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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


FORM 10-Q


[X] Quarterly Report Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934


For the Quarterly Period Ended March 31, 2003


Commission File No. 0-14710


XOMA Ltd.

(Exact Name of Registrant as specified in its charter)



Bermuda 52-2154066
(State or other jurisdiction of (I.R.S. Employer Identification No.)
incorporation or organization)

2910 Seventh Street, Berkeley, CA 94710
(Address of principal executive offices) (Zip Code)

(510) 204-7200
(Registrant's telephone number, including area code)

Not Applicable
(Former name, former address and former fiscal year, if changed since
last report)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.

Yes /X/ No / /



Indicate by check mark whether the registrant is an accelerated filer (as
defined in Rule 12b-2 of the Securities Exchange Act of 1934).

Yes /X/ No / /


Indicate the number of shares outstanding of each of the issuer's classes of
common stock, as of the latest practicable date.

Common shares US$.0005 par value 71,999,924
Class Outstanding at May 12, 2003

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XOMA Ltd.
FORM 10-Q
TABLE OF CONTENTS


Page


PART I FINANCIAL INFORMATION
Item 1. Condensed Consolidated Financial Statements (Unaudited)
Condensed Consolidated Balance Sheets as of March 31, 2003 and
December 31, 2002..............................................1
Condensed Consolidated Statements of Operations for the Three
Months Ended March 31, 2003 and 2002...........................2
Condensed Consolidated Statements of Cash Flows for the Three
Months Ended March 31, 2003 and 2002...........................3
Notes to Condensed Consolidated Financial Statements..............4
Item 2. Management's Discussion and Analysis of Financial Condition and
Results of Operations.........................................11
Item 3. Quantitative and Qualitative Disclosures
About Market Risk.............................................26
Item 4. Controls and Procedures..........................................26
PART II OTHER INFORMATION
Item 1. Legal Proceedings................................................26
Item 2. Changes in Securities and Use of Proceeds........................26
Item 3. Defaults upon Senior Securities..................................27
Item 4. Submission of Matters to a Vote of Security Holders..............27
Item 5. Other Information................................................27
Item 6. Exhibits and Reports on Form 8-K.................................27
Signatures.................................................................28

Certifications.............................................................28





PART I - FINANCIAL INFORMATION

ITEM 1. CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

XOMA Ltd.
CONDENSED CONSOLIDATED BALANCE SHEETS
(In thousands)




March 31, December 31,
2003 2002
--------------- ----------------
ASSETS (Unaudited) (Note 1)

Current assets:
Cash and cash equivalents $ 32,745 $ 36,262
Short-term investments 357 391
Restricted cash - 1,500
Receivables 4,407 8,656
Related party receivables - current 100 206
Inventory 1,306 1,306
Prepaid expenses and other 261 449
--------------- ----------------
Total current assets 39,176 48,770
Property and equipment, net 22,664 22,650
Related party receivables - long-term 190 190
Deposits and other 147 172
--------------- ----------------
Total assets $ 62,177 $ 71,782
=============== ================




LIABILITIES AND SHAREHOLDERS' EQUITY (Net Capital Deficiency)

Current liabilities:

Accounts payable $ 1,278 $ 3,201
Accrued liabilities 5,160 7,096
Short-term loan - 763
Capital lease obligations - current 622 667
Deferred revenue - current 1,314 1,729
Convertible subordinated note - current 5,180 5,146
--------------- ----------------
Total current liabilities 13,554 18,602

Capital lease obligations - long-term 592 729
Deferred revenue - long-term 760 800
Note payable long-term 3,562 -
Convertible subordinated note - long-term 67,416 63,016
--------------- ----------------
Total liabilities 85,884 83,147

Shareholders' equity (Net capital deficiency):
Common shares 36 36
Additional paid-in capital 530,138 529,354
Accumulated comprehensive income 87 121
Accumulated deficit (553,968) (540,876)
--------------- ----------------
Total shareholders' equity (Net capital deficiency) (23,707) (11,365)
--------------- ----------------
Total liabilities and shareholders' equity $ 62,177 $ 71,782
=============== ================


Note 1 - Amounts derived from the Company's audited financial statements
appearing in the Annual Report on Form 10-K for the year ended December 31, 2002
as filed with the Securities and Exchange Commission.

See accompanying notes to condensed consolidated financial statements.

-1-



XOMA Ltd.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(Unaudited, in thousands except per share amounts)




Three months ended March
31,
---------------------------
2003 2002
------------- -------------

Revenues:

License and collaborative fees $ 1,155 $ 6,313
Contract and other revenue 2,009 2,909
------------- -------------

Total revenues 3,164 9,222
------------- -------------

Operating costs and expenses:
Research and development 11,982 9,935
Marketing, general and administrative 3,905 4,849
------------- -------------
Total operating costs and expenses 15,887 14,784
------------- -------------

Loss from operations (12,723) (5,562)

Other income (expense):
Investment and other income 115 272
Interest expense (486) (649)
------------- -------------
Net loss $ (13,094) $ (5,939)
============= =============

Basic and diluted net loss per common share $ (0.18) $ (0.08)
============= =============

Shares used in computing basic and diluted net loss per common share 71,843 70,229
============= =============











See accompanying notes to condensed consolidated financial statements.


-2-



XOMA Ltd.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(Unaudited, in thousands)




Three months ended
March 31,
-------------------------
2003 2002
------------ ------------

Cash flows from operating activities:

Net loss $ (13,094) $ (5,939)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization 860 373
Common shares contribution to 401(k) and management incentive plans 666 541
Increase (decrease) in notes to (from) a collaborative partner
for cost allocations (255) 700
Accrued interest on convertible notes 414 589
(Gain) loss on disposal/retirement of property and equipment - 1
Changes in assets and liabilities:
Receivables and related party and other receivables 4,355 (4,570)
Inventory - (7)
Prepaid expenses and other 188 60
Deposits and other 25 (7)
Accounts payable (1,923) 2,820
Accrued liabilities (1,934) 337
Deferred revenue (455) (1,303)
------------ ------------

Net cash used in operating activities (11,153) (6,405)
------------ ------------




Cash flows from investing activities:

Transfer from restricted cash 1,500 -
Purchase of property and equipment, net of sale proceeds (874) (2,852)
------------ ------------

Net cash provided by (used in) investing activities 626 (2,852)
------------ ------------

Cash flows from financing activities:
Principal payments - short-term loan (763) -
Principal payments under capital lease obligations (182) (161)
Proceeds from issuance of convertible notes 7,837 -
Proceeds from issuance of common or convertible preference shares and warrants 118 281
------------ ------------

Net cash provided by financing activities 7,010 120
------------ ------------

Net increase (decrease) in cash and cash equivalents (3,517) (9,137)
Cash and cash equivalents at the beginning of the period 36,262 67,320
------------ ------------

Cash and cash equivalents at the end of the period $ 32,745 $ 58,183
============ ============



See accompanying notes to condensed consolidated financial statements.


-3-





XOMA Ltd.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(Unaudited)


1. OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Business

XOMA Ltd. ("XOMA" or the "Company"), a Bermuda company, is a
biopharmaceutical company that develops and manufactures products to treat
cancer, immunologic and inflammatory disorders, and infectious diseases. The
Company's products are presently in various stages of development and all are
subject to regulatory approval before the Company or its collaborators can
commercially introduce any products. There can be no assurance that any of the
products under development by the Company will be developed successfully, obtain
the requisite regulatory approval or be successfully manufactured or marketed.

Basis of Presentation

The interim information contained in this report is unaudited but, in
management's opinion, includes all normal recurring adjustments necessary for a
fair presentation of results for the periods presented. Interim results may not
be indicative of results to be expected for the full year or future periods. The
condensed consolidated balance sheet as of December 31, 2002 has been derived
from the audited consolidated financial statements included in the Company's
2002 Annual Report on Form 10-K. The unaudited consolidated condensed financial
statements should be read in conjunction with the Company's audited consolidated
financial statements for the year ended December 31, 2002 included in its Annual
Report on Form 10-K.

Consolidation

The consolidated financial statements include the accounts of the
Company and its wholly owned subsidiaries. All significant intercompany accounts
and transactions have been eliminated in consolidation.

Estimates

The preparation of financial statements in conformity with accounting
principles generally accepted in the United States requires management to make
estimates and assumptions that affect the reported amounts of assets and
liabilities and disclosure of contingent assets and liabilities, if any, at the
date of the financial statements and the reported amounts of revenues and
expenses during the reporting period. Actual results could differ materially
from those estimates.

Concentration of Risk

Cash, cash equivalents, short-term investments and accounts receivable
are financial instruments, which potentially subject the Company to
concentrations of credit risk. The Company maintains and invests excess cash in
money market funds and short-term investments, which bear minimal risk. The
Company has not experienced any significant credit losses and does not generally
require collateral on receivables. For the three months ended March 31, 2003,
three customers represented 40%, 34% and 16% of total revenues and as of March
31, 2003 billed and unbilled receivables totaled $0.2 million, $0 and $0 for
these customers, respectively. For the three months ended March 31, 2002, three
customers represented 54%, 28% and 16% of total revenues for these customers,
respectively.

