
warrants arose out of negotiations regarding the provision of the
$2,910,800 ((pound)2,000,000) loan facility made available to the Company
on September 25, 2000 by Mr. Baker who controls FHP.

(5) Brian Cass, President and Managing Director of LSR, acquired 400,000 shares
of LSR Common Stock in the Private Placement. Mr. Cass acquired such shares
through the delivery of two promissory notes. Both such promissory notes,
each in the amount of (pound)211,679 ($406,403), are due on March 28, 2007;
bear interest at the rate of 5% per annum; and are secured by the 200,000
shares of LSR Common Stock purchased with the proceeds of each such loan.
The due date of each promissory note would be accelerated if Mr. Cass
voluntarily resigned from his employment with LSR or had his employment
terminated. Repayment of one of the promissory notes will be made by
automatic deduction of (pound)44,000 ($84,476) per year from the
(pound)66,000 ($126,713) per year pension contribution made by the Company
to a pension plan established by Mr. Cass. The other note is further
collateralized by the (pound)214,500 ($412,000) accrued in such pension
account. In addition, one-third of any yearly bonus received by Mr. Cass
will be used to reduce principal of the promissory notes. Total amount of
this loan as of December 31, 2004 is (pound)363,000 ($697,000 at year-end
foreign exchange rates).

(6) Julian Griffiths, a former director of LSR and current Director of
Operations of Huntingdon, acquired 50,000 shares of LSR Common Stock in the
Private Placement. Mr. Griffiths acquired such shares through the delivery
of a promissory note in the principal amount of (pound)52,817 ($101,403),
which was due on March 28, 2007; bears interest at the rate of 5% per
annum; and was secured by the 50,000 shares of LSR Common Stock purchased
with the proceeds of the loan. This loan was fully repaid during 2003.


ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES

The aggregate fees billed for professional services rendered by Hugh Scott PC
for the audit of the Company's annual financial statements for the year ended
December 31, 2004 and for review of financial statements included in Form 10-Q
Filings for 2004 were $377,364, (2003 $107,147).

The aggregate fees billed for professional services rendered by Deloitte &
Touche for the audit of the Company's annual financial statements for the year
ended December 31, 2002 were $295,000.

Audit Related Fees

There were no fees billed for assurance and related services by the Company's
principal accountant in either 2004, 2003 or 2002.

Tax Fees

Fees billed for tax compliance, tax advice and tax planning by the Company's
principal accountant in 2004, 2003, and 2002 was $27,176, $10,155, and $0
respectively.

All Other Fees

The fees billed for services other than those reported above by the Company's
principal accountant in 2004 were $36,229 (2003 $NIL). These services were for
work on Sarbanes Oxley and other miscellaneous accounting research.

The aggregate fees billed for services other than those reported above by
Deloitte & Touche in 2002 were $92,000. Such services included $72,000 in
services provided in connection with the Company's registration statement on
Forms S-4 regarding LSR's acquisition of Huntingdon. The remainder of non-audit
fees primarily related to foreign payroll consultation.

The Audit Committee has established a pre-approval process to review and
pre-approve all non-audit fees and services of the principal accountants that
are not `de minimis' (defined as amounts greater than 5% of the principal
accountant's audit fees). There were no such fees to be approved in 2004 or
2003.



PART IV

ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

1. List of documents filed as part of this report

2. Index to Financial Statements
Life Sciences Research, Inc.

Independent Auditors' Report

Consolidated Statements of Operations- Years ended
December 31, 2004, 2003, and 2002

Consolidated Balance Sheets - December 31, 2004 and 2003

Consolidated Statements of Changes in Shareholders' (Deficit)/Equity
and Comprehensive Income/(Loss) Years ended December 31, 2004, 2003,
and 2002

Consolidated Statements of Cash Flows - Years ended December 31, 2004,
2003, and 2002

Notes to Consolidated Financial Statements

3. Financial Statement Schedules

Schedules are omitted because they are not applicable or the required
information is shown in the consolidated financial statements or notes
thereto.



List of Exhibits

Exhibit No. Description of Exhibit

2.1 Letter of Intent, dated August 27, 2001, between the Registrant and HLS.
INCORPORATED BY REFERENCE TO REGISTRANT'S REGISTRATION STATEMENT ON FORM
S-4, REGISTRATION NUMBER 333-71408.

3.1 Articles of Amendment and Restatement of the Registrant adopted on November
7, 2001. INCORPORATED BY REFERENCE TO REGISTRANT'S REGISTRATION STATEMENT
ON FORM S-4, REGISTRATION NUMBER 333-71408.

3.2 Bylaws of the Registrant. INCORPORATED BY REFERENCE TO REGISTRANT'S
REGISTRATION STATEMENT ON FORM S-4, REGISTRATION NUMBER 333-71408.

4.1 Subscription Agreement dated August 1, 1991 among HIH Capital Limited
("HCL"), HLS, Chase Manhattan Bank Luxembourg S.A. (the "Custodian"), J
Henry Schroder Wagg & Co. Limited and Others. INCORPORATED BY REFERENCE TO
HLS' ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR ENDED SEPTEMBER 30,
1991.

4.2 Trust Deed, dated August 12, 1991 among HCL, HLS and The Law Debenture
Trust Corporation plc INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON
FORM 10-K FOR THE FISCAL YEAR ENDED SEPTEMBER 30, 1991.

4.3 Deed Poll, dated August 12, 1991, executed by HLS. INCORPORATED BY
REFERENCE TO HLS' ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR ENDED
SEPTEMBER 30, 1991.

4.4 Custodian Agreement, dated August 1, 1991 among the Custodian, HCL, and
HLS. INCORPORATED BY REFERENCE TO HLS'S ANNUAL REPORT ON FORM 10-K FOR THE
FISCAL YEAR ENDED SEPTEMBER 30, 1991.

4.5 Deed Poll, dated October 16, 2001, executed by Registrant. INCORPORATED BY
REFERENCE TO REGISTRANT'S REGISTRATION STATEMENT ON FORM S-4, REGISTRATION
NO. 333-71408.

10.1 Security Agreement dated April 30, 1998 between Huntingdon Life Sciences
Inc., National Westminster Bank PLC and various other banks. INCORPORATED
BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 20-F FOR THE FISCAL YEAR ENDED
DECEMBER 31, 1998.

10.2 An agreement dated August 7, 1998 between, inter alia, HLS, Huntingdon Life
Sciences Limited, Huntingdon Life Sciences Inc. and National Westminster
Bank PLC replacing the facilities agreement dated November 1995.
INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 20-F FOR THE FISCAL
YEAR ENDED DECEMBER 31, 1998.

10.3 An agreement between HLS, Huntingdon Life Sciences Limited, Huntingdon Life
Sciences Inc. and various banks replacing the third intercreditor agreement
between the parties dated March 17, 1998. INCORPORATED BY REFERENCE TO HLS'
ANNUAL REPORT ON FORM 20-F FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998.

10.4 A Management Services Agreement dated August 7, 1998 between HLS and
Focused Healthcare Partners. INCORPORATED BY REFERENCE TO HLS' ANNUAL
REPORT ON FORM 20-F FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998.

10.5 A Deed of Undertaking between HLS and Andrew Baker. INCORPORATED BY
REFERENCE TO HLS' ANNUAL REPORT ON FORM 20-F FOR THE FISCAL YEAR ENDED
DECEMBER 31, 1998.

10.6 Amendment dated January 26, 2000 to the Management Services Agreement dated
August 7, 1999 between HLS and Focused Healthcare Partners. INCORPORATED BY
REFERENCE TO HLS' ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR ENDED
DECEMBER 31, 1999.

10.7 Service Contract dated April 29, 1999 between Huntingdon Life Sciences Ltd
and Mr. B Cass INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 20-F
FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998.