-4-


XOMA Ltd.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)
(Unaudited)

Share-Based Compensation

In accordance with the provisions of the Statement of Financial
Accounting Standards No. 123, "Accounting for Stock-Based Compensation" (SFAS
123), the Company has elected to continue to follow Accounting Principles Board
Opinion No. 25, "Accounting for Stock Issued to Employees" (APB 25) and related
interpretations, and to adopt the "disclosure only" alternative described in
SFAS 123. Under APB 25, if the exercise price of the Company's employee share
options equals or exceeds the fair market value on the date of the grant or the
fair value of the underlying shares on the date of the grant as determined by
the Company's Board of Directors, no compensation expense is recognized.
Accordingly, the financial statements reflect amortization of compensation
resulting from options granted at exercise prices which were below market price
at the grant date. Had compensation cost for the Company's shares-based
compensation plans been based on the fair value method at the grant dates for
awards under these plans consistent with the provisions of FASB Statement 123,
the Company's net loss and loss per share would have been increased to the pro
forma amounts indicated below for the three months ended March 31, 2003 and 2002
(in thousands, except per share amounts):



Three months ended
March 31,
----------------------------------
2003 2002
--------------- --------------


Net loss - as reported $ (13,094) $ (5,939)
Deduct:
Total share-based employee compensation
expense determined under fair value method (654) (793)
--------------- --------------
Pro forma net loss $ (13,748) $ (6,732)
=============== ==============

Loss per share
Basic and diluted - as reported $ (0.18) $ (0.08)
Basic and diluted - pro forma $ (0.19) $ (0.10)


The fair value of each option grant under these plans is estimated on the date
of grant using the Black-Scholes option-pricing model with the following
weighted-average assumptions used for grants during the periods indicated below:


Three months ended
March 31,
----------------------------------
2003 2002
--------------- --------------

Dividend yield 0% 0%
Expected volatility 99% 99%
Risk-free interest rate 1.27% 1.50%
Expected life 4.9 years 6.2 years

Revenue Recognition

Revenue is recognized when the related costs are incurred and the four
basic criteria of revenue recognition are met: (1) persuasive evidence of an
arrangement exists; (2) delivery has occurred or services rendered; (3) the fee
is fixed and determinable; and (4) collectibility is reasonably assured.
Determination of criteria (3) and (4) are based on management's judgments
regarding the nature of the fee charged for products or services delivered and
the collectibility of those fees.


-5-


XOMA Ltd.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)
(Unaudited)


License and Collaborative Fees

Revenue from non-refundable, license or technology access payments
under license and collaborative agreements where the Company has a continuing
obligation to perform is recognized as revenue over the period of the continuing
performance obligation.

Milestone payments under collaborative arrangements are recognized as
revenue upon achievement of the milestone events, which represent the
culmination of the earnings process because the Company has no future
performance obligations related to the payment. Milestone payments that require
a continuing performance obligation on the part of the Company are recognized
over the period of the continuing performance obligation. Amounts received in
advance are recorded as deferred revenue until the related milestone is
completed.

Contract Revenue

Contract revenue for research and development involves the Company
providing research, development, or manufacturing services to collaborative
partners. The Company recognizes revenue under these arrangements as the related
research and development costs are incurred and collectibility is reasonably
assured.

Product Sales

The Company recognizes product revenue upon shipment when there is
persuasive evidence that an arrangement exists, delivery has occurred, the price
is fixed and determinable, and collectibility is reasonably assured. Allowances
are established for estimated uncollectible amounts, product returns, and
discounts, if any.

Research and Development

Research and development expenses consist of direct and
research-related allocated overhead costs such as facilities costs, salaries and
related personnel costs, and material and supply costs. In addition, research
and development expenses include costs related to clinical trials to validate
the Company's testing processes and procedures and related overhead expenses.
From time to time, research and development expenses may include upfront fees
and milestones paid to collaborative partners for the purchase of rights to
in-process research and development. Such amounts are expensed as incurred.

Comprehensive Income (Loss)

Unrealized gains or losses on the Company's available-for-sale
securities are included in other comprehensive income (loss). Comprehensive loss
and its components for the three months ended March 31, 2003 and 2002 are as
follows (in thousands):



Three months ended
March 31,
------------------------
2003 2002
------------ -----------


Net loss $ (13,094) $ (5,939)
Unrealized gain (loss) on securities available-for-sale (34) --
------------ -----------
Comprehensive loss $ (13,128) $ (5,939)
============ ===========


-6-


XOMA Ltd.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)
(Unaudited)


Net Loss Per Share

Basic and diluted net loss per share is based on the weighted average
number of shares outstanding during the period in accordance with Financial
Accounting Standard No. 128. The following potentially dilutive outstanding
securities were not considered in the computation of diluted net loss per share
because they would be antidilutive for the three months ended March 31, 2003 and
2002 (in thousands):



Three months ended March
31,
---------------------------
2003 2002
--------------- -----------


Options for shares 5,673 4,585
Warrants for shares 700 700
Convertible notes, debentures and related interest, as if converted* 20,857 6,573


*The number of shares, as if converted represents a conversion price equal to
the prevailing market prices of $3.46 and $8.59 at the close of business on
March 31, 2003 and March 28, 2002, respectively.

Recent Accounting Pronouncements

In November of 2002, the FASB issued Interpretation No. 45 (or FIN 45),
"Guarantor's Accounting and Disclosure Requirements for Guarantees, Including
Indirect Guarantees of Indebtedness of Others." FIN 45 elaborates on the
existing disclosure requirements for most guarantees, including residual value
guarantees issued in conjunction with operating lease agreements. It also
clarifies that at the time a company issues a guarantee, the company must
recognize an initial liability for the fair value of the obligation it assumes
under that guarantee and must disclose that information in its interim and
annual financial statements. The initial recognition and measurement provisions
apply on a prospective basis to guarantees issued or modified after December 31,
2002. The Company's adoption of the recognition requirements in January of 2003
of FIN 45 did not have a material impact on the Company's results of operations
and financial position.


In November of 2002, the Financial Accounting Standards Board issued
Emerging Issues Task Force (referred to as EITF) Issue No. 00-21, "Revenue
Arrangements with Multiple Deliverables." EITF Issue No. 00-21 addresses certain
aspects of the accounting by a company for arrangements under which it will
perform multiple revenue-generating activities. EITF Issue No. 00-21 addresses
when and how an arrangement involving multiple deliverables should be divided
into separate units of accounting. EITF Issue No. 00-21 provides guidance with
respect to the effect of certain customer rights due to company nonperformance
on the recognition of revenue allocated to delivered units of accounting. EITF
Issue No. 00-21 also addresses the impact on the measurement and/or allocation
of arrangement consideration of customer cancellation provisions and
consideration that varies as a result of future actions of the customer or the
company. Finally, EITF Issue No. 00-21 provides guidance with respect to the
recognition of the cost of certain deliverables that are excluded from the
revenue accounting for an arrangement. The provisions of EITF Issue No. 00-21
will apply to revenue arrangements entered into in fiscal periods beginning
after June 15, 2003. The Company is currently evaluating the effect that the
adoption of EITF Issue No. 00-21 will have on its consolidated financial
statements.

In December of 2002, the FASB issued Statement No. 148, "Accounting for
Stock-Based Compensation - Transition and Disclosure." FAS 148 amends FAS 123
"Accounting for Stock-Based Compensation" to provide alternative methods of
transition for a voluntary change to the fair based method of accounting for
stock-based employee compensation. In addition, FAS 148 amends the disclsoure
requirements of FAS 123 to require more prominent disclosures in both annual and
interim financial statements about the method of accounting for stock-based
employee compensation and the effect of the method used on reported results. The
additional disclosure


-7-


XOMA Ltd.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)
(Unaudited)


requirements of FAS 148 are effective for fiscal years ending after December 15,
2002. The Company elected to continue to follow the intrinsic value method of
accounting as prescribed by Accounting Principles Board Opinion No. 25 (or APB
25), "Accounting for Stock Issued to Employees," to account for employee stock
options. See above in the "Significant Accounting Policies" note for the
disclosure required by FAS 148.

In January of 2003, the FASB issued Interpretation No. 46 (or FIN 46),
"Consolidation of Variable Interest Entities." FIN 46 requires a variable
interest entity to be consolidated by a company if that company is subject to a
majority of the risk of loss from the variable interest entity's activities or
entitled to receive a majority of the entity's residual returns or both. A
variable interest entity is a corporation, partnership, trust, or any other
legal structure used for business purposes that either (a) does not have equity
investors with voting rights or (b) has equity investors that do not provide
sufficient financial resources for the entity to support its activities. A
variable interest entity often holds financial assets, including loans or
receivables, real estate or other property. A variable interest entity may be
essentially passive or it may engage in research and development or other
activities on behalf of another company. The consolidation requirements of FIN
46 apply immediately to variable interest entities created after January 31,
2003. The consolidation requirements apply to older entities in the first fiscal
year or interim period beginning after June 15, 2003. Certain of the disclosure
requirements apply to all financial statements issued after January 31, 2003,
regardless of when the variable interest entity was established. The Company's
adoption of the disclosure requirements in January of 2003 did not have an
impact on the Company's financial position and results of operations. The
ultimate adoption of the recognition requirements of FIN 46 in June 2003 is not
expected to have a material impact on the Company's financial position or result
of operations.