10.8 Service Contract dated April 29, 1999 between Huntingdon Life Sciences Ltd
and Mr. J Griffiths. INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON
FORM 20-F FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998.

10.9 Service Contract dated April 29, 1999 between Huntingdon Life Sciences Ltd
and Dr F Bonner. INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON FORM
20-F FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998.

10.10A letter of appointment dated March 21, 2000 between HLS and Mr. G
Balthazar. INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 10-K FOR
THE FISCAL YEAR ENDED DECEMBER 31, 1999.

10.11Option Deed dated September 2, 1998 between HLS and Andrew Baker
INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 20-F FOR THE FISCAL
YEAR ENDED DECEMBER 31, 1998.

10.12Rules of the Huntingdon Life Sciences Group Unapproved Share Option Scheme
as amended on June 3, 1998. INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT
ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31, 1999.

10.13Rules of the Huntingdon Life Sciences Group Incentive Option Plan
INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 10-K FOR THE FISCAL
YEAR ENDED DECEMBER 31, 1999.

10.14Registrant's 2001 Equity Incentive Plan. INCORPORATED BY REFERENCE TO
REGISTRANT'S REGISTRATION STATEMENT ON FORM S-4, REGISTRATION NUMBER
333-71408.

10.15Loan Facility Letter, dated September 25, 2000, between HLS and Andrew
Baker. INCORPORATED BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 10-K FOR THE
FISCAL YEAR ENDED DECEMBER 31, 2000.

10.16Amendment No. 1 to Loan Facility Letter, dated as of February 22, 2001,
between HLS and Andrew Baker. INCORPORATED BY REFERENCE TO HLS' ANNUAL
REPORT ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31, 2000.

10.17Amendment No. 2 to Loan Facility Letter, dated as of March 20, 2001, by
and among Andrew Baker, HLS and Focused Healthcare Partners. INCORPORATED
BY REFERENCE TO REGISTRANT'S ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR
ENDED DECEMBER 31, 2002.

10.18Amendment Agreement dated February 19, 2001 relating to a Facilities
Agreement dated August 7, 1998 among HLS, Huntingdon Life Sciences Limited
(HLSL), Huntingdon Life Sciences Inc. (HLSI), the Banks (as defined
therein) and Stephens Group Inc. as Agent. INCORPORATED BY REFERENCE TO
HLS' ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31,
2000.

10.19Fifth Intercreditor Agreement, dated February 19, 2001 among Stephens
Group Inc. (as Agent), HLSF LLC, Allfirst Bank, Comerica Bank, the Company,
HLSL, HLSI, Andrew Baker and Stephens Group Inc. (as Funder). INCORPORATED
BY REFERENCE TO HLS' ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR ENDED
DECEMBER 31, 2000.

10.20Subscription and Investor Rights Agreement, dated October 9, 2001, between
LSR and Walter Stapfer. INCORPORATED BY REFERENCE TO REGISTRANT'S
REGISTRATION STATEMENT ON FORM S-4, REGISTRATION STATEMENT NUMBER
333-71408.

10.21Subscription and Investor Rights Agreement, dated October 9, 2001, between
LSR and the persons named therein as Investors. INCORPORATED BY REFERENCE
TO REGISTRANT'S REGISTRATION STATEMENT ON FORM S-4, REGISTRATION STATEMENT
NUMBER 333-71408.

10.22Warrant, dated October 9, 2001, issued by the Registrant. INCORPORATED BY
REFERENCE TO REGISTRANT'S REGISTRATION STATEMENT ON FORM S-4, REGISTRATION
STATEMENT NUMBER 333-71408.

10.23Form of Director's Irrevocable Undertaking. INCORPORATED BY REFERENCE TO
REGISTRANT'S REGISTRATION STATEMENT ON FORM S-4, REGISTRATION STATEMENT
NUMBER 333-71408.