2. BALANCE SHEET COMPONENTS

Inventories

Inventories are stated at the lower of standard cost (which
approximates first-in, first-out cost) or market. Inventories, which relate
principally to the Company's agreement with Baxter Healthcare Corporation,
consist of the following (in thousands):

March 31, December 31,
2003 2002
---------------- ---------------

Raw materials $ 202 $ 202
Finished goods 1,104 1,104
---------------- ---------------
Total $ 1,306 $ 1,306
================ ===============

Accrued Liabilities

Accrued liabilities consist of the following (in thousands):

March 31, December 31,
2003 2002
---------------- ---------------

Accrued payroll expenses $ 2,443 $ 3,198
Accrued clinical trial expenses 682 559
Accrued legal fees 1,160 2,425
Other 875 914
---------------- ---------------
Total $ 5,160 $ 7,096
================ ===============

-8-


XOMA Ltd.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)
(Unaudited)


3. LICENSE AGREEMENTS AND RELATED CONTINGENCIES

In February of 2002, XOMA and MorphoSys AG announced cross-licensing
agreements for antibody-related technologies. The term of this license agreement
commenced in February of 2002 and remains in effect until the expiration of the
last patent within the XOMA patent rights provided under the terms of the
agreement. Because there are no continuing performance obligations on the part
of the Company under the MorphoSys agreement, the license fee provided for in
that agreement was recognized as revenue in the first quarter of 2002. Under the
terms of the agreement, the $5.0 million license fee was to be paid in two
installments. The first $1.0 million installment was due and paid in the first
quarter of 2002, and the second portion in the amount of $4.0 million was due in
the fourth quarter of 2002. The second installment could be paid in either cash
or with MorphoSys shares valued at the time of MorphoSys' election to pay the
second installment.

During the fourth quarter of 2002, we were notified by MorphoSys of its
intention to exercise its option to pay the second installment totaling $4.0
million owed to XOMA under a license agreement with 363,466 of its ordinary
shares, which number of shares was determined with reference to the market price
of MorphoSys shares at the time of such notice (October 23, 2002). XOMA applied
for, and on January 31, 2003 was granted, an exemption from German withholding
tax on the full license fee from MorphoSys. The administrative process in
Germany for the issuance of the shares was delayed pending resolution of the
withholding tax matter. Upon receipt of the tax exemption, MorphoSys
re-initiated the process, but XOMA had not received the shares as of March 31,
2003. On May 6, 2003, the shares were issued to XOMA (see Note 5 - Subsequent
Events).

4. GENENTECH AGREEMENT MODIFICATION

In the first quarter of 2003 the Company's financing arrangement with
Genentech related to development and commercialization of Raptiva(TM) was
modified to provide the following terms:

The credit limit under the convertible subordinated debt agreement was
increased to $80.0 million to finance XOMA's share of development costs. The
loan is due upon the earlier of (a) April of 2005, except for advances made
after April 2003 in which case payment will be due on the second anniversary
date of such advances or (b) within 90 days after first product approval (which
could be before the end of 2003). At XOMA's election, the loan may be repaid in
cash or with shares with the conversion price to be calculated at the time of
payment based on the fair market value at the time of election. If repayment is
triggered by product approval, XOMA may elect to defer payment of up to $40.0
million as an offset against the Company's proceeds from its 25% share of U.S.
operating profits on the product. At March 31, 2003, the outstanding balance
under this note totaled $67.4 million.

A new $15.0 million loan facility was established to finance XOMA's
share of U.S. commercialization costs. The loan is due upon the earlier of (a)
the later of April of 2005 or the second anniversary of funding under the loan
or (b) 90 days after first product approval by the FDA (which could be before
the end of 2003). The commercial loan must be repaid in cash. At March 31, 2003
the outstanding balance under this note totaled $3.6 million.

XOMA granted Genentech a security interest in the Company's profit
share on Raptiva(TM) as collateral against any unpaid past due amounts of the
loans.

-9-


XOMA Ltd.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)
(Unaudited)

5. SUBSEQUENT EVENTS

On May 12, 2003, XOMA and Genentech announced their decision to
terminate Phase II testing of Raptiva(TM) in patients with moderate-to-severe
rheumatoid arthritis based on an evaluation by an independent Data Safety
Monitoring Board that suggested no overall net clinical benefit in patients
receiving the study drug.

On May 6, 2003, 363,466 shares of MorphoSys were issued to XOMA as
payment for the second installment of $4.0 million due under the terms of the
license agreement entered into in February 2002. Those shares will be classified
as available-for-sale. Since the date of MorphoSys' election on October 23,
2002, the per share closing price for MorphoSys shares has ranged from
approximately $4.64 to $15.20. On the date of issuance, the net fair market
value of the shares approximated $4.0 million.



-10-



ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

Results of Operations

Revenues for the three months ended March 31, 2003 were $3.2 million, a
66% decrease compared with $9.2 million for the three months ended March 31,
2002. The decrease was primarily due to a non-recurring $5.0 million license fee
from MorphoSys AG in the first quarter of 2002. Also, in the first quarter of
2003, contract revenue was lower by $1.0 million compared to the first quarter
of 2002. This decrease was primarily related to lower development services from
Onyx Pharmaceuticals, Inc.

Research and development expenses for the three months ended March 31,
2003 increased to $12.0 million, or by 21%, from $9.9 million for the three
months ended March 31, 2002. Spending in the three months ended March 31, 2003
reflected increased development costs associated with Raptiva(TM) (Efalizumab,
formerly Xanelim(TM)), MLN01, and CAB-2. The increase was partially offset by
decreased spending on ONYX-015 and NEUPREX(R).

Our research and development activities can be divided into earlier
stage programs, which include molecular biology, process development,
pilot-scale production and preclinical testing, and later stage programs, which
include clinical testing, regulatory affairs and manufacturing clinical
supplies. The cost associated with these programs approximate the following (in
thousands):

Three Months Ended March
31,
---------------------------
2003 2002
-------------- ------------
Earlier stage programs $ 7,199 $ 4,664
Later stage programs 4,783 5,271
-------------- ------------
Total $ 11,982 $ 9,935
============== ============

Our research and development activities also can be divided into those
related to our internal projects and those related to collaborative
arrangements. The cost related to internal projects versus collaborative
arrangements approximate the following (in thousands):

Three Months Ended March
31,
---------------------------
2003 2002
-------------- ------------
Internal projects $ 4,422 $ 4,960
Collaborative arrangements 7,560 4,975
-------------- ------------
Total $ 11,982 $ 9,935
============== ============

For the three months ended March 31, 2003, one project accounted for
approximately 25% of our total research and development costs. No other single
project was greater than 20% of our total research and development costs during
the three months ended March 31, 2003 and 2002.

Marketing, general and administrative expenses for the three months
ended March 31, 2003 decreased to $3.9 million, or 19%, from $4.8 million for
the three months ended March 31, 2002. The most significant component of this
decrease was legal expenses related primarily to our litigation against Biosite
Incorporated and certain shareholder litigation. The litigation matters to which
these expenses related have been settled or otherwise resolved. The three months
ended March 31, 2003 and 2002 also included expenses related to pre-launch
activities for Raptiva(TM). These expenses are expected to continue at similar
or higher levels until the product launch date.

-11-


Investment income for the three months ended March 31, 2003 decreased
to $0.1 million, or 58%, compared to $0.3 million for the three months ended
March 31, 2002 due to lower interest rates and lower average cash balances.
Interest expense for the three months ended March 31, 2003 decreased to $0.5
million, or 25%, compared to $0.6 million for the three months ended March 31,
2002. This decrease reflected lower interest rates on a higher average
outstanding balance of the convertible notes due to Genentech and Millennium.
Interest expense for the remainder of 2003 is expected to increase due to
anticipated higher development and commercial loan balances due to Genentech.

On March 31, 2003, XOMA had not received from MorphoSys the 363,466
ordinary shares issued by MorphoSys in settlement of its $4.0 million obligation
to XOMA arising from our 2002 license agreement. On May 6, 2003, the shares were
issued to XOMA. These shares will be classified as available-for-sale. Since the
date of MorphoSys' election on October 23, 2002, the per share closing price for
MorphoSys shares has ranged from approximately $4.64 to $15.20. On the date of
issuance, the net fair market value of the shares approximated $4.0 million. If
the future value of MorphoSys shares results in an unfavorable outcome for XOMA,
the Company's financial position and results of operations would be adversely
impacted.

Liquidity and Capital Resources

Cash, cash equivalents, short-term investments and restricted cash
decreased during the first three months of 2003 by $5.1 million to $33.1 million
at March 31, 2003. The Company's cash, cash equivalents and short-term
investments are expected to decrease through 2003, except to the extent that the
Company may utilize debt funding by Genentech for XOMA's share of Raptiva(TM)
development and marketing costs, obtain additional funding under the terms of
our investment agreement with Millennium, or secure additional sources of
funding.

Net cash used in operating activities was $11.2 million for the three
months ended March 31, 2003, compared with $6.4 million for the three months
ended March 31, 2002. The increase in the first quarter of 2003 when compared
with the first quarter of 2002 primarily reflected a higher net loss and
reductions in accounts payable and accrued expenses related primarily to legal
expenses, partially offset by reductions in accounts receivable from licensing
activities in the first quarter of 2003 compared to increases in the first
quarter of 2002.

Net cash provided by investing activities was $0.6 million for the
three months ended March 31, 2003, compared to cash used in investing activities
of $2.9 million for the three months ended March 31, 2002. The increase in the
first quarter of 2003 when compared to the first quarter of 2002 was primarily
due to restrictions on $1.5 million of cash being released, which was securing
the short-term loan that was paid off during the first quarter of 2003. This
increase was offset by $0.9 million in purchases of property and equipment
during the first quarter of 2003 compared to $2.9 million during the first
quarter of 2002. Capital programs in 2002 included renovating and expanding our
manufacturing and warehouse facilities and other infrastructure investments.
Capital spending is expected to continue at this lower level for the remainder
of 2003.

Net cash provided by financing activities was $7.0 million for the
three months ended March 31, 2003, compared with $0.1 million for the three
months ended March 31, 2002. The increase in the first quarter of 2003 when
compared to the first quarter of 2002 primarily consisted of $7.8 million net
funding from Genentech under our development agreement. This was offset by a
principal payment of $0.8 million, which paid off our short-term loan
obligation.

In the first quarter of 2003 the Company's financing arrangement with
Genentech related to development and commercialization of Raptiva(TM) was
modified to provide the following terms:

The credit limit under the convertible subordinated debt agreement was
increased to $80.0 million to finance XOMA's share of development costs. The
loan is due upon the earlier of (a) the later of April of 2005 or the second
anniversary of funding under the loan or (b) within 90 days after first product
approval (which could be before the end of 2003). At XOMA's election, the loan
may be repaid in cash or stock. If repayment is triggered by

-12-


product approval, XOMA may elect to defer payment of up to $40.0 million as an
offset against the Company's proceeds from its 25% share of U.S. operating
profits on the product. At March 31, 2003, the outstanding balance under this
note totaled $67.4 million.

A new $15.0 million loan facility was established to finance XOMA's
share of U.S. commercialization costs. The loan is due upon the earlier of (a)
the later of April of 2005 or the second anniversary of funding under the loan
or (b) 90 days after first product approval by the FDA (which could be before
the end of 2003). The commercial loan must be repaid in cash. At March 31, 2003
the outstanding balance under this note totaled $3.6 million.

XOMA granted Genentech a security interest in the Company's profit
share on Raptiva(TM) as collateral against any unpaid past due amounts of the
loans.

The present outlook is for higher losses in 2003 than recorded in 2002,
primarily due to increased expenses on Raptiva(TM) and on the Millennium
collaboration, as well as lower licensing and contract services revenue. The
Company's strategy is to attempt to continue broadening its product pipeline
through additional development collaborations such as its arrangements with
Genentech, Onyx and Millennium. To support these activities, the Company
expanded its manufacturing capacity and other development capabilities during
2001 and 2002. For example, the Company relocated its technical development and
pilot plant facilities from Santa Monica to Berkeley in 2001 to improve
efficiencies. XOMA also installed a third 2750-liter fermentation line in its
Berkeley production facility, which became operational in the second half of
2002.

Based on current spending levels, anticipated revenues, debt financing
provided by Genentech for XOMA's share of Raptiva(TM) development and marketing
costs, and financing commitments from Millennium under the collaborative
agreement between the companies, the Company estimates it has sufficient cash
resources to meet its operating needs through at least the end of 2004. Any
significant revenue shortfalls, or increases in planned spending on development
programs could shorten this period. Any change in spending on Raptiva(TM) prior
to approval should have no impact on liquidity due to the Company's financing
arrangement with Genentech. Approval of Raptiva(TM) during this period would be
expected to improve operating cash flow to the extent of XOMA's share of
operating profits from sales of Raptiva(TM) in the U.S., but require repayment
of amounts owed to Genentech under the financial arrangements discussed above.
Additional licensing arrangements or collaborations or otherwise entering into
new equity or other financing arrangements could extend this period. In December
of 2002, Genentech submitted a BLA to the U.S. Food and Drug Administration for
marketing approval of Raptiva(TM) for the treatment of moderate-to-severe plaque
psoriasis. The timeliness of review of the BLA by the FDA may have a material
impact on the Company's cash flow, and its ability to raise new funding on
acceptable terms. Progress or setbacks by the Company in its other development
programs or by potentially competing companies' products may also affect XOMA's
ability to raise new funding on acceptable terms. For a further discussion of
the risks related to our business and their effects on our cash flow and ability
to raise new funding on acceptable terms, see "Forward-Looking Statements and
Cautionary Factors that May Affect Future Results," included in this Item 2
below.


-13-



As of March 31, 2003, future contractual obligations are as follows (in
thousands):



Note Capital Operating Convertible
Payable* Leases Leases Notes** Total
--------------- ---------------- ------------- ------------- -------------

Remainder

of 2003 $ - $ 421 $ 2,086 $ 5,180 $ 7,687
2004 - 572 2,894 - 3,466
2005 3,562 221 2,890 67,416 74,089
2006 - - 2,900 - 2,900
2007 - - 2,730 - 2,730
Thereafter - - 708 - 708
--------------- ---------------- ------------- ------------- -------------

Total $ 3,562 $ 1,214 $ 14,208 $ 72,596 $ 91,580
=============== ================ ============= ============= =============


* The amount due in 2005 relates to XOMA's commercial loan agreement with
Genenetech. This amount is due at the earlier of (a) the later of April of 2005
or the second anniversary of funding under the loans or (b) 90 days after first
product approval (which could be before the end of 2003).

** The amount due in 2005 relates to XOMA's convertible subordinated debt
agreement with Genentech. This amount is due at the earlier of (a) the later of
April of 2005 or the second anniversary of funding under the loans or (b) within
90 days after the first product approval (which could be before the end of
2003).

Under an effective shelf registration statement filed on November 17,
2000, we registered 10,000,000 common shares, of which 7,000,000 common shares
have not been issued and remain available to be sold from time to time by us. In
addition, pursuant to our agreements with Millennium, we have an effective
registration statement filed on December 12, 2002 covering the resale by
Millennium of up to 5,000,000 common shares we have issued or may issue to
Millennium, and we have issued a total of 1,443,418 shares to Millennium which
may be resold under that registration statement. Pursuant to our arrangement
with Genentech, we have an effective registration statement filed on August 5,
1999 covering the resale by Genentech of up to 2,000,000 common shares we may
issue to Genentech, of which 482,000 have been issued and resold.

Critical Accounting Policies

The preparation of our financial statements in conformity with
accounting principles generally accepted in the United States requires
management to make estimates and assumptions that affect the reported amounts of
assets and liabilities and disclosure of contingent assets and liabilities, if
any, at the date of the financial statements and the reported amounts of
revenues and expenses during the reporting period. Actual results could differ
materially from those estimates. The following critical accounting policies are
important to our financial condition and results of operations presented in the
financial statements and require management to make judgments, assumptions and
estimates that are inherently uncertain:

Revenue Recognition

Revenue is recognized when the related costs are incurred and the four
basic criteria of revenue recognition are met: (1) persuasive evidence of an
arrangement exists; (2) delivery has occurred or services rendered; (3) the fee
is fixed and determinable; and (4) collectibility is reasonably assured.
Determination of criteria (3) and (4) are based on management's judgments
regarding the nature of the fee charged for products or services delivered and
the collectibility of those fees.


-14-



License and Collaborative Fees

Revenue from non-refundable license or technology access payments under
license and collaborative agreements where the Company has a continuing
obligation to perform is recognized as revenue over the period of the continuing
performance obligation.

Milestone payments under collaborative arrangements are recognized as
revenue upon completion of the milestone events, which represent the culmination
of the earnings process because the Company has no future performance
obligations related to the payment. Milestone payments that require a continuing
performance obligation on the part of the Company are recognized over the period
of the continuing performance obligation. Amounts received in advance are
recorded as deferred revenue until the related milestone is completed.

Contract Revenue

Contract revenue for research and development involves the Company
providing research, development or manufacturing services to collaborative
partners. The Company recognizes revenue under these arrangements as the related
research and development costs are incurred and collectibility is reasonably
assured.

Product Sales

The Company recognizes product revenue upon shipment when there is
persuasive evidence that an arrangement exists, delivery has occurred, the price
is fixed and determinable and collectibility is reasonably assured. Allowances
are established for estimated uncollectible amounts, product returns, and
discounts, if any.

Research and Development Expenses

Research and development expenses consist of direct and
research-related allocated overhead costs such as facilities costs, salaries and
related personnel costs and material and supply costs. In addition, research and
development expenses include costs related to clinical trials to validate our
testing processes and procedures and related overhead expenses. From time to
time, research and development expenses may include upfront fees and milestones
paid to collaborative partners for the purchase of rights to in-process research
and development. Such amounts are expensed as incurred. The timing of upfront
fees and milestone payments in the future may cause variability in our future
research and development expenses.

Forward-Looking Statements And Cautionary Factors That May Affect Future Results

Certain statements contained herein related to the relative size of the
Company's loss for 2002 and the first quarter of 2003, the estimated levels of
its expenses and revenues for the balance of 2003, the sufficiency of its cash
resources, existing and potential collaborative and licensing relationships and
current plans for product development including the progress of clinical trials
and the regulatory process, as well as timing of clinical trials and regulatory
filings and approvals or that otherwise relate to future periods, are
forward-looking statements within the meaning of Section 27A of the Securities
Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These
statements are based on assumptions that may not prove accurate. Actual results
could differ materially from those anticipated due to certain risks inherent in
the biotechnology industry and for companies engaged in the development of new
products in a regulated market. Among other things, the actual loss for 2003
could be higher depending on revenues from licensees and collaborators, the size
and timing of expenditures, and whether there are unanticipated expenses. The
sufficiency of cash resources could be shortened if expenditures are made
earlier or in larger amounts than anticipated or are unanticipated or if funds
are not available; and regulatory approvals could be delayed or denied as a
result of safety or efficacy issues regarding the products being tested, action,
inaction or delay by the FDA, European or other regulators, or issues relating
to analysis, interpretation or submission of scientific data. These and other
risks, including those related to changes in the status of existing
collaborative relationships, availability of additional licensing or
collaboration opportunities, the timing or results of pending and future
clinical trials, the ability of collaborators and other partners to meet their
obligations, market demand for products, actions by the Food and Drug
Administration or the U.S. Patent and Trademark Office, scale-up and marketing
capabilities, competition, international operations, share price volatility, the
Company's financing needs and opportunities

-15-


uncertainties regarding the status of biotechnology patents, uncertainties as to
the costs of protecting intellectual property, and risks associated with our
status as a Bermuda company are described in more detail in the remainder of
this section.