10.24Inducement Agreement, dated October 9, 2001 between the Registrant and
HLS. INCORPORATED BY REFERENCE TO REGISTRANT'S REGISTRATION STATEMENT ON
FORM S-4, REGISTRATION STATEMENT NUMBER 333-71408.

10.25Warrant, dated June 11, 2002, issued by the Registrant. INCORPORATED BY
REFERENCE TO REGISTRANT'S PROXY STATEMENT ON SCHEDULE 14A, DATED MAY 10,
2002.

10.26Service Agreement, dated as of April 1, 2000, between Huntingdon Life
Sciences, Inc. and Richard Michaelson. INCORPORATED BY REFERENCE TO
REGISTRANT'S ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER
31, 2002.

10.27Amendment No. 1 to Service Agreement between Huntingdon Life Sciences,
Inc. and Richard Michaelson, dated as of April 15, 2002. INCORPORATED BY
REFERENCE TO REGISTRANT'S ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR
ENDED DECEMBER 31, 2002.

10.28Amendment No. 1 to Service Agreement between Huntingdon Life Sciences
Limited and Brian Cass, dated as of April 15, 2002. INCORPORATED BY
REFERENCE TO REGISTRANT'S ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR
ENDED DECEMBER 31, 2002.

10.29Amendment No. 1 to Service Agreement between Huntingdon life Sciences
Limited and Julian Griffiths, dated as of April 15, 2002. INCORPORATED BY
REFERENCE TO REGISTRANT'S ANNUAL REPORT ON FORM 10-K FOR THE FISCAL YEAR
ENDED DECEMBER 31, 2002.

10.30Amendment No. 2 to Management Services Agreement between Huntingdon Life
Sciences Group plc and Focused Healthcare Partners, dated as of April 15,
2002. INCORPORATED BY REFERENCE TO REGISTRANT'S ANNUAL REPORT ON FORM 10-K
FOR THE FISCAL YEAR ENDED DECEMBER 31, 2002.

14 Code of Ethics - FILED HEREWITH

21.1 Subsidiaries - FILED HEREWITH

31.1 Certification of Chief Executive Officer pursuant to SEC Rule 13(a) -
14(a). FILED HEREWITH

31.2 Certification of Chief Financial Officer pursuant to SEC Rule 13(a) -
14(a). FILED HEREWITH

32.1 Certification of Chief Executive Officer pursuant to 18 U.S.C.Section 1350.
FILED HEREWITH

32.2 Certification of Chief Financial Officer pursuant to 18 U.S.C.Section 1350.
FILED HEREWITH

99.1 Press Release dated March 7, 2005, announcing fourth quarter and full year
2004 results. INCORPORATED BY REFERENCE TO REGISTRANT'S CURRENT REPORT ON
FORM 8-K DATED MARCH 7, 2005.




SIGNATURE

Pursuant to the requirements of Section 13 or 15 (d) of the Securities Exchange
Act of 1934, the registrant has duly caused this report to be signed on its
behalf by the undersigned, thereunto duly authorized.

Life Sciences Research Inc.
(Registrant)



By: /s/ Andrew Baker
Name: Andrew Baker
Title: Chairman and Chief Executive Officer
and Director - Principal Executive Officer
Date: March 30, 2005


By: /s/ Richard Michaelson
Name: Richard Michaelson
Title: CFO & Secretary - Principal Financial and Accounting Officer
Date: March 30, 2005





Pursuant to the requirements of the Securities Exchange Act of 1934, this report
has been signed below by the following persons on behalf of the registrant and
in the capacities and on the dates indicated.

Signature Title Date

/s/ Gabor Balthazar Director March 30, 2005
Gabor Balthazar

/s/ Brian Cass Director March 30, 2005
Brian Cass

/s/ Afonso Junqueiras Director March 30, 2005
Afonso Junqueiras

/s/ Yaya Sesay Director March 30, 2005
Yaya Sesay