None Of Our Therapeutic Products Have Received Regulatory Approval. If Our
Products Do Not Receive Regulatory Approval, Neither Our Third Party
Collaborators Nor We Will Be Able To Manufacture And Market Them.

Even our most advanced therapeutic product has not received regulatory
approval. Our products cannot be manufactured and marketed in the United States
and other countries without required regulatory approvals. The United States
government and governments of other countries extensively regulate many aspects
of our products, including:

o testing,

o manufacturing,

o promotion and marketing, and

o exporting.

In the United States, the FDA regulates pharmaceutical products under
the Federal Food, Drug, and Cosmetic Act and other laws, including, in the case
of biologics, the Public Health Service Act. At the present time, we believe
that our products will be regulated by the FDA as biologics. The FDA has
announced that it is consolidating its responsibility for reviewing new
pharmaceutical products into its Center for Drug Evaluation and Research, the
body that currently reviews drug products, combining that operation with part of
its biologics review operation, the Center for Biologics Evaluation and
Research. Because implementation of this plan may not be complete, we do not
know when or how this change will affect us. State regulations may also affect
our proposed products.

The FDA has substantial discretion in both the product approval process
and manufacturing facility approval process and, as a result of this discretion
and uncertainties about outcomes of testing, we cannot predict at what point, or
whether, the FDA will be satisfied with our or our collaborators' submissions or
whether the FDA will raise questions which may be material and delay or preclude
product approval or manufacturing facility approval. As we accumulate additional
clinical data, we will submit it to the FDA, which may have a material impact on
the FDA product approval process.

Our potential products will require significant additional research and
development, extensive preclinical studies and clinical trials and regulatory
approval prior to any commercial sales. This process is lengthy, often taking a
number of years, and expensive. As clinical results are frequently susceptible
to varying interpretations that may delay, limit or prevent regulatory
approvals, the length of time necessary to complete clinical trials and to
submit an application for marketing approval for a final decision by a
regulatory authority varies significantly. As a result, it is uncertain whether:

o our future filings will be delayed,

o our studies will be successful,

o we will be able to provide necessary additional data,

o our future results will justify further development, or

o we will ultimately achieve regulatory approval for any of these
products.

-16-


For example,

o in 1996, we and Genentech began testing Raptiva(TM) (Efalizumab,
formerly Xanelim(TM)) in patients with moderate-to-severe psoriasis.
In April of 2002, we and Genentech announced that a pharmacokinetic
study conducted on Raptiva(TM) comparing XOMA-produced material and
Genentech-produced material did not achieve the pre-defined
statistical definition of comparability, and the FDA requested that
another Phase III study be completed before the filing of a Biologics
License Application for Raptiva(TM), delaying the filing of a
Biologics Licensing Application with the FDA for Raptiva(TM) beyond
the previously-planned time frame of summer 2002. In September of
2002, we and Genentech announced the results of the additional Phase
III study which achieved its primary efficacy endpoint. In December of
2002, Genentech submitted a Biologics License Application for
Raptiva(TM) for the treatment of moderate-to-severe plaque psoriasis,
which was accepted by the FDA in February of 2003. Genentech has
projected a 10-month regulatory review period, which could potentially
lead to FDA action in late 2003. However, we do not yet know what
issues the FDA may raise with respect to efficacy or safety of the
drug or other elements of the application. In March 2003, we announced
completion of enrollment in a Phase II study of Raptiva(TM) in
patients suffering from rheumatoid arthritis. In May of 2003, we and
Genentech announced our decision to terminate Phase II testing of
Raptiva(TM) in patients suffering from rheumatoid arthritis based on
an evaluation by an independent Data Safety Monitoring Board that
suggested no overall net clinical benefit in patients receiving the
study drug. We have also announced the initiation of enrollment in a
Phase II study of Raptiva(TM) as a possible treatment for patients
with psoriatic arthritis. We do not know whether or when any such
testing will demonstrate product safety and efficacy in these patient
populations or result in regulatory approval.

o in December of 1992, we began human testing of our NEUPREX(R) product,
a genetically engineered fragment of a particular human protein, and
have licensed certain worldwide rights to Baxter. In April of 2000,
members of the FDA and representatives of XOMA and Baxter discussed
results from the Phase III trial that tested NEUPREX(R) in pediatric
patients with a potentially deadly bacterial infection called
meningococcemia, and senior representatives of the FDA indicated that
the data presented were not sufficient to support the filing of an
application for marketing approval at that time. Because neither
Baxter nor we have generated any additional data or completed any
further analysis, we do not know whether we will be able to supply
such additional data. If we conduct an additional trial to provide the
requested additional data, we will not know whether the results will
be adequate for approval until the trial has been completed and the
resulting data reviewed by the FDA. In November of 2002, Baxter
completed enrollment in a small Phase II study with NEUPREX(R) in
Crohn's disease patients, but because we do not know the results, we
do not know whether the results will justify further development.

Given that regulatory review is an interactive and continuous process,
we maintain a policy of limiting announcements and comments upon the specific
details of the ongoing regulatory review of our products, subject to our
obligations under the securities laws, until definitive action is taken.

Because All Of Our Products Are Still In Development, We Will Require
Substantial Funds To Continue; We Cannot Be Certain That Funds Will Be Available
And, If Not Available, We May Have To Take Actions Which Could Adversely Affect
Your Investment.

If adequate funds are not available, we may have to dilute or otherwise
adversely affect the rights of existing shareholders, curtail or cease
operations or, in extreme circumstances, file for bankruptcy protection. We have
spent, and we expect to continue to spend, substantial funds in connection with:

o research and development relating to our products and production
technologies

o expansion of our production capabilities

o extensive human clinical trials and

o protection of our intellectual property.

-17-


Based on current spending levels, anticipated revenues, debt financing
provided by Genentech for our share of Raptiva(TM) development and marketing
costs, and financing commitments from Millennium under the collaborative
agreement between the companies, we estimate we have sufficient cash resources
to meet our operating needs through at least the end of 2004. However, to the
extent we experience changes in the timing or size of expenditures or
unanticipated expenditures, or if our collaborators do not meet their
obligations to us or anticipated revenues otherwise do not materialize, these
funds may not be adequate for this period. As a result, we do not know whether:

o operations will generate meaningful funds

o additional agreements for product development funding can be reached

o strategic alliances can be negotiated or

o adequate additional financing will be available for us to finance our
own development on acceptable terms, if at all.

Cash balances and operating cash flow are influenced primarily by the
timing and level of payments by our licensees and development partners, as well
as by our operating costs.

Specifically, although changes in spending on Raptiva(TM) should not
impact liquidity due to our financing arrangements with Genentech and FDA
approval of Raptiva(TM) would generally be expected to improve operating cash
flow to the extent of XOMA's share of opertaing profits from sales of
Raptiva(TM) in the U.S., such approval will also require repayment in cash,
shares or deferred repayment of up to $40.0 million of amounts owed to Genentech
(approximately $71.0 million under both loan agreements as of March 31, 2003).
In addition, any delays in the review by the FDA of the Biologics License
Application for Raptiva(TM) may have a material impact on our cash flow and on
our ability to raise new funding on acceptable terms.

The Financial Terms Of Some Of Our Existing Collaborative Arrangements Could
Result In Dilution Of Our Share Value.

We have financed, and anticipate continuing to finance, our most
significant development program, Raptiva(TM), principally by borrowing from
Genentech, and this debt is convertible at XOMA's option into our common shares
with the conversion price to be calculated at the time of conversion. The
outstanding amount of such convertible debt as of March 31, 2003 was
approximately $67.4 million. This debt will come due at the earlier of April of
2005 or within 90 days after first product approval (which could be before the
end of 2003). Unless we secure substantial alternative financing, it is likely
that some or all of this debt, as well as some or all of any convertible debt
issued in the future as part of this financing arrangement, will be converted
into equity when it comes due rather than be repaid in cash, resulting in the
issuance of additional common shares.

Our financing arrangement with Millennium includes a $5.0 million
convertible note we issued to Millennium in November of 2001, which comes due
in May of 2003 and may be converted into common shares at that time. In
addition, we have the option to issue up to $42.5 million worth of common shares
to Millennium over the next 15 months, including the conversion of current
outstanding convertible debt. The total amount issuable in 2003, including debt
conversion, could be $27.5 million. The number of shares to be issued will be
based on a conversion price to be calculated at the time of conversion.

These arrangements, as well as future arrangements we may enter into
with similar effect, could result in dilution in the value of our shares.

Because All Of Our Products Are Still In Development, We Have Sustained Losses
In The Past And We Expect To Sustain Losses In The Future.

We have experienced significant losses and, as of March 31, 2003, we
had an accumulated deficit of $554.0 million.

-18-


For the quarter ended March 31, 2003, we had a net loss of
approximately $13.1 million, or $0.18 per common share (basic and diluted). For
the year ended December 31, 2002, we had a net loss of approximately $33.2
million, or $0.47 per common share (basic and diluted). We expect to incur
additional losses in the future, primarily due to increased expenses on
Raptiva(TM) and on the Millennium collaboration, as well as lower licensing and
contract services revenue.

Our ability to make profits is dependent in large part on obtaining
regulatory approval for our products and entering into agreements for product
development and commercialization, both of which are uncertain. Our ability to
fund our ongoing operations is dependent on the foregoing factors and on our
ability to secure additional funds. Because all of our products are still in
development, we do not know whether we will ever make a profit or whether cash
flow from future operations will be sufficient to meet our needs.

If Third Party Collaborators Do Not Successfully Develop And Market Our
Products, We May Not Be Able To Do So On Our Own.

Our financial resources and our marketing experience and expertise are
limited. Consequently, we depend to a large extent upon securing the financial
resources and marketing capabilities of third parties with whom we collaborate.

o In April of 1996, we and Genentech entered into an agreement whereby
we agreed to co-develop Genentech's humanized monoclonal antibody
product Raptiva(TM). In April of 1999, the companies extended and
expanded the agreement. In March 2003, the Company further expanded
the agreement.

o In January of 2000, we licensed the worldwide rights to all
pharmaceutical compositions containing a particular human protein for
treatment of meningococcemia and additional potential future human
clinical indications to Baxter.

o In January of 2001, we entered into a strategic process development
and manufacturing alliance with Onyx Pharmaceuticals, Inc. pursuant to
which we are scaling up production to commercial volume to manufacture
one of Onyx's cancer products.

o In November of 2001, we entered into a collaboration with Millennium
Pharmaceuticals, Inc. to develop two of Millennium's products for
certain vascular inflammation indications.

Because our collaborators are independent third parties, they may be
subject to different risks than we are and have significant discretion in
determining the efforts and resources they will apply. We do not know whether
Genentech, Baxter, Onyx or Millennium will successfully develop or market any of
the products we are collaborating on.

Specifically, in January of 2003, Onyx announced suspension of
development activities, including manufacturing, related to the product that is
the subject of our alliance, while Onyx seeks a marketing partner for the
product to enable it to reinitiate development, and we are not involved in
assisting Onyx in this process. In addition, plans for further development,
including a potential collaboration with another pharmaceutical company, are
being pursued with Baxter to provide additional resources for development.
Because these efforts are on going, we do not know whether any additional
partners or resources will be found in either of these situations.

In March 2003, the Company announced that it and Baxter would be
seeking an additional partner to bring development resources and expertise to
support NEUPREX(TM) development. There can be no assurance that the companies
will be successful in securing such an additional partner, and if not, this
could have an adverse impact on clinical development activities.

Even when we have a collaborative relationship, other circumstances may
prevent it from resulting in successful development of marketable products. For
example, in June of 1999, we licensed certain genetically engineered fragments
of a particular human protein to Allergan Inc. to treat bacterial ophthalmic
infections. In May of 2000, following successful product testing at Allergan, we
expanded the collaboration. In November of 2000,

-19-


Allergan advised us that for internal economic reasons they planned to
discontinue development of ophthalmic anti-infective products derived from this
protein.

Although we continue to evaluate additional strategic alliances and
potential partnerships, we do not know whether or when any such alliances or
partnerships will be entered into.

Because We Have No History Of Profitability And Because The Biotechnology Sector
Has Been Characterized By Highly Volatile Stock Prices, Announcements We Make
And General Market Conditions For Biotechnology Stocks Could Result In A Sudden
Change In The Value Of Our Common Shares.

As a biopharmaceutical company, we have experienced significant
volatility in our common shares. Fluctuations in our operating results and
general market conditions for biotechnology stocks could have a significant
impact on the volatility of our common share price. From December 31, 2001
through May 12, 2003, our share price has ranged from a high of $12.19 to a low
of $2.84. On May 12, 2003, the last reported sale price of the common shares as
reported on the Nasdaq National Market was $4.72 per share. Factors contributing
to such volatility include, but are not limited to:

o results of preclinical studies and clinical trials

o information relating to the safety or efficacy of our products

o developments regarding regulatory filings

o announcements of new collaborations

o failure to enter into collaborations

o developments in existing collaborations

o our funding requirements and the terms of our financing arrangements

o announcements of technological innovations or new indications for our
therapeutic products

o government regulations

o developments in patent or other proprietary rights

o the number of shares outstanding

o the number of shares trading on an average trading day

o announcements regarding other participants in the biotechnology and
pharmaceutical industries

o market speculation regarding any of the foregoing

Because Many Of The Companies We Do Business With Are Also In The Biotechnology
Sector, The Volatility Of That Sector Can Affect Us Indirectly As Well As
Directly.

The same factors that affect us directly because we are a biotechnology
company can also adversely impact us indirectly by affecting the ability of our
collaborators, partners and others we do business with to meet their obligations
to us or our ability to realize the value of the consideration provided to us by
these other companies. For example, in connection with our licensing transaction
with MorphoSys AG, MorphoSys has announced that it has exercised its option to
pay a portion of the license fee owed to us in the form of equity securities of
MorphoSys. XOMA has only recently received these shares and the future value of
these shares is subject both to market risks affecting our ability to realize
the value of these shares and more generally to the business and other risks to
which

-20-


the issuer of these shares is subject. Since the date of MorphoSys' election on
October 23, 2002, the per share closing price for MorphoSys shares has ranged
from approximately $4.64 to $15.20, which demonstrates the volatility of these
shares in the current market.

If Any Of Our Products Receives Regulatory Approval, We May Not Be Able To
Increase Existing Or Acquire New Manufacturing Capacity Sufficient To Meet
Market Demand.

Because we have never commercially introduced any pharmaceutical
products and none of our products have received regulatory approval, we do not
know whether the capacity of our existing manufacturing facilities can be
increased to produce sufficient quantities of our products to meet market
demand. Also, if we need additional manufacturing facilities to meet market
demand, we cannot predict that we will successfully obtain those facilities
because we do not know whether they will be available on acceptable terms. In
addition, any manufacturing facilities acquired or used to meet market demand
must meet the FDA's quality assurance guidelines.

Because We Do Not And Cannot Currently Market Any Of Our Products For Commercial
Sale, We Do Not Know Whether There Will Be A Viable Market For Our Products.

Even if we receive regulatory approval for our products and we or our
third party collaborators successfully manufacture them, our products may not be
accepted in the marketplace. For example, physicians and/or patients may not
accept a product for a particular indication because it has been biologically
derived (and not discovered and developed by more traditional means) if no
biologically derived products are currently in widespread use in that
indication, as is currently the case with psoriasis. Consequently, we do not
know if physicians or patients will adopt or use our products for their approved
indications.

If Our And Our Partners' Patent Protection For Our Principal Products And
Processes Is Not Enforceable, We May Not Realize Our Profit Potential.

Because of the length of time and the expense associated with bringing
new products to the marketplace, we and our partners hold and are in the process
of applying for a number of patents in the United States and abroad to protect
our products and important processes and also have obtained or have the right to
obtain exclusive licenses to certain patents and applications filed by others.
However, the patent position of biotechnology companies generally is highly
uncertain and involves complex legal and factual questions, and no consistent
policy regarding the breadth of allowed claims has emerged from the actions of
the U.S. Patent and Trademark Office with respect to biotechnology patents.
Legal considerations surrounding the validity of biotechnology patents continue
to be in transition, and historical legal standards surrounding questions of
validity may not continue to be applied, and current defenses as to issued
biotechnology patents may not in fact be considered substantial in the future.
These factors have contributed to uncertainty as to:

o the degree and range of protection any patents will afford against
competitors with similar technologies

o if and when patents will issue

o whether or not others will obtain patents claiming aspects similar to
those covered by our patent applications or

o the extent to which we will be successful in avoiding infringement of
any patents granted to others.

The Patent Office has issued approximately 63 patents to us related to
our products based on human bactericidal permeability-increasing protein, which
we call BPI, including novel compositions, their manufacture, formulation, assay
and use. In addition, we are the exclusive licensee of BPI-related patents and
applications owned by New York University and Incyte Pharmaceuticals Inc. The
Patent Office has also issued nine patents to us related to our bacterial
expression technology.

If certain patents issued to others are upheld or if certain patent
applications filed by others issue and are upheld, we may require licenses from
others in order to develop and commercialize certain potential products


-21-


incorporating our technology or we may become involved in litigation to
determine the proprietary rights of others. These licenses, if required, may not
be available on acceptable terms, and any such litigation may be costly and may
have other adverse effects on our business, such as inhibiting our ability to
compete in the marketplace and absorbing significant management time.

Due to the uncertainties regarding biotechnology patents, we also have
relied and will continue to rely upon trade secrets, know-how and continuing
technological advancement to develop and maintain our competitive position. All
of our employees have signed confidentiality agreements under which they have
agreed not to use or disclose any of our proprietary information. Research and
development contracts and relationships between us and our scientific
consultants and potential customers provide access to aspects of our know-how
that are protected generally under confidentiality agreements. These
confidentiality agreements may not be honored or may not be enforced by a court.
To the extent proprietary information is divulged to competitors or to the
public generally, such disclosure may adversely affect our ability to develop or
commercialize our products by giving others a competitive advantage or by
undermining our patent position.

Protecting Our Intellectual Property Can Be Costly And Expose Us To Risks Of
Counterclaims Against Us.

We may be required to engage in litigation or other proceedings to
protect our intellectual property. The cost to us of this litigation, even if
resolved in our favor, could be substantial. Such litigation could also divert
management's attention and resources. In addition, if this litigation is
resolved against us, our patents may be declared invalid, and we could be held
liable for significant damages. In addition, if the litigation included a claim
of infringement by us of another party's patent that was resolved against us, we
or our collaborators may be enjoined from developing, manufacturing, selling or
importing products, processes or services without a license from the other
party.

Other Companies May Render Some Or All Of Our Products Noncompetitive Or
Obsolete.

Developments by others may render our products or technologies obsolete
or uncompetitive. Technologies developed and utilized by the biotechnology and
pharmaceutical industries are continuously and substantially changing.
Competition in the areas of genetically engineered DNA-based and antibody-based
technologies is intense and expected to increase in the future as a number of
established biotechnology firms and large chemical and pharmaceutical companies
advance in these fields. Many of these competitors may be able to develop
products and processes competitive with or superior to our own for many reasons,
including that they may have:

o significantly greater financial resources

o larger research and development and marketing staffs

o larger production facilities

o entered into arrangements with, or acquired, biotechnology companies
to enhance their capabilities or

o extensive experience in preclinical testing and human clinical trials.

These factors may enable others to develop products and processes
competitive with or superior to our own or those of our collaborators. In
addition, a significant amount of research in biotechnology is being carried out
in universities and other non-profit research organizations. These entities are
becoming increasingly interested in the commercial value of their work and may
become more aggressive in seeking patent protection and licensing arrangements.

Furthermore, positive or negative developments in connection with a
potentially competing product may have an adverse impact on our ability to raise
additional funding on acceptable terms. For example, if another product is
perceived to have a competitive advantage, or another product's failure is
perceived to increase the likelihood that our product will fail, then investors
may choose not to invest in us on terms we would accept or at all.


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Without limiting the foregoing, we are aware that:


o Biogen Inc. has announced that the FDA has approved Amevive(R) to
treat moderate-to-severe chronic plaque psoriasis in adult patients
who are candidates for systematic therapy or phototherapy;

o Centocor Inc., a unit of Johnson & Johnson, has announced that it has
tested its rheumatoid arthritis and Crohn's disease drug, Remicade(R),
in psoriasis showing clinical benefits (and it has been announced that
the drug has shown promising results in patients with psoriatic
arthritis);

o it has been announced that Amgen Inc. tested its rheumatoid arthritis
and psoriatic arthritis drug, Enbrel(R), in a Phase III clinical trial
in patients with moderate-to-severe plaque psoriasis; meeting the
primary endpoint and all secondary endpoints, that the primary and key
secondary endpoints were met in a second Phase III trial, and that
filing for regualtory approval with the U.S. FDA for this medication
is expected in 2003;

o MedImmune, Inc. has completed enrollment in three Phase II trials to
evaluate its anit-T cell monoclonal antibody in psoriasis;

o GenMab A/S has announced that its investigational new drug application
for HuMax-CD4 for psoriasis has been cleared through the FDA to
initiate a Phase II study;

o Abbott Laboratories has announced the commencement of a Phase II
psoriasis trial and Phase III psoriatic arthritis trial of its
rheumatoid arthritis drug Humira(TM); and

o other companies, including Medarex, Inc., are developing monoclonal
antibody or other products for treatment of inflammatory skin
disorders.

A number of companies are developing monoclonal antibodies targeting
cancers, which may prove more effective than ONYX-015 or the ING-1 antibody.

It is possible that one or more other companies may be developing one
or more products based on the same human protein as our NEUPREX(R) product, and
these product(s) may prove to be more effective than NEUPREX(R) or receive
regulatory approval prior to NEUPREX(R) or any BPI-derived ophthalmic product
developed by XOMA.

As We Do More Business Internationally, We Will Be Subject To Additional
Political, Economic And Regulatory Uncertainties.

We may not be able to successfully operate in any foreign market. We
believe that, because the pharmaceutical industry is global in nature,
international activities will be a significant part of our future business
activities and that, when and if we are able to generate income, a substantial
portion of that income will be derived from product sales and other activities
outside the United States. Foreign regulatory agencies often establish standards
different from those in the United States, and an inability to obtain foreign
regulatory approvals on a timely basis could put us at a competitive
disadvantage or make it uneconomical to proceed with a product's development.
International operations may be limited or disrupted by:

o imposition of government controls,

o export license requirements,

o political or economic instability,

o trade restrictions,

o changes in tariffs,

-23-


o restrictions on repatriating profits,

o exchange rate fluctuations,

o withholding and other taxation, and

o difficulties in staffing and managing international operations.

Because We Are A Relatively Small Biopharmaceutical Company With Limited
Resources, We May Not Be Able To Attract And Retain Qualified Personnel, And The
Loss Of Key Personnel Could Delay Or Prevent Achieving Our Objectives.

Our success in developing marketable products and achieving a
competitive position will depend, in part, on our ability to attract and retain
qualified scientific and management personnel, particularly in areas requiring
specific technical, scientific or medical expertise. There is intense
competition for such personnel. Our research, product development and business
efforts would be adversely affected by the loss of one or more of key members of
our scientific or management staff, particularly our executive officers: John L.
Castello, our Chairman of the Board, President and Chief Executive Officer;
Patrick J. Scannon, M.D., Ph.D., our Senior Vice President and Chief Scientific
and Medical Officer; Clarence L. Dellio, our Senior Vice President and Chief
Operating Officer; Peter B. Davis, our Vice President, Finance and Chief
Financial Officer; and Christopher J. Margolin, our Vice President, General
Counsel and Secretary. We have employment agreements with Mr. Castello, Dr.
Scannon and Mr. Davis. We currently have no key person insurance on any of our
employees.

Even If We Bring Products To Market, We May Be Unable To Effectively Price Our
Products Or Obtain Adequate Reimbursement For Sales Of Our Products, Which Would
Prevent Our Products From Becoming Profitable.

If we succeed in bringing our product candidates to the market, they
may not be considered cost-effective, and reimbursement to the patient may not
be available or may not be sufficient to allow us to sell our products on a
competitive basis. In both the United States and elsewhere, sales of medical
products and treatments are dependent, in part, on the availability of
reimbursement to the patient from third-party payors, such as government and
private insurance plans. Third-party payors are increasingly challenging the
prices charged for pharmaceutical products and services. Our business is
affected by the efforts of government and third-party payors to contain or
reduce the cost of health care through various means. In the United States,
there have been and will continue to be a number of federal and state proposals
to implement government controls on pricing. In addition, the emphasis on
managed care in the United States has increased and will continue to increase
the pressure on the pricing of pharmaceutical products. We cannot predict
whether any legislative or regulatory proposals will be adopted or the effect
these proposals or managed care efforts may have on our business.

Because We Engage In Human Testing, We Are Exposed To An Increased Risk Of
Product Liability Claims.

The testing and marketing of medical products entails an inherent risk
of allegations of product liability. We believe that we currently have adequate
levels of insurance for our clinical trials, however, in the event of one or
more large, unforeseen awards, such levels may not provide adequate coverage. We
will seek to obtain additional insurance, if needed, if and when our products
are commercialized; however, because we do not know when this will occur, we do
not know whether adequate insurance coverage will be available or be available
at acceptable costs. A significant product liability claim for which we were not
covered by insurance would have to be paid from cash or other assets. To the
extent we have sufficient insurance coverage, such a claim would result in
higher subsequent insurance rates.

We May Be Subject To Increased Risks Because We Are A Bermuda Company.

Alleged abuses by certain companies that have changed their legal
domicile from jurisdictions within the United States to Bermuda have created an
environment where, notwithstanding that we changed our legal domicile

-24-


in a transaction that was approved by our shareholders and fully taxable to our
company under U.S. law, we may be exposed to various prejudicial actions,
including:

o "blacklisting" of our common shares by certain pension funds;

o legislation restricting certain types of transactions; and

o punitive tax legislation.

We do not know whether any of these things will happen, but if
implemented one or more of them may have an adverse impact on our future
operations or our share price.

If You Were To Obtain A Judgment Against Us, It May Be Difficult To Enforce
Against Us Because We Are A Foreign Entity.

We are a Bermuda company. All or a substantial portion of our assets
may be located outside the United States. As a result, it may be difficult for
shareholders and others to enforce in United States courts judgments obtained
against us. We have irrevocably agreed that we may be served with process with
respect to actions based on offers and sales of securities made hereby in the
United States by serving Christopher J. Margolin, c/o XOMA Ltd., 2910 Seventh
Street, Berkeley, California 94710, our United States agent appointed for that
purpose. We have been advised by our Bermuda counsel, Conyers Dill & Pearman,
that there is doubt as to whether Bermuda courts would enforce judgments of
United States courts obtained in (1) actions against XOMA or our directors and
officers that are predicated upon the civil liability provisions of the U.S.
securities laws or (2) original actions brought in Bermuda against XOMA or such
persons predicated upon the U.S. securities laws. There is no treaty in effect
between the United States and Bermuda providing for such enforcement, and there
are grounds upon which Bermuda courts may not enforce judgments of United States
courts. Certain remedies available under the United States federal securities
laws may not be allowed in Bermuda courts as contrary to that nation's policy.

Our Shareholder Rights Agreement Or Bye-laws May Prevent Transactions That Could
Be Beneficial To Our Shareholders And May Insulate Our Management From Removal.

In February of 2003, we renewed our shareholder rights agreement, which
could make it considerably more difficult or costly for a person or group to
acquire control of XOMA in a transaction that our board of directors opposes.

Our bye-laws:

o require certain procedures to be followed and time periods to be met
for any shareholder to propose matters to be considered at annual
meetings of shareholders, including nominating directors for election
at those meetings;

o authorize our board of directors to issue up to 1,000,000 preference
shares without shareholder approval and to set the rights, preferences
and other designations, including voting rights, of those shares as
the board of directors may determine; and

o contain provisions, similar to those contained in the Delaware General
Corporation Law, that may make business combinations with interested
shareholders more difficult.

These provisions of our shareholders rights agreement and our bye-laws,
alone or in combination with each other, may discourage transactions involving
actual or potential changes of control, including transactions that otherwise
could involve payment of a premium over prevailing market prices to holders of
common shares, could limit the ability of shareholders to approve transactions
that they may deem to be in their best interests, and could make it considerably
more difficult for a potential acquiror to replace management.

-25-


ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Interest Rate Risk

The Company's exposure to market rate risk due to changes in interest
rates relates primarily to the Company's investment portfolio. The Company does
not use derivative financial instruments in its investment portfolio. By policy,
the Company places its investments with high quality debt security issuers,
limits the amount of credit exposure to any one issuer, limits duration by
restricting the term, and holds investments to maturity except under rare
circumstances. The Company classifies its cash equivalents as fixed rate if the
rate of return on an instrument remains fixed over its term. As of March 31,
2003, all the Company's cash equivalents are classified as fixed rate.

The Company also has a long-term convertible note due to Genentech in
2005. Interest on this note of LIBOR plus 1% is reset at the end of June and
December each year and is therefore variable.

The table below presents the amounts and related weighted interest
rates of the Company's cash equivalents at March 31, 2003:

Fair Value



Maturity (in thousands) Average Interest Rate
----------- ----------------- -------------------------


Cash equivalents, fixed rate Daily $ 32,745 1.32%


Other Market Risk

At March 31, 2003, the Company had a long-term convertible note
outstanding which is convertible into common shares based on the market price of
the Company's common shares at the time of conversion. A 10% decrease in the
market price of the Company's common shares would increase the number of shares
issuable upon conversion of either security by approximately 11%. An increase in
the market price of Company common shares of 10% would decrease the shares
issuable by approximately 9%.

ITEM 4. CONTROLS AND PROCEDURES

Under the supervision and with the participation of our management,
including Chairman of the Board, President and Chief Executive Officer and our
Vice President, Finance and Chief Financial Officer, we conducted an evaluation
of our disclosure controls and procedures, as such term is defined under Rule
13a-14(c) promulgated under the Securities Exchange Act of 1934, as amended,
within 90 days of the filing date of this report. Based on this evaluation, our
Chairman of the Board, President and Chief Executive Officer and our Vice
President, Finance and Chief Financial Officer concluded that our disclosure
controls and procedures are effective in timely alerting them to material
information relating to the Company and its consolidated subsidiaries required
to be included in our periodic SEC filings.

There have been no significant changes in our internal controls or in
other factors that could significantly affect these controls subsequent to the
date of the evaluation referenced above.

PART II - OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

None

ITEM 2. CHANGES IN SECURITIES AND USE OF PROCEEDS

The Company continues to use the net proceeds from its June 2001
registered offering of common shares for general corporate purposes, including
leasehold improvements, equipment acquisitions, current research and

-26-


development projects, the development of new products or technologies, general
working capital and operating expenses. Pending application of the net proceeds
as described above, the Company has invested the remaining net proceeds of the
offering in short-term, investment-grade, interest-bearing securities.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

None

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

None

ITEM 5. OTHER INFORMATION

None

ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

Exhibits:

Exhibit 1. Press Release dated April 10, 2003. (1)

Exhibit 2. Amended and Restated Collaboration Agreement, dated March
31, 2003, by and between XOMA (US) LLC and Genentech, Inc.
(with certain confidential information omitted, which
omitted information is the subject of a confidential
treatment request and has been filed separately with the
Securities and Exchange Commission). (2)

Exhibit 3. Amended and Restated Convertible Secured Note Agreement
(Development Loan), dated as of March 31, 2003. (2)

Exhibit 4. Secured Note Agreement (Commercial Launch Loan), dated as of
March 31, 2003. (2)

Exhibit 5. Security Agreement, dated as of March 31, 2003, by and
between XOMA Ltd. and Genentech, Inc. (2)

Exhibit 6. Registration Rights Agreement, dated as of March 31, 2003,
by and between XOMA Ltd. and Genentech, Inc. (2)

-------------------

(1) Incorporated by reference to the referenced exhibit to XOMA's
Current Report on Form 8-K dated and filed April 11, 2003 (File
No. 0-14710).

(2) Incorporated by reference to the referenced exhibit to XOMA's
Amendment No. 1 to Current Report on Form 8-K/A dated and filed
April 18, 2003 (File No. 0-14710).

Reports on Form 8-K:

We did not file any Reports on Form 8-K during the quarter
ended March 31, 2003.


-27-



XOMA Ltd.

SIGNATURES


Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.


XOMA Ltd.

Date: May 15, 2003 By: /s/ JOHN L. CASTELLO
--------------------
John L. Castello
Chairman of the Board, President and
Chief Executive Officer

Date: May 15, 2003 By: /s/ PETER B. DAVIS
------------------
Peter B. Davis
Vice President, Finance and
Chief Financial Officer


CERTIFICATION ACCOMPANYING PERIODIC REPORT

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (18 U.S.Css.1350)

Each of the undersigned officers of XOMA Ltd. (the "Company") hereby certifies
that (1) the Quarterly Report of the Company on Form 10-Q for the period ended
March 31, 2003 (the "Report") fully complies with the requirements of Section 13
(a) or 15 (d) of the Securities Exchange Act of 1934 and (2) the information
contained in the Report fairly presents, in all material respects, the financial
condition and the results of operations of the Company.


XOMA Ltd.

Date: May 15, 2003 By: /s/ JOHN L. CASTELLO
--------------------
John L. Castello
Chairman of the Board, President and
Chief Executive Officer

Date: May 15, 2003 By: /s/ PETER B. DAVIS
------------------
Peter B. Davis
Vice President, Finance and
Chief Financial Officer


-28-




CERTIFICATIONS


I, JOHN L. CASTELLO, certify that:

1. I have reviewed this quarterly report on Form 10-Q of XOMA, Ltd.

2. Based on my knowledge, this quarterly report does not contain any untrue
statement of a material fact or omit to state a material fact necessary to
make the statements made, in light of the circumstances under which such
statements were made, not misleading with respect to the period covered by
this quarterly report.

3. Based on my knowledge, the financial statements, and other financial
information included in this quarterly report, fairly present in all
material respects the financial condition, results of operations and cash
flows of the registrant as of, and for, the periods presented in this
quarterly report.

4. The registrant's other certifying officers and I are responsible for
establishing and maintaining disclosure controls and procedures (as defined
in Exchange Act Rules 13a-14 and 15d-14) for the registrant and we have:

a) designed such disclosure controls and procedures to ensure that
material information relating to the registrant, including its
consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this quarterly
report is being prepared;

b) evaluated the effectiveness of the registrant's disclosure controls
and procedures as of a date within 90 days prior to the filing date of
this quarterly report (the "Evaluation Date"); and

c) presented in this quarterly report our conclusions about the
effectiveness of the disclosure controls and procedures based on our
evaluation as of the Evaluation Date.

5. The registrant's other certifying officers and I have disclosed, based on
our most recent evaluation, to the registrant's auditors and the audit
committee of the registrant's board of directors (or persons performing the
equivalent function):

a) all significant deficiencies in the design or operation of internal
controls which could adversely affect the registrant's ability to
record, process, summarize and report financial data and have
identified for the registrant's auditors any material weaknesses in
internal controls; and

b) any fraud, whether or not material, that involves management or other
employees who have a significant role in the registrant's internal
controls.

6. The registrant's other certifying officers and I have indicated in this
quarterly report whether or not there were significant changes in internal
controls or in other factors that could significantly affect internal
controls subsequent to the date of our most recent evaluation, including
any corrective actions with regard to significant deficiencies and material
weaknesses.

Date: May 15, 2003 By: /s/ JOHN L. CASTELLO
--------------------

John L. Castello
Chairman of the Board, President and
Chief Executive Officer


-29-





I, PETER B. DAVIS, certify that:

1. I have reviewed this quarterly report on Form 10-Q of XOMA, Ltd.

2. Based on my knowledge, this quarterly report does not contain any untrue
statement of a material fact or omit to state a material fact necessary to
make the statements made, in light of the circumstances under which such
statements were made, not misleading with respect to the period covered by
this quarterly report.

3. Based on my knowledge, the financial statements, and other financial
information included in this quarterly report, fairly present in all
material respects the financial condition, results of operations and cash
flows of the registrant as of, and for, the periods presented in this
quarterly report.

4. The registrant's other certifying officers and I are responsible for
establishing and maintaining disclosure controls and procedures (as defined
in Exchange Act Rules 13a-14 and 15d-14) for the registrant and we have:

a) designed such disclosure controls and procedures to ensure that
material information relating to the registrant, including its
consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this quarterly
report is being prepared;

b) evaluated the effectiveness of the registrant's disclosure controls
and procedures as of a date within 90 days prior to the filing date of
this quarterly report (the "Evaluation Date"); and

c) presented in this quarterly report our conclusions about the
effectiveness of the disclosure controls and procedures based on our
evaluation as of the Evaluation Date.

5. The registrant's other certifying officers and I have disclosed, based on
our most recent evaluation, to the registrant's auditors and the audit
committee of the registrant's board of directors (or persons performing the
equivalent function):

a) all significant deficiencies in the design or operation of internal
controls which could adversely affect the registrant's ability to
record, process, summarize and report financial data and have
identified for the registrant's auditors any material weaknesses in
internal controls; and

b) any fraud, whether or not material, that involves management or other
employees who have a significant role in the registrant's internal
controls.

6. The registrant's other certifying officers and I have indicated in this
quarterly report whether or not there were significant changes in internal
controls or in other factors that could significantly affect internal
controls subsequent to the date of our most recent evaluation, including
any corrective actions with regard to significant deficiencies and material
weaknesses.

Date: May 15, 2003 By: /s/ PETER B. DAVIS
------------------

Peter B. Davis
Vice President, Finance and
Chief Financial Officer




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